Translational Vision Science & Technology最新文献

{"title":"Choroidal and Choriocapillaris OCT-A Analysis in Patients Affected by Active Central Serous Chorioretinopathy.","authors":"Maria Ludovica Ruggeri, Marzia Passamonti, Alberto Quarta, Olgers Koci, Annamaria Porreca, Marta Di Nicola, Lucio Zeppa, Rodolfo Mastropasqua, Lisa Toto","doi":"10.1167/tvst.13.12.14","DOIUrl":"10.1167/tvst.13.12.14","url":null,"abstract":"<p><strong>Purpose: </strong>To analyze choroidal and choriocapillaris changes in eyes affected by active unilateral central serous chorioretinopathy (CSC).</p><p><strong>Methods: </strong>A total of 17 eyes suffering from naïve CSC were enrolled. In addition, 17 healthy fellow eyes were analyzed, and 10 eyes were enrolled as controls. Main outcome measures were choroidal vascularity index (CVI), best-corrected visual acuity (BCVA), central macular thickness (CMT), subfoveal choroidal thickness (SFCT), and pigment epithelial detachment (PED) presence and maximum height (PED-MH). In addition, choriocapillaris and choroidal flow analysis in the two concentric areas surrounding the fovea were analyzed.</p><p><strong>Results: </strong>CCT was higher in affected eyes than healthy ones (P = 0.007). CVI was significantly higher in affected eyes (P = 0.027) and in fellow eyes (P = 0.027) compared to healthy. The choriocapillaris analysis showed interesting results in the first ring, with statistically significant differences between diseased eyes and fellow eyes and in diseased eyes compared to healthy ones. Besides, in the second ring analysis a lower flow in choriocapillaris was found in diseased eyes compared with healthy (P = 0.019). The choroidal flow analysis showed lower flow in affected eyes in the first and second ring when comparing diseased eyes with healthy controls (P = 0.006).</p><p><strong>Conclusions: </strong>Choroidal and choriocapillaris flow abnormalities occur in both eyes affected by CSC and fellow eyes with different trends depending on the area of study reinforcing the key role of choroid and choriocapillaris in the pathogenesis of disease.</p><p><strong>Translational relevance: </strong>Understanding choroidal and choriocapillaris flow abnormalities in CSC eyes could give us new biomarkers able to monitor disease.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"13 12","pages":"14"},"PeriodicalIF":2.6,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11636658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Five-Year Incidence of Age-Related Macular Degeneration and Its Risk Factors in Adult Chinese Population: The Tongren Health Care Study.","authors":"Ying Cui, Jing Cui, Can Can Xue, Yu Mao, Jost B Jonas, Ya Xing Wang, Dong Ning Chen","doi":"10.1167/tvst.13.12.10","DOIUrl":"10.1167/tvst.13.12.10","url":null,"abstract":"<p><strong>Purpose: </strong>To examine the 5-year incidence of age-related macular degeneration (AMD) and its associated factors in an adult Chinese population.</p><p><strong>Methods: </strong>The Tongren Health Care Study included individuals attending regular health care check-up examinations in the Beijing Tongren Hospital. Baseline examinations were performed from 2014 to 2015, with 5-year follow-up examinations conducted between 2019 and 2020. Fundus photographs were graded according to the Beckman Initiative guidelines.</p><p><strong>Results: </strong>A total of 5658 participants with gradable photographs at both examinations were included in the study, comprising 58.0% women, with a mean age of 54.9 ± 11.0 years. The 5-year incidence of any, early, intermediate, and late AMD were 6.1% (95% confidence interval [CI], 5.5%-6.8%), 5.0% (95% CI, 4.4%-5.6%), 3.4% (95% CI, 2.9%-3.9%), and 0.3% (95% CI, 0.2%-0.4%), respectively. In multivariate analysis, incident early AMD was associated with older age (P < 0.001; odds ratio [OR], 1.04; 95% CI, 1.02-1.06), female sex (P = 0.011; OR, 1.42; 95% CI, 1.08-1.86), and a higher estimated glomerular filtration rate (P = 0.020; OR, 1.15; 95% CI, 1.02-1.30), whereas having diabetes was a protective factor (P = 0.019; OR, 0.61; 95% CI, 0.41-0.92). Incident intermediate AMD was associated with older age (P < 0.001; OR, 1.05; 95% CI, 1.04-1.07), a higher high-density lipoprotein cholesterol level (P < 0.001; OR, 1.97; 95% CI, 1.38-2.83) and a lower triglyceride level (P = 0.008; OR, 0.77; 95% CI, 0.64-0.93).</p><p><strong>Conclusions: </strong>A higher estimated glomerular filtration rate level was a risk factor for incident early AMD. A higher high-density lipoprotein cholesterol level and lower triglyceride level were risk factors for incident intermediate AMD. This finding may point to the role of renal circulation and lipid metabolism in incident AMD.</p><p><strong>Translational relevance: </strong>This community-based longitudinal study may provide a valuable understanding of AMD and its associated factors for targeted prevention and management strategies.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"13 12","pages":"10"},"PeriodicalIF":2.6,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eye-Rubbing Detection Tool Using Artificial Intelligence on a Smartwatch in the Management of Keratoconus.","authors":"Ines Drira, Ayoub Louja, Layth Sliman, Vincent Soler, Maha Noor, Abdellah Jamali, Pierre Fournie","doi":"10.1167/tvst.13.12.16","DOIUrl":"10.1167/tvst.13.12.16","url":null,"abstract":"<p><strong>Purpose: </strong>Eye rubbing is considered to play a significant role in the progression of keratoconus and of corneal ectasia following refractive surgery. To our knowledge, no tool performs an objective quantitative evaluation of eye rubbing using a device that is familiar to typical patients. We introduce here an innovative solution for objectively quantifying and preventing eye rubbing. It consists of an application that uses a deep-learning artificial intelligence (AI) algorithm deployed on a smartwatch.</p><p><strong>Methods: </strong>A Samsung Galaxy Watch 4 smartwatch collected motion data from eye rubbing and everyday activities, including readings from the gyroscope, accelerometer, and linear acceleration sensors. The training of the model was carried out using two deep-learning algorithms, long short-term memory (LSTM) and gated recurrent unit (GRU), as well as four machine learning algorithms: random forest, K-nearest neighbors (KNN), support vector machine (SVM), and XGBoost.</p><p><strong>Results: </strong>The model achieved an accuracy of 94%. The developed application could recognize, count, and display the number of eye rubbings carried out. The GRU model and XGBoost algorithm also showed promising performance.</p><p><strong>Conclusions: </strong>Automated detection of eye rubbing by deep-learning AI has been proven to be feasible. This approach could radically improve the management of patients with keratoconus and those undergoing refractive surgery. It could detect and quantify eye rubbing and help to reduce it by sending alerts directly to the patient.</p><p><strong>Translational relevance: </strong>This proof of concept could confirm one of the most prominent paradigms in keratoconus management, the role of abnormal eye rubbing, while providing the means to challenge or even negate it by offering the first automated and objective tool for detecting eye rubbing.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"13 12","pages":"16"},"PeriodicalIF":2.6,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11645754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-Omics Integration With Machine Learning Identified Early Diabetic Retinopathy, Diabetic Macula Edema and Anti-VEGF Treatment Response.","authors":"Yuhui Pang, Chaokun Luo, Qingruo Zhang, Xiongze Zhang, Nanying Liao, Yuying Ji, Lan Mi, Yuhong Gan, Yongyue Su, Feng Wen, Hui Chen","doi":"10.1167/tvst.13.12.23","DOIUrl":"10.1167/tvst.13.12.23","url":null,"abstract":"<p><strong>Purpose: </strong>Identify optimal metabolic features and pathways across diabetic retinopathy (DR) stages, develop risk models to differentiate diabetic macular edema (DME), and predict anti-vascular endothelial growth factor (anti-VEGF) therapy response.</p><p><strong>Methods: </strong>We analyzed 108 aqueous humor samples from 78 type 2 diabetes mellitus patients and 30 healthy controls. Ultra-high-performance liquid chromatography-high-resolution-mass-spectrometry detected lipidomics and metabolomics profiles. DME patients received ≥3 anti-VEGF treatments, categorized into strong and weak response groups. Machine learning (ML) screened prospective metabolic features, developing prediction models.</p><p><strong>Results: </strong>Key metabolic features identified in the metabolomics and lipidomics datasets included n-acetyl isoleucine (odds ratio [OR] = 1.635), cis-aconitic acid (OR = 3.296), and ophthalmic acid (OR = 0.836) for DR. For early-DR, n-acetyl isoleucine (OR = 1.791) and decaethylene glycol (PEG-10) (OR = 0.170) were identified as key markers. L-kynurenine (OR = 0.875), niacinamide (OR = 0.843), and linoleoyl ethanolamine (OR = 0.941) were identified as significant indicators for DME. Trigonelline (OR = 1.441) and 4-methylcatechol-2-sulfate (OR = 1.121) emerged as predictors for strong response to anti-VEGF. Predictive models achieved R² values of 99.9%, 97.7%, 93.9%, and 98.4% for DR, early-DR, DME, and strong response groups in the calibration set, respectively, and validated well with R² values of 96.3%, 96.8%, 79.9%, and 96.3%.</p><p><strong>Conclusions: </strong>This research used ML to identify differential metabolic features from metabolomics and lipidomics datasets in DR patients. It implies that metabolic indicators can effectively predict early disease progression and potential weak responders to anti-VEGF therapy in DME eyes.</p><p><strong>Translational relevance: </strong>The identified metabolic indicators may aid in predicting the early progression of DR and optimizing therapeutic strategies for DME.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"13 12","pages":"23"},"PeriodicalIF":2.6,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11645727/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inherited Retinal Degenerations and Non-Neovascular Age-Related Macular Degeneration: Progress and Unmet Needs.","authors":"Jacque L Duncan, Angela Bowman, Amy Laster, Claire Gelfman, David G Birch, Shannon E Boye, Stephen P Daiger, Lucian Del Priore, Donald J Zack, James T Handa","doi":"10.1167/tvst.13.12.28","DOIUrl":"https://doi.org/10.1167/tvst.13.12.28","url":null,"abstract":"<p><p>Inherited retinal degeneration (IRD) disease and age-related macular degeneration (AMD) are leading causes of irreversible vision loss and blindness. Although significant progress has advanced the field in the past 5 years, significant challenges remain. The current article reviews the accomplishments and research advances that have fueled the development of treatments for patients with IRD and AMD, including the first approved gene-augmentation treatment for RPE65-related retinal degeneration and complement inhibition therapies to slow progression of geographic atrophy (GA) in AMD. The article outlines opportunities to address gaps and unmet needs that should lead to additional progress toward the development of treatments for patients with IRDs and non-neovascular AMD in the future.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"13 12","pages":"28"},"PeriodicalIF":2.6,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142839607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visual Quality and Accommodation With Novel Optical Designs for Myopia Control.","authors":"Sara Aissati, Tianlun Zou, Sabyasachi Goswami, Len Zheleznyak, Susana Marcos","doi":"10.1167/tvst.13.12.6","DOIUrl":"10.1167/tvst.13.12.6","url":null,"abstract":"<p><strong>Purpose: </strong>We evaluated through-focus visual performance and accommodative response in young subjects through three segmented multifocal designs for myopia control, mapped on the spatial light modulator of a monocular adaptive optics visual simulator (AOVS), and compared with single vision (SV).</p><p><strong>Methods: </strong>The segmented multifocal patterns included a 4 mm diameter center distance zone and offset peripheral defocus (MP1), astigmatism and coma (MP2), or a combination (MP3). High-contrast logMAR visual acuity (VA) was measured with monochromatic stimuli (555 nm). Ocular aberrations were measured using the Hartmann-Shack aberrometry channel. Measurements were taken for distance viewing and five accommodative demands (AD, up to 4.5 D). Accommodative lag was calculated from the dioptric shift of the maximum retinal image quality metric from the corresponding wave aberrations.</p><p><strong>Results: </strong>Best-corrected logMAR VA was -0.11 ± 0.02 (SV) and slightly reduced by multifocal patterns (-0.08 ± 0.03 [MP1], -0.07 ± 0.04 [MP2], -0.05 ± 0.04 [MP3]). Accommodative lag with SV was lower in emmetropes than myopes (by 0.43D for the largest demand). MP1 significantly decreased accommodative lag in myopes (P = 0.03), unlike MP2 or MP3. Multifocal patterns reduced pupil diameter in myopes at all distances. MP1 improved accommodative response in myopes without compromising distance vision.</p><p><strong>Conclusions: </strong>AOVS helped to understand the interplay of physiological and lens design factors, potentially guiding custom corrections. A center distance with off-centered positive power in the lens periphery could feature suitable properties (peripheral focus and accommodative focus control) for myopia control.</p><p><strong>Translational relevance: </strong>We demonstrate a two-zone contact lens design that provides excellent visual quality and accommodative response, important properties for myopia control lenses.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"13 12","pages":"6"},"PeriodicalIF":2.6,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11622158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Response: Effect of Depth-Dependent Integrated Visual Field on Vision-Related Quality of Life in Glaucoma.","authors":"Andrew Turpin, Allison M McKendrick","doi":"10.1167/tvst.13.12.2","DOIUrl":"10.1167/tvst.13.12.2","url":null,"abstract":"","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"13 12","pages":"2"},"PeriodicalIF":2.6,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11613997/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Strain Response to Intraocular Pressure Increase in the Lamina Cribrosa of Control Subjects and Glaucoma Patients.","authors":"Cameron A Czerpak, Michael Saheb Kashaf, Brandon K Zimmerman, Rebecca Mirville, Nicolas C Gasquet, Harry A Quigley, Thao D Nguyen","doi":"10.1167/tvst.13.12.7","DOIUrl":"10.1167/tvst.13.12.7","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to measure biomechanical strains in the lamina cribrosa (LC) of living human eyes undergoing intraocular pressure (IOP) increase.</p><p><strong>Methods: </strong>Healthy control subjects and patients with glaucoma underwent optical coherence tomographic (OCT) imaging of the LC before and after wearing of swim goggles that increased IOP (57 image pairs, 39 persons). Digital volume correlation was used to measure biomechanical strains in optic nerve head tissue and change in depth of the anterior border of the LC.</p><p><strong>Results: </strong>The mean IOP increase in both glaucoma and control eyes was 7.1 millimeters of mercury (mm Hg) after application of the goggles. Among glaucoma eyes, strains that were significant were: contractile Ezz (average = -0.33%, P = 0.0005), contractile Eθθ (average = -0.23%, P = 0.03), Emax (average = 0.83%, P < 0.0001), and Γmax (average = 0.95%, P < 0.0001), whereas the average anterior LC depth (ALD) decreased by 2.39 µm (anterior; P = 0.0002). In glaucoma eyes, shear strain Ezθ was greater with worse mean deviation (MD) and visual function index (P = 0.044 and P = 0.006, respectively, multivariate models). Strain compliance for Erθ, Ezθ, and Eθθ all increased with greater MD worsening prior to imaging (P = 0.04, P = 0.007, and P = 0.03).</p><p><strong>Conclusions: </strong>LC strains were measurable 20 minutes after IOP increase, producing axial compression and greater peripheral strain than centrally. Some strain compliances were greater with worse existing visual field loss or with more progressive past field loss.</p><p><strong>Translational relevance: </strong>Biomechanical strains are related to measures of glaucoma damage, supporting the hypothesis that optic nerve head biomechanical responses represent a noninvasive biomarker for glaucoma.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"13 12","pages":"7"},"PeriodicalIF":2.6,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11627119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of Bias When Using Early Failure Criteria in Randomized Clinical Trials With Stereoacuity Outcomes.","authors":"Meet Panjwani, Jonathan M Holmes","doi":"10.1167/tvst.13.12.1","DOIUrl":"10.1167/tvst.13.12.1","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to explore the effects of early failure criteria for participants in randomized clinical trials (RCTs) on overall trial conclusions.</p><p><strong>Method: </strong>We simulated 10,000 hypothetical RCTs with 2 treatments, 1 linear improvement and 1 with increasing rate of improvement and 6 follow-up visits. Each RCT had 400 participants, with the same baseline stereoacuity distribution. We incorporated random test-retest noise for every visit, and scores were rounded to the nearest observable score. Early failure was defined as worsening of two or more levels. We compared mean outcome stereoacuity between treatment groups, with and without the failure rule, using the two-sample t-test and the proportion of erroneous RCTs (significantly different mean outcome values, where truth is known to be no different). Sensitivity analyses were performed to explore the influence of sample size, baseline distribution of stereoacuity, overall magnitude of mean improvement, magnitude of change for the failure rule, and distribution of noise.</p><p><strong>Results: </strong>A greater proportion of 10,000 simulated RCTs had an erroneous mean difference in outcome with the early failure rule than without (5.49%, 95% confidence interval [CI] = 5.05% to 5.94% vs. 0, 0%, 95% CI = 0% to 0.000001%, difference 5.49%, P < 0.0001). Sensitivity analysis revealed that increased sample size and wider distribution of noise had the greatest influence on increasing proportions of erroneous RCT conclusions.</p><p><strong>Conclusions: </strong>Study designs incorporating participant-level early failure rules increase the risk of erroneous RCT conclusions and should be avoided.</p><p><strong>Translational relevance: </strong>We provide data informing the design of future clinical trials. Earlier failure rules at the participant level should be avoided.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"13 12","pages":"1"},"PeriodicalIF":2.6,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11614026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of an Open-Source Dataset of Flat-Mounted Images for the Murine Oxygen-Induced Retinopathy Model of Ischemic Retinopathy.","authors":"Kyle V Marra, Jimmy S Chen, Hailey K Robles-Holmes, Kristine B Ly, Joseph Miller, Guoqin Wei, Edith Aguilar, Felicitas Bucher, Yoichi Ideguchi, Fritz Gerald P Kalaw, Andrew C Lin, Napoleone Ferrara, J Peter Campbell, Martin Friedlander, Eric Nudleman","doi":"10.1167/tvst.13.12.4","DOIUrl":"10.1167/tvst.13.12.4","url":null,"abstract":"<p><strong>Purpose: </strong>To describe an open-source dataset of flat-mounted retinal images and vessel segmentations from mice subject to the oxygen-induced retinopathy (OIR) model.</p><p><strong>Methods: </strong>Flat-mounted retinal images from mice killed at postnatal days 12 (P12), P17, and P25 used in prior OIR studies were compiled. Mice subjected to normoxic conditions were killed at P12, P17, and P25, and their retinas were flat-mounted for imaging. Major blood vessels from the OIR images were manually segmented by four graders (JSC, HKR, KBL, JM), with cross-validation performed to ensure similar grading.</p><p><strong>Results: </strong>Overall, 1170 images were included in this dataset. Of these images, 111 were of normoxic mice retina, and 1048 were mice subject to OIR. The majority of images from OIR mice were obtained at P17. The 50 images obtained from an external dataset, OIRSeg, did not have age labels. All images were manually segmented and used in the training or testing of a previously published deep learning algorithm.</p><p><strong>Conclusions: </strong>This is the first open-source dataset of original and segmented flat-mounted retinal images. The dataset has potential applications for expanding the development of generalizable and larger-scale artificial intelligence and analyses for OIR. This dataset is published online and publicly available at dx.doi.org/10.6084/m9.figshare.23690973.</p><p><strong>Translational relevance: </strong>This open access dataset serves as a source of raw data for future research involving big data and artificial intelligence research concerning oxygen-induced retinopathy.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"13 12","pages":"4"},"PeriodicalIF":2.6,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11620014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}