Transplant Infectious Disease最新文献_第10页

Donor-derived dengue infections - A review of screening protocol and outcomes in an endemic country. 来自捐献者的登革热感染--一个登革热流行国家的筛查方案和结果回顾。

IF 2.6 4区医学

Transplant Infectious Disease Pub Date : 2024-11-01 Epub Date: 2024-08-16 DOI: 10.1111/tid.14356

Sophie Seine Xuan Tan, Samsudin Bin Nordin, Chee-Kiat Tan, Thuan Tong Tan, Shimin Jasmine Chung, Kian Sing Chan, Ban Hock Tan

{"title":"Donor-derived dengue infections - A review of screening protocol and outcomes in an endemic country.","authors":"Sophie Seine Xuan Tan, Samsudin Bin Nordin, Chee-Kiat Tan, Thuan Tong Tan, Shimin Jasmine Chung, Kian Sing Chan, Ban Hock Tan","doi":"10.1111/tid.14356","DOIUrl":"10.1111/tid.14356","url":null,"abstract":"Background: Donor-derived dengue infections present significant challenges to organ transplantation, particularly in endemic regions like Singapore. Although primarily transmitted by Aedes mosquitoes, dengue can also be transmitted through organ transplantation, occasionally with fatal outcomes. This study aims to evaluate the outcomes and evolution of dengue screening protocols for potential deceased donors in Singapore from 2006 to 2022.Methods: Initially, screening was done via dengue immunoglobulin M (IgM), targeting donors with specific clinical criteria (thrombocytopenia, drop in platelet count, prolonged prothrombin time/partial thromboplastin time, and discretion of the transplant team), later transitioning to blood dengue reverse transcription-polymerase chain reaction (RT-PCR) in 2007 with similar criteria, and subsequently universal screening in 2016. In 2021, urine dengue RT-PCR was added following a case of donor-derived dengue infection from an aviremic but viruric donor.Results: Out of 431 potential deceased donors, 395 (91.6%) underwent dengue screening, with six (1.5%) testing positive for dengue. In 2006, three positive screens were identified: two through dengue IgM and one via blood dengue RT-PCR; subsequent years saw one positive screen each in 2007, 2008, and 2019 via blood dengue RT-PCR. Potential deceased donors with a positive blood dengue screen were rejected as solid organ and tissue donors. Those with negative blood dengue RT-PCR but positive urine dengue RT-PCR would be rejected as kidney donors, but the use of other organs and tissues was at the discretion of the transplantation team.Conclusion: The optimal screening protocol remains uncertain, but our findings suggest that a universal screening strategy utilizing both blood and urine dengue RT-PCR could be considered in dengue-endemic countries.","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e14356"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141989006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of blood donation biovigilance and transfusion-transmitted infections on organ transplantation. 献血生物警戒和输血传播感染对器官移植的影响。

IF 2.6 4区医学

Transplant Infectious Disease Pub Date : 2024-11-01 Epub Date: 2024-06-27 DOI: 10.1111/tid.14324

Adam G Stewart, Camille Nelson Kotton

{"title":"Impact of blood donation biovigilance and transfusion-transmitted infections on organ transplantation.","authors":"Adam G Stewart, Camille Nelson Kotton","doi":"10.1111/tid.14324","DOIUrl":"10.1111/tid.14324","url":null,"abstract":"Over 118 million blood donations are collected globally each year. Recipients of blood products include those who experience major trauma or surgery, have acute blood loss and anemia, or impaired bone marrow function. Solid organ transplant recipients often require transfusion of blood products which places them at risk of transfusion-associated adverse events including transfusion-transmitted infection. National hemovigilance networks have documented low rates of transfusion-transmitted infection in the general population. Incidence transfusion-transmitted infection continues to occur in solid organ transplant patients and arises mainly from existing gaps in blood donor biovigilance processes. Emerging infectious diseases have highlighted existing gaps in the donor-recipient pathway to administering safe blood products. This article reviews the current process and regulatory oversight of blood donor biovigilance, including donor screening and microbiological testing, highlights cases of transfusion-transmitted infection documented in the literature, and addresses ways in which biovigilance may be improved, with a focus on the impact of solid organ transplantation.","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e14324"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141459514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perspectives on donor-derived infections from Germany. 德国对供体源性感染的看法。

IF 2.6 4区医学

Transplant Infectious Disease Pub Date : 2024-11-01 Epub Date: 2024-09-23 DOI: 10.1111/tid.14372

Ana Paula Barreiros, Klaus Böhler, Kerstin Mönch, Carl-Ludwig Fischer-Fröhlich, Axel Rahmel

{"title":"Perspectives on donor-derived infections from Germany.","authors":"Ana Paula Barreiros, Klaus Böhler, Kerstin Mönch, Carl-Ludwig Fischer-Fröhlich, Axel Rahmel","doi":"10.1111/tid.14372","DOIUrl":"10.1111/tid.14372","url":null,"abstract":"Aim: Often, organ transplantation is the only option to improve the life expectancy and quality of life of patients with terminal organ failure. Despite improved donor and organ assessment, a residual risk remains for transmitting infection, tumor, or other disease from the donor to recipients. Analysis, reporting, and managing of donor-derived diseases through a vigilance and surveillance system (V&S) is mandatory in many countries. We report on suspected and proven/probable donor-derived infections (DDI) in Germany over a period of 8 years (2016-2023).Methods: All incoming serious-adverse-event and serious-adverse-reaction (SAE/SAR) reports from 01.01.2016 to 31.12.2023 were evaluated for suspected DDI. Analysis of imputability followed the definition of the US Disease Transmission Advisory Committee (DTAC). Only probable and proven cases according to DTAC classification were defined as DDI.Results: During the study period, 9771 donors in Germany donated post-mortem organs to 27 919 recipients. In that period 612 SAE/SAR cases were reported, 377 (62%) involved infections. 41 cases were proven/probable DDI affecting 58 recipients (seven recipients died, 12%). Suspected infections were bacterial (182/377, 48%), fungal (135/377, 36%), viral (55/377, 15%), and parasitic (5/377, 1%). In case of bacterial DDI, no recipient died, but organ loss occurred in six recipients. In case of fungal or viral DDI, 19% (3/16) and 21% (3/14) of the recipients died, respectively.Conclusions: DDI are rare in solid organ transplantation (58/27 919, 0.21%), but when they occur, they are associated with high morbidity and mortality in affected recipients. Careful and detailed donor evaluation and a reliable V&S help improve recipient safety.","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e14372"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Organ vigilance in the Middle East: Challenges and prospects. 中东的器官警戒：挑战与前景。

IF 2.6 4区医学

Transplant Infectious Disease Pub Date : 2024-11-01 Epub Date: 2024-11-08 DOI: 10.1111/tid.14392

Reem Alameer, Yamama Aljishi, Ahmed Alhammadi, Yasar Bayindir, Reem S Almaghrabi

引用次数: 0

Perspective on donor-derived infections in Italy. 透视意大利的供体源性感染。

IF 2.6 4区医学

Transplant Infectious Disease Pub Date : 2024-11-01 Epub Date: 2024-10-15 DOI: 10.1111/tid.14398

Paolo Antonio Grossi, Letizia Lombardini, Raffaele Donadio, Daniela Peritore, Giuseppe Feltrin

{"title":"Perspective on donor-derived infections in Italy.","authors":"Paolo Antonio Grossi, Letizia Lombardini, Raffaele Donadio, Daniela Peritore, Giuseppe Feltrin","doi":"10.1111/tid.14398","DOIUrl":"10.1111/tid.14398","url":null,"abstract":"Background: Expected and unexpected donor-derived infections (DDI) are a rare event in solid organ transplant (SOT) recipients but are potentially associated with significant morbidity and mortality. To assure the microbial safety of transplantation, both national guidelines and the current, regional, and local epidemiology of infectious diseases must be considered.Methods: In the present paper the strategies adopted by the Italian National Center for Transplantation (CNT) since 2003 and their evolution to guarantee the safety of organ transplantation are reported. Starting in 2012 mandatory reporting to the CNT of all adverse reactions was started. The number and type of DDI reported to the CNT are currently being analyzed.Results: The infectious diseases second opinion has written and updated the guidelines on the safety of organs for transplantation and supported the Italian transplant network for the use of organs from donors with suspected or documented potentially transmissible infections.Conclusion: A transplant safety network was developed in Italy in 2003 and has been updated according to the evolving knowledge and the changing epidemiology. This is an evolving field, and a continuous update of the recommendation is needed.","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e14398"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11578278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Donor-derived infections in the United States: Opportunities to learn from the Disease Transmission Advisory Committee's experience. 美国的供体源性感染：从疾病传播咨询委员会的经验中学习的机会。

IF 2.6 4区医学

Transplant Infectious Disease Pub Date : 2024-11-01 Epub Date: 2024-06-17 DOI: 10.1111/tid.14316

Lara Danziger-Isakov, Ricardo M La Hoz, Cameron R Wolfe, Emily A Blumberg

引用次数: 0

Minding the gap: How transplant infectious disease can help close the organ donation gap. 弥合差距：移植传染病如何帮助缩小器官捐献缺口。

IF 2.6 4区医学

Transplant Infectious Disease Pub Date : 2024-11-01 Epub Date: 2024-09-28 DOI: 10.1111/tid.14383

Rachel Sigler, Nancy Law

引用次数: 0

Clinical approach to donor-derived infection in solid organ transplant recipients. 实体器官移植受者感染供体源性感染的临床方法。

IF 2.6 4区医学

Transplant Infectious Disease Pub Date : 2024-11-01 Epub Date: 2024-07-16 DOI: 10.1111/tid.14344

Varun K Phadke

{"title":"Clinical approach to donor-derived infection in solid organ transplant recipients.","authors":"Varun K Phadke","doi":"10.1111/tid.14344","DOIUrl":"10.1111/tid.14344","url":null,"abstract":"Donor-derived infection is an uncommon but potentially devastating complication of solid organ transplantation (SOT). Accurate and timely identification of unexpected infectious disease transmission events has implications not only for the recipient(s) experiencing infection, but also other recipients of organs or tissues from the same donor who may require additional testing or risk mitigation, as well as the broader organ transplant regulatory framework. This narrative review synthesizes data from published reports of symptomatic unexpected donor-derived infections in SOT recipients to provide clinicians with a systematic approach to the evaluation of undifferentiated illnesses that may be of donor origin. Key reasons to consider donor-derived infection include certain microbiologically proven infections in the recipient, especially early after transplant, characteristics of the donor or their management that suggest potential exposure to or infection with specific pathogens prior to organ procurement, and select clinical syndromes that occur in the post-transplant period. Syndromes for which expedited consideration and evaluation of donor-derived infection may be warranted include central nervous system infection, graft or perigraft complications developing in the absence of typical risk factors, and unexplained critical illness/sepsis syndrome in the early post-transplant period. When embarking on an investigation of a suspected donor-derived infection, clinicians should apply knowledge of the entire continuum of the organ procurement and transplant process to ensure unbiased and comprehensive data collection that will facilitate appropriate adjudication of these uncommon but high-consequence events.","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e14344"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141621015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antimicrobial stewardship for organ donors: Importance, current practice, and challenges. 器官捐献者的抗菌管理：重要性、当前做法和挑战。

IF 2.6 4区医学

Transplant Infectious Disease Pub Date : 2024-11-01 Epub Date: 2024-09-28 DOI: 10.1111/tid.14385

Miranda So

引用次数: 0

Risk and benefits of expanded donor screening: A viewpoint from Germany. 扩大捐献者筛查范围的风险和益处：来自德国的观点。

IF 2.6 4区医学

Transplant Infectious Disease Pub Date : 2024-11-01 Epub Date: 2024-10-05 DOI: 10.1111/tid.14384

Carl-Ludwig Fischer-Fröhlich, Paolo Grossi, Axel Rahmel, Ana-Paula Barreiros

{"title":"Risk and benefits of expanded donor screening: A viewpoint from Germany.","authors":"Carl-Ludwig Fischer-Fröhlich, Paolo Grossi, Axel Rahmel, Ana-Paula Barreiros","doi":"10.1111/tid.14384","DOIUrl":"10.1111/tid.14384","url":null,"abstract":"This review describes the risks and benefits of expanding screening for transmissible pathogens in deceased organ donors. The focus is on the experience and procedure in Germany to make a decision on how to proceed with a possible donor. Three issues are of interest in how screening policies impact the process with the aim of mitigating unexpected transmission risks: (1) Should we add universal or targeted nucleic acid testing to serological tests for common blood-borne viruses (BBVs; HIV, HBV, and HCV)? (2) Which tests should be added for screening in a geographically restricted region beyond testing for these BBVs? (3) Being faced with changes (e.g., climate and population) in the own geographically restricted region, what strategies are needed before implementing new tests, and which considerations apply for proper indication to do this? Testing may only be effective when during donor characterization the appropriate conclusions are drawn from the existing findings and screening tests are initiated. This statement overlaps the need to implement universal screening for a pathogen or targeted screening based on the risk that the donor has acquired the transmissible pathogen or is not as possible to identify by current methods of clinical judgment and/or specific tests.","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e14384"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142378254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0