Translational Vision Science & Technology最新文献

{"title":"Corneal Confocal Microscopy Identifies and Differentiates Patients With Multiple Sclerosis and Epilepsy.","authors":"Ioannis N Petropoulos, Kareem Essam Aly, Shaikha Al-Thani, Georgios Ponirakis, Hoda Gad, Adnan Khan, Beatriz Canibano, Dirk Deleu, Naveed Akhtar, Gayane Melikyan, Boulenouar Mesraoua, Maria Siddiqi, Jon Perkins, Novsheen Mir, Reny Francis, Abdul Salam, Ahmed El-Sotouhy, Surjith Vattoth, Ahmed Own, Saadat Kamran, Rayaz A Malik","doi":"10.1167/tvst.13.12.22","DOIUrl":"10.1167/tvst.13.12.22","url":null,"abstract":"<p><strong>Purpose: </strong>To assess whether corneal nerve analysis can identify and differentiate patients with multiple sclerosis (MS) from those with epilepsy.</p><p><strong>Methods: </strong>Participants with MS (n = 83), participants with epilepsy (n = 50), and healthy controls (HCs) (n = 20) underwent corneal confocal microscopy (CCM) and quantification of automated corneal nerve fiber length (ACNFL), automated corneal nerve fractal dimension (ACNFrD), and ACNFrD/ACNFL ratio of the subbasal nerve plexus.</p><p><strong>Results: </strong>ACNFL (MS: P < 0.0001; epilepsy: P = 0.002) and ACNFrD (MS: P < 0.0001; epilepsy: P = 0.025) were significantly lower and the ACNFrD/ACNFL ratio (MS: P < 0.0001; epilepsy: P = 0.018) was significantly higher compared to HCs. ACNFL (P = 0.001), ACNFrD (P = 0.0003), and ACNFrD/ACNFL ratio (P = 0.006) were significantly lower in patients with MS compared to those with epilepsy. ACNFL had the highest diagnostic utility for identifying patients with MS (sensitivity/specificity 0.86/0.85, area under the curve [AUC] 0.90, P < 0.0001), and ACNFrD had the highest diagnostic utility for identifying patients with epilepsy (sensitivity/specificity 0.78/0.75, AUC 0.76, P = 0.0008). ACNFrD had the highest diagnostic utility for differentiating patients with MS from epilepsy (sensitivity/specificity 0.66/0.65, AUC 0.70, <0.0001).</p><p><strong>Conclusions: </strong>Corneal neurodegeneration occurs in and is characterized by a distinct pattern that differentiates patients with MS and epilepsy.</p><p><strong>Translational relevance: </strong>CCM identifies and differentiates patients with MS and epilepsy, albeit with moderate performance. Further validation, with a larger sample size, is needed.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"13 12","pages":"22"},"PeriodicalIF":2.6,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11645731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relating Standardized Automated Perimetry Performed With Stimulus Sizes III and V in Eyes With Field Loss Due to Glaucoma and NAION.","authors":"David Szanto, Michael Wall, Luke X Chong, Mark J Kupersmith","doi":"10.1167/tvst.13.12.8","DOIUrl":"10.1167/tvst.13.12.8","url":null,"abstract":"<p><strong>Purpose: </strong>Standard automated perimetry (SAP) visual field (VF) results are more repeatable using Goldmann stimulus size V (size V) in eyes with moderate/severe deficits due to glaucoma. There are few reports relating VFs using stimulus size V and III, typically used in the clinic for glaucoma, and none for non-arteritic anterior ischemic optic neuropathy (NAION). We hypothesized that we could compare and relate the VFs with both stimuli for glaucoma and NAION.</p><p><strong>Methods: </strong>We utilized 1992 same-day pairs of size III and size V SAP VFs using the 24-2 strategy for eyes with glaucoma or NAION. We explored the optimal threshold to censor the raw sensitivities, prior to calculating age-standardized total deviations (TDs). We determined the mean and standard deviation of the differences among all TD pairs. We computed a line of best fit to determine closeness to the line of unity.</p><p><strong>Results: </strong>The ideal censoring conversion threshold was 21 decibel (dB) for size III and 24 dB for size V. The difference between size V and size III censored (0.0 ± 1.9 dB) and uncensored (0.4 ± 2.6 dB) TD pairings highly correlate with each other (r2 = 0.70, P < 0.001). The line of best fit from these pairings has a slope of 0.92, which is close to that of the line of unity (m = 1).</p><p><strong>Conclusions: </strong>Censoring plus age correction is a valid method of comparison between size III and size V SAP VFs with moderate to severe VF loss due to optic nerve disorders.</p><p><strong>Translational relevance: </strong>Size III and size V TDs are comparable in clinical practice.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"13 12","pages":"8"},"PeriodicalIF":2.6,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11622156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refining Flash Visual Evoked Potential Analysis in Rats: A Novel Approach Using Bilateral Epidural Electrodes.","authors":"Kwang Min Woo, Yan Guo, Zara Mehrabian, Neil R Miller, Steven L Bernstein","doi":"10.1167/tvst.13.12.24","DOIUrl":"10.1167/tvst.13.12.24","url":null,"abstract":"<p><strong>Purpose: </strong>Visual evoked potentials (VEPs) are electrical signals generated at the visual cortex following visual stimulation. Flash VEPs (fVEPs) are produced by global retinal stimulation and are considered an objective measure of the integrity of the entire visual pathway. However, fVEP measurements are highly sensitive to external variables, making relative comparisons of the fVEP waveforms between the two eyes in the same individual challenging.</p><p><strong>Methods: </strong>We used the rodent non-arteritic anterior ischemic optic neuropathy (rNAION) model to induce unilateral ischemic optic neuropathy. The severity of optic disc edema was measured with spectral-domain optical coherence tomography, and visual acuity was measured using a virtual optokinetic system. We developed a procedure utilizing implanted bilateral epidural electrodes and derived a mathematical formula to accurately estimate functional differences between the optic nerves. Immunohistology was performed to quantify retinal ganglion cell (RGC) survival using stereology.</p><p><strong>Results: </strong>Compared to subcutaneous methods, the new approach significantly improves the signal-to-noise ratio and is more repeatable when comparing the two eyes. The derived formula accounts for asymmetry in the afferent inputs to the visual cortex. Visual function calculated using the formula correlates strongly with other recognized metrics of visual function, including RGC survival and visual acuity.</p><p><strong>Conclusions: </strong>We have developed a repeatable and accurate method to calculate the relative visual function of diseased optic nerves compared with a contralateral control eye.</p><p><strong>Translational relevance: </strong>Our novel method improves fVEP measurement sensitivity and accuracy in rodent preclinical trials, reducing the number of animals needed to achieve statistical significance.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"13 12","pages":"24"},"PeriodicalIF":2.6,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Deep Learning Network for Accurate Retinal Multidisease Diagnosis Using Multiview Fusion of En Face and B-Scan Images: A Multicenter Study.","authors":"Chubin Ou, Xifei Wei, Lin An, Jia Qin, Min Zhu, Mei Jin, Xiangbin Kong","doi":"10.1167/tvst.13.12.31","DOIUrl":"10.1167/tvst.13.12.31","url":null,"abstract":"<p><strong>Purpose: </strong>Accurate diagnosis of retinal disease based on optical coherence tomography (OCT) requires scrutiny of both B-scan and en face images. The aim of this study was to investigate the effectiveness of fusing en face and B-scan images for better diagnostic performance of deep learning models.</p><p><strong>Methods: </strong>A multiview fusion network (MVFN) with a decision fusion module to integrate fast-axis and slow-axis B-scans and en face information was proposed and compared with five state-of-the-art methods: a model using B-scans, a model using en face imaging, a model using three-dimensional volume, and two other relevant methods. They were evaluated using the OCTA-500 public dataset and a private multicenter dataset with 2330 cases; cases from the first center were used for training and cases from the second center were used for external validation. Performance was assessed by averaged area under the curve (AUC), accuracy, sensitivity, specificity, and precision.</p><p><strong>Results: </strong>In the private external test set, our MVFN achieved the highest AUC of 0.994, significantly outperforming the other models (P < 0.01). Similarly, for the OCTA-500 public dataset, our proposed method also outperformed the other methods with the highest AUC of 0.976, further demonstrating its effectiveness. Typical cases were demonstrated using activation heatmaps to illustrate the synergy of combining en face and B-scan images.</p><p><strong>Conclusions: </strong>The fusion of en face and B-scan information is an effective strategy for improving the diagnostic accuracy of deep learning models.</p><p><strong>Translational relevance: </strong>Multiview fusion models combining B-scan and en face images demonstrate great potential in improving AI performance for retina disease diagnosis.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"13 12","pages":"31"},"PeriodicalIF":2.6,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11668356/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sterile Caliper Anterior Chamber Decompression Mitigates Intraocular Pressure Spikes in Intravitreal Injections.","authors":"Mahsaw Mansoor, Noor-Us-Sabah Ahmad, S Bilal Ahmed, Samuel Tadros, James Folk, Michael D Abramoff","doi":"10.1167/tvst.13.12.13","DOIUrl":"10.1167/tvst.13.12.13","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the efficacy of a novel approach using a sterile caliper for anterior chamber (AC) decompression in reducing post-intravitreal injection (IVI) intraocular pressure (IOP) spikes.</p><p><strong>Methods: </strong>A prospective interventional case series conducted at the Iowa City Veterans Affairs Medical Center (VAMC) with Institutional Review Board approval. Patients were randomized to receive conventional IVI or IVI with sterile caliper decompression. Fifty eyes from 47 patients underwent IVI for various retinal pathologies. Subjects were randomly assigned to the intervention or control arm. Two resident physician providers performed injections, with one applying sterile caliper decompression (intervention) and the other following the standard technique (control). Baseline and postinjection IOP were measured using Tonopen (Reichert, Depew, NY).</p><p><strong>Results: </strong>In both groups there was a significant IOP rise following IVI (P < 0.0001). There was no significant difference in baseline IOP between groups (P = 0.082), but postinjection IOP was significantly lower in the intervention group (23.52 ± 5.98 mm Hg) compared to the control group (44.08 ± 8.48 mm Hg). There were no patients with an IOP spike >25 mm Hg in the intervention arm. The technique was effective regardless of lens status.</p><p><strong>Conclusions: </strong>Sterile caliper AC decompression significantly reduced post-IVI IOP spikes presenting an efficient and cost-effective alternative to previously proposed methods of IOP reduction. Further studies are warranted to validate these findings and explore broader applications in ophthalmic interventions.</p><p><strong>Translational relevance: </strong>The caliper decompression technique presents potential benefit in preventing short-term morbidity associated with IOP spikes after IVI and addressing long-term concerns in patients with pre-existing glaucoma.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"13 12","pages":"13"},"PeriodicalIF":2.6,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11636662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A New Method for Lateral Visualization of the Primary Cilia on the Surfaces of Cells Cultured on White Glass Rods.","authors":"Hidetoshi Tanioka, Hideto Deguchi, Shigeru Kinoshita, Chie Sotozono","doi":"10.1167/tvst.13.11.19","DOIUrl":"10.1167/tvst.13.11.19","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the motility of the primary cilia of corneal endothelial cells (CECs), which exist like a hair on the cell surface, using our new in vitro method.</p><p><strong>Methods: </strong>A white glass rod was heated with a gas burner to produce a rod approximately 0.5 mm in diameter and 20 mm in length and then coated with collagen. A suspension of cultured human CECs (HCECs) was then added to the rod and cultured for 20 days. Cells on the rod's side were then observed using phase-contrast microscopy, and videos and images of the primary cilia were obtained. After fixing the cells cultured on the rod's surface, immunofluorescence staining was performed and fluorescence and phase contrast images were taken.</p><p><strong>Results: </strong>Hair-like structures were observed on the surface of live HCECs on the rod's surface. Video images revealed that the structures sometimes swayed owing to slight convection of the medium, yet had no motile function, and immunostaining with acetylated α-tubulin antibody confirmed that the structures were primary cilia.</p><p><strong>Conclusions: </strong>Our new method using white glass rods provided the ability to observe the movement of primary cilia in cultured living HCECs, and the findings clearly showed that the primary cilia of HCECs are passive rather than motile. This novel procedure can be applied widely to other cultured cells as a method to observe the movement of primary cilia from the lateral aspect of the cell.</p><p><strong>Translational relevance: </strong>This method may help to clarify the role of primary cilia in the anterior chamber.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"13 11","pages":"19"},"PeriodicalIF":2.6,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11578158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Psychometric Assessment of a Chinese Version of the Ultra-Low Vision Visual Functioning Questionnaire-50.","authors":"Jing Cong, Xinyuan Wu, Chunqiong Dong, Jing Wang, Chenli Feng, Gechun Wang, Yiting Wu, Gislin Dagnelie, Jinhui Dai, Yuanzhi Yuan","doi":"10.1167/tvst.13.11.20","DOIUrl":"10.1167/tvst.13.11.20","url":null,"abstract":"<p><strong>Purpose: </strong>To develop a short form of Chinese ULV-VFQ-50 based on the ULV-VFQ-150 and compare the psychometrical properties of the two questionnaires.</p><p><strong>Methods: </strong>We selected candidate items from the ULV-VFQ-150, considering the item response among ultra-low vision (ULV) participants, the even distribution of item measures, visual aspects, and visual domains, to construct a 50-item ULV-VFQ-50 questionnaire. Then, ULV participants were recruited to evaluate its psychometric characteristics by using Rasch analysis.</p><p><strong>Results: </strong>In total, 79 out of 79 completed questionnaires of ULV-VFQ-50 were collected, of which 11 filled questionnaires were excluded because the participants' vision did not meet the inclusion criteria. Thus 68 valid questionnaires were analyzed (valid response rate 91.9%). The average age of the eligible responders was 45.0 years (standard deviation [SD] = 16.7), with 42.6% females (29/68). As per Rasch analysis, the person measures ranged from -1.74 to 4.91 logits, and the item measures ranged from -1.56 to 1.15 logits. The mean value of item difficulty was 0.00 logits, whereas the mean value of personnel distribution was -0.35 logits. The item reliability was 0.95, and the person reliability was 0.98. The items conform to unidimensionality as indicated by principal component analysis of the residuals, which showed that the first principal component unexplained only 5.5% of the total variance, and each component after that unexplained even less.</p><p><strong>Conclusions: </strong>The Chinese ULV-VFQ-50 exhibits excellent psychometric properties. The short form of Chinese ULV-VFQ, with fewer items and less administration time is better suited for clinical practice and research settings.</p><p><strong>Translational relevance: </strong>The Chinese version of ULV-VFQ-50 is a reliable assessment of the visual function for people with ULV in China.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"13 11","pages":"20"},"PeriodicalIF":2.6,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11578157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differentiating Multiple Sclerosis and Glaucoma With Sectoral Pattern Analysis of Peripapillary Nerve Fiber Layer.","authors":"Po-Han Yeh, Ou Tan, Elizabeth Silbermann, Elizabeth White, Dongseok Choi, Aiyin Chen, Eliesa Ing, Dennis Bourdette, Jie Wang, Yali Jia, David Huang","doi":"10.1167/tvst.13.11.11","DOIUrl":"10.1167/tvst.13.11.11","url":null,"abstract":"<p><strong>Purpose: </strong>To distinguish between multiple sclerosis (MS) and glaucoma by nerve fiber layer (NFL) thinning patterns.</p><p><strong>Methods: </strong>MS patients were diagnosed by the 2017 McDonald Criteria; glaucoma patients had disc rim thinning or an NFL defect, with or without perimetric defect. The peripapillary NFL thickness was divided into eight sectors, and percentage reduction (% reduction) was calculated relative to normative reference values. The MS and glaucoma eyes were grouped based on the severity of NFL thinning in the worst sector: significant reduction (<1 percentile of normal reference), borderline reduction (1%∼5%), and no reduction (>5%). We devised four diagnostic indexes, and the area under the curve of receiver operating characteristics (AROC) and accuracy were used to evaluate the indexes.</p><p><strong>Results: </strong>We enrolled 58 control subjects (58 eyes), 56 MS subjects (112 eyes), and 92 glaucoma subjects (92 eyes) at two centers. The most pronounced percent reduction in MS eyes occurred in the temporal-upper and temporal-lower sectors. In glaucoma eyes, this occurred in the inferior-temporal, inferior-nasal, and superior-temporal sectors. The temporal pattern index had the best AROC (0.96, 0.91-1.00) and accuracy (92.6%) in the significant reduction group. It had good AROC (0.88, 0.78-0.99) and accuracy (76.7%) in the borderline reduction group.</p><p><strong>Conclusions: </strong>Normalizing NFL reduction as a percentage of normal reference accentuated patterns characteristic of MS and glaucoma. Quantitative pattern indexes were effective in differentiating the two diseases.</p><p><strong>Translational relevance: </strong>The utility of optical coherence tomography in the differential diagnosis of optic neuropathies is enhanced by analyzing the retinal nerve fiber layer percentage reduction pattern.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"13 11","pages":"11"},"PeriodicalIF":2.6,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11562973/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Choroidal Thickness and Visual Acuity in High Myopia Without Myopic Maculopathy: Insights From a Chinese Population Study.","authors":"Yueye Wang, Decai Wang, Qiuxia Yin, Jiayong Li, Zhixi Li, Mingguang He","doi":"10.1167/tvst.13.11.9","DOIUrl":"10.1167/tvst.13.11.9","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the association of choroidal thickness (ChT) with best-corrected visual acuity (BCVA) in patients with high myopia (HM) and without myopic maculopathy.</p><p><strong>Methods: </strong>This study was a retrospective, cross-sectional study of participants aged 7 to 70 years with bilateral HM but without myopic maculopathy. Swept-source optical coherence tomography was used to measure ChT at the fovea. A BCVA of logMAR 0.1 was regarded as the benchmark for normal. The association between ChT and BCVA was evaluated by linear regression models with confounders fully adjusted. Subgroup analyses were performed across sex and age groups.</p><p><strong>Results: </strong>A total of 412 eligible participants were enrolled in this study. The mean age, spherical equivalence, and subfoveal (SF) ChT of the included participants were 21.17 ± 9.55 years, -9.77 ± 2.40 diopters, and 171.56 ± 61.33 µm, respectively. The SF ChT was thinner in participants with abnormal BCVA (normal. 176.74 ± 60.24 µm; abnormal, 139.30 ± 58.63 µm). A thinner ChT in all subregions of the posterior pole of the Early Treatment Diabetic Retinopathy Study grid was associated significantly with a worse BCVA after adjusting for age, sex, and axial length (SF ChT: coefficient, × 10-4, -2.64; 95% confidence interval, -4.73 to -0.55; P < 0.05 in all subregions). The strongest correlation was observed in the outer inferior region, where a per 21 µm thinning of ChT led to a 0.01 worsening of BCVA. This correlation presented a stronger magnitude in male aged more than 40 years.</p><p><strong>Conclusions: </strong>In patients with HM without myopic maculopathy, a thinner ChT was associated independently with a worse BCVA.</p><p><strong>Translational relevance: </strong>The findings of this study suggest that thinning ChT should be considered a vital risk factor for irreparable visual acuity impairment.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"13 11","pages":"9"},"PeriodicalIF":2.6,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11562976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum in: How Modifications of Corneal Cross-Linking Protocols Influence Corneal Resistance to Enzymatic Digestion and Treatment Depth.","authors":"","doi":"10.1167/tvst.13.11.23","DOIUrl":"10.1167/tvst.13.11.23","url":null,"abstract":"","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"13 11","pages":"23"},"PeriodicalIF":2.6,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11578160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}