Transplant Infectious Disease最新文献

{"title":"From Surviving to Thriving: Overcoming Early Career Challenges in Transplant Infectious Diseases.","authors":"Courtney E Harris, Chelsea A Gorsline, Ruth Adekunle, Christina Vojtek, Eric Altneu, Julia Bini Viotti, Michael Scolarici, Chia-Yu Chiu, Rebecca N Kumar","doi":"10.1111/tid.70281","DOIUrl":"10.1111/tid.70281","url":null,"abstract":"<p><p>Transplant infectious diseases (TID) is a highly specialized subspecialty situated at the intersection of immunosuppression, emerging pathogens, antimicrobial stewardship, and multidisciplinary transplant care. Early-career TID physicians must balance high-acuity clinical responsibilities with expectations for scholarly productivity, programmatic engagement, and leadership development while establishing credibility within transplant programs. This \"Experience from the Field\" report highlights key domains that shape early-career success in TID, including mentorship, trainee development, skill acquisition, research strategy, time management within unpredictable clinical environments, maintenance of scientific currency, professional visibility, and long-term sustainability. Intentional alignment of clinical, academic, and personal priorities is required to move from professional survival toward sustained impact within the evolving landscape of TID.</p>","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70281"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13638767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148580051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Positive Strongyloides Serology: A Descriptive Analysis Across Geographically Distinct Academic Medical Centers.","authors":"Sandhya R Nagarakanti, Jamilah L Shubeilat, Ali Abdulsahib, Natasha P Dyal, Matt Biondi, Joseph Hentz, Erin Kaleta, Holenarasipur R Vikram","doi":"10.1111/tid.70276","DOIUrl":"10.1111/tid.70276","url":null,"abstract":"<p><strong>Background: </strong>Strongyloides stercoralis is an intestinal parasitic nematode that can infect humans with a 2%-7% prevalence in the United States. Immunosuppression is a crucial risk factor for disseminated infection. Diagnosis is often delayed and targeted treatment is frequently initiated late. We therefore sought to review the prevalence of positive Strongyloides antibody results and undertook a descriptive analysis of such patients.</p><p><strong>Methods: </strong>We retrospectively reviewed patients with positive Strongyloides IgG serology from August 2012 to April 2023 across geographically distinct academic medical centers. Study period pre-dated universal donor and recipient Strongyloides screening recommendation by the Organ Procurement and transplantation network (OPTN). Clinical presentation was classified into three categories: chronic infection (positive Strongyloides IgG serology without additional clinical manifestations), hyperinfection syndrome (positive serology with involvement of the skin, gastrointestinal tract, or lungs), and disseminated infection (positive serology with involvement beyond those typically involved in hyperinfection).</p><p><strong>Results: </strong>A total of 412 patients were identified; median age was 59 years and 66% (272) were male. The primary indication for testing was pretransplant evaluation in 230 (56%), eosinophilia workup in 84 (20%), suspicion of symptomatic infection in 74 (18%), testing based on travel history in 27 (7%), and pre-immunosuppression screening in 27 (7%). Furthermore, 401 patients (97.3%) were categorized as having chronic infection, 10 patients (2.42%) had hyperinfection, and one patient (0.24%) had disseminated infection, presenting with Escherichia coli bacteremia and meningitis. Symptomatic infection was more common at the Mayo Clinic in Rochester and Mayo Clinic Health Sciences than at the Arizona and Florida Mayo Clinic sites (6% vs. 2%, p = 0.079). Treatment was administered to 366/412 (89%) patients.</p><p><strong>Conclusion: </strong>Most patients with positive Strongyloides serology were asymptomatic, and treatment regimens were not uniform. Patients who tested positive should be treated prior to immunosuppression initiation, though this was not systematically assessed in this cohort. The observed variability in treatment regimens highlights the need for standardized protocols.</p>","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70276"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148438133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-Engraftment Kinetics of Cross-Reactive Cryptococcal Antigenemia in Disseminated Trichosporon asahii Infection After Haploidentical Peripheral Blood Stem Cell Transplantation.","authors":"Te-Fu Weng, Kang-Hsi Wu","doi":"10.1111/tid.70280","DOIUrl":"10.1111/tid.70280","url":null,"abstract":"","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70280"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148438187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual Viral Insult Leading to Prolonged Cytopenia in a Renal Transplant Recipient: Beyond Cytomegalovirus in Tropical Settings.","authors":"Thotanolla Surya Prakash, Kokila Raghavendra","doi":"10.1111/tid.70259","DOIUrl":"10.1111/tid.70259","url":null,"abstract":"","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70259"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148157811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Achieving Beta-Lactam Goals During the Critical Collision of ARC in OLT Patients.","authors":"Benjamin Albrecht, Sarah Green, Heather Snyder","doi":"10.1111/tid.70265","DOIUrl":"10.1111/tid.70265","url":null,"abstract":"","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70265"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148273158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metagenomic Next-Generation Sequencing for Diagnosis of Infectious Diseases in Pediatric Transplant Patients.","authors":"Denver T Niles, Elizabeth A Moulton, Claire E Bocchini","doi":"10.1111/tid.70272","DOIUrl":"10.1111/tid.70272","url":null,"abstract":"<p><p>Metagenomic next-generation sequencing (mNGS) is a significant advancement in the diagnostic evaluation of infectious diseases, especially in immunocompromised patients at risk for complex, atypical, and opportunistic infections. In pediatric solid organ transplant (SOT) and hematopoietic stem cell transplant (HSCT) recipients, mNGS can augment a diagnostic evaluation when conventional microbiological testing (CMT) fails to identify the infectious etiology. Current evidence supports the use of mNGS for specific syndromes, including complicated pneumonia, central nervous system infections, and febrile neutropenia, due to greater sensitivity. While it is considered a second-line test, early application for high-risk infections, such as diagnosis of invasive fungal disease, has been shown to be impactful. Furthermore, mNGS can detect donor-derived infections (DDIs), where the breadth of the assay can identify unexpected pathogens transmitted via the graft that are often omitted from routine screening protocols. Despite the potential, interpretation remains challenging due to the detection of DNA from commensal organisms, latent viral reactivation, and low-level detection of pathogens that do not correlate with disease. Establishing diagnostic stewardship is key to directing testing to maximize diagnostic yield and improve clinical outcomes.</p>","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70272"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148593310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Powerful Predictor Is Not yet an Actionable One: Contextualizing the Posttransplant VRE Colonization Score.","authors":"Lin Xu, Hong Liu, Xiaona Zhang, Siyu Mu","doi":"10.1111/tid.70269","DOIUrl":"10.1111/tid.70269","url":null,"abstract":"","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70269"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148473056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Onset Bacteremia in Kidney Transplant Recipients in the Current Era.","authors":"Lana Hasan, Nabin K Shrestha, Mathew Duck, Joshua Augustine, Richard Fatica, Alvin Wee, Christine E Koval","doi":"10.1111/tid.70278","DOIUrl":"10.1111/tid.70278","url":null,"abstract":"<p><strong>Background: </strong>Bloodstream infection (BSI) after kidney transplantation increases the risk of graft loss and mortality. We aimed to identify contemporary risk factors and outcomes of early BSI (eBSI) at our transplant center.</p><p><strong>Methods: </strong>We conducted a retrospective chart review of adult kidney transplant recipients (KTRs) from 2019 to 2023. Those with the eBSI (within 90 days of KTR) were matched by age and gender to controls. Risk factors were identified using multivariable logistic regression. All KTRs surviving to 90 days, were included in graft and patient survival analysis.</p><p><strong>Results: </strong>Among 1408 KTRs, 75 (5.3%) developed eBSI, at a median of 21 days (IQR: 12-42.5). On multivariable analysis, each doubling of hospital duration was independently associated with a 49% increase in the risk of eBSI (OR: 1.49, 95% CI: 1.19-1.91; p < 0.001), and each doubling of postsurgical drain retention duration was independently associated with a 68% increase in the risk of eBSI (OR: 1.68, 95% CI: 1.17-2.48; p 0.006). eBSI was associated with 1-year mortality (aHR: 3.32, 95% CI: 1.51-7.28; p 0.003) and 3-year graft failure (aHR: 2.78, 95% CI: 1.31-5.93; p 0.008).</p><p><strong>Conclusion: </strong>eBSI was associated with graft failure and mortality. The donor and recipient factors identified highlight the need for further studies to better characterize their impact on eBSI.</p>","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70278"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13638765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148473124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidental Detection of Respiratory Viruses in Lung Transplant Donor-Recipient Pairs: Exploratory Associations With Clinical Outcomes in a Post Hoc Analysis.","authors":"Andrea Lombardi, Letizia Corinna Morlacchi, Giulia Renisi, Lorenzo Rosso, Jacopo Fumagalli, Patrizia Bono, Ilaria Righi, Valeria Rossetti, Arianna Liparoti, Cecilia Azzarà, Davide Mangioni, Laura Alagna, Anna Celotti, Claudia Alteri, Chiara Abbruzzese, Annapaola Callegaro, Francesco Blasi, Giacomo Grasselli, Mario Nosotti, Alessandra Bandera","doi":"10.1111/tid.70275","DOIUrl":"10.1111/tid.70275","url":null,"abstract":"<p><strong>Background: </strong>Infections caused by community-acquired respiratory viruses (CARV) are very common among lung transplant recipients and have been linked to acute rejection and chronic lung allograft dysfunction (CLAD). However, the clinical relevance of CARV detection in donor-recipient pairs at the time of lung transplantation remains unclear.</p><p><strong>Methods: </strong>Post hoc analysis of the Pneumoarray study, evaluating the clinical significance of incidentally detected CARV identified by syndromic molecular panels (PNplus) in BAL samples collected 72 h after transplantation from donors and recipients.</p><p><strong>Results: </strong>Among 53 donor-recipient pairs, CARV were identified in 7 (13.2%) and 11 (20.8%) BAL samples from donors and recipients, respectively. Unadjusted analyses showed a link between CARV PNplus positivity in donor samples and longer hospitalization (Δ+30.3 days, 95% CI 7.1-53.5; p = 0.011). Any CARV PNplus positivity during the transplant episode also indicated a potential link with longer hospital stays (Δ+19.2 days, 95% CI 1.4-37.0; p = 0.035). Donor CARV PNplus positivity showed a signal suggesting a potential association with higher odds of CLAD within 12 months (OR 8.40, 95% CI 0.84-83.89; p = 0.030). CARV PNplus positivity in the recipient for rhinovirus indicated a potential link with baseline lung allograft dysfunction (p = 0.016), while no other relationships were observed between clinical outcomes and being PNplus positive for a viral pathogen.</p><p><strong>Conclusion: </strong>CARV genome detection in donor BAL samples was numerically associated with longer posttransplant hospitalization, and a potential signal between rhinovirus detection in recipient BAL and baseline lung allograft dysfunction was observed. However, these findings should be regarded as exploratory and hypothesis-generating, and they do not support the routine baseline screening for CARV in lung transplant donor-recipient pairs.</p>","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70275"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13638784/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148424498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CMV-Associated Worsening of Neurological Symptoms in Kearns-Sayre Syndrome After Heart Transplantation: A Case Report.","authors":"Alejandro Cerezo Rivas, Volkmar Falk, Linda Juergens","doi":"10.1111/tid.70268","DOIUrl":"10.1111/tid.70268","url":null,"abstract":"","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70268"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148412976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}