Translational Vision Science & Technology最新文献

{"title":"Development of Deep Learning Models to Screen Posterior Staphylomas in Highly Myopic Eyes Using UWF-OCT Images.","authors":"Yining Wang, Changyu Chen, Ziye Wang, Yijin Wu, Hongshuang Lu, Jianping Xiong, Keigo Sugisawa, Koju Kamoi, Kyoko Ohno-Matsui","doi":"10.1167/tvst.14.6.25","DOIUrl":"10.1167/tvst.14.6.25","url":null,"abstract":"<p><strong>Purpose: </strong>To develop a deep learning (DL) model for screening posterior staphylomas in highly myopic patients using ultra-widefield optical coherence tomography (UWF-OCT) images.</p><p><strong>Methods: </strong>Our retrospective single-center study collected 1428 qualified UWF-OCT images from 438 highly myopic patients between 2017 and 2019 for model development. An independent test dataset for internal validation included 216 images from 69 highly myopic patients obtained between June 2020 and December 2020. Posterior staphylomas were detected by identifying the staphyloma edges. Seven independent architectures (VGG16, VGG19, ResNet18, ResNet50, ResNet101, DenseNet121, and DenseNet161) were used to train the models and identify staphyloma edges. The area under the receiver operating characteristic (ROC) curve (AUC) was used to evaluate and compare the performance of each model.</p><p><strong>Results: </strong>The AUCs of seven DL models ranged from 0.794 (95% confidence interval [CI], 0.708-0.875) to 0.903 (95% CI, 0.846-0.953) for staphyloma edge detection in the internal test dataset. VGG19, with the highest AUC, achieved sensitivity (0.871; 95% CI, 0.773-0.931) that was comparable to or better than those of retina specialists. Heatmaps showed that the DL models could precisely identify the region of staphyloma edges.</p><p><strong>Conclusions: </strong>Our models reliably identified staphyloma edges with high sensitivity and specificity. Given that posterior staphylomas are a key contributor to various fundus complications, the development of DL models holds significant promise for improving the clinical management of highly myopic patients.</p><p><strong>Translational relevance: </strong>This effective artificial intelligence system can help ophthalmologists screen posterior staphylomas in highly myopic eyes.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 6","pages":"25"},"PeriodicalIF":2.6,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12169481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Valproic Acid Application to Modify Post Surgical Fibrosis in a Model of Minimally Invasive Bleb Surgery.","authors":"Phey Feng Lo, Merry Gunawan, Zhu Li Yap, Carol Leong, Fuxuan Kwek, Jayasudha Varadarajan, Xiaomeng Wang, Masaaki Kageyama, Tina T Wong","doi":"10.1167/tvst.14.6.6","DOIUrl":"10.1167/tvst.14.6.6","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate different routes of valproic acid (VPA) administration in modulating various phases of wound healing events after minimally invasive bleb surgery (MIBS).</p><p><strong>Methods: </strong>Thirty New Zealand White rabbits underwent surgical implantation of PRESERFLO MicroShunts. Animals were divided into treatment groups of mitomycin C (MMC) 0.4 mg/mL, MMC 0.1 mg/mL, VPA 1 mg/mL, and VPA 30 mg/mL. Treatments with topical and subconjunctival administration were investigated in the combination groups of low-dose MMC (0.1 mg/mL) and VPA. IOP was measured and slit-lamp photographs were taken weekly. Fibrotic gene expression was analyzed in the bleb by quantitative polymerase chain reaction and western blot. Histology was performed following sacrifice on day 28.</p><p><strong>Results: </strong>Low-dose MMC (0.1 mg/mL) combined with VPA resulted in prolonged bleb survival to day 28. This was associated with reduced collagen 1 and fibronectin gene and protein expression (P < 0.05). There was also a favorable extracellular matrix structure on histological analysis due to the presence of fine immature collagen fibrils surrounding the shunt opening. Intraocular pressure lowering was seen, with a reduction of 20% from baseline IOP until day 14. Both topical and subconjunctival administration of VPA demonstrated similar outcomes, with no overt side effects observed throughout the experimental period at different doses or dosing regimens.</p><p><strong>Conclusions: </strong>VPA is a versatile and effective adjunctive agent that can be used in combination with low-dose MMC to produce favorable bleb characteristics in MIBS.</p><p><strong>Translational relevance: </strong>VPA is both efficacious and safe as an antifibrotic agent, and different routes of administration are available to target different stages of fibrosis after filtration surgery.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 6","pages":"6"},"PeriodicalIF":2.6,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12136099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing Retinal Imaging Interpretation: The Role of Optical Properties and Wavelength Selection.","authors":"Jessica Galvan, Mariana Gouveia Bastos Meirelles, Ricardo Luz Leitão Guerra","doi":"10.1167/tvst.14.6.28","DOIUrl":"10.1167/tvst.14.6.28","url":null,"abstract":"","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 6","pages":"28"},"PeriodicalIF":2.6,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12180599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence Aided Analysis of Anterior Segment Optical Coherence Tomography Imaging to Monitor the Device-Cornea Joint After Synthetic Cornea Implantation.","authors":"Esen Karamursel Akpek, Gavin Li, Anthony J Aldave, Guillermo Amescua, Kathryn A Colby, Maria S Cortina, Jose de la Cruz, Jean-Marie A Parel, Thomas Schmiedel","doi":"10.1167/tvst.14.6.1","DOIUrl":"10.1167/tvst.14.6.1","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to assess the utility of artificial intelligence (AI) assisted analysis of anterior segment optical coherence tomography (AS-OCT) imaging of the device-cornea joint in predicting outcomes of an intrastromal synthetic cornea device in a rabbit model.</p><p><strong>Methods: </strong>Sixteen rabbits underwent intrastromal synthetic cornea implantation. Baseline anterior lamellar thickness was established using AS-OCT intraoperatively. Monthly postoperative clinical examinations and AS-OCT imaging were performed, focusing on the peri-optic zone. A convolutional neural network was trained using a subset of manually marked images to automatically detect anterior lamellar tissue. Images were aligned manually using reference coordinates. The tissue volume data were evaluated as both absolute volume and percentage change from baseline using AI.</p><p><strong>Results: </strong>Sixteen rabbits were observed for 6 (n = 8) and 12 (n = 8) months. Mild focal anterior lamella thinning without retraction was seen near tight sutures in 2 rabbits (2/8) in the 6-month cohort, whereas 2 rabbits (2/8) in the 12-month cohort showed mild focal retraction from the optic stem with thinning. AI-assisted AS-OCT image analyses detected tissue volume reduction up to 3 months before clinical examination, with a reliable threshold of 5% change in tissue volume.</p><p><strong>Conclusions: </strong>AI-assisted AS-OCT can detect peri-prosthetic tissue loss and predicting postoperative complications following an intrastromal synthetic cornea implantation in a rabbit model. Further studies are warranted to explore its clinical utility in human patients.</p><p><strong>Translational relevance: </strong>AI-assisted monitoring of peri-optic corneal tissue volume may be a useful screening modality to detect subclinical thinning after artificial corneal implantation and inform clinical decision making.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 6","pages":"1"},"PeriodicalIF":2.6,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12136127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Applications of Artificial Intelligence for Fuchs Endothelial Corneal Dystrophy: A Systematic Review.","authors":"Siyin Liu, Lynn Kandakji, Aleksander Stupnicki, Dayyanah Sumodhee, Marcello T Leucci, Scott Hau, Shafi Balal, Arthur Okonkwo, Ismail Moghul, Sandor P Kanda, Bruce D Allan, Dan M Gore, Kirithika Muthusamy, Alison J Hardcastle, Alice E Davidson, Petra Liskova, Nikolas Pontikos","doi":"10.1167/tvst.14.6.12","DOIUrl":"10.1167/tvst.14.6.12","url":null,"abstract":"<p><strong>Purpose: </strong>Fuchs endothelial corneal dystrophy (FECD) is a common, age-related cause of visual impairment. This systematic review synthesizes evidence from the literature on artificial intelligence (AI) models developed for the diagnosis and management of FECD.</p><p><strong>Methods: </strong>We conducted a systematic literature search in MEDLINE, PubMed, Web of Science, and Scopus from January 1, 2000, to June 31, 2024. Full-text studies utilizing AI for various clinical contexts of FECD management were included. Data extraction covered model development, predicted outcomes, validation, and model performance metrics. We graded the included studies using the Quality Assessment of Diagnostic Accuracies Studies 2 tool. This review adheres to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations.</p><p><strong>Results: </strong>Nineteen studies were analyzed. Primary AI algorithms applied in FECD diagnosis and management included neural network architectures specialized for computer vision, utilized on confocal or specular microscopy images, or anterior segment optical coherence tomography images. AI was employed in diverse clinical contexts, such as assessing corneal endothelium and edema and predicting post-corneal transplantation graft detachment and survival. Despite many studies reporting promising model performance, a notable limitation was that only three studies performed external validation. Bias introduced by patient selection processes and experimental designs was evident in the included studies.</p><p><strong>Conclusions: </strong>Despite the potential of AI algorithms to enhance FECD diagnosis and prognostication, further work is required to evaluate their real-world applicability and clinical utility.</p><p><strong>Translational relevance: </strong>This review offers critical insights for researchers, clinicians, and policymakers, aiding their understanding of existing AI research in FECD management and guiding future health service strategies.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 6","pages":"12"},"PeriodicalIF":2.6,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12155719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-Dimensional Choroidal Contour Mapping in Healthy and Diseased Eyes.","authors":"Supriya Arora, Sumit Randhir Singh, Sharat Chandra Vupparaboina, Brian Rosario, Mohammed Nasar Ibrahim, Amrish Selvam, Arman Zarnegar, Sanjana Harihar, Vinisha Sant, Jose Alain Sahel, Kiran Kumar Vupparaboina, Jay Chhablani","doi":"10.1167/tvst.14.6.16","DOIUrl":"10.1167/tvst.14.6.16","url":null,"abstract":"<p><strong>Purpose: </strong>Quantitative evaluation of choroidal curvature including choroidal inner boundary (CIB) and choroidal outer boundary (COB) and report a comparison between healthy and diseased eyes.</p><p><strong>Methods: </strong>This retrospective study was conducted on 97 eyes of 97 patients. Eyes were divided into three groups: central serous chorioretinopathy (CSCR), dry age-related macular degeneration (AMD), and healthy eyes. Delineation of CIB and COB was performed using a hybrid method based on our previously validated deep learning and three-dimensional (3D) smoothing methods for choroidal layer segmentation. Quantitative analysis of the surfaces was based on best-fit spherical radius (R). R for overall surface, as well as for each region (central/nasal/temporal/superior/inferior region), was estimated. Statistical analysis was done using SPSS software.</p><p><strong>Results: </strong>There were 35 healthy eyes, 32 eyes with CSCR, and 30 eyes with dry AMD. At CIB and COB; RCSCR > Rhealthy > RAMD (P ≤ 0.001). The central region had the lowest R among all the regions within a group at CIB and COB (P < 0.001) in healthy, CSCR, and AMD eyes. There was moderate positive correlation of R of CIB and COB with subfoveal choroidal thickness in healthy eyes and a negligible/weak correlation in CSCR and AMD eyes.</p><p><strong>Conclusions: </strong>Contour of choroid at CIB and COB was the flattest in CSCR and steepest in AMD. Central region was the steepest among all sectors in both healthy and diseased eyes.</p><p><strong>Translational relevance: </strong>Quantitative study of surface at CIB and COB in diseases helps in understanding the pathophysiological changes and provides a clinical biomarker in disease monitoring and treatment as well.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 6","pages":"16"},"PeriodicalIF":2.6,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12161364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimizing Pupil Size Dependence in Flicker ERG Using Stiles-Crawford Compensation.","authors":"Kumiko Kato, C Quentin Davis, Nooshin Zeinali, Asako Sugawara, Hisashi Matsubara, Masahiko Sugimoto, Yuzen Kashima, Keitaro Mizumoto, Hidetaka Kudo, Eiichiro Nagasaka, Daphne L McCulloch, Mineo Kondo","doi":"10.1167/tvst.14.6.23","DOIUrl":"10.1167/tvst.14.6.23","url":null,"abstract":"<p><strong>Purpose: </strong>This study determined the impact of the Stiles-Crawford effect (SCE) on electroretinograms (ERGs). Compensating for the SCE can improve the diagnostic reliability of ERGs by providing a stimulus minimally affected by pupil size.</p><p><strong>Methods: </strong>Flicker ERGs were recorded from 10 healthy subjects at 3-minute intervals over 21 minutes after mydriasis. The RETeval system adjusted retinal illuminance in real time based on pupil size measurements, using a Troland stimulus and preset SCE compensation factors (ρdevice) of 0, 0.05, 0.085, and 0.12 mm-2.</p><p><strong>Results: </strong>Larger pupil areas led to prolonged implicit times with ρdevice = 0 and 0.05 mm-2, whereas ρdevice = 0.12 mm-2 reduced implicit time. Amplitudes were lower with ρdevice = 0 mm-2 but increased with ρdevice = 0.085 and 0.12 mm-2. The values that minimized pupil size dependence were ρdevice = 0.086 mm-2 for the implicit time of the fundamental component of the ERG and ρdevice = 0.05 mm-2 for all other measures. Variability in ERGs based on pupil size is predicted to be ≤7% of the associated 95% reference interval for Troland stimuli over the range of nonmydriatic pupil sizes, compared to ≤43% for luminance stimuli over the range of mydriatic pupil sizes.</p><p><strong>Conclusions: </strong>Using Troland stimuli with ρdevice = 0.05 mm-2 for all cone-mediated ERGs would minimize the impact of pupil size, although the improvement would be modest for ERGs performed with Troland stimulation without SCE compensation on non-dilated subjects.</p><p><strong>Translational relevance: </strong>Applying the appropriate SCE coefficient (ρdevice) enables more reliable ERG measurements, improving diagnostic accuracy despite pupil size variations in clinical settings.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 6","pages":"23"},"PeriodicalIF":2.6,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12166502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment Efficacy of a Dual Release of Aflibercept and Dexamethasone From a Single Hydrogel Drug Delivery System in a Rodent Model.","authors":"Kayla M Rudeen, Chryssa M Maloney, Katherine L Lydon, Leandro B C Teixeria, William F Mieler, Jennifer J Kang-Mieler","doi":"10.1167/tvst.14.6.31","DOIUrl":"10.1167/tvst.14.6.31","url":null,"abstract":"<p><strong>Purpose: </strong>Age-related macular degeneration (AMD) is the leading cause of vision loss for the elderly population. Wet AMD, which accounts for approximately 15% of AMD cases, is characterized by abnormal blood vessel growth from the choroid into the subretinal space. Although intravitreal anti-vascular endothelial growth factor (VEGF) agents have become the standard of care for wet AMD, there is a growing subset of patients who do not fully respond to monotherapy anti-VEGF treatment. In previously published reports, corticosteroids have shown improvements in treatment efficacy when administered with anti-VEGF in a subset of non-responders to anti-VEGF monotherapy.</p><p><strong>Methods: </strong>A combination dexamethasone and aflibercept drug delivery system (Combo-DDS) was evaluated in a laser-induced rodent model of choroidal neovascularization (CNV). Longitudinal monitoring was done through week 22 using fluorescein angiography (FA) and spectral domain optical coherence tomography (SD-OCT). Multi-Otsu thresholding was used to quantify the lesion area based on late-phase FA images. In addition, preliminary safety and biocompatibility of the Combo-DDS were evaluated by intraocular pressure (IOP) measurements, electroretinogram (ERG), and histology (n = 6 eyes/group).</p><p><strong>Results: </strong>In the laser-induced CNV model, CNV lesions (n = 28-36 lesions/group) were monitored longitudinally. Combo-DDS showed a regression in lesion size starting at week 2 that continued through the end of study. IOP, ERG, and histology showed preliminary safety and biocompatibility of the Combo-DDS.</p><p><strong>Conclusions: </strong>This study demonstrated that Combo-DDS maintained treatment efficacy in a laser-induced CNV rodent model for 6 months.</p><p><strong>Translational relevance: </strong>The Combo-DDS shows the potential to eliminate the need for separate dosing regiments of anti-VEGF and corticosteroids for non-responders to anti-VEGF monotherapy.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 6","pages":"31"},"PeriodicalIF":2.6,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interocular Asymmetry of OCT Retinal Nerve Fiber Layer Values in a Normative Population: The Framingham Heart Study.","authors":"Louay Almidani, Jasdeep Sabharwal, Anoush Shahidzadeh, Ana Collazo Martinez, Shu Jie Ting, Brinda Vaidya, Xuejuan Jiang, Tim Kowalczyk, Alexa Beiser, Lucia Sobrin, Sudha Seshadri, Pradeep Ramulu, Amir H Kashani","doi":"10.1167/tvst.14.6.7","DOIUrl":"10.1167/tvst.14.6.7","url":null,"abstract":"<p><strong>Purpose: </strong>To explore interocular asymmetry in retinal nerve fiber layer (RNFL) thickness using optical coherence tomography (OCT), assess factors that predict this asymmetry, and quantify the 95% central range for OCT-defined average cup-disc ratio (CDR).</p><p><strong>Methods: </strong>Participants from the Framingham Heart Study were included. Interocular differences in OCT parameters were calculated by subtracting left eye values from the right eye. To quantify the range for interocular differences, the percentile distributions were described, with normal ranges established as 2.5th to 97.5th percentiles. Multivariable linear regression models were employed to explore predictors of interocular differences in RNFL thickness.</p><p><strong>Results: </strong>In total, 522 participants were studied with a mean (standard deviation [SD]) age of 74.5 (6.9) years, and most were female (59.4%) and white (88.3%). The mean (SD) peripapillary RNFL thickness was 88.1 (9.7) in the right eye and 87.7 (9.7) in the left eye, with a nonstatistically significant difference (mean [SD], 0.4 [6.1]; P = 0.18). The 2.5th and 97.5th percentiles for the interocular difference in average RNFL were -12.7 µm and 12.7 µm, while that of average CDR was -0.19 and 0.21, respectively. In multivariable models, only differences in rim area (β = 8.06/mm2; P < 0.001) and differences in signal strength (β = 1.37/unit; P < 0.001) were significantly and positively associated with interocular differences in average RNFL thickness.</p><p><strong>Conclusions: </strong>The 95% limits for average RNFL and CDR were within 12.7 microns and 0.2 units, respectively, between eyes.</p><p><strong>Translational relevance: </strong>Comparing OCT RNFL of both eyes may aid in detecting early cases of unilateral/asymmetric glaucoma or other optic nerve-related pathology when used in conjunction with other clinically or biologically relevant findings.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 6","pages":"7"},"PeriodicalIF":2.6,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12136102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144209618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing Myopia Control Effects of Three Different Orthokeratology Lenses and Spectacle Lenses With Highly Aspherical Lenslets in Low Myopia Children.","authors":"Na Li, Luodian Luobu, Bei Du, Weiping Lin, Ruihua Wei","doi":"10.1167/tvst.14.6.27","DOIUrl":"10.1167/tvst.14.6.27","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the effectiveness of three different orthokeratology (OK) lenses and highly aspherical-lenslet spectacle lenses (HAL) for myopia control in young children with low myopia, and to compare the relative corneal refractive power (RCRP) distributions among the three OK lenses with different designs.</p><p><strong>Methods: </strong>This retrospective study involved 166 children aged eight to 11 years with myopia of -0.50 to -3.00 D treated with ProTong OK lenses with aspheric base curve (APOK), ProTong OK lenses with spherical base curve (SPOK), Euclid OK lenses (EOK), HAL, or single-vision spectacle lenses (SVL). Axial length (AL) was measured at baseline and the 12-month visit. Corneal topography was measured for OK wearers to determine the distance from the apex RCRP profile to its three-quarter-peak.</p><p><strong>Results: </strong>The axial elongation for the APOK, SPOK, HAL, EOK, and SVL groups were 0.17 ± 0.14 mm, 0.25 ± 0.17 mm, 0.11 ± 0.15 mm, 0.37 ± 0.12 mm, and 0.45 ± 0.16 mm after 12 months, respectively. Axial elongation was significantly slower for the APOK, SPOK, and HAL groups than for the EOK or SVL groups (all P < 0.05); and it was significantly slower in HAL than in SPOK wearers (P < 0.05). 59.5% and 42.9% of HAL and APOK wearers experienced axial elongation of ≤0.15 mm, respectively. The HAL and APOK, SPOK and APOK, or EOK and SVL groups showed no significant differences in axial elongation. Both SPOK and APOK groups had lower 3/4X values than the EOK group.</p><p><strong>Conclusions: </strong>HAL and APOK wear, relative to EOK or SVL wear, by eight- to 11-year-old children with low myopia led to comparable yet slower axial elongation. APOK and SPOK led to a steeper distribution of the RCRP profile within the pupillary range and yielded better myopia control than EOK.</p><p><strong>Translational relevance: </strong>HAL and APOK are recommended for effective myopia control in children aged eight to 11 years with mild myopia.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 6","pages":"27"},"PeriodicalIF":2.6,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12186544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}