Transplant Infectious Disease最新文献

{"title":"Infectious Complications in Living Donation Versus Donation After Brain Death Kidney Transplantation.","authors":"Isabel Rodríguez-Goncer, Gabriel Motoa, Esther González, Francisco López-Medrano, Tamara Ruiz-Merlo, Hernando Trujillo, Ana Hernández, Fernando Caravaca-Fontán, José Enrique Ruiz-Cabello, Rafael San-Juan, Camille N Kotton, Amado Andrés, José María Aguado, Mario Fernández-Ruiz","doi":"10.1111/tid.70301","DOIUrl":"https://doi.org/10.1111/tid.70301","url":null,"abstract":"<p><strong>Background: </strong>Kidney transplantation from living donors (LDs) offers benefits over donation after brain death (DBD). Whether LD independently protects against infection incidence remains unclear.</p><p><strong>Methods: </strong>We compared posttransplant infection between LD (n = 102) and DBD (n = 401) groups in a prospective observational cohort of 503 KT recipients at a tertiary-care center. Crude and adjusted associations between donor type and infection risk were assessed using propensity score (PS) modeling and multivariable Cox regression.</p><p><strong>Results: </strong>Cumulative incidence rates of overall and bacterial infection were 58.6% and 43.7%, respectively. Compared to DBD recipients, LD patients had lower crude risks for overall (hazard ratio [HR]: 0.53; 95% confidence interval [CI]: 0.39-0.74; p-value < 0.001) and bacterial infection (HR: 0.59; 95% CI: 0.41-0.87; p-value = 0.007). In PS-based models, donor type was no longer significant for overall (PS-adjusted HR: 0.78; 95% CI: 0.52-1.18; p-value = 0.244) or bacterial infection (PS-adjusted HR: 0.94, 95% CI: 0.59-1.50; p-value = 0.802). Similar effect modification appeared for secondary outcomes and adjusted multivariable models.</p><p><strong>Conclusion: </strong>Donor type did not independently influence posttransplant infection risk after adjustment for baseline recipient factors. Lower infection incidence in LD recipients may reflect favorable recipient- and transplant-related characteristics rather than donor-specific factors.</p>","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70301"},"PeriodicalIF":2.5,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Liver Transplantation From HBV-Viremic Donor in Acute Liver Failure.","authors":"Gaia Cologgi, Federica Portunato, Matteo Bassetti","doi":"10.1111/tid.70305","DOIUrl":"https://doi.org/10.1111/tid.70305","url":null,"abstract":"","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70305"},"PeriodicalIF":2.5,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatitis E Virus Infection in Swiss Transplant Recipients: Seroprevalence, Incidence, and the Role of Transfused Blood Products.","authors":"Nadja Widmer, Peter Gowland, Beat Müllhaupt, Urs Schanz, Soraya Amar, Isabelle Binet, Aylin Jaspersen, Laure Elkrief, Hans H Hirsch, Cédric Hirzel, Darius Moradpour, Nicolas J Mueller, Simona Rossi, Stefan Schaub, Guido Stirnimann, Martin Stolz, Christian Van Delden, Julien Vionnet, Christoph Niederhauser","doi":"10.1111/tid.70296","DOIUrl":"https://doi.org/10.1111/tid.70296","url":null,"abstract":"<p><strong>Background: </strong>In Switzerland, hepatitis E virus (HEV) Genotype 3 is the leading cause of acute viral hepatitis and is mainly transmitted via contaminated pork, but also through solid organ transplantation and blood transfusion. Immunocompromised patients are particularly at risk, as chronic hepatitis may develop. This nationwide cross-sectional study aimed to retrospectively assess HEV epidemiology in SOT and allogeneic hematopoietic stem cell transplant recipients.</p><p><strong>Methods: </strong>A total of 2942 patients from the Swiss Transplant Cohort Study sampled at transplantation date (T0) and at 1-year follow-up (T12) were tested for anti-HEV IgG and HEV RNA. For seroconverted or HEV RNA-positive patients, further analyses were performed, including characterization of samples collected 6 months posttransplantation (T6). Furthermore, 587 archived blood donor samples were retrospectively examined to investigate their potential role in HEV transmission.</p><p><strong>Results: </strong>The anti-HEV IgG seroprevalence of 21.6% at T0 and 19.4% at T12 in transplant recipients was comparable to that of Swiss blood donors. However, the overall incidence of HEV RNA of 1:210 was more than 20-fold higher, with 53% of infections persisting for 6 months or more. Except for one imported genotype 1g case, all infections were of Genotype 3, predominantly subtype 3h3, which is endemic in Switzerland. Notably, a transfusion-transmitted HEV infection was identified.</p><p><strong>Conclusion: </strong>Given the increased susceptibility of transplant recipients to HEV and their reduced ability to clear the infection, surveillance and dietary advisory measures are crucial to reduce the risk of potentially deleterious outcomes. HEV screening of blood donors should be maintained as an important preventive measure.</p>","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70296"},"PeriodicalIF":2.5,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148707624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Two Strategies for Preventing Cytomegalovirus Disease in Solid Organ Transplant Recipients.","authors":"Shaúl Ariel Navarro-Lara, Juan José Calva-Mercado, Tomas Rafael Mercado-Torres, Mariana Vélez-Pintado, Bernardo Alfonso Martínez-Guerra, Carla Marina Román-Montes, Sandra Rajme-López, Ever Arturo Corral-Herrera, Héctor Orlando Rivera-Villegas, Nayelli Cointa Flores-García, Luis Eduardo Morales-Buenrostro, María Fernanda González-Lara, Karla María Tamez-Torres","doi":"10.1111/tid.70297","DOIUrl":"https://doi.org/10.1111/tid.70297","url":null,"abstract":"<p><strong>Background: </strong>Cytomegalovirus (CMV) remains a major cause of morbidity in solid organ transplant (SOT) recipients. While universal prophylaxis and preemptive therapy (PET) are standard strategies, comparative data in Latin American populations-characterized by high CMV seroprevalence-are limited.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study of 731 adult recipients (2016-2024). Patients were stratified into intermediate (R+) or high-risk (D+/R- or thymoglobulin induction) groups. The primary outcome was proven CMV disease at 12 months. Bias was addressed using Inverse Probability Weighting (IPW).</p><p><strong>Results: </strong>Of 731 transplants, 311 were high-risk and 420 intermediate-risk. No significant difference was observed in CMV disease incidence between PET (1.9%) and prophylaxis (2.4%) (p = 0.943). IPW confirmed no association between the strategy and CMV infection (OR: 1.21; 95% CI: 0.25-5.57; p = 0.810). Notably, the absence of lymphopenia at 1 month posttransplantation was found to be protective against CMV disease (p < 0.001).</p><p><strong>Conclusion: </strong>Both strategies were associated with a low incidence of CMV disease. A DNAemia threshold of 4000 IU/mL for PET proved safe across all risk strata. Early absolute lymphocyte count > 1000 cells/µL is a strong predictor of protection against CMV disease.</p>","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70297"},"PeriodicalIF":2.5,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148707299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Training the Next Generation of Immunocompromised Host Infectious Diseases Clinicians.","authors":"Varun K Phadke, Michael G Ison","doi":"10.1111/tid.70285","DOIUrl":"https://doi.org/10.1111/tid.70285","url":null,"abstract":"","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70285"},"PeriodicalIF":2.5,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148702344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2026 American Society of Transplantation Infectious Diseases Community of Practice Awards.","authors":"Ricardo M La Hoz, Aruna K Subramanian, Fernanda P Silveira","doi":"10.1111/tid.70292","DOIUrl":"https://doi.org/10.1111/tid.70292","url":null,"abstract":"","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70292"},"PeriodicalIF":2.5,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148702251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Putting Principles Into Practice: Curricular Resources for Transplant Infectious Diseases Educators.","authors":"Varun K Phadke, Sara W Dong, Rachel Bartash, Courtney E Harris","doi":"10.1111/tid.70277","DOIUrl":"https://doi.org/10.1111/tid.70277","url":null,"abstract":"<p><p>Transplant infectious diseases (ID) has emerged as a distinct area of clinical expertise within the specialty of ID. While formal curricular recommendations for both adult and pediatric TID have been published, there is substantial heterogeneity in how they are operationalized. In this review, we describe a practical framework and tools for building and implementing a TID curriculum and provide concrete guidance for translating high-level recommendations about content and experience into actionable strategies for training programs. This framework draws from curricular components and innovations from four US-based training programs, spanning adult and pediatric TID, and representing both dedicated TID fellowships and TID tracks within general ID training. We highlight components that would be important to any TID educational program, including key personnel, structured didactic offerings, curated external educational resources, experiential learning and professional development opportunities, and assessment tools aligned with TID-specific competencies. We provide concrete examples and adaptable tools, such as didactic schedules and self-directed curricula; guidance for leveraging podcasts, curated medical literature, and other external resources for TID education; as well as strategies to incorporate nonclinical experiential learning opportunities, such as participation in center-specific or professional society meetings, simulation-based donor call training, and protocol development. These frameworks and resources are adaptable to a range of institutional contexts, can supplement the heterogeneity in clinical exposure between programs, and support trainee competence in nonclinical skills unique to TID practice. As the field continues to evolve, scalable curricula will be essential to train the next generation of TID clinicians and educators and ensure high-quality care for an increasingly complex immunocompromised host population.</p>","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70277"},"PeriodicalIF":2.5,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148702324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transplant Infectious Diseases Work Standards-Results From a Mid-Atlantic Regional Survey.","authors":"Nicole C Vissichelli, Lora Thomas, Rebecca Kumar, Catharine I Paules, Shmuel Shoham, Megan K Morales","doi":"10.1111/tid.70289","DOIUrl":"https://doi.org/10.1111/tid.70289","url":null,"abstract":"<p><strong>Background: </strong>As transplantation and cellular therapy expand, so must the transplant infectious diseases (TID) workforce; yet little is known about regional or national TID work standards for the existing workforce. This survey of TID clinicians in the mid-Atlantic region seeks to outline current work standards used to define a 1.0 FTE practice.</p><p><strong>Methods: </strong>This is a cross-sectional study evaluating the current compensation structure for TID providers, conducted July-October 2025 via REDCap survey distributed to the Mid-Atlantic Transplant Infectious Diseases Society (MATIDS). The survey consisted of 18 multiple-choice questions with ranges for quantitative answers. Data were analyzed in Excel and R and descriptive statistics were used.</p><p><strong>Results: </strong>Approximately one-third of eligible members responded, the majority being from academic medical centers. At least eight regional medical groups were represented. Physicians reported a mix of RVU and time-based models for defining their work standards. For a 1.0 FTE, most reported 26-30 weeks of inpatient service in academic centers and 31-35 for all respondents. Among those with set RVU targets, most were < 2000-5000. Nearly all physicians receive subsidized cFTE support, averaging 0.6 for academic faculty and 0.7 across all practice settings. Non-billable work supporting the transplant program was ubiquitous.</p><p><strong>Conclusion: </strong>TID work standards are often identical to those of general ID colleagues, despite substantial differences in patient population and consultation volume/practices, as well as non-billable work for the transplant program. To fairly compensate TID work, retain physicians, and attract new specialists to this increasingly complex field, we must define work standards tailored to TID.</p>","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70289"},"PeriodicalIF":2.5,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148702400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Liver Transplantation Under Antimicrobial Therapy in a Patient With Preexisting Pulmonary Mycobacterium avium Complex Disease.","authors":"Masaaki Watanabe, Sho Nakakubo, Akinobu Taketomi","doi":"10.1111/tid.70286","DOIUrl":"https://doi.org/10.1111/tid.70286","url":null,"abstract":"","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70286"},"PeriodicalIF":2.5,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148670574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Use of Rezafungin: A Case Report and Insights Into Real-World Access.","authors":"Jian Mei Li, Jacqueline E Clark, Tiffany Wu","doi":"10.1111/tid.70262","DOIUrl":"https://doi.org/10.1111/tid.70262","url":null,"abstract":"","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70262"},"PeriodicalIF":2.5,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148670614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}