Transplant Infectious Disease最新文献

{"title":"EBV-Related Posttransplant Lymphoproliferative Disorder After Transplantation of EBV-Infected Peripheral Blood Stem Cell Collection With Posttransplant Cyclophosphamide as GVHD Prophylaxis.","authors":"Raymond Ruibo Zhang, Ashvind Prabahran, Andrew Grigg","doi":"10.1111/tid.70287","DOIUrl":"https://doi.org/10.1111/tid.70287","url":null,"abstract":"","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70287"},"PeriodicalIF":2.5,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148607847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Significance of Organ Preservation Fluid Cultures in Pediatric Abdominal Solid Organ Transplantation.","authors":"Hassan A Jamal, Yong K Kwon, Pamela L Valentino, Jodi M Smith, Patrick J Healey, Zheyi Teoh","doi":"10.1111/tid.70282","DOIUrl":"https://doi.org/10.1111/tid.70282","url":null,"abstract":"<p><strong>Background: </strong>Pediatric data on preservation fluid cultures (PFCs) and their ability to predict preservation fluid-related posttransplant infections (PF-I) remain uncertain. In addition, clinical guidelines do not provide uniform recommendations regarding when to obtain PFC or how to manage positive results, particularly for children. In this study, we aimed to evaluate PFC-positive status and PF-I in pediatric abdominal solid organ transplant (aSOT) recipients.</p><p><strong>Methods: </strong>We conducted a retrospective, single pediatric center study of aSOT-recipients between 2012 and 2024, where PFCs were obtained routinely. Data were collected via chart review and included prespecified outcomes such as posttransplant bacterial infections, allograft rejection, unexpected return to the operating room, prolonged hospitalization, and death within 30 days posttransplant. PF-I was defined as a culture-concordant infection in the setting of PFC-positive status.</p><p><strong>Results: </strong>Among 337 aSOT recipients, PFCs were positive in 49 patients (14.5%). Coagulase-negative Staphylococci and Cutibacterium spp. were the most isolated organisms (63%). Infectious complications were more frequent in patients with PFC-positive status (30.6% vs. 18.4%; p = 0.049). Two PF-I episodes (4.1% of PFC-positive status) were identified, both in infant liver transplant recipients, involving vancomycin-resistant Enterococcous and methicillin-sensitive Staphylococcus aureus. At 30 days after transplantation, a higher percentage of the PFC-positive group remained hospitalized (18.4% vs. 8.7%; p = 0.037), whereas of the proportion of rejection, reoperation, and mortality was similar.</p><p><strong>Conclusions: </strong>PFC-positive status and PF-I were uncommon in this cohort. The utility of routine bacterial PFC is primarily to identify the growth of organisms considered pathogenic and to guide preemptive antibiotic therapy.</p>","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70282"},"PeriodicalIF":2.5,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148550778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real World Utilization of Protocolized T-Cell Immunity Panel Screening in Cytomegalovirus Seropositive Kidney Transplant Recipients.","authors":"Hanna Kleiboeker, Cassilyn Streblow, Jillian Descourouez, Christopher Saddler, John Rice, Didier Mandelbrot, Jon Odorico, Margaret Jorgenson","doi":"10.1111/tid.70283","DOIUrl":"https://doi.org/10.1111/tid.70283","url":null,"abstract":"<p><strong>Background: </strong>Recently updated guidelines suggest monthly cytomegalovirus (CMV) cell-mediated immunity (CMI) testing in seropositive (R+) kidney transplant recipients to stratify posttransplant CMV risk and guide prophylaxis. UW Health has protocolized T-cell immunity panel (TCIP) testing since 2023. The purpose was to assess real-world implementation of TCIP testing and the feasibility of this approach.</p><p><strong>Methods: </strong>This retrospective cohort study included adult R+ renal transplant (RTX) recipients transplanted March 1, 2023, to April 9, 2025, received lymphocyte depleting induction and completed TCIP testing at 3 months posttransplant.</p><p><strong>Results: </strong>Here, 234 patients were eligible for protocolized TCIP testing during the study period, with 160 patients obtaining a TCIP (68.4%). Mean time to TCIP draw was 94 ± 15.6 days post-RTX. Of those who obtained TCIP, 75 had positive, 57 negative, and 28 with indeterminate results. Significantly more patients with indeterminate TCIP received alemtuzumab induction (8.0% vs. 8.8%vs. 89.3%, p < 0.0001). Positive TCIP facilitated significantly shorter prophylaxis duration (153.8 vs. 172.2 vs. 180.1 days, p = 0.003). WBC were significantly lower among patients with an indeterminate TCIP (6.3 vs. 6.1 vs. 4.4 × 10³ cells/mm³, p = 0.0006). Patients with indeterminate TCIP were more likely to have ALC ≤ 400 cells/µL (32.0% vs. 33.3% vs. 89.3%, p < 0.0001). Incidence of post-prophylaxis CMV infection was comparable.</p><p><strong>Conclusion: </strong>In this study, implementing protocolized TCIP testing at 3 months posttransplant in R+ kidney transplant recipients was feasible, with the main limitation being lab related draw-time considerations. Based on our center specific experience, stratification based on patient-specific factors should be considered before widespread implementation to optimize evaluable results given cost burden associated with testing.</p>","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70283"},"PeriodicalIF":2.5,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148550828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Possible Donor-Derived Tuberculosis in an Orthotopic Heart Transplant Recipient.","authors":"Phani V Akella, Rachel Sigler","doi":"10.1111/tid.70243","DOIUrl":"10.1111/tid.70243","url":null,"abstract":"","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70243"},"PeriodicalIF":2.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13450340/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147983486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty Status Predicts Urinary Tract Infection Risk Following Kidney Transplant.","authors":"Rebecca Unterborn, Liza M Creel, Kristine M Erlandson, Maheen Z Abidi","doi":"10.1111/tid.70204","DOIUrl":"10.1111/tid.70204","url":null,"abstract":"<p><strong>Introduction: </strong>Urinary tract infections (UTIs) are the most common infectious complication in kidney transplant (KT) recipients. UTI risk is associated with frailty in older adults, and UTIs may exacerbate frailty. However, this relationship has not been described in KT recipients who are at both greater risk of frailty and UTIs.</p><p><strong>Methods: </strong>We conducted a retrospective chart review of 90 KT recipients aged ≥ 50 years who underwent KT between January and July 2021 and had ≥ 12 months of post-transplant follow-up. UTIs were identified at the time of each occurrence. Frailty was assessed at baseline using the modified Rockwood-20 frailty index (mFI); scores ≥ 0.25 were considered frail, 0.08-0.24 pre-frail, and < 0.08 non-frail. The primary outcome was cumulative UTI occurrence based on frailty status, analyzed using Cox proportional hazards regression.</p><p><strong>Results: </strong>Among 90 KT recipients, 33 (37%) developed ≥ 1 UTI. Notably, 45% of KT recipients with UTIs were frail, compared to 25% of KT recipients without UTIs. Compared to non-frail KT recipients, frail KT recipients had a significantly higher risk of UTIs (HR 8.13, 95% CI 1.89, 34.91; p = 0.005), as did pre-frail KT recipients (HR 4.51, 95% CI 1.02, 19.92; p = 0.047). Frail KT recipients also experienced earlier UTI onset, with 12 out of 21 total UTIs (57%) occurring within the first 30 days post-KT.</p><p><strong>Conclusion: </strong>Frailty and prefrailty are associated with increased UTI risk in KT recipients. These findings highlight the importance of frailty assessment in post-transplant care and suggest the need for targeted interventions to reduce UTI risk in this vulnerable population.</p>","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70204"},"PeriodicalIF":2.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13253013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147463767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparing for the Next Pandemic: Novel Insights, Prevention and Treatment of Emerging and Established Respiratory Viruses.","authors":"Victoria G Hall, Gemma K Reynolds, Joanna M Schaenman","doi":"10.1111/tid.70274","DOIUrl":"10.1111/tid.70274","url":null,"abstract":"","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70274"},"PeriodicalIF":2.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13450346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148424429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infectious Risk Donor Status in Uncontrolled Donation After Circulatory Death and Liver Transplantation.","authors":"Chiara Lazzeri, Paolo Antonio Grossi, Manuela Bonizzoli, Davide Ghinolfi, Arianna Trizzino, Giuseppe Feltrin, Adriano Peris","doi":"10.1111/tid.70248","DOIUrl":"10.1111/tid.70248","url":null,"abstract":"<p><strong>Backgrounds: </strong>Few data are so far available concerning the infectious risk donor profile in uncontrolled donation after circulatory death (uDCDs), despite the high incidence of infectious complications observed in out-of-hospital cardiac arrest patients.</p><p><strong>Methods: </strong>We assessed the donor risk profile in utilized uDCD donors consecutively assessed from 2018 to 2024, focusing on the outcome of liver transplant recipients.</p><p><strong>Results: </strong>Fifty-two consecutive utilized uDCDs were included. In 16 uDCDs, blood cultures were positive. In all these cases, Gram-positive bacteria were observed, mainly cocci (14/16, 88%). These microorganisms were considered contaminants. None of these microorganisms were isolated in recipients. No donor-related infection was detected in the 24 liver transplant recipients.</p><p><strong>Conclusions: </strong>According to our results, uDCDs show a low risk of infection transmission to the recipients. Nevertheless, a careful and systematic approach to donor evaluation should be pursued and implemented, considering the restricted time frame for assessment and the urgent procedures performed, considering the characteristics of uDCD (comprising the performance of an urgent procedure). Transplant coordinators should promptly report culture positivity in one of the collected samples, thus allowing the timely initiation of antibiotic therapy in the recipients. In uDCD donors, some information on infectious risk may be lacking, considering the limited time and that a urine culture may not be feasible since these donors may be anuric.</p>","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70248"},"PeriodicalIF":2.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13450114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147989211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology and Outcomes of Extrapulmonary Invasive Fungal Infections After Kidney Transplantation in Northern India.","authors":"Abdullah, Anupma Kaul, Rungmei Marak, Manas Behera, Narayan Prasad, Manas Patel, Dharmendra Bhaduaria, Ravi Kushwaha, Monika Yachha, Akash Mishra","doi":"10.1111/tid.70218","DOIUrl":"10.1111/tid.70218","url":null,"abstract":"<p><strong>Background: </strong>Extrapulmonary invasive fungal infections (IFIs) in kidney transplant recipients (KTRs) are understudied, particularly in endemic, resource-limited settings. This study evaluated the epidemiology, risk factors, and outcomes of extrapulmonary IFIs in KTRs in northern India.</p><p><strong>Methods: </strong>In this nested case-control study of 1649 KTRs (2007-2022), microbiologically proven extrapulmonary IFI cases were identified from microbiology and histopathology databases.</p><p><strong>Results: </strong>Extrapulmonary IFI occurred in 67 KTRs (4.1%). Cryptococcosis (46.3%) and candidiasis (20.9%) were the predominant infections. The central nervous system was the most common site (44.8%), followed by the bloodstream (22.4%). The mean age was 46.78 years, and 85.1% were males. The median time to infection was 55 months posttransplant, and 79.1% of infections occurred beyond 1 year posttransplant. Median estimated glomerular filtration rate (eGFR) was 43 mL/min/1.73 m², and acute graft dysfunction was present in 49.3% cases. Comorbidities included diabetes (44.8%), chronic renal allograft injury (59.7%), acute rejection (38.8%), bacterial infection (26.9%), and cytomegalovirus disease (13.4%). Diabetes (OR 2.27, p = 0.038) and methylprednisolone pulses for rejection (OR 3.19, p = 0.025) were independently associated with IFI. Infection-related mortality was 35.8%; disseminated infection (HR 3.72, p = 0.020) and requirement for kidney replacement therapy (KRT) (HR 3.98, p = 0.011) independently predicted death. Note that, 5- and 10-year patient survival was significantly lower in cases than in controls (74.1% and 48.3% vs. 92.3% and 74.9%; p = 0.008), whereas death-censored graft survival was comparable.</p><p><strong>Conclusions: </strong>Extrapulmonary IFIs are late-onset and commonly present as cryptococcal meningitis or candidemia. Diabetes and methylprednisolone pulses increase infection risk, while dissemination and KRT requirement predict mortality.</p>","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70218"},"PeriodicalIF":2.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13450239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147942723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immediate Donor-Derived Hepatitis C Transmission Following Kidney Transplantation: A Two-Case Observation.","authors":"I-Ru Chen, Wen-Pang Su, Ping-Chin Lai","doi":"10.1111/tid.70225","DOIUrl":"10.1111/tid.70225","url":null,"abstract":"","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70225"},"PeriodicalIF":2.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13450370/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multidrug-Resistant Gram-Negative Urinary Tract Infections (UTIs) Increase the Risk of Rejection, CMV Viremia, and Graft Loss After Kidney Transplantation.","authors":"Alessandra Palmisano, Marta D'Angelo, Federica Brillo, Daniel Salvetti, Alice Parmigiani, Alessio Di Maria, Francesco Saracino, Eleonora Salsi, Micaela Gentile, Giuseppe Daniele Benigno, Ilaria Gandolfini, Enrico Fiaccadori, Paolo Cravedi, Umberto Maggiore","doi":"10.1111/tid.70212","DOIUrl":"10.1111/tid.70212","url":null,"abstract":"<p><strong>Background: </strong>Multidrug-resistant (MDR) Gram-negative UTIs caused by extended-spectrum β-lactamases (ESBL) and carbapenem-resistant Enterobacteriaceae (CRE) are increasingly common in kidney transplant recipients (KTR), yet their clinical consequences relative to other Gram-negative infections remain unclear.</p><p><strong>Methods: </strong>In this single-center study from a high-endemic area, we retrospectively evaluated the impact of MDR colonization (Colonization), MDR Gram-negative infection (MDR Infection), presumptive MDR infection (i.e., no isolates available; Presump. MDR), and non-MDR Gram-negative infection (non-MDR Inf.) on major post-transplant complications, including CMV and BKPyV viremia, acute rejection, donor-specific antibodies (DSA), graft function, and overall transplant failure. We used multivariable cause-specific hazard Cox regression models with time-varying covariates and random-coefficient mixed models.</p><p><strong>Results: </strong>Among 521 KTRs, distributed across overlapping conditions, 212 (40.7%) had MDR Colonization, 92 (17.7%) MDR Infection, 61 (11.7%) Presump. MDR, 67 (12.9%) non-MDR Inf., and 242 (46.4%) had no infection. Compared with No Infection group, only MDR infection was associated with a steeper decline in eGFR slope (_-5.50-2.91_-0.33 mL/min/1.73 m² per year; p = 0.027) and increased incidence of transplant failure (adjusted hazard, aHR, associated with history of MDR Infection = _1.76 4.11_9.61; p = 0.001. MDR infection history was also the only condition associated with CMV viremia (aHR = _1.051.83_3.18; p = 0.034), and with rejection (aHR = _1.031.69_2.76; p = 0.036), though it was not associated with BKPyV viremia or de novo DSA. Colonization, Presump. Inf., and non-MDR Inf. were not independently associated with complications or transplant failure.</p><p><strong>Conclusion: </strong>Documented MDR Gram-negative UTIs, but not colonization or non-MDR UTI, are independently associated with acute rejection, CMV viremia, and poorer kidney allograft outcomes.</p>","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70212"},"PeriodicalIF":2.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13450159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147595017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}