Transplant Infectious Disease最新文献

Cytomegalovirus, the Troll of Transplantation and Cellular Therapy? 巨细胞病毒：移植和细胞治疗的巨魔？

IF 2.6 4区医学

Transplant Infectious Disease Pub Date : 2025-06-16 DOI: 10.1111/tid.70065

Joseph Sassine, Emily A Siegrist

引用次数: 0

Talk About a Bad Reputation: Is It OK to Continue Trimethoprim-Sulfamethoxazole Prophylaxis in the Face of Hyper K. 谈论坏名声：面对高K，是否可以继续使用甲氧苄啶-磺胺甲恶唑预防？

IF 2.6 4区医学

Transplant Infectious Disease Pub Date : 2025-06-10 DOI: 10.1111/tid.70062

Sonya M Kothadia, Madeleine R Heldman

引用次数: 0

Transplant Infectious Disease Training: Bridging the Gap. 移植传染病培训：弥合差距。

IF 2.6 4区医学

Transplant Infectious Disease Pub Date : 2025-06-10 DOI: 10.1111/tid.70060

Ankit Mittal, Parikshit Prayag, Hanna Alexander, Priscilla Rupali

{"title":"Transplant Infectious Disease Training: Bridging the Gap.","authors":"Ankit Mittal, Parikshit Prayag, Hanna Alexander, Priscilla Rupali","doi":"10.1111/tid.70060","DOIUrl":"https://doi.org/10.1111/tid.70060","url":null,"abstract":"An increasing complexity of organ transplantation, newer immunosuppressives, and an expanded donor pool requires a well-trained multidisciplinary workforce with surgeons, physicians, and infectious diseases (ID) physicians working together. In most countries, solid organ transplantation preceded the development of ID as a specialty leading to a lag in transplant infectious diseases (TID) physicians being a member of this team. This gap is further widened in low middle-income countries (LMIC) like India, where there is a dearth of laboratory facilities, which are essential for pretransplant screening and diagnosis of posttransplant infections. India though an LMIC does large volumes of organ and bone marrow transplantations. This article examines the current state of ID and TID training in India with an emphasis on the need for a structured and standardized educational pathway for future transplant professionals. Drawing on examples from existing programs and workforce data using a qualitative survey, we identify paramount challenges such as inconsistent exposure during medical and surgical training, limited access to transplant-specific education, and insufficient support for career development in transplant-related specialties. We propose a strategic framework to address these challenges with an emphasis on early exposure, interprofessional education, mentorship, and the integration of transplant content within undergraduate and postgraduate curricula. By encouraging a comprehensive national strategy, we aspire to bridge this training gap, ensuring workforce sustainability and ultimately improving patient outcomes for those awaiting transplantation.","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70060"},"PeriodicalIF":2.6,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic and Therapeutic Challenges of Neurocysticercosis in a Liver Transplant Recipient. 肝移植受者神经囊虫病的诊断和治疗挑战。

IF 2.6 4区医学

Transplant Infectious Disease Pub Date : 2025-06-10 DOI: 10.1111/tid.70064

Emily Wong, Hanine El Haddad, Vivek B Beechar

引用次数: 0

"B-yond the Status Quo: Utilization of Hepatitis B-Positive Lung Donors". “超越现状：对乙型肝炎阳性肺供体的利用”。

IF 2.6 4区医学

Transplant Infectious Disease Pub Date : 2025-06-06 DOI: 10.1111/tid.70051

Ann E Woolley, Karen Doucette

引用次数: 0

Histoplasmosis-Induced HLH in Immunosuppressed Host: Lessons from a Kidney Transplant Case. 免疫抑制宿主组织胞浆菌诱导的HLH：来自一个肾移植病例的教训。

IF 2.6 4区医学

Transplant Infectious Disease Pub Date : 2025-06-04 DOI: 10.1111/tid.70058

Ayman Salih, Mai Safi, Fadi Safi

引用次数: 0

Disseminated Blastomycosis Presenting With Skin Lesions in a Renal Transplant Recipient. 肾移植受者播散性芽孢菌病伴皮肤病变。

IF 2.6 4区医学

Transplant Infectious Disease Pub Date : 2025-06-04 DOI: 10.1111/tid.70061

Ashley Zeoli, Adriana Della Porta, Kaitlyn Reasoner, Eva Niklinska, Christina Vojtek, Eva Rawlings Parker, Lili Tao, Kevin Dee, Augusto Dulanto Chiang, Richard W LaRue

引用次数: 0

Impact of Pretransplant Antimicrobial Sulfonamide Allergy Label in Kidney Transplant Recipients. 移植前抗菌磺胺过敏标签对肾移植受者的影响。

IF 2.6 4区医学

Transplant Infectious Disease Pub Date : 2025-06-04 DOI: 10.1111/tid.70063

Harry Ross Powers, Hani M Wadei, Cesar Campos Cuellar, Amogharvasha Venugopal, Vasili Pleqi, Alex Hochwald, Yaohua Ma, Alexei Gonzales

{"title":"Impact of Pretransplant Antimicrobial Sulfonamide Allergy Label in Kidney Transplant Recipients.","authors":"Harry Ross Powers, Hani M Wadei, Cesar Campos Cuellar, Amogharvasha Venugopal, Vasili Pleqi, Alex Hochwald, Yaohua Ma, Alexei Gonzales","doi":"10.1111/tid.70063","DOIUrl":"https://doi.org/10.1111/tid.70063","url":null,"abstract":"Background: Sulfa antibiotic allergy labels (SALs) are encountered frequently in kidney transplant recipients (KTs). This often results in patients receiving second-line prophylaxis for both Pneumocystis jiroveci and urinary tract infections (UTIs). The effect of SAL on outcomes including UTIs after KT is unclear.Methods: In our single-center retrospective cohort study, we investigated the effect of SALs on bacteriuria after KT. We identified patients with pre-KT SALs from 2011 to 2022. A matched cohort was then created using KT with no pretransplant SALs. The groups were compared using proportional analysis and univariable and multivariable Cox proportional regression models. The primary outcome of interest was the proportion of individuals experiencing one or more episodes of bacteriuria within 1 year posttransplant. Secondary outcomes included bacteremic UTIs, acute kidney injury, and opportunistic infections.Results: We found that the proportion of individuals experiencing bacteriuria within the first-year posttransplant was significantly greater in the SAL group versus the control group (n = 21, 28% vs. n = 22, 14.7%, p = 0.012). This result was also seen in univariable and multivariable survival analysis. In addition, episodes of UTI with associated bacteremia (n = 11, 14.7% vs. n = 5, 3.3%, p = 0.002) were statistically significantly higher in the SAL group.Conclusion: There was a significantly greater number of episodes of bacteriuria in the first-year posttransplant in subjects with pretransplant SAL. Based on our findings, we suggest that all KTs with pretransplant SALs undergo evaluation and intervention prior to transplantation.","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70063"},"PeriodicalIF":2.6,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144226853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Premature Discontinuation of Trimethoprim/Sulfamethoxazole Prophylaxis in Abdominal Transplant Recipients: A Deeper Dive. 腹部移植受者过早停用甲氧苄啶/磺胺甲恶唑预防：深入研究。

IF 2.6 4区医学

Transplant Infectious Disease Pub Date : 2025-05-21 DOI: 10.1111/tid.70057

Madeline R Hudson, Tyler T Tinkham, Dan Ilges, Cassandra D Votruba, Rebecca Corey, Alyssa K McGary, Alan Gonzalez, McKenna J Beemiller, Justin M Potter, Ashkan Rastegar, Lavanya Kodali, Blanca C Lizaola-Mayo, Holenarasipur R Vikram

{"title":"Premature Discontinuation of Trimethoprim/Sulfamethoxazole Prophylaxis in Abdominal Transplant Recipients: A Deeper Dive.","authors":"Madeline R Hudson, Tyler T Tinkham, Dan Ilges, Cassandra D Votruba, Rebecca Corey, Alyssa K McGary, Alan Gonzalez, McKenna J Beemiller, Justin M Potter, Ashkan Rastegar, Lavanya Kodali, Blanca C Lizaola-Mayo, Holenarasipur R Vikram","doi":"10.1111/tid.70057","DOIUrl":"https://doi.org/10.1111/tid.70057","url":null,"abstract":"Trimethoprim/sulfamethoxazole (TMP/SMX) prophylaxis can prevent Pneumocystis jirovecii pneumonia (PJP) and other opportunistic infections (OI). We sought to assess the frequency, causative factors, and impact of early TMP/SMX discontinuation in abdominal solid organ transplant (SOT). This is a single-center, retrospective cohort study of abdominal SOT recipients at Mayo Clinic Arizona (MCA) between January 2021 and June 2023. Primary study goals were to determine the rate and reasons behind early TMP/SMX discontinuation and whether TMP/SMX prophylaxis was reinitiated. Secondary outcomes included mean duration of therapy, alternative prophylactic agent utilized, and incidence of TMP/SMX-preventable OI. A total of 930 abdominal SOT recipients were included (592 kidney, 253 liver, 85 multiorgan transplants). TMP/SMX was discontinued early in 184 (20%) patients: 77 kidney, 84 liver, 23 multiorgan. Predominant reasons for discontinuation were hyperkalemia (39%) and cytopenias (35%). Median duration of TMP/SMX prophylaxis before discontinuation was 54.5 (18.0, 93.2) days. TMP/SMX was not resumed in 62% of cases (36% kidney, 89% liver, 52% multi-organ). The predominant reason for non-resumption was alternative prophylaxis with no clear intent to rechallenge TMP/SMX (70%). Alternative prophylaxis included pentamidine (43%), none (30%), dapsone (22%), and atovaquone (5%). Of patients reinitiated, 86% (59/69) successfully remained on TMP/SMX through the prophylaxis period. One TMP-SMX-preventable OI (nocardiosis) was observed in the TMP/SMX discontinuation group. TMP/SMX is often discontinued prematurely in SOT recipients without resumption despite resolution of the offending cause. TMP/SMX prophylaxis should be maintained where possible, as alternative therapy may not offer the same broad spectrum of protection against OI.","PeriodicalId":23318,"journal":{"name":"Transplant Infectious Disease","volume":" ","pages":"e70057"},"PeriodicalIF":2.6,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peripheral Blood Lymphocyte Dynamics and Hidden Immune Effects of Severe Acute Respiratory Syndrome Coronavirus 2 Messenger RNA Vaccination in Kidney Transplant Recipients. 肾移植受者外周血淋巴细胞动力学及冠状病毒2信使RNA疫苗的隐性免疫效应

IF 2.6 4区医学

Transplant Infectious Disease Pub Date : 2025-05-19 DOI: 10.1111/tid.70056

Sara Querido, Maria Jorge Arroz, André Weigert, Catarina Martins

引用次数: 0