Translational Vision Science & Technology最新文献

{"title":"Artificial Intelligence-Driven Detection of LASIK Using Corneal Optical Coherence Tomography Maps.","authors":"Jiachi Hong, Afshan A Nanji, Richard D Stutzman, Winston D Chamberlain, Xubo Song, David Huang, Yan Li","doi":"10.1167/tvst.14.3.17","DOIUrl":"10.1167/tvst.14.3.17","url":null,"abstract":"<p><strong>Purpose: </strong>To train and validate a convolutional neural network (CNN) to detect the history of laser-assisted in situ keratomileusis (LASIK) surgeries using corneal optical coherence tomography (OCT) maps.</p><p><strong>Methods: </strong>Five corneal OCT maps (pachymetry, epithelial thickness, posterior mean curvature, anterior axial power, and anterior stroma reflectance) were utilized as the input of a lightweight CNN model. OCT scans of healthy volunteers and patients who had undergone myopic or hyperopic LASIK were included. Repeated fivefold cross-validation was used to train and evaluate the proposed CNN. In addition, a separate group of post-LASIK participants, who were not included in the cross-validation, was used for out-of-sample testing to assess the CNN model performance.</p><p><strong>Results: </strong>In the cross-validation, the proposed CNN model achieved an overall balanced accuracy of 90.2% ± 3.6% with 93.5% ± 5.2% sensitivity and 97.8% ± 1.7% area under the receiver operating characteristic curve (AUC) in detecting myopic LASIK and 90.2% ± 5.8% sensitivity and 98.2% ± 1.9% AUC in identifying the hyperopic LASIK. In the out-of-sample test, all eyes were classified correctively.</p><p><strong>Conclusions: </strong>The lightweight CNN model with corneal OCT maps provides a useful tool for detecting LASIK history.</p><p><strong>Translational relevance: </strong>Artificial intelligence-assisted OCT may offer better management for patients with LASIK history who need cataract surgeries.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 3","pages":"17"},"PeriodicalIF":2.6,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carboxyamidotriazole Complexed to PLGA Is Safe, Effective, and Durable in Models of Neovascular Retinal Disease.","authors":"Sergio Li Calzi, Ayaka Fujihashi, Dibyendu Chakraborty, Yvonne Adu-Rutledge, Ram Prasad, Edgar L V Ready, Sarbodeep Paul, Srikanth Kakumanu, Xiaoping Qi, Michael E Boulton, Alan J Franklin, Bob H Katz, Maria B Grant","doi":"10.1167/tvst.14.3.21","DOIUrl":"10.1167/tvst.14.3.21","url":null,"abstract":"<p><strong>Purpose: </strong>We evaluated the safety and bioactivity of carboxyamidotriazole (CAI) using two approaches, a polymeric CAI-PLGA nanoemulsion in the mouse model of choroidal neovascularization (CNV) and CAI-loaded bioresorbable intravitreal implant in a rabbit model of vascular leakage.</p><p><strong>Methods: </strong>Mice underwent laser rupture of Bruch's membrane to induce CNV followed by a single (2 µL volume) intravitreal injection of either vehicle (n = 11); CAI nanoparticles (0.5 µg, 1 µg, 2 µg, 400 nM, 800 nM, and 1.6 µM, respectively); aflibercept 10 µg; or CAI nanoparticles (1 µg) + aflibercept 10 µg. New Zealand white rabbits underwent either sham intravitreal injection, aflibercept 500 µg injection, or CAI-PLGA intravitreal implant. Vascular leakage was induced with injections of VEGF on days 23 and 53. On days 30 and 60, all groups underwent vitreous fluorophotometry and fundus imaging. On day 60, the rabbits were euthanized, and their eyes were enucleated.</p><p><strong>Results: </strong>Intravitreal injection of the CAI-Nano at the dose of 1 µg significantly decreased choroidal neovascular volume, to 25% of saline on day 7 and 30% on day 14, which was comparable to aflibercept. Vitreous fluorophotometry revealed significantly lower levels of fluorescein in the aflibercept and CAI implant groups compared to the sham group on day 30. On day 60, the CAI implant group showed significantly reduced neovascularization as compared with the aflibercept groups. No toxicity was observed in any group.</p><p><strong>Conclusions: </strong>CAI in nanoparticle formulation or as a sustained release bioresorbable implant showed potent efficacy and caused no retinal toxicity in murine and rabbit models.</p><p><strong>Translational significance: </strong>CAI demonstrates strong potential as a sustained release anti-angiogenic therapy with effective long-term durability.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 3","pages":"21"},"PeriodicalIF":2.6,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing Multiplicity in Retinal Sensitivity Analysis: An Alternative Approach to Assessing Gene Therapy Efficacy in Inherited Retinal Diseases.","authors":"Antonio Yaghy, David G Birch, Yunchan Hwang, Edmund Luo, JungAh Jung, Darin Curtiss, Nadia K Waheed","doi":"10.1167/tvst.14.3.25","DOIUrl":"10.1167/tvst.14.3.25","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to propose an alternative statistical approach that addresses the issue of multiplicity in microperimetry data analysis, offering a more balanced and sensitive measure of the efficacy of gene therapy in inherited retinal diseases (IRDs).</p><p><strong>Methods: </strong>We analyzed microperimetry data from a phase II trial of AGTC-501 in patients with X-linked retinitis pigmentosa (XLRP). The Macular Integrity Assessment (MAIA; CenterVue, Padova, Italy) device was used to evaluate test-retest repeatability. A binomial model was used to calculate the probability of ≥7 decibel (dB) improvements due to chance alone across a 68-locus grid. We proposed an alternative approach to detect changes using a threshold of ≥7 loci with ≥7 dB mean improvement.</p><p><strong>Results: </strong>Test-retest repeatability analysis showed a probability of < 5% for observing pointwise improvements ≥7 dB between 2 baseline visits. Applying the binomial distribution model, we found that the probability of observing improvements ≥7 dB in at least 7 unspecified loci purely by chance was 5.3%.</p><p><strong>Conclusions: </strong>The proposed approach provides a balanced way to address multiplicity while maintaining reasonable statistical significance. Using ≥7 unspecified loci as the criterion for assessing sensitivity changes, offers a comprehensive assessment that can detect genuine treatment effects without being overly conservative.</p><p><strong>Translational relevance: </strong>This alternative statistical method has the potential to improve the evaluation of retinal sensitivity changes in gene therapy trials for IRDs, providing a more accurate measure of therapeutic efficacy and enhancing clinical decision making.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 3","pages":"25"},"PeriodicalIF":2.6,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Long-Term Corneal Biomechanics Following SMILE With Different Residual Stromal Bed Thickness in Rabbits.","authors":"Hongwei Qin, Xin Yang, Rui He, Yaowen Song, Junchao Wei, Xiaona Liu, Chenyan Wang, Ce Wu, Jie Hou, Zhipeng Gao, Lingfeng Chen, Xiaona Li, Weiyi Chen","doi":"10.1167/tvst.14.3.3","DOIUrl":"10.1167/tvst.14.3.3","url":null,"abstract":"<p><strong>Purpose: </strong>The long-term safety of small-incision lenticule extraction (SMILE) surgery for correcting high myopia with a residual stromal bed thickness (RST) less than 50% of the central corneal thickness (CCT) was investigated from a biomechanical perspective.</p><p><strong>Methods: </strong>Twelve rabbits were enrolled in this study, in which the right eye underwent SMILE surgery (the corneal cap thickness was one third of the preoperative CCT, approximately 120 µm), and the left eye served as the control. The rabbits were evenly divided into two groups, with the RST of 50% and 30% of the preoperative CCT in each group, respectively. Corneal morphology parameters in vivo and biomechanical properties in vitro were determined at 11 months after SMILE surgery. Moreover, the distribution of displacement and Von Mises stress across the cornea were evaluated using finite element analysis.</p><p><strong>Results: </strong>At 11 months after SMILE surgery, there was no obvious forward shift in the posterior corneal elevation and no significant increase in the mean keratometry from the posterior corneal surface. The elastic modulus of the RST 30% group increased significantly compared to the control, although no significant differences were found in the creep rate, elongation rate, and equilibrium modulus among all groups. Compared to the control, the displacement was smaller in the RST 30% group, while the maximum stress was obviously higher.</p><p><strong>Conclusions: </strong>No iatrogenic keratectasia occurred in a rabbit model of high myopic SMILE surgery with an RST of less than 50% of preoperative CCT at 11-month follow-up.</p><p><strong>Translational relevance: </strong>Our findings could provide valuable insights into the safety of performing SMILE with reduced RST values for high myopia correction and guide SMILE procedures.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 3","pages":"3"},"PeriodicalIF":2.6,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Combination of Retinal Neurovascular Unit Changes With Carotid Artery Stenosis Enhances the Prediction of Ischemic Stroke.","authors":"Zhifan Chen, Shuoxin Liao, Guangzhong Chen, Changmao Li, Chunling Liu, Junbin Liu, Guangyu Wu, Zheng Lyu, Mengya Liu, Xiyu Wu, Guixian Ma, Qianli Meng","doi":"10.1167/tvst.14.3.14","DOIUrl":"10.1167/tvst.14.3.14","url":null,"abstract":"<p><strong>Purpose: </strong>We aimed to analyze retinal neurovascular unit (RNVU) alterations and function via optical coherence tomography angiography (OCTA) and full-field electroretinography (ERG) in patients with ischemic stroke (IS).</p><p><strong>Methods: </strong>OCTA was used to measure RNVU changes in 229 participants (101 with IS and 128 healthy controls). The RETeval device was used to record full-field electroretinograms (FERGs) in 40 participants (14 with IS and 26 healthy controls). Logistic regression models for IS were constructed. Receiver operating characteristic (ROS) curves were constructed to assess the predictive value of various models for IS.</p><p><strong>Results: </strong>Patients with ipsilateral internal carotid artery stenosis (ICAS) had a greater occurrence of IS. A decrease in the vascular density (VD) of the parafovea, FD-300, and nasal optic disc; a decrease in the thickness of the retinal nerve fiber layer (RNFL) around the nasal optic disc; and an increase in the acircularity index (AI) were observed in patients with IS (P < 0.05). An increase in the AI was identified as a risk factor for IS, whereas the other factors were found to be protective factors. The IS group presented a delayed a-wave implicit time and decreased b-wave amplitudes at the scotopic point. By incorporating traditional risk factors, the degree of ipsilateral ICAS, and OCTA parameters, a high predictive value for IS was achieved (area under the curve [AUC] = 0.933).</p><p><strong>Conclusions: </strong>Patients with IS without visible fundus lesions presented changes in the RNVU, characterized by reductions in retinal VD and RNFL thickness, alongside dysfunction of photoreceptor cells and bipolar cells. The combination of RNVU changes with traditional risk factors can enhance the prediction of IS, which provides valuable guidance for monitoring this disease.</p><p><strong>Translational relevance: </strong>This study demonstrated that the combination of OCTA parameters, the degree of ipsilateral ICAS, and traditional risk factors could can enhance the prediction of IS. These findings provide valuable guidance for monitoring IS by assessing RNVUs.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 3","pages":"14"},"PeriodicalIF":2.6,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918090/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photoreceptor Outer Segment Reflectivity With Ultrahigh-Resolution Visible-Light Optical Coherence Tomography in Systemic Hydroxychloroquine Use.","authors":"Anupam K Garg, Jingyu Wang, Bailee Alonzo, Ji Yi, Amir H Kashani","doi":"10.1167/tvst.14.3.2","DOIUrl":"10.1167/tvst.14.3.2","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate outer retinal organization in normal subjects and those using hydroxychloroquine (HCQ) with ultrahigh-resolution visible-light optical coherence tomography (VIS-OCT).</p><p><strong>Methods: </strong>Forty eyes of 22 adult subjects were recruited from a tertiary-care retina practice, including controls (20 eyes, 12 subjects, 40 ± 22 years old) and subjects with a history of HCQ use (20 eyes, 10 subjects, 62 ± 17 years old). Each subject was imaged using a custom-built VIS-OCT device (axial resolution 1.3 µm) and U.S. Food and Drug Administration-approved OCT devices.</p><p><strong>Results: </strong>With the use of VIS-OCT, control subjects demonstrated five and six hyperreflective bands in the foveal and parafoveal regions, respectively, between the outer nuclear layer and Bruch's membrane. These bands demonstrated intensity profiles complementary to the known histopathologic distribution of rods and cones. In comparison to controls, subjects taking HCQ demonstrated reduced intensity of all bands, particularly bands two to four. In all cases of suspected or known toxicity, VIS-OCT demonstrated attenuation of band 3i, and in no cases was there attenuation of other bands that was more severe than band 3i, suggesting that changes in the reflectivity of band 3i may be the earliest identifiable sign of HCQ toxicity.</p><p><strong>Conclusions: </strong>VIS-OCT of the outer retina revealed a unique outer retinal banding pattern corresponding to photoreceptor density distributions. Notable attenuation of the photoreceptor outer segment reflectivity profile was associated with early HCQ toxicity. This finding may be an early, and possibly reversible, sign of HCQ toxicity, primarily impacting the cones.</p><p><strong>Translational relevance: </strong>VIS-OCT is useful in detecting subclinical outer retinal structural changes found in subjects using hydroxychloroquine.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 3","pages":"2"},"PeriodicalIF":2.6,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Suprachoroidal Injection in Cadaveric and Preclinical Models.","authors":"Mark Hedgeland, Sergio Camacho Gonzalez, Dimitrios Stampoulis, Vivian Lee, Kate Powell, Yubin Qiu, Robert Hodge, Greg Bell, Amanda Fago, Rebecca Atkinson-Dell, Nadya Choti, Kirsten Stoner","doi":"10.1167/tvst.14.3.20","DOIUrl":"10.1167/tvst.14.3.20","url":null,"abstract":"<p><strong>Purpose: </strong>The suprachoroidal space (SCS) is a new route for delivering therapeutics to the posterior eye. Reliably reaching the SCS is difficult in humans and animal models and necessitates thorough validation of drug delivery techniques. This study quantified SCS coverage in human cadaveric eyes using micro-computed tomography (μCT) and developed injectors optimized for preclinical animal anatomy resulting in reliable SCS access.</p><p><strong>Methods: </strong>Dynamic μCT captured volumetric images during a 100 µL SCS injection in 10 cadaveric human eyes from five donors. Quantitative measurements of injection coverage, thickness, distribution, and center of volume were calculated. To improve preclinical SCS delivery, our novel TS-Micro injector was scaled to accommodate non-human primate (NHP) anatomy. Devices were tested in vivo (30 total injections, 14 animals) where delivery success was evaluated via direct visualization, and intraoperative imaging.</p><p><strong>Results: </strong>Delivery to the SCS was successful in 100% of uncompromised human cadaver eyes (80% of all eyes). Injections of 100 µL in human SCS covered 33.3% ± 5.9%. Four-dimensional μCT showed that infusate initially spreads circumferentially from the injection point then posteriorly. Delivery to NHP eyes was successful in 95% of procedures resulting in coverage consistent to human cadaveric testing.</p><p><strong>Conclusions: </strong>Results provide the first quantifiable measurement of SCS injection spread in human anatomy with validation of suprachoroidal drug delivery in the NHP that mirrors coverage in human.</p><p><strong>Translational relevance: </strong>Cell and gene therapies require precise delivery for therapeutic efficacy, necessitating quantification of delivery in preclinical and human anatomy, as inaccurate delivery impacts efficacy of drug candidates and confounds toxicology/dose range studies.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 3","pages":"20"},"PeriodicalIF":2.6,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regional Biomechanical Weakening in Keratoconus Corneas Detected by In Vivo High-Frequency Ultrasound Elastography.","authors":"Sunny Kwok, Xueliang Pan, Manqi Pan, Zihao Chen, Madison Ammon, Andrew Hendershot, Jun Liu","doi":"10.1167/tvst.14.3.22","DOIUrl":"10.1167/tvst.14.3.22","url":null,"abstract":"<p><strong>Purpose: </strong>In vivo biomechanical characterization of the cornea remains a challenge. We have developed a high-resolution ultrasound elastography technique, termed ocular pulse elastography (OPE), to measure corneal deformation in response to the intraocular pressure (IOP) pulsation at each heartbeat. In this study, we aimed to compare corneal axial strains (CASs) between patients with keratoconus and normal subjects and evaluate the spatial mapping of CAS in high grade keratoconus.</p><p><strong>Methods: </strong>Forty patients with keratoconus (63 eyes) and 40 normal controls (80 eyes) were enrolled in this study. Each eye underwent 4 ultrasound measurements using the Vevo2100 high-frequency ultrasound system. Each measurement acquired 1000 continuous B-mode scans in 8 seconds. Corneal axial displacements and strains were quantified using an ultrasound speckle tracking algorithm.</p><p><strong>Results: </strong>CAS magnitude was significantly higher in keratoconus than normal corneas (-0.13% ± 0.09% vs. -0.06% ± 0.04%, P < 0.001) with an increasing trend in higher grades (P < 0.001). CAS in keratoconus corneas had a greater spatial variance as higher strains were observed in the cone center than its surrounding regions in grade 3 and 4 keratoconus corneas.</p><p><strong>Conclusions: </strong>Our results showed that high-frequency ultrasound elastography was able to detect and quantify the larger deformation of keratoconus corneas than normal corneas in response to the natural fluctuations of IOP at each heartbeat, and it also detected the spatial variance showing greater deformation in the cone region.</p><p><strong>Translational relevance: </strong>High-resolution ultrasound may provide a sensitive tool for quick, spatially resolved characterization of corneal biomechanics to aid keratoconus detection and diagnosis.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 3","pages":"22"},"PeriodicalIF":2.6,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal Artificial Intelligence Models Predicting Glaucoma Progression Using Electronic Health Records and Retinal Nerve Fiber Layer Scans.","authors":"Abigail Koornwinder, Youchen Zhang, Rohith Ravindranath, Robert T Chang, Isaac A Bernstein, Sophia Y Wang","doi":"10.1167/tvst.14.3.27","DOIUrl":"10.1167/tvst.14.3.27","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to develop models that predict which patients with glaucoma will progress to require surgery, combining structured data from electronic health records (EHRs) and retinal fiber layer optical coherence tomography (RNFL OCT) scans.</p><p><strong>Methods: </strong>EHR data (demographics and clinical eye examinations) and RNFL OCT scans were identified for patients with glaucoma from an academic center (2008-2023). Comparing the novel TabNet deep learning architecture to a baseline XGBoost model, we trained and evaluated single modality models using either EHR or RNFL features, as well as fusion models combining both EHR and RNFL features as inputs, to predict glaucoma surgery within 12 months (binary).</p><p><strong>Results: </strong>We had 1472 patients with glaucoma who were included in this study, of which 29.9% (N = 367) progressed to glaucoma surgery. The TabNet fusion model achieved the highest performance on the test set with an area under the receiver operating characteristic curve (AUROC) of 0.832, compared to the XGBoost fusion model (AUROC = 0.747). EHR only models performed with an AUROC of 0.764 and 0.720 for the deep learning model and XGBoost models, respectively. RNFL only models performed with an AUROC of 0.624 and 0.633 for the deep learning and XGBoost models, respectively.</p><p><strong>Conclusions: </strong>Fusion models which integrate both RNFL with EHR data outperform models only utilizing one datatype or the other to predict glaucoma progression. The deep learning TabNet architecture demonstrated superior performance to traditional XGBoost models.</p><p><strong>Translational relevance: </strong>Prediction models that utilize the wealth of structured clinical and imaging data to predict glaucoma progression could form the basis of future clinical decision support tools to personalize glaucoma care.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 3","pages":"27"},"PeriodicalIF":2.6,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143731650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative Evaluation of Changes in Retinal and Choroidal Blood Flow Following Strabismus Surgery.","authors":"Sayuri Yasuda, Yoshiko Takai, Yuma Yasuda, Takanori Yamamoto, Ryo Tomita, Takeshi Iwase, Norie Nonobe, Jun Takeuchi, Taiki Kojima, Koji M Nishiguchi, Hiroki Kaneko","doi":"10.1167/tvst.14.3.12","DOIUrl":"10.1167/tvst.14.3.12","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate the effects of extraocular muscle recession performed as part of strabismus surgery on posterior retinal and choroidal blood flow.</p><p><strong>Methods: </strong>A single-center prospective study was conducted on patients who underwent strabismus surgery. Optical coherence tomography, optical coherence tomography angiography, and laser speckle flowgraphy of the macula were performed before surgery and at one week, one month, and four months after surgery. Preoperative and postoperative ratios were calculated, and longitudinal changes in retinal blood flow, choroidal thickness, and choroidal blood flow were analyzed. Furthermore, the changes based on the types of resected muscle were examined.</p><p><strong>Results: </strong>In total, 254 eyes from 127 patients were included. The subfoveal choroidal thickness increased significantly at one week and one month after surgery, with no significant change at four months after surgery. The choroidal blood flow increased significantly at one week after surgery, with no significant changes at one and four months after surgery. The retinal vessel density significantly decreased at one week after surgery, with no significant changes at one and four months after surgery. Analysis of groups that had various muscles excised showed no significant changes in any measurements. Choroidal thickness and blood flow were significantly correlated at one week after surgery.</p><p><strong>Conclusions: </strong>Strabismus surgery decreased retinal blood flow but increased choroidal thickness and blood flow in the early postoperative period. Moreover, no significant changes were observed in the long term compared to the preoperative period.</p><p><strong>Translational relevance: </strong>Strabismus surgery affects the retina and choroid in the early postoperative period but not in the long term.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 3","pages":"12"},"PeriodicalIF":2.6,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}