Wenyan Xu, Xiaoman Li, Jianing Zhang, Hongyi Li, Xuewen Ding, Xiaoyue Hu, Xinyue Quan, Yue Su, Fan Lu, Jie Chen
{"title":"The Peripheral Defocus Designed Spectacle Lenses Might Increase Astigmatism in Myopic Children.","authors":"Wenyan Xu, Xiaoman Li, Jianing Zhang, Hongyi Li, Xuewen Ding, Xiaoyue Hu, Xinyue Quan, Yue Su, Fan Lu, Jie Chen","doi":"10.1167/tvst.14.3.8","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to explore the impact of wearing peripheral defocus spectacle lenses (PDSL) on cylindrical refractive error (CYL) in myopic children.</p><p><strong>Methods: </strong>This study included 1057 myopic children and divided the participants into three groups: the HAL group (spectacle lens with highly aspherical lenslets), the MPV group (spectacle lens based on manipulating peripheral vision), and a control group (without myopia control interventions). The study analyzed the effect of wearing PDSL on changes in spherical equivalent refraction, CYL, and corneal astigmatism (CA). The mediating effect between changes in spherical refractive errors (SPH) and CYL was also investigated.</p><p><strong>Results: </strong>Compared to the control group (0.05 ± 0.33 D), the annual CYL progression was faster in the HAL group (-0.15 ± 0.33 D, P < 0.001) and the MPV group (-0.09 ± 0.27 D, P = 0.019). More children in the HAL group had an annual CYL progression ≥0.50 D (HAL: 23.6%, Control: 16.2%, P = 0.012). The annual CYL and CA progression were consistent within the PDSL groups (HAL: P = 0.677, MPV: P = 0.683). The total effect of CYL progression in the HAL group was primarily due to direct induction from wearing HAL and indirect induction through the SPH control effect.</p><p><strong>Conclusions: </strong>The application of PDSL could cause increase in astigmatism in myopic children, which could mainly be contributed to cornea astigmatism change.</p><p><strong>Translational relevance: </strong>PDSL may passively affect the anterior ocular biomechanics during myopia control, leading to an increase in astigmatism.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 3","pages":"8"},"PeriodicalIF":2.6000,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918031/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Translational Vision Science & Technology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1167/tvst.14.3.8","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Purpose: This study aims to explore the impact of wearing peripheral defocus spectacle lenses (PDSL) on cylindrical refractive error (CYL) in myopic children.
Methods: This study included 1057 myopic children and divided the participants into three groups: the HAL group (spectacle lens with highly aspherical lenslets), the MPV group (spectacle lens based on manipulating peripheral vision), and a control group (without myopia control interventions). The study analyzed the effect of wearing PDSL on changes in spherical equivalent refraction, CYL, and corneal astigmatism (CA). The mediating effect between changes in spherical refractive errors (SPH) and CYL was also investigated.
Results: Compared to the control group (0.05 ± 0.33 D), the annual CYL progression was faster in the HAL group (-0.15 ± 0.33 D, P < 0.001) and the MPV group (-0.09 ± 0.27 D, P = 0.019). More children in the HAL group had an annual CYL progression ≥0.50 D (HAL: 23.6%, Control: 16.2%, P = 0.012). The annual CYL and CA progression were consistent within the PDSL groups (HAL: P = 0.677, MPV: P = 0.683). The total effect of CYL progression in the HAL group was primarily due to direct induction from wearing HAL and indirect induction through the SPH control effect.
Conclusions: The application of PDSL could cause increase in astigmatism in myopic children, which could mainly be contributed to cornea astigmatism change.
Translational relevance: PDSL may passively affect the anterior ocular biomechanics during myopia control, leading to an increase in astigmatism.
期刊介绍：
Translational Vision Science & Technology (TVST), an official journal of the Association for Research in Vision and Ophthalmology (ARVO), an international organization whose purpose is to advance research worldwide into understanding the visual system and preventing, treating and curing its disorders, is an online, open access, peer-reviewed journal emphasizing multidisciplinary research that bridges the gap between basic research and clinical care. A highly qualified and diverse group of Associate Editors and Editorial Board Members is led by Editor-in-Chief Marco Zarbin, MD, PhD, FARVO.
The journal covers a broad spectrum of work, including but not limited to:
Applications of stem cell technology for regenerative medicine,
Development of new animal models of human diseases,
Tissue bioengineering,
Chemical engineering to improve virus-based gene delivery,
Nanotechnology for drug delivery,
Design and synthesis of artificial extracellular matrices,
Development of a true microsurgical operating environment,
Refining data analysis algorithms to improve in vivo imaging technology,
Results of Phase 1 clinical trials,
Reverse translational ("bedside to bench") research.
TVST seeks manuscripts from scientists and clinicians with diverse backgrounds ranging from basic chemistry to ophthalmic surgery that will advance or change the way we understand and/or treat vision-threatening diseases. TVST encourages the use of color, multimedia, hyperlinks, program code and other digital enhancements.
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