Comparing the Performance of Stress-Strain Index Versions 1 and 2 in Normal and Keratoconus Patients.

IF 2.6 3区医学 Q2 OPHTHALMOLOGY

Translational Vision Science & Technology Pub Date : 2025-03-03 DOI:10.1167/tvst.14.3.23

Nan-Ji Lu, Marta Jiménez-García, Ahmed Elsheikh, Ahmed Makarem, Carina Koppen, Jos J Rozema

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引用次数: 0

Abstract

Purpose: The purpose of this study was to compare the performance of the Stress-Strain Index versions 1 and 2 (SSI and SSI2) in healthy patients and patients with keratoconus (KC).

Methods: Fifty-two healthy and 104 KC eyes were examined using Scheimpflug-based tomography and air-puff tonometry (Pentacam and Corvis). Correlations between both versions of SSI and age, thinnest pachymetry, and tomographic parameters were assessed. To discriminate KC eyes from healthy eyes, receiver operating characteristic curves were generated to calculate the area under the curve (AUC) for both versions of SSI and compared with a Delong test.

Results: Both versions of SSI showed statistical differences between the healthy group and the group of patients with KC (all P < 0.001). In the healthy group, significant correlations were found between both versions of SSI and age, K1, K2, and Kmax, between SSI and average relational thickness (ART) Max (R2 = 0.23) and between SSI2 and Belin A (R2 = 0.08). In the KC group, significant correlations were found between both versions of SSI and all tomographic parameters (all P < 0.01, except for SSI2 with age P = 0.346); the R2 values in SSI2 were consistently higher than in SSI. AUC for SSI and SSI2 when comparing normal and KC eyes was 0.772 and 0.740, respectively (P = 0.468).

Conclusions: Both versions of SSI correlated with tomographic parameters describing KC severity, but correlations were higher for SSI2 and were not affected by age. Both versions demonstrated the same diagnostic ability for KC.

Translational relevance: Both versions of SSI are not interchangeable, SSI2 may be preferred to depict the corneal stiffness.

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来源期刊

Translational Vision Science & Technology Engineering-Biomedical Engineering

CiteScore

5.70

自引率

3.30%

发文量

346

审稿时长

25 weeks

期刊介绍： Translational Vision Science & Technology (TVST), an official journal of the Association for Research in Vision and Ophthalmology (ARVO), an international organization whose purpose is to advance research worldwide into understanding the visual system and preventing, treating and curing its disorders, is an online, open access, peer-reviewed journal emphasizing multidisciplinary research that bridges the gap between basic research and clinical care. A highly qualified and diverse group of Associate Editors and Editorial Board Members is led by Editor-in-Chief Marco Zarbin, MD, PhD, FARVO. The journal covers a broad spectrum of work, including but not limited to: Applications of stem cell technology for regenerative medicine, Development of new animal models of human diseases, Tissue bioengineering, Chemical engineering to improve virus-based gene delivery, Nanotechnology for drug delivery, Design and synthesis of artificial extracellular matrices, Development of a true microsurgical operating environment, Refining data analysis algorithms to improve in vivo imaging technology, Results of Phase 1 clinical trials, Reverse translational ("bedside to bench") research. TVST seeks manuscripts from scientists and clinicians with diverse backgrounds ranging from basic chemistry to ophthalmic surgery that will advance or change the way we understand and/or treat vision-threatening diseases. TVST encourages the use of color, multimedia, hyperlinks, program code and other digital enhancements.