Translational Vision Science & Technology最新文献

{"title":"Identification of Subtypes of Herpetic Anterior Uveitis and Characterization of Their Clinical Features and Visual Outcome in a Chinese Population.","authors":"Hui Liu, Suo Guo, Yaning Liu, Guannan Su, Peizeng Yang","doi":"10.1167/tvst.14.4.2","DOIUrl":"https://doi.org/10.1167/tvst.14.4.2","url":null,"abstract":"<p><strong>Purpose: </strong>To identify the subtypes among patients clinically diagnosed as herpetic anterior uveitis (HAU) and characterize their clinical features and visual prognosis.</p><p><strong>Methods: </strong>Three hundred and seventeen patients were clinically diagnosed as HAU in our department. Aqueous humor (AqH) and serum were collected from 43 of 317 HAU patients during eye surgery. Pathogens were identified using droplet digital polymerase chain reaction and the Goldmann-Witmer coefficient. The AqH levels of 10 inflammatory cytokines were measured. The demographics, clinical features, treatment, and visual prognosis of the subtypes of HAU identified by AqH analysis were analysed.</p><p><strong>Results: </strong>DNA for herpes simplex virus (HSV), varicella-zoster virus (VZV), and cytomegalovirus (CMV) were identified in 13,18 and 12 eyes, respectively. The AqH levels of interleukin-13, interferon-γ, and tumor necrosis factor-α were significantly higher in VZV-AU as compared with HSV-AU and CMV-AU (all P < 0.05). In general, all these three subtypes of HAU had clinical features in common, including mutton-fat keratic precipitates usually toned with pigmentation, iris atrophy, elevated intraocular pressure (IOP), and posterior synechia with pupil pulling appearance unlike that caused by other uveitis. A much higher IOP and poor visual acuity at first visit were more commonly observed in VZV-AU and CMV-AU as compared with HSV-AU (both P < 0.05). A poor visual prognosis was noted in VZV-AU as compared with HSV-AU and CMV-AU (P = 0.010).</p><p><strong>Conclusions: </strong>Our study identified three subtypes of HAU and characterized their clinical features. VZV-AU is frequently associated with much higher IOP and a poor visual prognosis.</p><p><strong>Translational relevance: </strong>We addressed the similarity and difference regarding clinical features and visual prognosis among three subtypes of HAU and also found droplet digital polymerase chain reaction is a sensitive technique for identifying its subtypes throughout the disease course.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 4","pages":"2"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Per- and Polyfluoroalkyl Substance Exposure With Cataract Prevalence Among U.S. Adults: A NHANES Analysis (2005-2008).","authors":"Yuti Liu, Jiazhen Yao, Mingxue Ren, Lingxia Ye, An-Peng Pan, Xu Xu","doi":"10.1167/tvst.14.4.1","DOIUrl":"https://doi.org/10.1167/tvst.14.4.1","url":null,"abstract":"<p><strong>Purpose: </strong>Cataract, a major health concern among the elderly, can be influenced by environmental exposures. This study examines the association between per- and polyfluoroalkyl substance (PFAS) exposure and cataract prevalence.</p><p><strong>Methods: </strong>Six serum PFAS concentrations were detected among 2119 U.S. adults aged 40 years or older based on the National Health and Nutrition Examination Survey. Multivariable models, including weighted logistic regression, weighted quantile sum (WQS) regression, and Bayesian kernel machine regression, were used to assess the association between individual and overall PFAS exposure and cataract prevalence. A mediation analysis was conducted for inflammation biomarkers.</p><p><strong>Results: </strong>Single exposure to perfluorohexane sulfonic acid (PFHS) and perfluorononanoic acid (PFNA) was found to be markedly associated with cataract prevalence after adjustment for covariates (PFHS: odds ratio [OR], 1.579; 95% CI, 1.003-2.514; PFNA: OR, 1.629; 95% CI, 1.065-2.506). The WQS index was significantly associated with cataract (OR, 1.441; 95% CI, 1.130-1.837). PFNA and PFHS were the most influential exposures in the PFAS mixture. In the Bayesian kernel machine regression model, PFNA and PFHS exhibited the highest group posterior inclusion probability, aligning with the WQS results. Moreover, serum albumin and neutrophil counts were found to mediate the relationship between PFHS and cataract, accounting for -26.20% and -5.95% of the mediation effect, respectively.</p><p><strong>Conclusions: </strong>Exposure to PFAS was positively associated with cataract, primarily driven by PFHS and PFNA. Mediation of serum albumin and neutrophil count was observed.</p><p><strong>Translational relevance: </strong>This study links PFAS exposure to cataract prevalence, suggesting reducing exposure could help in cataract prevention.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 4","pages":"1"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Change in Retinal Nerve Fiber Layer Thickness and Intraocular Pressure in Young Adults.","authors":"Samantha Sze-Yee Lee, Gareth Lingham, Alex W Hewitt, David A Mackey","doi":"10.1167/tvst.14.4.3","DOIUrl":"https://doi.org/10.1167/tvst.14.4.3","url":null,"abstract":"<p><strong>Purpose: </strong>Age-related changes in glaucoma endophenotypes have been described thoroughly, yet, there are limited data on the normal age-related changes in young adults. This study profiles the 8-year longitudinal change in peripapillary retinal nerve fiber layer (pRNFL), intraocular pressure (IOP), and central corneal thickness (CCT) in young adults.</p><p><strong>Methods: </strong>A community-based cohort of young adults from the Raine Study underwent eye examinations that included optical coherence tomography of the optic disc, tonometry, and pachymetry when they were 20 and 28 years old. The main outcome measures were the changes in pRNFL thickness, IOP, and CCT over 8 years, adjusted for sex, ethnicity, and other potential confounders.</p><p><strong>Results: </strong>A total of 693, 712, and 680 participants were included in the pRNFL, IOP, and CCT analyses, respectively. Over the 8 years, the global pRNFL reduced from a mean of 100.6 ± 9.3 to 97.9 ± 9.4 µm, at an average rate of 0.27 µm/year (95% confidence interval [CI], 0.24-0.30). Sectoral pRNFL similarly thinned by 0.06 to 0.38 µm/year, but this thinning was not statistically significant at the superotemporal and inferonasal sectors. IOP decreased and CCT increased between 20 and 28 years old, at an average rate of 0.18 mm Hg/year (95% CI, 0.15-0.20) and 0.18 µm/year (95% CI, 0.10-0.27), respectively.</p><p><strong>Conclusions: </strong>During the third decade of life, there is a decrease in pRNFL thickness and IOP in healthy adults.</p><p><strong>Translational relevance: </strong>The current study findings will enable clinicians to differentiate potential pathological change from normal age-related variations in these measures.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 4","pages":"3"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Corneal Biomechanical Changes After Discontinuation of Long-Term Orthokeratology: A 2-Year Prospective Study.","authors":"Hou-Ren Tsai, Jeng-Hung Wang, Cheng-Jen Chiu","doi":"10.1167/tvst.14.4.5","DOIUrl":"https://doi.org/10.1167/tvst.14.4.5","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigated the long-term changes in the corneal biomechanical properties (CBPs) during and shortly after orthokeratology (ortho-k). We further explored the associations between selected CBPs and the effectiveness of ortho-k in mitigating axial elongation in patients with myopia.</p><p><strong>Methods: </strong>This prospective 25-month follow-up study included children ages 8 to 16 years with low to moderate myopia undergoing ortho-k treatment. They underwent 24 months of ortho-k followed by 1-month discontinuation. Their ocular biometric parameters and CBPs were monitored throughout the study. Axial length was measured at baseline, at 1 month, and then every 6 months after ortho-k treatment.</p><p><strong>Results: </strong>Dynamic changes in CBPs were observed during the 24-month ortho-k treatment. Parameters such as the stiffness parameter at the first applanation time (SP-A1), biomechanically corrected intraocular pressure, and Ambrósio's relational horizontal thickness showed initial reductions. After the 1-month discontinuation, most CBPs returned to baseline levels, except biomechanically corrected intraocular pressure and SP-A1. Multiple linear regression analysis revealed that differences in the deformation amplitude ratio or SP-A1 during the initial 2 weeks independently predicted axial elongation at 1 and 2 years after treatment initiation.</p><p><strong>Conclusions: </strong>Long-term ortho-k treatment may lead to sequential variations in CBPs; however, most of these variations may be reversed within 1 month of discontinuation. Further, changes in the deformation amplitude ratio or SP-A1 values during the early stages of treatment may predict subsequent axial elongation.</p><p><strong>Translational relevance: </strong>This study highlights the value of corneal biomechanics in guiding myopia control during orthokeratology treatment in clinical practice.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 4","pages":"5"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Emerging Global Threat of Mycotic Keratitis Caused by Uncommon Fungal Species: A Systematic Review and Meta-Analysis.","authors":"Megha Gautam, Babu Lal, Smita Patel, Rajiv R Mohan, Arivarasan Barathi, Nikita Yadav, Sunil Kumar Verma, Richa Nyodu, Ananyan Sampath, Darshna Koshti, Bhavana Sharma","doi":"10.1167/tvst.14.4.4","DOIUrl":"https://doi.org/10.1167/tvst.14.4.4","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to analyze epidemiological characteristics, clinical spectrum, and treatment outcome of mycotic keratitis (MK) caused by uncommon species.</p><p><strong>Methods: </strong>The systematic review in compliance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines has been registered on \"PROSPERO\" (CRD42023410825), whereas the systematic literature search was conducted on PubMed, Cochrane, Google Scholar, and Semantic Scholar on uncommon MK from January 1963 to March 2023. The main keywords for the literature search comprised: \"mycotic keratitis,\" \"fungal keratitis,\" \"keratomycosis,\" \"oculomycosis,\" \"uncommon,\" \"rare,\" \"emerging,\" \"atypical,\" \"unusual,\" and various combinations of it.</p><p><strong>Results: </strong>The study identified a pool of 13,662 articles. Five hundred sixty-six studies were deemed suitable, and 186 studies met the inclusion criteria to ascertain the pooled prevalence. A total of 154 uncommon fungal species/genera were identified among 61 countries. Australia exhibited the highest pooled prevalence, whereas India reported the maximum number of cases, genera, and species. Clinical presentation varied from mild to severe disease with unequivocal response to standard therapeutic regimes. Microbiologically proven species with reported sensitivity had better visual and structural outcomes.</p><p><strong>Conclusions: </strong>The study provides the first-ever global prevalence estimate of MK caused by uncommon species, estimating 154 fungal genera/species with varying severity, assuming that several culture-negative cases with specific predispositions would also qualify as cases of MK. Microbiologically proven species with reported sensitivity have better visual and structural outcomes. Cases that fail to respond to standard therapy should be re-evaluated for uncommon species with a high index of suspicion. Prompt diagnosis with culture and sensitivity analysis, PCR or in vivo confocal microscopy (IVCM)-based test and timely treatment remain the most important factors in salvaging visual and structural function.</p><p><strong>Translational relevance: </strong>This review catalogues the epidemiological, clinical, and morphological traits of rare fungi implicated in atypical MK and also provides a global prevalence estimate. Further, it emphasizes the role of implementation of specialized diagnostic techniques and collaborative efforts to combat the visual disability stemming from afflictions due to rare or atypical fungal species. Information on continent and country wise prevalence of atypical species would be helpful in appropriate management of such cases, in event of inconclusive diagnosis and consequent suboptimal response to treatment.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 4","pages":"4"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Predictive and Explanatory Power of the Contrast Theory of Myopia.","authors":"Jay Neitz, Maureen Neitz","doi":"10.1167/tvst.14.3.11","DOIUrl":"10.1167/tvst.14.3.11","url":null,"abstract":"","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 3","pages":"11"},"PeriodicalIF":2.6,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Peripheral Defocus Designed Spectacle Lenses Might Increase Astigmatism in Myopic Children.","authors":"Wenyan Xu, Xiaoman Li, Jianing Zhang, Hongyi Li, Xuewen Ding, Xiaoyue Hu, Xinyue Quan, Yue Su, Fan Lu, Jie Chen","doi":"10.1167/tvst.14.3.8","DOIUrl":"10.1167/tvst.14.3.8","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to explore the impact of wearing peripheral defocus spectacle lenses (PDSL) on cylindrical refractive error (CYL) in myopic children.</p><p><strong>Methods: </strong>This study included 1057 myopic children and divided the participants into three groups: the HAL group (spectacle lens with highly aspherical lenslets), the MPV group (spectacle lens based on manipulating peripheral vision), and a control group (without myopia control interventions). The study analyzed the effect of wearing PDSL on changes in spherical equivalent refraction, CYL, and corneal astigmatism (CA). The mediating effect between changes in spherical refractive errors (SPH) and CYL was also investigated.</p><p><strong>Results: </strong>Compared to the control group (0.05 ± 0.33 D), the annual CYL progression was faster in the HAL group (-0.15 ± 0.33 D, P < 0.001) and the MPV group (-0.09 ± 0.27 D, P = 0.019). More children in the HAL group had an annual CYL progression ≥0.50 D (HAL: 23.6%, Control: 16.2%, P = 0.012). The annual CYL and CA progression were consistent within the PDSL groups (HAL: P = 0.677, MPV: P = 0.683). The total effect of CYL progression in the HAL group was primarily due to direct induction from wearing HAL and indirect induction through the SPH control effect.</p><p><strong>Conclusions: </strong>The application of PDSL could cause increase in astigmatism in myopic children, which could mainly be contributed to cornea astigmatism change.</p><p><strong>Translational relevance: </strong>PDSL may passively affect the anterior ocular biomechanics during myopia control, leading to an increase in astigmatism.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 3","pages":"8"},"PeriodicalIF":2.6,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association of Social Determinants of Health on Monitoring for Disease Progression Among Patients With Primary Open-Angle Glaucoma.","authors":"Kunal Kanwar, Rithambara Ramachandran, Joshua D Stein, Chris A Andrews, Azraa S Chaudhury, Maryam Ige, Xueqing Zhou, Shikha Marwah, Yang Li, Charlesnika T Evans, Abel N Kho, Paul J Bryar, Dustin D French","doi":"10.1167/tvst.14.3.15","DOIUrl":"10.1167/tvst.14.3.15","url":null,"abstract":"<p><strong>Purpose: </strong>To examine the association of race, ethnicity, and other social determinants of health (SDH) on receipt of optic nerve (ON) evaluation in accordance with National Quality Forum (NQF) and the American Academy of Ophthalmology (AAO) guideline-based metrics.</p><p><strong>Methods: </strong>This was a retrospective cohort study consisting of 13,582 patients with POAG receiving care across 12 tertiary care health. The odds of receiving ≥1 ON evaluations to monitor for glaucoma progression over 45 months of follow-up was evaluated.</p><p><strong>Results: </strong>White patients (61%) with primary open angle glaucoma (POAG) had more guideline recommended ON evaluations during the 45-month follow-up period, compared with Asian American (52%) and Black (53%) patients (P < 0.001 for both). More non-Hispanic patients with POAG (58%) had ON evaluations in all 3 time periods compared with persons of Latinx ethnicity (52%) (P = 0.045). The odds of undergoing ON evaluations were 17% lower for Black patients compared with White patients (odds ratio [OR] = 0.83; confidence interval [CI], 0.74-0.94), 56% lower for patients living in isolated rural communities (OR = 0.44; CI, 0.25-0.77) compared to urban areas, and 9% lower for patients residing in more impoverished communities (OR = 0.91; CI, 0.86-0.96).</p><p><strong>Conclusions: </strong>Racial and ethnic minorities and those residing in lesser affluent or rural communities are less likely to receive monitoring for POAG progression in accordance with NQF and AAO guidelines.</p><p><strong>Translational relevance: </strong>This study aimed to determine the association between SDH and receiving POAG testing according to clinical practice guidelines, with a goal of identifying factors contributing to disparities in care. This should facilitate development of targeted clinical interventions for vulnerable patients with POAG while factoring technology, economic sustainability, and policy.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 3","pages":"15"},"PeriodicalIF":2.6,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anomaly Detection in Retinal OCT Images With Deep Learning-Based Knowledge Distillation.","authors":"Guilherme Aresta, Teresa Araújo, Ursula Schmidt-Erfurth, Hrvoje Bogunovic","doi":"10.1167/tvst.14.3.26","DOIUrl":"10.1167/tvst.14.3.26","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to develop a robust and general purpose artificial intelligence (AI) system that allows the identification of retinal optical coherence tomography (OCT) volumes with pathomorphological manifestations not present in normal eyes in screening programs and large retrospective studies.</p><p><strong>Methods: </strong>An unsupervised anomaly detection deep learning approach for the screening of retinal OCTs with any pathomorphological manifestations via Teacher-Student knowledge distillation is developed. The system is trained with only normal cases without any additional manual labeling. At test time, it scores how anomalous a sample is and produces localized anomaly maps with regions of interest in a B-scan. Fovea-centered OCT scans acquired with Spectralis (Heidelberg Engineering) were considered. A total of 3358 patients were used for development and testing. The detection performance was evaluated in a large data cohort with different pathologies including diabetic macular edema (DME) and the multiple stages of age-related macular degeneration (AMD) and on external public datasets with various disease biomarkers.</p><p><strong>Results: </strong>The volume-wise anomaly detection receiver operating characteristic (ROC) area under the curve (AUC) was 0.94 ± 0.05 in the test set. Pathological B-scan detection on external datasets varied between 0.81 and 0.87 AUC. Qualitatively, the derived anomaly maps pointed toward diagnostically relevant regions. The behavior of the system across the datasets was similar and consistent.</p><p><strong>Conclusions: </strong>Anomaly detection constitutes a valid complement to supervised systems aimed at improving the success of vision preservation and eye care, and is an important step toward more efficient and generalizable screening tools.</p><p><strong>Translational relevance: </strong>Deep learning approaches can enable an automated and objective screening of a wide range of pathological retinal conditions that deviate from normal appearance.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 3","pages":"26"},"PeriodicalIF":2.6,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measurement of Aqueous Humor Viscosity in an Experimental Rabbit Model With Corneal Neovascularization.","authors":"Dong Eun Kim, Do Young Park, Jong Chul Han","doi":"10.1167/tvst.14.3.9","DOIUrl":"10.1167/tvst.14.3.9","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigated the relationship between aqueous humor (AH) viscosity and vascular endothelial growth factor-A (VEGF-A) in a corneal neovascularization (CNV) model.</p><p><strong>Methods: </strong>Ten female New Zealand rabbits were divided into two groups (n = 5 each). CNV was induced by alkaline burns on the right corneas of group B, whereas group A underwent a sham procedure. After 14 days, at least 150 µL of AH was extracted from both eyes. VEGF-A concentration was measured using ELISA, and AH viscosity was determined using a viscometer. Correlations between VEGF-A concentration, total protein concentration, and AH viscosity were assessed.</p><p><strong>Results: </strong>VEGF-A concentration was significantly elevated in CNV-induced eyes than in noninduced eyes (6029.06 ± 7116.50 pg/mL vs. 115.63 ± 33.19 pg/mL, P < 0.01). Total protein concentration was also elevated in CNV-induced eyes (11.66 ± 9.86 mg/mL) than in noninduced eyes (0.69 ± 0.06 mg/mL, P < 0.01), and correlated positively with VEGF-A (r = 0.84, P < 0.01). AH viscosity was significantly increased in CNV-induced eyes (1.82 ± 1.28 mPa-s) compared to noninduced eyes (1.05 ± 0.01 mPa-s, P < 0.01) and correlated strongly with VEGF-A concentration in CNV-induced eyes (r = 1.00, p = 0.02).</p><p><strong>Conclusions: </strong>AH viscosity positively correlated with VEGF-A concentration, particularly in CNV-induced eyes with elevated VEGF-A levels.</p><p><strong>Translational relevance: </strong>The correlation between VEGF-A levels and AH viscosity in an experimental model of corneal neovascularization suggests that AH viscosity could serve as a biomarker for predicting IOP or surgical outcomes in conditions like neovascular glaucoma.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 3","pages":"9"},"PeriodicalIF":2.6,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}