Transplant Infectious Disease最新文献_第9页

Risk and benefits of expanded donor screening: A viewpoint from Germany. 扩大捐献者筛查范围的风险和益处：来自德国的观点。

IF 2.6 4区医学

Transplant Infectious Disease Pub Date : 2024-11-01 Epub Date: 2024-10-05 DOI: 10.1111/tid.14384

Carl-Ludwig Fischer-Fröhlich, Paolo Grossi, Axel Rahmel, Ana-Paula Barreiros

{"title":"Risk and benefits of expanded donor screening: A viewpoint from Germany.","authors":"Carl-Ludwig Fischer-Fröhlich, Paolo Grossi, Axel Rahmel, Ana-Paula Barreiros","doi":"10.1111/tid.14384","DOIUrl":"10.1111/tid.14384","url":null,"abstract":"This review describes the risks and benefits of expanding screening for transmissible pathogens in deceased organ donors. The focus is on the experience and procedure in Germany to make a decision on how to proceed with a possible donor. Three issues are of interest in how screening policies impact the process with the aim of mitigating unexpected transmission risks: (1) Should we add universal or targeted nucleic acid testing to serological tests for common blood-borne viruses (BBVs; HIV, HBV, and HCV)? (2) Which tests should be added for screening in a geographically restricted region beyond testing for these BBVs? (3) Being faced with changes (e.g., climate and population) in the own geographically restricted region, what strategies are needed before implementing new tests, and which considerations apply for proper indication to do this? Testing may only be effective when during donor characterization the appropriate conclusions are drawn from the existing findings and screening tests are initiated. This statement overlaps the need to implement universal screening for a pathogen or targeted screening based on the risk that the donor has acquired the transmissible pathogen or is not as possible to identify by current methods of clinical judgment and/or specific tests.","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e14384"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142378254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Donor-derived infections: Current practice, global strategies, and future challenges. 供体源性感染：当前实践、全球战略和未来挑战。

IF 2.6 4区医学

Transplant Infectious Disease Pub Date : 2024-11-01 Epub Date: 2024-09-23 DOI: 10.1111/tid.14380

Karen M J Waller, Stephanie M Pouch

引用次数: 0

Impact of machine perfusion on transplant infectious diseases: New challenges and opportunities. 机器灌注对移植感染性疾病的影响：新的挑战和机遇。

IF 2.6 4区医学

Transplant Infectious Disease Pub Date : 2024-11-01 Epub Date: 2024-07-30 DOI: 10.1111/tid.14348

Andrew Purssell, Deepali Kumar

{"title":"Impact of machine perfusion on transplant infectious diseases: New challenges and opportunities.","authors":"Andrew Purssell, Deepali Kumar","doi":"10.1111/tid.14348","DOIUrl":"10.1111/tid.14348","url":null,"abstract":"Preservation techniques that maintain the viability of an organ graft between retrieval from the donor and implantation into the recipient remain a critical aspect of solid organ transplantation. While traditionally preservation is accomplished with static cold storage, advances in ex vivo dynamic machine perfusion, both hypothermic and normothermic, have allowed for prolongation of organ viability and recovery of marginal organs effectively increasing the usable donor pool. However, the use of these novel machine perfusion technologies likely exposes the recipient to additional infectious risk either through clonal expansion of pathogens derived during organ recovery or de novo exogenous acquisition of pathogens while the organ remains on the machine perfusion circuit. There is a paucity of high-quality studies that have attempted to quantify infection risk, although it appears that prolonging the time on the machine perfusion circuit and normothermic parameters increases the risk of infection. Conversely, the use of ex vivo machine perfusion unlocks new opportunities to detect and treat donor-derived infections before implantation into the recipient. This review seeks to reveal how the use of ex vivo machine perfusion strategies may augment the risk of infection in the organ recipient as well as outline ways that this technology could be leveraged to enhance our ability to manage donor-derived infections.","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e14348"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141793607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Malignancy following solid organ transplantation: Current techniques for determination of donor versus recipient origin. 实体器官移植后的恶性肿瘤：确定供体与受体来源的现有技术。

IF 2.6 4区医学

Transplant Infectious Disease Pub Date : 2024-11-01 Epub Date: 2024-07-14 DOI: 10.1111/tid.14330

Rebecca Rojansky, Charles C Marboe, Gerald J Berry

引用次数: 0

Donor-derived infections-Insights from Singapore, Japan, and Thailand. 来自新加坡、日本和泰国的捐献者衍生感染。

IF 2.6 4区医学

Transplant Infectious Disease Pub Date : 2024-11-01 Epub Date: 2024-09-03 DOI: 10.1111/tid.14370

Sophie Seine Xuan Tan, Pakpoom Phoompoung, Koh Okamoto, Methee Chayakulkeeree, Xiu Xian Koh, Chee-Kiat Tan, Sally Nyuk Min Kong, Thuan Tong Tan, Shimin Jasmine Chung, Ban Hock Tan

{"title":"Donor-derived infections-Insights from Singapore, Japan, and Thailand.","authors":"Sophie Seine Xuan Tan, Pakpoom Phoompoung, Koh Okamoto, Methee Chayakulkeeree, Xiu Xian Koh, Chee-Kiat Tan, Sally Nyuk Min Kong, Thuan Tong Tan, Shimin Jasmine Chung, Ban Hock Tan","doi":"10.1111/tid.14370","DOIUrl":"10.1111/tid.14370","url":null,"abstract":"Background: Solid organ transplantation (SOT) has expanded significantly in Asia over past few decades. Donor-derived infections (DDIs) remain a significant concern as they may adversely impact transplant outcomes. We aim to review the existing regulatory frameworks, screening protocols, and management practices for DDIs in Asia.Methods: We reached out to transplant infectious diseases experts in Asia to provide standardized data on annual SOT numbers, incidence of DDIs, regulatory frameworks, donor and recipient screening protocols, and DDI surveillance measures. We present the data from Singapore, Japan, and Thailand.Results: Donor screening for HIV, hepatitis B, hepatitis C, and syphilis is mandatory in all countries. Additionally, Japan screens for HTLV-1 antibody due to its endemicity. We also reviewed the protocols for screening and prevention of endemic infections in Asia. Singapore is the only country implementing universal screening for all donors for dengue, Zika, and chikungunya via blood and urine RT-PCR. Strongyloidiasis screening is not routinely done, although some transplant centers empirically give ivermectin prophylaxis to organ recipients. Tuberculosis screening with a donor questionnaire and chest radiograph is common for deceased donors, and some centers do Interferon Gamma Release Assay test for living donors. We also found a significant gap in the surveillance and reporting of potential DDIs in Asia and the overall incidence of DDIs in Asia is unknown and likely underreported.Conclusion: The experiences of Singapore, Japan, and Thailand offer valuable insights into current practices and the unmet needs regarding a DDI registry and call for coordinated efforts to address this critical issue in the region.","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e14370"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142126780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Donor-derived mold infections in lung transplant recipients: The importance of active surveillance. 肺移植受者中源自供体的霉菌感染：积极监控的重要性。

IF 2.6 4区医学

Transplant Infectious Disease Pub Date : 2024-11-01 Epub Date: 2024-06-03 DOI: 10.1111/tid.14304

Alessandra Mularoni, Andrea Cona, Giulia Coniglione, Floriana Barbera, Giuseppina Di Martino, Giovanni Mulè, Maria Campanella, Giuseppina Di Mento, Giuseppe Nunnari, Paolo Antonio Grossi, Maurizio Sanguinetti, Malgorzata Mikulska, Elena De Carolis, Alessandro Bertani

{"title":"Donor-derived mold infections in lung transplant recipients: The importance of active surveillance.","authors":"Alessandra Mularoni, Andrea Cona, Giulia Coniglione, Floriana Barbera, Giuseppina Di Martino, Giovanni Mulè, Maria Campanella, Giuseppina Di Mento, Giuseppe Nunnari, Paolo Antonio Grossi, Maurizio Sanguinetti, Malgorzata Mikulska, Elena De Carolis, Alessandro Bertani","doi":"10.1111/tid.14304","DOIUrl":"10.1111/tid.14304","url":null,"abstract":"Unexpected donor-derived fungal infections represent a rare but potentially fatal complication in lung transplant (Tx) recipients. Timely communication of the results of donor cultures and prompt treatment of recipients are crucial to mitigate the consequences of donor-derived transmissions. In this prospective cohort study, all consecutive patients who underwent lung transplantation from 2015 to 2022 were included. In December 2015, a Local Active Surveillance System has been implemented to provide biovigilance of donor culture results and optimize recipients' management. The aim of this study is to investigate the incidence of unexpected, mold-positive cultures among lung donors and the rate of transmission to recipients. Furthermore, management strategies and outcome of recipients with mold transmission are described. In case of isolation of the same mold in donor and recipient cultures, when possible, transmission was confirmed by dendrogram analysis. During the study period, 82 lung Tx were performed from 80 donors. The prevalence of donors with \"unexpected\" mold isolation from the respiratory tract was 3.75% (3/80). Isolated molds were Aspergillus niger, Rhizopus oryzae, and Aspergillus flavus. Transmissions occurred in all the three cases (100%) with a mean time of 5 days from lung Tx but none of the recipients developed invasive mold disease. Our Local Active Surveillance System allowed prompt recognition of lung donors unexpected mold colonization. Even though transmission occurred, introduction of early targeted antifungal therapy prevented potential catastrophic consequence of mold donor-derived infection in the immediate post-Tx period.","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e14304"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11578279/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141237991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surveillance for donor-derived infections in Australia. 澳大利亚对捐赠者感染的监控。

IF 2.6 4区医学

Transplant Infectious Disease Pub Date : 2024-11-01 Epub Date: 2024-06-10 DOI: 10.1111/tid.14315

Helen Ingrid Opdam, Peter Boan, Lucinda Barry, Jeremy R Chapman

{"title":"Surveillance for donor-derived infections in Australia.","authors":"Helen Ingrid Opdam, Peter Boan, Lucinda Barry, Jeremy R Chapman","doi":"10.1111/tid.14315","DOIUrl":"10.1111/tid.14315","url":null,"abstract":"Background: Systems for quality and safety assurance in organ donation and transplantation are vital, especially those that seek to minimize donor disease transmission. Australia has developed a national vigilance and surveillance system to identify, review, and analyze actual and potential donor-derived infections and other disease transmissions.Methods: The system involves notification of incidents to the Australian Organ and Tissue Authority for review by a Vigilance and Surveillance Expert Advisory Committee (VSEAC). The VSEAC grades incidents, O makes recommendations, and issues communications both publicly and to the clinical donation and transplant sector.Results: Annual notifications have increased since the inception of the system in 2012 until 2022. The vast majority relate to procedural aspects including donor assessment, information/data issues, and the recovery, offer, allocation, preservation and transportation of organs. Possible donor-derived disease accounted for 19% of all notifications, and those related to possible donor-derived infection only 12%. The VSEAC, as a result of reviewing these incidents, has made recommendations resulting in revisions to donor screening, organ allocation, packaging and transportation. The review of incidents has led to changes in clinical guidance for increased viral risk donor assessment, testing, and ensuing organ utilization and recipient surveillance. Guidance has also been reviewed for other infectious risks including strongyloides, human T-lymphotropic virus, and HEV.Conclusion: The Australian vigilance and surveillance system has enabled national retrospective reporting and evaluation of serious adverse events or reactions to identify trends and inform processes and guidelines, therefore improving the safety of donation and transplantation.","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e14315"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141296776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Donor-derived infections: The Swiss perspective. 来自捐赠者的感染：瑞士的视角。

IF 2.6 4区医学

Transplant Infectious Disease Pub Date : 2024-11-01 Epub Date: 2024-06-09 DOI: 10.1111/tid.14314

Nicolas J Mueller, Oriol Manuel, Cédric Hirzel

引用次数: 0

Donor-derived strongyloidiasis: The beginning of the end? 供体源性强直性脊柱炎：终结的开始？

IF 2.6 4区医学

Transplant Infectious Disease Pub Date : 2024-11-01 Epub Date: 2024-06-14 DOI: 10.1111/tid.14313

John I Hogan, Sapna A Mehta, Ricardo M La Hoz

引用次数: 0

Global perspectives on donor-derived infections: Brazil and Argentina. 从全球角度看捐赠者引发的感染：巴西和阿根廷。

IF 2.6 4区医学

Transplant Infectious Disease Pub Date : 2024-11-01 Epub Date: 2024-10-07 DOI: 10.1111/tid.14389

Alice T W Song, Maria de Los Angeles Yrbas, Ligia Camera Pierrotti, Richard Malan, Cecilia Delfino, Daniela Ferreira Salomão Pontes, Luiz Augusto Carneiro D'Albuquerque, Wellington Andraus, Edson Abdala

引用次数: 0