Comparing Myopia Control Effects of Three Different Orthokeratology Lenses and Spectacle Lenses With Highly Aspherical Lenslets in Low Myopia Children.
Na Li, Luodian Luobu, Bei Du, Weiping Lin, Ruihua Wei
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引用次数: 0
Abstract
Purpose: To compare the effectiveness of three different orthokeratology (OK) lenses and highly aspherical-lenslet spectacle lenses (HAL) for myopia control in young children with low myopia, and to compare the relative corneal refractive power (RCRP) distributions among the three OK lenses with different designs.
Methods: This retrospective study involved 166 children aged eight to 11 years with myopia of -0.50 to -3.00 D treated with ProTong OK lenses with aspheric base curve (APOK), ProTong OK lenses with spherical base curve (SPOK), Euclid OK lenses (EOK), HAL, or single-vision spectacle lenses (SVL). Axial length (AL) was measured at baseline and the 12-month visit. Corneal topography was measured for OK wearers to determine the distance from the apex RCRP profile to its three-quarter-peak.
Results: The axial elongation for the APOK, SPOK, HAL, EOK, and SVL groups were 0.17 ± 0.14 mm, 0.25 ± 0.17 mm, 0.11 ± 0.15 mm, 0.37 ± 0.12 mm, and 0.45 ± 0.16 mm after 12 months, respectively. Axial elongation was significantly slower for the APOK, SPOK, and HAL groups than for the EOK or SVL groups (all P < 0.05); and it was significantly slower in HAL than in SPOK wearers (P < 0.05). 59.5% and 42.9% of HAL and APOK wearers experienced axial elongation of ≤0.15 mm, respectively. The HAL and APOK, SPOK and APOK, or EOK and SVL groups showed no significant differences in axial elongation. Both SPOK and APOK groups had lower 3/4X values than the EOK group.
Conclusions: HAL and APOK wear, relative to EOK or SVL wear, by eight- to 11-year-old children with low myopia led to comparable yet slower axial elongation. APOK and SPOK led to a steeper distribution of the RCRP profile within the pupillary range and yielded better myopia control than EOK.
Translational relevance: HAL and APOK are recommended for effective myopia control in children aged eight to 11 years with mild myopia.
期刊介绍:
Translational Vision Science & Technology (TVST), an official journal of the Association for Research in Vision and Ophthalmology (ARVO), an international organization whose purpose is to advance research worldwide into understanding the visual system and preventing, treating and curing its disorders, is an online, open access, peer-reviewed journal emphasizing multidisciplinary research that bridges the gap between basic research and clinical care. A highly qualified and diverse group of Associate Editors and Editorial Board Members is led by Editor-in-Chief Marco Zarbin, MD, PhD, FARVO.
The journal covers a broad spectrum of work, including but not limited to:
Applications of stem cell technology for regenerative medicine,
Development of new animal models of human diseases,
Tissue bioengineering,
Chemical engineering to improve virus-based gene delivery,
Nanotechnology for drug delivery,
Design and synthesis of artificial extracellular matrices,
Development of a true microsurgical operating environment,
Refining data analysis algorithms to improve in vivo imaging technology,
Results of Phase 1 clinical trials,
Reverse translational ("bedside to bench") research.
TVST seeks manuscripts from scientists and clinicians with diverse backgrounds ranging from basic chemistry to ophthalmic surgery that will advance or change the way we understand and/or treat vision-threatening diseases. TVST encourages the use of color, multimedia, hyperlinks, program code and other digital enhancements.