Transplant Infectious Disease最新文献

{"title":"Peripheral Blood Lymphocyte Dynamics and Hidden Immune Effects of Severe Acute Respiratory Syndrome Coronavirus 2 Messenger RNA Vaccination in Kidney Transplant Recipients.","authors":"Sara Querido, Maria Jorge Arroz, André Weigert, Catarina Martins","doi":"10.1111/tid.70056","DOIUrl":"10.1111/tid.70056","url":null,"abstract":"","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70056"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Practice Patterns and Educational Needs of the ESCMID Study Group for Infections in Compromised Hots.","authors":"Maddalena Giannella, Daniele Riccucci, Renato Pascale, Elisa Cordero, Nicolas J Mueller, Monica Slavin, Michael Ison","doi":"10.1111/tid.70076","DOIUrl":"10.1111/tid.70076","url":null,"abstract":"<p><strong>Background: </strong>The ESCMID Study Group for Infection in Compromised Hosts (ESGICH) conducted a survey to assess its members' demographics, clinical focus, training pathways, research activities, and educational needs. The primary objective was identifying the current expertise and challenges professionals face in immunocompromised host infectious diseases (ICH-ID) and determining how ESGICH can better support their clinical and research endeavors.</p><p><strong>Methods: </strong>A structured questionnaire was distributed to ESGICH members by email and was posted on X to collect information on work settings, patient populations, training, collaborative networks, research involvement, and educational experiences. The survey also assessed interest in future educational initiatives, including certification programs and targeted training opportunities.</p><p><strong>Results: </strong>Overall, 119 colleagues participated in the survey, with the majority being members of ESGICH, which had approximately 230 participants, yielding a response rate of 52%. Most of the respondents were from Europe and noted significant involvement in ICH-ID clinical care and research. Many respondents provide care for transplant recipients and haemato-oncology patients, with varying levels of institutional support, and often had clinical responsibility beyond the ICH-ID population. Training in ICH-ID is inconsistent, with many participants expressing a need for more structured training pathways. Research engagement was high, though support structures varied. Participants identified key educational gaps and expressed interest in webinars, in-person meetings, and certification programs.</p><p><strong>Conclusion: </strong>The findings highlight the need for ESGICH to enhance educational opportunities, strengthen research networks, and advocate for standardized ICH-ID training. Addressing these gaps will improve professional development and ultimately enhance patient care for ICHs.</p>","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70076"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of Cytomegalovirus Quantitative Polymerase Chain Reaction in Tissue Biopsy for the Diagnosis of Cytomegalovirus Gastrointestinal Disease Among Solid Organ Transplant Recipients.","authors":"Lucila Baldassarre, Koray Demir, Camille Pelletier Vernooy, Guillaume Butler Laporte, Geneviève Huard, Catherine Girardin, Katarzyna Orlicka, Bich Ngoc Nguyen, Christian Renaud, Charles Poirier, Julie Morisset, Me-Linh Luong","doi":"10.1111/tid.70082","DOIUrl":"10.1111/tid.70082","url":null,"abstract":"<p><strong>Background: </strong>Gastrointestinal (GI) cytomegalovirus (CMV) infection is an important cause of morbidity after solid organ transplantation (SOT), and diagnosis mainly relies on histopathology of GI tissue biopsies. CMV detection by quantitative polymerase chain reaction (qPCR) on tissue biopsy is not routinely performed, but potentially holds many practical advantages.</p><p><strong>Methods: </strong>We compared the performance of CMV qPCR on fresh GI biopsies to histopathologic identification for the detection of CMV GI disease.</p><p><strong>Results: </strong>Sixty-one SOT patients with GI symptoms underwent endoscopic assessment, with tissue biopsies obtained. Eleven patients had proven CMV disease by histopathologic detection. Among them, all had a positive qPCR on tissue biopsy (median of 8.7 × 10⁷ IU/mL [interquartile range {IQR} 3.1 × 10⁷, 18.2 × 10⁷]). Of the 49 patients with negative histopathology, 27 (55%) had CMV qPCR-positive tissue biopsy specimens (median of 43 604 IU/mL [IQR 2923, 497 570]). Receiver operating characteristic analysis for optimal threshold value for CMV qPCR on tissue biopsy for diagnosis of proven CMV GI disease was 147 906 IU/mL (sensitivity 100%, specificity 80%, area under the curve = 0.975).</p><p><strong>Conclusion: </strong>Compared to histopathologic detection, CMV qPCR on GI tissue biopsy is highly sensitive for the diagnosis of CMV GI disease in SOT patients, making it a potentially useful adjunctive diagnostic tool for rapid diagnosis in this population.</p>","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70082"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measles and Solid Organ Transplantation: Diagnosis, Treatment, and Prevention.","authors":"Stephanie M Pouch, Akshatha Ravindra, Sara W Dong, Wanessa Trindade Clemente, Ricardo M La Hoz, Aaron Mishkin, Jonathan Hand, Maristela Pinheiro Freire, Jacques Simkins, Cameron Wolfe, John W Baddley","doi":"10.1111/tid.70066","DOIUrl":"https://doi.org/10.1111/tid.70066","url":null,"abstract":"<p><p>The recent international resurgence of measles has led to significant public health concerns and poses significant risks to immunocompromised patients, including those who have undergone solid organ transplantation (SOT). SOT recipients may present atypically and are at an increased risk of severe complications of measles infection, underscoring the importance of preventative measures. This review summarizes contemporary data regarding measles transmission, the clinical presentation, diagnosis, and treatment of SOT recipients, as well as strategies for measles prevention, infection control considerations, postexposure prophylaxis, and opportunities for the mitigation of donor-derived measles and measles vaccine viruses.</p>","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70066"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144545003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytomegalovirus Retinitis During Idecabtagene Vicleucel Therapy in Patients With Relapsed/Refractory Multiple Myeloma.","authors":"Taku Kikuchi, Miyu Watanabe, Nobuhiro Tsukada, Chiaki Matsumoto, Moe Nomura-Yogo, Kodai Kunisada, Haruka Sawada, Kota Sato, Tomomi Takei, Mizuki Ogura, Yu Abe, Kenshi Suzuki, Osamu Hosoya, Tadao Ishida","doi":"10.1111/tid.70040","DOIUrl":"10.1111/tid.70040","url":null,"abstract":"<p><strong>Background: </strong>Chimeric antigen receptor T-cell (CAR-T) therapy has improved outcomes in patients with triple-class-exposed relapsed/refractory multiple myeloma (RRMM); however, it is associated with complications, including infections. Cytomegalovirus (CMV) infection is one of the infections associated with idecabtagene vicleucel (ide-cel) treatment. While there have been several reports on CMV replication, CMV retinitis has only been documented in case reports, making it a severe but under-reported complication.</p><p><strong>Study design: </strong>This retrospective single-institution study was conducted at the Japanese Red Cross Medical Center. The study analyzed the clinical features of CMV retinitis in 53 patients with RRMM treated with ide-cel between December 2022 and December 2024. CMV retinitis was diagnosed based on ophthalmological findings, with CMV polymerase chain reaction (PCR) confirmation in the vitreous fluid, if necessary.</p><p><strong>Results: </strong>The cumulative incidence of CMV retinitis at 6 months was 9.2%, with a median onset time of 2.2 months postinfusion. Among the four patients with CMV retinitis, three patients experienced visual impairment and one patient was asymptomatic. One patient was diagnosed with CMV retinitis, despite having negative serum CMV PCR results, which highlights the limitations of replication-based screening. All patients required treatment, with one patient achieving improvement and three patients undergoing ongoing treatments.</p><p><strong>Conclusions: </strong>CMV retinitis is a significant complication of ide-cel therapy. Regular CMV PCR is important, but early ophthalmological consultations are crucial for timely detection and management, even in the absence of CMV replication, particularly when visual impairment develops. Further studies are needed to identify the risk factors and establish preventive strategies.</p>","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70040"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Discrepant Infectious Disease Results in Deceased Organ Donors: Insights From a Retrospective Analysis of Post-Policy Testing.","authors":"Sara Dionne, Hillary Akana, Chris Curran, Sean Van Slyck","doi":"10.1111/tid.70055","DOIUrl":"10.1111/tid.70055","url":null,"abstract":"<p><strong>Background: </strong>In 2021, a new policy was implemented by the Organ Procurement Transplant Network requiring Organ Procurement Organizations to draw a repeat blood sample for deceased organ donors if donation had not proceeded within 96-h after the initial blood sample for screening was obtained. We performed an analysis of over 2600 deceased donor test results, comparing initial results to repeated blood draw results for human immunodeficiency virus, Hepatitis B virus, and Hepatitis C virus serology and nucleic acid test (NAT) tests. This study reviews result discrepancies and explores investigations behind peculiar results.</p><p><strong>Methods: </strong>Infectious disease results from deceased organ donors were analyzed retrospectively for this study. Donor specimens were collected throughout the United States and tested at eleven laboratories. Food & Drug Administration-approved donor screening tests were used to determine donor eligibility.</p><p><strong>Results: </strong>There was a 1.69% discrepancy rate comparing results from repeat blood draw specimens to original specimen results. Of these discrepancies, 0.75% of the donors had results (enzyme-linked immunoassay and/or NAT) that changed from non-reactive to reactive. 0.68% of donors had results that changed from reactive to non-reactive. 0.26% of results changed from Ultrio repeatedly reactive, non-discriminated to either non-reactive or reactive.</p><p><strong>Conclusion: </strong>This study represents that there is more than a 1% chance that discrepant results will be obtained. Despite the low incidence of discrepancies, these rare occurrences can complicate clinical decision-making, requiring case-by-case assessments. We present several cases in which variability in results can make clinical decisions complex with limited information and the inability to perform timely confirmatory testing using tests not required by Organ Procurement Transplant Network regulations.</p>","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70055"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Don't Test Twice, It's All Right.","authors":"Zoe Raglow, Daniel R Kaul","doi":"10.1111/tid.70047","DOIUrl":"10.1111/tid.70047","url":null,"abstract":"","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70047"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and Timing of Epstein-Barr Virus Whole Blood DNAemia in Epstein-Barr Virus-Mismatched Adult and Pediatric Solid Organ Transplant Recipients.","authors":"Catherine Burton, Curtis Mabilangan, Jutta Preiksaitis","doi":"10.1111/tid.70042","DOIUrl":"10.1111/tid.70042","url":null,"abstract":"<p><strong>Background: </strong>Epstein-Barr virus (EBV) viral load (VL) monitoring is recommended post-transplant for EBV-mismatched (donor EBV seropositive/recipient EBV seronegative) solid organ transplant (SOT) recipients as a component of post-transplant lymphoproliferative disorder (PTLD) prevention, but the optimal frequency and timing of EBV VL monitoring remains unknown.</p><p><strong>Methods: </strong>In this retrospective cohort study, we investigated the incidence and timing of whole blood EBV DNAemia in EBV-mismatched adult and pediatric SOT recipients, who had EBV VL monitoring as part of a pre-emptive approach to PTLD prevention to optimize monitoring algorithms. We explored associations between donor-acquired EBV DNAemia (DA-EBV), defined as EBV DNAemia within 1 year post-transplant, and donor and recipient characteristics, and determined the proportion who developed PTLD.</p><p><strong>Results: </strong>We analyzed 257 D⁺/R^- recipients (kidney n = 64, heart n = 75, liver n = 93, lung n = 25); 126/257 (49.0%) developed DA-EBV at a median of 83 days (Q1-Q3: 50-130 days) post-transplant. Incidence of DA-EBV varied by organ and was highest in liver (62.4%) and lowest in heart recipients (28.0%). PTLD was diagnosed in 38/257 (14.8%) EBV-mismatched recipients, 25/162 (15.4%) children, and 13/95 (13.7%) adults. DA-EBV was uncommon in recipients less than 6 months old (3/29, 10.3%) and among recipients less than 12 months with donors less than 12 months (2/29, 6.9%); possible mechanisms of protection other than recipient passive maternal antibody and false-positive donor serostatus are discussed.</p><p><strong>Conclusion: </strong>Monitoring for DA-EBV should be focused on months 2-6 post-transplant. Less frequent whole blood EBV VL monitoring is likely a safe option in recipients less than 6 months old and recipients 6-12 months old with donors less than 12 months old.</p>","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70042"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can Quantitative Polymerase Chain Reaction in Tissue Improve Cytomegalovirus Management? Balancing Diagnostic Sensitivity and the Risk of Overtreatment.","authors":"Eleftheria Kampouri, Oriol Manuel","doi":"10.1111/tid.70045","DOIUrl":"10.1111/tid.70045","url":null,"abstract":"","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70045"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Talk About a Bad Reputation: Is It OK to Continue Trimethoprim-Sulfamethoxazole Prophylaxis in the Face of Hyper K.","authors":"Sonya M Kothadia, Madeleine R Heldman","doi":"10.1111/tid.70062","DOIUrl":"10.1111/tid.70062","url":null,"abstract":"","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70062"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}