Translational Vision Science & Technology最新文献

{"title":"Anti-Syndecan 2 Antibody Treatment Reduces Edema Formation and Inflammation of Murine Laser-Induced CNV.","authors":"Federico Corti, Filippo Locri, Flavia Plastino, Paola Perrotta, Krisztina Zsebo, Emma Ristori, Xiangyun Yin, Eric Song, Helder André, Michael Simons","doi":"10.1167/tvst.14.1.10","DOIUrl":"10.1167/tvst.14.1.10","url":null,"abstract":"<p><strong>Purpose: </strong>Alteration of visual acuity in wet age-related macular degeneration (AMD) is mostly driven by vascular endothelial growth factor A (VEGF-A)-induced edema from leaky newly forming blood vessels below the retina layers. To date, all therapies aimed at alleviation of this process have relied on inhibition of VEGF-A activity. Although effective in preventing vascular leak and edema, this approach also leads to the loss of normal vasculature and multiple related side effects.</p><p><strong>Methods: </strong>We have developed an alternative strategy that uses anti-syndecan-2 polyclonal antibody (anti-Sdc2 pAb) to block VEGF-A-induced permeability without interfering with other VEGF-A activities. The effect of anti-Sdc2 pAb therapy was assessed in vitro using a transendothelial electrical resistance (TEER) assay, as well as staining of the endothelial cell junction, and in vivo in the laser-induced choroidal neovascularization (CNV) model.</p><p><strong>Results: </strong>Anti-Sdc2 pAb blocked VEGF-A-induced permeability in vitro, and both local intravitreal injections and systemic intravenous treatments with anti-Sdc2 pAb were as effective as intravitreal anti-VEGF therapy in reducing edema, size of retinal lesions, and local inflammation in this model. Post-injury neovascularization was not affected by treatment with anti-Sdc2 pAb.</p><p><strong>Conclusions: </strong>These findings indicate that anti-Sdc2 pAb therapy can be an effective alternative to anti-VEGF-A approaches for suppression of edema and to prevent retinal lesions in wet neovascular AMD (nAMD).</p><p><strong>Translational relevance: </strong>Intravitreal anti-Sdc2 treatment may avoid side effects observed with the long-term anti-VEGF therapy, and systemic treatment with an anti-Sdc2 pAb antibody can address the issues associated with repeated intravitreal injections.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 1","pages":"10"},"PeriodicalIF":2.6,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11730891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Aqueous Angiopoietin-1/2 Concentrations During the Induction Phase of Intravitreal Faricimab Injections for Diabetic Macular Edema.","authors":"Masahiko Shimura, Shotaro Sasaki, Ryota Nonaka, Ikumi Kashiwagi, Kanako Yasuda, Hidetaka Noma, Hitoshi Takagi","doi":"10.1167/tvst.13.12.35","DOIUrl":"10.1167/tvst.13.12.35","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to investigate the dynamic changes in aqueous concentrations of angiopoietin (Ang)-1/2 and vascular endothelial growth factor (VEGF) during injection in treatment-naïve patients with diabetic macular edema (DME) receiving faricimab during the induction phase (3 consecutive monthly doses) and retrospectively analyze the data.</p><p><strong>Methods: </strong>Thirty-five eyes of 26 patients (age = 63.1 ± 12.9 years) with treatment-naïve DME received faricimab injections monthly, 3 consecutive times. Additionally, 59 eyes of 59 patients (age = 63.9 ± 8.8 years) who underwent cataract surgery were recruited as controls. Aqueous humor samples were collected from each injection or surgery and stored at -80°C, and the concentration of each cytokine was quantified using a multiple enzyme-linked immunosorbent assay (Luminex). The clinical parameters of best-corrected visual acuity (BCVA) and central foveal thickness (CFT) at each visit were also recorded.</p><p><strong>Results: </strong>Three induction phases of faricimab significantly suppressed each aqueous cytokine, rapidly for VEGF, gradually for Ang-2, and slightly for Ang-1. The Ang-1/2 ratio was lower (<1.0) at baseline and gradually increased, but did not reach a control ratio of 1.58. The baseline CFT correlated with VEGF, but not with the Ang-2, Ang-1, or Ang-1/2 ratios. After three injections, CFT did not correlate with VEGF, but it positively correlated with Ang-2 and negatively correlated with Ang-1, and it strongly negatively correlated with the Ang-1/2 ratio.</p><p><strong>Conclusions: </strong>The Ang-1/2 ratio in the aqueous humor significantly negatively correlated with the degree of residual edema after faricimab treatment for DME.</p><p><strong>Translational relevance: </strong>The Ang-1/2 ratio in aqueous humor is thus a useful biomarker of the treatment response for DME.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"13 12","pages":"35"},"PeriodicalIF":2.6,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11681914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142898345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Choroidal and Choriocapillaris OCT-A Analysis in Patients Affected by Active Central Serous Chorioretinopathy.","authors":"Maria Ludovica Ruggeri, Marzia Passamonti, Alberto Quarta, Olgers Koci, Annamaria Porreca, Marta Di Nicola, Lucio Zeppa, Rodolfo Mastropasqua, Lisa Toto","doi":"10.1167/tvst.13.12.14","DOIUrl":"10.1167/tvst.13.12.14","url":null,"abstract":"<p><strong>Purpose: </strong>To analyze choroidal and choriocapillaris changes in eyes affected by active unilateral central serous chorioretinopathy (CSC).</p><p><strong>Methods: </strong>A total of 17 eyes suffering from naïve CSC were enrolled. In addition, 17 healthy fellow eyes were analyzed, and 10 eyes were enrolled as controls. Main outcome measures were choroidal vascularity index (CVI), best-corrected visual acuity (BCVA), central macular thickness (CMT), subfoveal choroidal thickness (SFCT), and pigment epithelial detachment (PED) presence and maximum height (PED-MH). In addition, choriocapillaris and choroidal flow analysis in the two concentric areas surrounding the fovea were analyzed.</p><p><strong>Results: </strong>CCT was higher in affected eyes than healthy ones (P = 0.007). CVI was significantly higher in affected eyes (P = 0.027) and in fellow eyes (P = 0.027) compared to healthy. The choriocapillaris analysis showed interesting results in the first ring, with statistically significant differences between diseased eyes and fellow eyes and in diseased eyes compared to healthy ones. Besides, in the second ring analysis a lower flow in choriocapillaris was found in diseased eyes compared with healthy (P = 0.019). The choroidal flow analysis showed lower flow in affected eyes in the first and second ring when comparing diseased eyes with healthy controls (P = 0.006).</p><p><strong>Conclusions: </strong>Choroidal and choriocapillaris flow abnormalities occur in both eyes affected by CSC and fellow eyes with different trends depending on the area of study reinforcing the key role of choroid and choriocapillaris in the pathogenesis of disease.</p><p><strong>Translational relevance: </strong>Understanding choroidal and choriocapillaris flow abnormalities in CSC eyes could give us new biomarkers able to monitor disease.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"13 12","pages":"14"},"PeriodicalIF":2.6,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11636658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Five-Year Incidence of Age-Related Macular Degeneration and Its Risk Factors in Adult Chinese Population: The Tongren Health Care Study.","authors":"Ying Cui, Jing Cui, Can Can Xue, Yu Mao, Jost B Jonas, Ya Xing Wang, Dong Ning Chen","doi":"10.1167/tvst.13.12.10","DOIUrl":"10.1167/tvst.13.12.10","url":null,"abstract":"<p><strong>Purpose: </strong>To examine the 5-year incidence of age-related macular degeneration (AMD) and its associated factors in an adult Chinese population.</p><p><strong>Methods: </strong>The Tongren Health Care Study included individuals attending regular health care check-up examinations in the Beijing Tongren Hospital. Baseline examinations were performed from 2014 to 2015, with 5-year follow-up examinations conducted between 2019 and 2020. Fundus photographs were graded according to the Beckman Initiative guidelines.</p><p><strong>Results: </strong>A total of 5658 participants with gradable photographs at both examinations were included in the study, comprising 58.0% women, with a mean age of 54.9 ± 11.0 years. The 5-year incidence of any, early, intermediate, and late AMD were 6.1% (95% confidence interval [CI], 5.5%-6.8%), 5.0% (95% CI, 4.4%-5.6%), 3.4% (95% CI, 2.9%-3.9%), and 0.3% (95% CI, 0.2%-0.4%), respectively. In multivariate analysis, incident early AMD was associated with older age (P < 0.001; odds ratio [OR], 1.04; 95% CI, 1.02-1.06), female sex (P = 0.011; OR, 1.42; 95% CI, 1.08-1.86), and a higher estimated glomerular filtration rate (P = 0.020; OR, 1.15; 95% CI, 1.02-1.30), whereas having diabetes was a protective factor (P = 0.019; OR, 0.61; 95% CI, 0.41-0.92). Incident intermediate AMD was associated with older age (P < 0.001; OR, 1.05; 95% CI, 1.04-1.07), a higher high-density lipoprotein cholesterol level (P < 0.001; OR, 1.97; 95% CI, 1.38-2.83) and a lower triglyceride level (P = 0.008; OR, 0.77; 95% CI, 0.64-0.93).</p><p><strong>Conclusions: </strong>A higher estimated glomerular filtration rate level was a risk factor for incident early AMD. A higher high-density lipoprotein cholesterol level and lower triglyceride level were risk factors for incident intermediate AMD. This finding may point to the role of renal circulation and lipid metabolism in incident AMD.</p><p><strong>Translational relevance: </strong>This community-based longitudinal study may provide a valuable understanding of AMD and its associated factors for targeted prevention and management strategies.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"13 12","pages":"10"},"PeriodicalIF":2.6,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Anti-Vascular Endothelial Growth Factor Loading Injections on Retinal Microvasculature in Diabetic Macular Edema.","authors":"Kiyoung Kim, Junwoo Lee, Seung-Young Yu","doi":"10.1167/tvst.13.12.37","DOIUrl":"https://doi.org/10.1167/tvst.13.12.37","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate changes in the retinal microvasculature using widefield swept-source optical coherence tomography angiography (SS-OCTA) following three anti-vascular endothelial growth factor (anti-VEGF) loading injections for diabetic macular edema (DME).</p><p><strong>Methods: </strong>Thirty-four treatment-naïve patients with DME received an initial three loading injections, followed by injections on an as-needed basis. Macular ischemia was evaluated based on the foveal avascular zone (FAZ) area, perfusion density, and vessel density on a 3 × 3-mm SS-OCTA image. Midperipheral ischemia was analyzed by dividing a 12 × 12-mm image into 16 boxes to compare changes in the nonperfusion area (NPA). Participants were categorized as aggravated, stable, or improved based on changes in the NPA after three injections.</p><p><strong>Results: </strong>Of the 34 included patients, eight (23.5%) demonstrated aggravation of the NPA, 23 (67.6%) remained stable, and three (8.8%) exhibited improvement. Although FAZ area, perfusion, and vessel density increased, the differences were not significant compared to baseline. The number of injections and glycated hemoglobin (HbA1c) levels in the NPA aggravation group were significantly higher than in the stable and improvement groups. Logistic regression analysis revealed that NPA aggravation was independently associated with the number of anti-VEGF injections.</p><p><strong>Conclusions: </strong>Changes in NPA following anti-VEGF loading injections varied among patients with DME and were significantly associated with HbA1c levels and injection frequency. Worsening mid-peripheral NPA after the anti-VEGF injections independently risked DME recurrence.</p><p><strong>Translational relevance: </strong>We revealed that worsening mid-peripheral retinal ischemia after anti-VEGF loading injections contributes to the recurrence of DME.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"13 12","pages":"37"},"PeriodicalIF":2.6,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11684488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143056063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inherited Retinal Degenerations and Non-Neovascular Age-Related Macular Degeneration: Progress and Unmet Needs.","authors":"Jacque L Duncan, Angela Bowman, Amy Laster, Claire Gelfman, David G Birch, Shannon E Boye, Stephen P Daiger, Lucian Del Priore, Donald J Zack, James T Handa","doi":"10.1167/tvst.13.12.28","DOIUrl":"10.1167/tvst.13.12.28","url":null,"abstract":"<p><p>Inherited retinal degeneration (IRD) disease and age-related macular degeneration (AMD) are leading causes of irreversible vision loss and blindness. Although significant progress has advanced the field in the past 5 years, significant challenges remain. The current article reviews the accomplishments and research advances that have fueled the development of treatments for patients with IRD and AMD, including the first approved gene-augmentation treatment for RPE65-related retinal degeneration and complement inhibition therapies to slow progression of geographic atrophy (GA) in AMD. The article outlines opportunities to address gaps and unmet needs that should lead to additional progress toward the development of treatments for patients with IRDs and non-neovascular AMD in the future.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"13 12","pages":"28"},"PeriodicalIF":2.6,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142839607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-Omics Integration With Machine Learning Identified Early Diabetic Retinopathy, Diabetic Macula Edema and Anti-VEGF Treatment Response.","authors":"Yuhui Pang, Chaokun Luo, Qingruo Zhang, Xiongze Zhang, Nanying Liao, Yuying Ji, Lan Mi, Yuhong Gan, Yongyue Su, Feng Wen, Hui Chen","doi":"10.1167/tvst.13.12.23","DOIUrl":"10.1167/tvst.13.12.23","url":null,"abstract":"<p><strong>Purpose: </strong>Identify optimal metabolic features and pathways across diabetic retinopathy (DR) stages, develop risk models to differentiate diabetic macular edema (DME), and predict anti-vascular endothelial growth factor (anti-VEGF) therapy response.</p><p><strong>Methods: </strong>We analyzed 108 aqueous humor samples from 78 type 2 diabetes mellitus patients and 30 healthy controls. Ultra-high-performance liquid chromatography-high-resolution-mass-spectrometry detected lipidomics and metabolomics profiles. DME patients received ≥3 anti-VEGF treatments, categorized into strong and weak response groups. Machine learning (ML) screened prospective metabolic features, developing prediction models.</p><p><strong>Results: </strong>Key metabolic features identified in the metabolomics and lipidomics datasets included n-acetyl isoleucine (odds ratio [OR] = 1.635), cis-aconitic acid (OR = 3.296), and ophthalmic acid (OR = 0.836) for DR. For early-DR, n-acetyl isoleucine (OR = 1.791) and decaethylene glycol (PEG-10) (OR = 0.170) were identified as key markers. L-kynurenine (OR = 0.875), niacinamide (OR = 0.843), and linoleoyl ethanolamine (OR = 0.941) were identified as significant indicators for DME. Trigonelline (OR = 1.441) and 4-methylcatechol-2-sulfate (OR = 1.121) emerged as predictors for strong response to anti-VEGF. Predictive models achieved R² values of 99.9%, 97.7%, 93.9%, and 98.4% for DR, early-DR, DME, and strong response groups in the calibration set, respectively, and validated well with R² values of 96.3%, 96.8%, 79.9%, and 96.3%.</p><p><strong>Conclusions: </strong>This research used ML to identify differential metabolic features from metabolomics and lipidomics datasets in DR patients. It implies that metabolic indicators can effectively predict early disease progression and potential weak responders to anti-VEGF therapy in DME eyes.</p><p><strong>Translational relevance: </strong>The identified metabolic indicators may aid in predicting the early progression of DR and optimizing therapeutic strategies for DME.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"13 12","pages":"23"},"PeriodicalIF":2.6,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11645727/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eye-Rubbing Detection Tool Using Artificial Intelligence on a Smartwatch in the Management of Keratoconus.","authors":"Ines Drira, Ayoub Louja, Layth Sliman, Vincent Soler, Maha Noor, Abdellah Jamali, Pierre Fournie","doi":"10.1167/tvst.13.12.16","DOIUrl":"10.1167/tvst.13.12.16","url":null,"abstract":"<p><strong>Purpose: </strong>Eye rubbing is considered to play a significant role in the progression of keratoconus and of corneal ectasia following refractive surgery. To our knowledge, no tool performs an objective quantitative evaluation of eye rubbing using a device that is familiar to typical patients. We introduce here an innovative solution for objectively quantifying and preventing eye rubbing. It consists of an application that uses a deep-learning artificial intelligence (AI) algorithm deployed on a smartwatch.</p><p><strong>Methods: </strong>A Samsung Galaxy Watch 4 smartwatch collected motion data from eye rubbing and everyday activities, including readings from the gyroscope, accelerometer, and linear acceleration sensors. The training of the model was carried out using two deep-learning algorithms, long short-term memory (LSTM) and gated recurrent unit (GRU), as well as four machine learning algorithms: random forest, K-nearest neighbors (KNN), support vector machine (SVM), and XGBoost.</p><p><strong>Results: </strong>The model achieved an accuracy of 94%. The developed application could recognize, count, and display the number of eye rubbings carried out. The GRU model and XGBoost algorithm also showed promising performance.</p><p><strong>Conclusions: </strong>Automated detection of eye rubbing by deep-learning AI has been proven to be feasible. This approach could radically improve the management of patients with keratoconus and those undergoing refractive surgery. It could detect and quantify eye rubbing and help to reduce it by sending alerts directly to the patient.</p><p><strong>Translational relevance: </strong>This proof of concept could confirm one of the most prominent paradigms in keratoconus management, the role of abnormal eye rubbing, while providing the means to challenge or even negate it by offering the first automated and objective tool for detecting eye rubbing.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"13 12","pages":"16"},"PeriodicalIF":2.6,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11645754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Response: Effect of Depth-Dependent Integrated Visual Field on Vision-Related Quality of Life in Glaucoma.","authors":"Andrew Turpin, Allison M McKendrick","doi":"10.1167/tvst.13.12.2","DOIUrl":"10.1167/tvst.13.12.2","url":null,"abstract":"","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"13 12","pages":"2"},"PeriodicalIF":2.6,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11613997/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visual Quality and Accommodation With Novel Optical Designs for Myopia Control.","authors":"Sara Aissati, Tianlun Zou, Sabyasachi Goswami, Len Zheleznyak, Susana Marcos","doi":"10.1167/tvst.13.12.6","DOIUrl":"10.1167/tvst.13.12.6","url":null,"abstract":"<p><strong>Purpose: </strong>We evaluated through-focus visual performance and accommodative response in young subjects through three segmented multifocal designs for myopia control, mapped on the spatial light modulator of a monocular adaptive optics visual simulator (AOVS), and compared with single vision (SV).</p><p><strong>Methods: </strong>The segmented multifocal patterns included a 4 mm diameter center distance zone and offset peripheral defocus (MP1), astigmatism and coma (MP2), or a combination (MP3). High-contrast logMAR visual acuity (VA) was measured with monochromatic stimuli (555 nm). Ocular aberrations were measured using the Hartmann-Shack aberrometry channel. Measurements were taken for distance viewing and five accommodative demands (AD, up to 4.5 D). Accommodative lag was calculated from the dioptric shift of the maximum retinal image quality metric from the corresponding wave aberrations.</p><p><strong>Results: </strong>Best-corrected logMAR VA was -0.11 ± 0.02 (SV) and slightly reduced by multifocal patterns (-0.08 ± 0.03 [MP1], -0.07 ± 0.04 [MP2], -0.05 ± 0.04 [MP3]). Accommodative lag with SV was lower in emmetropes than myopes (by 0.43D for the largest demand). MP1 significantly decreased accommodative lag in myopes (P = 0.03), unlike MP2 or MP3. Multifocal patterns reduced pupil diameter in myopes at all distances. MP1 improved accommodative response in myopes without compromising distance vision.</p><p><strong>Conclusions: </strong>AOVS helped to understand the interplay of physiological and lens design factors, potentially guiding custom corrections. A center distance with off-centered positive power in the lens periphery could feature suitable properties (peripheral focus and accommodative focus control) for myopia control.</p><p><strong>Translational relevance: </strong>We demonstrate a two-zone contact lens design that provides excellent visual quality and accommodative response, important properties for myopia control lenses.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"13 12","pages":"6"},"PeriodicalIF":2.6,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11622158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}