Transplant Infectious Disease最新文献

{"title":"Current Practice Patterns and Educational Needs of Immunocompromised Infectious Diseases Physicians in Australia and New Zealand.","authors":"Tina Marinelli, Benjamin Teh, Maddalena Giannella, Michael G Ison, Matthew Blake Roberts, Olivia Bupha-Intr, Monica Slavin","doi":"10.1111/tid.70087","DOIUrl":"10.1111/tid.70087","url":null,"abstract":"<p><strong>Introduction: </strong>The Australasian Society for Infectious Diseases (ASID) Immunocompromised Host Special Interest Group conducted a survey of the immunocompromised host (ICH) infectious diseases (IDs) workforce in Australia and New Zealand (ANZ). The primary aim of the survey was to characterise the current working environments and training of ANZ ICH ID clinicians and to better understand the education and research needs.</p><p><strong>Methods: </strong>A four-part questionnaire was developed based on a survey designed by the European Society of Clinical Microbiology and Infectious Diseases Study Group for Infection in Compromised Hosts. A REDCap survey link was distributed by ASID email distribution lists and local networks. The survey collected anonymous data on respondents' demographic and practice setting, pathway to current position, educational needs, and research interests.</p><p><strong>Results: </strong>Thirty-five ID clinicians who self-identified as ICH ID clinicians completed the survey, with respondents distributed across ANZ. Respondents provide care for a wide spectrum of ICH patients, often with no specific institutional funding and concurrent clinical duties beyond ICH ID. Respondents identified limited local opportunities for dedicated ICH ID training. There was enthusiasm for more local educational opportunities and formal training.</p><p><strong>Conclusion: </strong>Immunocompromised IDs is a relatively new subspeciality in ANZ with a growing need for ICH ID specialists given the enlarging ICH population. This survey highlights many ANZ region-specific challenges faced by ICH ID clinicians in relation to ICH ID training, service provision, and research.</p>","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70087"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144745163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"B-yond the Status Quo: Utilization of Hepatitis B-Positive Lung Donors\".","authors":"Ann E Woolley, Karen Doucette","doi":"10.1111/tid.70051","DOIUrl":"10.1111/tid.70051","url":null,"abstract":"","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70051"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aspergillus After Lung Transplantation: Prophylaxis, Risk Factors, and the Impact on Chronic Lung Allograft Dysfunction.","authors":"Johanna P van Gemert, Ger Jan Fleurke, Onno W Akkerman, C Tji Gan, Willie N Steenhuis, Huib A M Kerstjens, Erik A M Verschuuren, Douwe F Postma","doi":"10.1111/tid.70020","DOIUrl":"10.1111/tid.70020","url":null,"abstract":"<p><strong>Background: </strong>Invasive pulmonary aspergillosis (IA) poses significant challenges for lung transplant (LTx) patients, with unclear risk factors and preventive strategies. The effectiveness of nebulized amphotericin B (AmB) or statins for IA prevention and the effect of IA on chronic lung allograft dysfunction (CLAD) and mortality remain questionable.</p><p><strong>Methods: </strong>Data were collected from all LTx patients transplanted between December 1, 2013 and January 1, 2022 at the University Medical Center Groningen. IA, was defined according to published criteria. Prespecified risk factors were compared between patients with and without IA post-LTx and were entered in a logistic regression model. Two additional logistic regression models were built with factors that might be associated with statin or AmB prophylaxis and IA. A matched case-control study was conducted for the association between statins and IA, with matching based on follow-up time.</p><p><strong>Results: </strong>Aspergillus was cultured in 110 /274 (40%) patients post-LTx and 89/110 (81%) were classified as probable IA. MMF use, airway stenosis, Aspergillus cultured pre-LTx, CLAD, and acute rejection (AR), were significantly associated with IA. Statin use was associated with a lower incidence of IA, while AmB prophylaxis showed no significant effect. A significant statin effect could not be confirmed by the case control analysis. There was no significant difference in all-cause mortality between patients with and without IA (34% vs. 29%).</p><p><strong>Conclusions: </strong>The high incidence of IA post-LTx necessitates more effective strategies. Key targets for intervention include prior positive cultures, airway stenosis, AR, and the use of MMF. The role of statins remains unclear and requires further research.</p>","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70020"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Profile and Dynamics of Commensal Viruses in Brazilian Patients Who Underwent Allogeneic Hematopoietic Stem Cell Transplantation.","authors":"Gabriel Montenegro de Campos, Thalita Cristina de Mello Costa, Anielly Sarana da Silva, Lara Okuyama Afonso Costa, Roberta Maraninchi Silveira, Ian Nunes Valença, Felipe Santos de Carvalho, Luiz Guilherme Darrigo Júnior, Rodrigo Haddad, Ana Carolina de Jesus Vieira, Camila Campos Mesquita, Patrícia da Silva Laurindo, Renato Guerino Cunha, Luiz Carlos Júnior Alcântara, Simone Kashima, Dimas Tadeu Covas, Belinda Pinto Simões, Sandra Coccuzzo Sampaio, Maria Carolina Elias, Marta Giovanetti, Dennis Maletich Junqueira, Svetoslav Nanev Slavov","doi":"10.1111/tid.70037","DOIUrl":"10.1111/tid.70037","url":null,"abstract":"<p><strong>Background: </strong>Commensal viruses are typically well-tolerated by healthy individuals, but their behavior in immunocompromised patients is not fully understood.</p><p><strong>Methods: </strong>This study investigated the prevalence, molecular dynamics, and circulating genotypes of human pegivirus-1 (HPgV-1) and three types of torque teno viruses (TTV-3, -16, and -22) in Brazilian patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT). Plasma samples from 20 patients were collected at three time points: pretransplantation (D+0), 30 days post-transplantation (D+30), and 100 days post-transplantation (D+100). We conducted longitudinal screening for HPgV-1 and three TTV variants using real-time PCR, comparing cycle threshold values across these intervals.</p><p><strong>Results: </strong>The overall HPgV-1 RNA prevalence at all collection points was 45% (n = 9/20), with all infected individuals carrying genotype 2. HPgV-1 infections exhibited stable, closely related strains over time, though virus evolution was highly individualized. The overall prevalence of TTV types was 5% for TTV-3, 30% for TTV-16, and 60% for TTV-22. Notably, all commensal viruses showed a decrease in cycle threshold at D+100, indicating a possible increase in viral load.</p><p><strong>Conclusion: </strong>These findings underscore the importance of commensal viruses in the context of HSCT and suggest their potential role as biomarkers for immune suppression and transplantation outcomes. Further research is warranted to elucidate their implications.</p>","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70037"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disseminated Blastomycosis Presenting With Skin Lesions in a Renal Transplant Recipient.","authors":"Ashley Zeoli, Adriana Della Porta, Kaitlyn Reasoner, Eva Niklinska, Christina Vojtek, Eva Rawlings Parker, Lili Tao, Kevin Dee, Augusto Dulanto Chiang, Richard W LaRue","doi":"10.1111/tid.70061","DOIUrl":"10.1111/tid.70061","url":null,"abstract":"","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70061"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144226851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Pretransplant Antimicrobial Sulfonamide Allergy Label in Kidney Transplant Recipients.","authors":"Harry Ross Powers, Hani M Wadei, Cesar Campos Cuellar, Amogharvasha Venugopal, Vasili Pleqi, Alex Hochwald, Yaohua Ma, Alexei Gonzales","doi":"10.1111/tid.70063","DOIUrl":"10.1111/tid.70063","url":null,"abstract":"<p><strong>Background: </strong>Sulfa antibiotic allergy labels (SALs) are encountered frequently in kidney transplant recipients (KTs). This often results in patients receiving second-line prophylaxis for both Pneumocystis jiroveci and urinary tract infections (UTIs). The effect of SAL on outcomes including UTIs after KT is unclear.</p><p><strong>Methods: </strong>In our single-center retrospective cohort study, we investigated the effect of SALs on bacteriuria after KT. We identified patients with pre-KT SALs from 2011 to 2022. A matched cohort was then created using KT with no pretransplant SALs. The groups were compared using proportional analysis and univariable and multivariable Cox proportional regression models. The primary outcome of interest was the proportion of individuals experiencing one or more episodes of bacteriuria within 1 year posttransplant. Secondary outcomes included bacteremic UTIs, acute kidney injury, and opportunistic infections.</p><p><strong>Results: </strong>We found that the proportion of individuals experiencing bacteriuria within the first-year posttransplant was significantly greater in the SAL group versus the control group (n = 21, 28% vs. n = 22, 14.7%, p = 0.012). This result was also seen in univariable and multivariable survival analysis. In addition, episodes of UTI with associated bacteremia (n = 11, 14.7% vs. n = 5, 3.3%, p = 0.002) were statistically significantly higher in the SAL group.</p><p><strong>Conclusion: </strong>There was a significantly greater number of episodes of bacteriuria in the first-year posttransplant in subjects with pretransplant SAL. Based on our findings, we suggest that all KTs with pretransplant SALs undergo evaluation and intervention prior to transplantation.</p>","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70063"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144226853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of the QuantiFERON Monitor Assay to Predict Clinical Outcomes in Solid Organ and Hematopoietic Cell Transplant Recipients: A Scoping Review.","authors":"Bradley J Gardiner, Roy F Chemaly, Vladyslav Nikolayevskyy, Riccardo Alagna, Davide Manissero, Camille N Kotton","doi":"10.1111/tid.70074","DOIUrl":"10.1111/tid.70074","url":null,"abstract":"<p><strong>Background: </strong>QuantiFERON Monitor (QFM) is an interferon-gamma release assay designed to provide a global measure of innate and adaptive cell-mediated immune function. We performed a scoping review to explore published evidence on the ability of QFM to predict clinical outcomes in solid organ transplant (SOT) and allogeneic hematopoietic cell transplant (HCT) recipients.</p><p><strong>Methods: </strong>A literature search was conducted using Embase, Cochrane, and PubMed databases and included studies reporting QFM values and the incidence of infection and/or organ rejection or graft-versus-host disease (GvHD).</p><p><strong>Results: </strong>Thirteen publications (9 SOT, 4 HCT) were included. Among SOT studies, infection (n = 8), rejection (n = 3), mortality (n = 2), and immunosuppression regimens (n = 7) were assessed as outcomes; low QFM values were associated with increased infection risk in 7/8 studies. Correlations were also identified between immunosuppression regimens and QFM results in 6/7 studies. No clear relationships between QFM values and rejection or mortality could be determined, possibly due to the low number of events reported. Infection (n = 4), GvHD (n = 3), and mortality (n = 1) were assessed in the HCT studies, with 3/4 reporting an association between low QFM values and infection. There was a high degree of heterogeneity in the transplant populations, outcome measures and definitions, QFM thresholds, and timing of sample collection.</p><p><strong>Conclusions: </strong>The available data suggest that QFM may be able to identify overly immunosuppressed individuals at higher risk of infection; additional studies are needed to further evaluate its predictive utility in transplant and other settings.</p>","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70074"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144545005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Unseen Battleground: How Anaerobic Antibiotics Shape GVHD Risk Post-HSCT.","authors":"Ildefonso Espigado, Laura de la Torre Corona","doi":"10.1111/tid.70075","DOIUrl":"10.1111/tid.70075","url":null,"abstract":"","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70075"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Building a Robust Immunocompromised Host Infectious Disease Workforce.","authors":"Michael G Ison","doi":"10.1111/tid.70071","DOIUrl":"https://doi.org/10.1111/tid.70071","url":null,"abstract":"","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":"27 4","pages":"e70071"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Six-Year-Old Boy With Fever and Deranged Liver Function Tests, Post-Living-Donor Liver Transplantation.","authors":"Dhiraj Agrawal, Shwetha Kamath, Dharmesh Kapoor","doi":"10.1111/tid.70035","DOIUrl":"10.1111/tid.70035","url":null,"abstract":"","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70035"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}