Transfusion Medicine最新文献_第4页

Transfusion training for haematology registrars: Results of a UK-wide survey. 血液学登记员输血培训：英国范围内的调查结果。

IF 1.4 4区医学

Transfusion Medicine Pub Date : 2025-08-01 Epub Date: 2025-05-19 DOI: 10.1111/tme.13146

Lorna Cain, Lucy Neave, Shubha Allard, Dora Foukaneli, Suzy Morton, Shruthi Narayan

{"title":"Transfusion training for haematology registrars: Results of a UK-wide survey.","authors":"Lorna Cain, Lucy Neave, Shubha Allard, Dora Foukaneli, Suzy Morton, Shruthi Narayan","doi":"10.1111/tme.13146","DOIUrl":"10.1111/tme.13146","url":null,"abstract":"Objectives: To understand the current status of transfusion training for haematology specialty registrars in the UK and identify potential solutions for improvement.Background: Transfusion knowledge and experience are essential for all haematologists. There are concerns regarding inconsistencies with the delivery of transfusion training.Methods: A 30-question online survey was distributed using the SurveyMonkey platform to UK haematology specialty trainees in June-July 2023.Results: A total of 150 responses (response rate 24%) were received from trainees at different stages of training in 17 training regions. Forty-four percent (66/150) trainees had undertaken or were expected to undertake a dedicated transfusion post during their training; these were deemed to be educationally useful. Ninety-nine percent (149/150) trainees had managed transfusion queries at work. Most trainees (69%, 103/150) had received teaching in hospitals outside of a dedicated transfusion post. A high proportion (87%, 131/150) had attended a transfusion course provided by a national blood service. Levels of overall satisfaction with the transfusion training provided varied: very satisfied/satisfied (30%), neutral (31%), dissatisfied/very dissatisfied (39%). The most common barriers to training selected were lack of exposure to the transfusion laboratory (75%), clashing clinical commitments taking priority (74%), and lack of provision of dedicated transfusion training (70%).Conclusion: There is mixed satisfaction with the transfusion training received by UK haematology registrars, evident from this survey. Protected time for transfusion training in dedicated transfusion posts and in other hospital posts, including laboratory time, is needed for all haematology trainees.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"330-336"},"PeriodicalIF":1.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12361835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Red blood cell transfusion practices in extracorporeal membrane oxygenation: A single-center study. 红细胞输血在体外膜氧合中的应用：一项单中心研究。

IF 1.4 4区医学

Transfusion Medicine Pub Date : 2025-08-01 Epub Date: 2025-07-04 DOI: 10.1111/tme.13154

Shailesh Balasubramanian, Mahmoud Alwakeel, Divyajot Sadana, Mani Latifi, Chase Donaldson, Brett Wakefield, Edward Soltesz, Kenneth McCurry, Sudhir Krishnan

{"title":"Red blood cell transfusion practices in extracorporeal membrane oxygenation: A single-center study.","authors":"Shailesh Balasubramanian, Mahmoud Alwakeel, Divyajot Sadana, Mani Latifi, Chase Donaldson, Brett Wakefield, Edward Soltesz, Kenneth McCurry, Sudhir Krishnan","doi":"10.1111/tme.13154","DOIUrl":"10.1111/tme.13154","url":null,"abstract":"Objectives: Evaluating blood transfusion practices and their impact on morbidity and mortality across extracorporeal membrane oxygenation (ECMO) configurations.Background: As ECMO becomes increasingly utilised in critical care, the ideal Hgb level remains uncertain. While guidelines recommend higher levels, emerging evidence suggests potential harm. Our study addresses this gap by investigating the optimal Hgb level for ECMO.Methods: A retrospective cohort study included all adult patients receiving ECMO between January 2016 and December 2018. The primary outcome assessed the optimal Hgb level associated with reduced ECMO duration and in-hospital mortality. Multivariable and Cox-proportional regression analyses were performed.Results: A total of 306 patients underwent ECMO, with 31 patients having mean Hgb levels 7-7.9 g/dL, 176 patients 8-8.9 g/dL, 72 patients 9-9.9 g/dL, and 27 patients ≥10 g/dL. The mean (SD) age was 56 years (15), with 60.8% male (186/306). ECMO configurations were primarily Venoarterial (VA) (59.8%), followed by Venovenous (VV) (36.9%) and Hybrid (3.3%). The 7-7.9 g/dL Hgb group was associated with longer ECMO duration (mean 17.5 days, coefficient 2.2, 95% CI 0.02-4.4, p = 0.048) compared to the ≥10 g/dL group, with no significant mortality differences across Hgb levels. VA ECMO patients had a significantly higher mortality risk than VV ECMO patients (aHR 2.33, 95% CI 1.50-3.60, p < 0.001). Blood product use, including RBC and Cryo, was associated with longer ECMO duration, while FFP reduced both duration (coefficient - 0.84, 95% CI -1.11--0.57, p < 0.001) and mortality risk (aHR 0.895, 95% CI 0.818-0.973, p = 0.012).Conclusion: Targeting Hgb level >8 g/dL in ECMO patients may help reduce ECMO duration.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"337-345"},"PeriodicalIF":1.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12361832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144565268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Performance of a large Brazilian network of blood banks during the COVID-19 pandemic: Impact assessment and time series analysis (2016-2023). 2019冠状病毒病大流行期间巴西大型血库网络的表现：影响评估和时间序列分析（2016-2023年）

IF 1.4 4区医学

Transfusion Medicine Pub Date : 2025-08-01 Epub Date: 2025-06-09 DOI: 10.1111/tme.13152

Maria Clara F Silva-Malta, Elias M Oliveira, Fabiana C C Piassi, Maisa A Ribeiro, Kátia C Coelho, Daniela O W Rodrigues, Ricardo V F Carvalho, Junia G M Cioffi, Marina L Martins

{"title":"Performance of a large Brazilian network of blood banks during the COVID-19 pandemic: Impact assessment and time series analysis (2016-2023).","authors":"Maria Clara F Silva-Malta, Elias M Oliveira, Fabiana C C Piassi, Maisa A Ribeiro, Kátia C Coelho, Daniela O W Rodrigues, Ricardo V F Carvalho, Junia G M Cioffi, Marina L Martins","doi":"10.1111/tme.13152","DOIUrl":"10.1111/tme.13152","url":null,"abstract":"Background: During the COVID-19 pandemic, blood banks faced the risk of shortages of blood components and adopted measures to mitigate this threat. The present study aims to describe the influence of the pandemic on a large hemotherapy centre, including data from 21 regional blood centres (Hemominas-Minas Gerais/Brazil).Methods: Time series for the blood donor attendance were constructed covering 8 years (2016-2023). Blood centre performance indicators from the pandemic period (2020-2023) were compared with the pre-pandemic period (2016-2019).Results: During the pandemic, a 11.6% decline in the production of blood components was observed (Semiannual average of 355 511 vs. 402 528 units). The first half of 2022 was the period with the highest number of COVID-19 cases (third wave) and the lowest production. The drop in the number of candidates for blood donation was more pronounced in the most populated cities. An increase in returning donors was observed, as well as a decrease in the deferral rate. The time series analysis indicated a strong downward trend in blood donors during the pandemic period but with a tendency to recover from the second half of 2023.Conclusion: The COVID-19 pandemic significantly affected the hemotherapy system in Minas Gerais, resulting in a drop in the production of blood components. The operation of Hemominas as a network of blood centers contributed to mitigating the effects of the pandemic, alleviating the scarcity of blood components, especially in the most populated cities, where blood donation was very affected and where the largest and most complex hospitals are located.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"312-321"},"PeriodicalIF":1.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pure red cell aplasia after ABO incompatible allogeneic stem cell transplantation treated with therapeutic plasma exchange: A case report. 治疗性血浆交换治疗ABO不相容异基因干细胞移植后的纯红细胞发育不全1例报告。

IF 1.4 4区医学

Transfusion Medicine Pub Date : 2025-08-01 Epub Date: 2025-05-28 DOI: 10.1111/tme.13153

Abhijit Baheti, Brinda Kakkar, Sameer Melinkeri, Anusree Prabhakaran, Urmi Sheth, Vijaya Gadage, Sanjiv Ketkar

引用次数: 0

Serological and genetic analysis of a B3 phenotype caused by c.259G > T in the ABO gene. ABO基因c.259G . > T引起的B3表型的血清学和遗传学分析。

IF 1.4 4区医学

Transfusion Medicine Pub Date : 2025-08-01 Epub Date: 2025-04-21 DOI: 10.1111/tme.13140

Min Zhang, Hongjun Gao, Yu Jiang, Fengxia Liu, Xisha Huan, Zhen Huang, Fen Yuan, Ping Lei

{"title":"Serological and genetic analysis of a B3 phenotype caused by c.259G > T in the ABO gene.","authors":"Min Zhang, Hongjun Gao, Yu Jiang, Fengxia Liu, Xisha Huan, Zhen Huang, Fen Yuan, Ping Lei","doi":"10.1111/tme.13140","DOIUrl":"10.1111/tme.13140","url":null,"abstract":"Background: Mixed agglutination is a serological pattern in some ambiguous ABO blood type identification. This study focused on the serological and molecular genetic characteristics of a B3 phenotype induced by a c.259G > T mutation in the ABO gene.Study design and methods: Serological methods such as gel cards and tubes were used to identify the ABO blood type of the patient, with fluorescent PCR for ABO genotyping and Sanger sequencing for analysing the ABO exons. Protein 3D Structure was simulated and further analysed using SWISS-MODLE and PyMOL. Both the wild-type (VAL-87, ABO*B.01) and the mutant (p.Val87Leu) plasmids were transfected into Hela cells to assess the agglutination intensity of the transfected cells with anti-B antibodies.Results: Serological testing showed weak expression of the B antigen and mixed agglutination with anti-B antibodies. ABO genotyping indicated the presence of a B allele, but exon sequencing revealed an additional c.259G > T mutation in exon 6 based on the ABO*B.01 allele. The simulated three-dimensional structures of the proteins showed increased steric hindrance with mutations, leading to a relatively loose structure. The transfected Hela cells with the mutant (p.Val87Leu) plasmid exhibited a significantly reduced agglutination intensity with anti-B antibodies.Conclusion: Based on comprehensive serological, genetic, and simulation analyses, it is concluded that the c.259G > T mutation in exon 6 of the ABO*B.01 allele results in an amino acid change within the enzymatic active site. This alteration likely impacts protein stability and reduces B antigen expression, leading to the B3 subtype phenotype.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"352-358"},"PeriodicalIF":1.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frequencies of different blood group antigens and phenotypes in Northern Vietnamese donors. 越南北部献血者不同血型抗原和表型的频率。

IF 1.4 4区医学

Transfusion Medicine Pub Date : 2025-08-01 Epub Date: 2025-03-10 DOI: 10.1111/tme.13136

Tung Quang Nguyen, Tuyen Thi Do, Nga Thanh Thi Hoang, Khanh Quoc Bach, Thanh Ha Nguyen

{"title":"Frequencies of different blood group antigens and phenotypes in Northern Vietnamese donors.","authors":"Tung Quang Nguyen, Tuyen Thi Do, Nga Thanh Thi Hoang, Khanh Quoc Bach, Thanh Ha Nguyen","doi":"10.1111/tme.13136","DOIUrl":"10.1111/tme.13136","url":null,"abstract":"Background and objectives: Blood safety is the top priority in transfusion medicine. However, patients in Vietnam are only transfused with ABO and RhD compatible blood products, which could pose a threat to induce alloimmunization. This study was performed to provide information about the frequencies of antigens and phenotypes of clinically significant blood groups in Vietnamese donors.Materials and methods: Blood samples were taken from donors to identify red cell antigens by column agglutination tests. Antigen and phenotype frequencies were calculated and expressed as percentages. Gene frequencies were calculated under the standard assumption of Hardy-Weinberg equilibrium.Results: Among the Rh antigens, e was the most common (96.96%) followed by D (96.72%), C (92.86%), c (43.10%), and E (32.59%) with D+C+E-c-e+(54.02%) being the most common phenotype. In the Lewis and Duffy blood group system, the major phenotypes found were Le (a-b+) (60.43%) and Fy (a+b-) (85.39%), respectively. In the Kell and Lutheran blood group system, k and Lub were present in 100% of the donors, respectively. The most common phenotypes in the Kidd and MNS blood group system were Jk (a+b+) (47.62%) and M + N+(46.63%), S-s+ (94.42%), respectively. Mia was seen in 9.20% of the donors. The frequency of P1 was 22.25%.Conclusion: This study shows the frequencies of 21 blood group antigens in Northern Vietnam donors. Knowledge of red cell antigen phenotype frequencies can help prepare indigenous cell panels, provide antigen-negative blood to patients with multiple alloantibodies, and prevent alloimmunisation.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"346-351"},"PeriodicalIF":1.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Apheresis procedures for the treatment of patients and for the collection of cellular therapy products: A British Society for Haematology guideline. 用于治疗患者和收集细胞治疗产品的单采程序：英国血液学学会指南。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2025-07-15 DOI: 10.1111/tme.13144

Catherine Howell, Annelies Billen, Therese Callaghan, Kenneth Douglas, James Griffin, Davina Potok, Tuula Rintala, Sara Trompeter, Robert Wynn, Julia Wolf, Susan Robinson

引用次数: 0

COVID-19 pandemic impact on blood donations and discards from screening tests for transfusion-transmitted infections in a Brazil Brazilian metropolitan area. 巴西大都市地区COVID-19大流行对献血量和输血传播感染筛查试验弃血量的影响

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2025-07-07 DOI: 10.1111/tme.13159

Laiane da Silva Santos, Sérgio Eduardo Soares Fernandes, Flávio Ferreira Pontes Amorim, Anna Luiza Oliveira Sant'Anna, Felipe Ferreira Pontes Amorim, Fábio Ferreira Amorim

{"title":"COVID-19 pandemic impact on blood donations and discards from screening tests for transfusion-transmitted infections in a Brazil Brazilian metropolitan area.","authors":"Laiane da Silva Santos, Sérgio Eduardo Soares Fernandes, Flávio Ferreira Pontes Amorim, Anna Luiza Oliveira Sant'Anna, Felipe Ferreira Pontes Amorim, Fábio Ferreira Amorim","doi":"10.1111/tme.13159","DOIUrl":"https://doi.org/10.1111/tme.13159","url":null,"abstract":"Background: The COVID-19 pandemic posed a worldwide challenge for blood services. We aimed to evaluate the impact of the COVID-19 pandemic on blood donations and blood discards resulting from screening tests for transfused-transmitted infections (TTIs) in a Brazilian metropolitan.Methods: Time-series cohort study including data of all blood donors from January 2018 to December 2021 at the Brasília Blood Center Foundation, Federal District, Brazil. The causal impact analysis was used to evaluate the impact of COVID-19 on blood donations, and a propensity score matching was used to evaluate the effect of the COVID-19 pandemic on the seroprevalence of TTIs.Results: There were 205 965 blood donations during the study period. The blood donations significantly reduced soon after the onset of the COVID-19 pandemic in Brasilia, Brazil, in March 2020 until August 2020 (absolute effect per week: -2952; 95% CI: -4627 to -1355). However, from September 2020 to December 2021, blood donations had returned to the levels foreseen by the time-series model. Compared to the pre-COVID-19 period, the period between September 2020 and December 2021 was associated with a decrease of at least one reactive or indeterminate screening test for TTI (OR: 0.753, 95% CI: 0.665-0.854, p <0.001).Conclusion: There was a substantial decrease in blood donations soon after COVID-19 onset in Brazil. However, within a few months, the donation levels had returned to those projected by the model, possibly due to measures implemented by the blood centre for blood donations. The seroprevalence of TTIs decreased during the COVID-19 pandemic.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recruiting racialised youth to a stem cell registry in Canada. 招募种族化的青年到加拿大的干细胞登记处。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2025-06-16 DOI: 10.1111/tme.13155

Kelly Holloway, Ufuoma Muwhen, Warren B Fingrut, Jennie Haw

{"title":"Recruiting racialised youth to a stem cell registry in Canada.","authors":"Kelly Holloway, Ufuoma Muwhen, Warren B Fingrut, Jennie Haw","doi":"10.1111/tme.13155","DOIUrl":"https://doi.org/10.1111/tme.13155","url":null,"abstract":"Objectives: The aim of this paper is to report results of racialised young adults' awareness of the stem cell registry. Further, we examine recruitment materials and outreach strategies to increase stem cell awareness and registration among young, racialised Canadians.Background: Patients who are not White face disparities in securing unrelated donors because of the disproportionate representation of White registrants on stem cell registries, differences in genetic diversity across ethnicities, and attrition rates for donor registries.Methods/materials: This qualitative study is informed by community-based participatory research. Focus groups were conducted with young adults ages 17-35 who self-identify as Black, Indigenous, and people of colour (BIPOC)/racialised, are comfortable speaking in English, and live in Canada.Results: Five 2-h focus groups were conducted with 17 participants in total. Participants spoke to the interconnected themes of knowledge, trust, and engagement with their community. They were motivated by the idea of contributing to a more diverse registry. These perspectives informed their insight into what materials and events would resonate with their peers and their communities.Conclusion: Our findings point to some concrete suggestions for materials that can resonate with young racialised Canadians. Further, stem cell registries should work collaboratively with young adults and young adult organisations to co-develop educational and recruitment materials and build relationships over time, developing their knowledge of stem cells and raising their confidence to host stem cell events within their communities.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracorporeal photopheresis-New insights into an old procedure. 体外光切除术-对旧手术的新见解。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2025-06-10 DOI: 10.1111/tme.13156

Sabine Seiffert, Janine Kirchberg, Enrica Bach, Victoria Menger, Mandy Brückner, Ulrich Sack, Ulrike Köhl, Uwe Platzbecker, Andreas Boldt, Marco Herling, Vladan Vučinić

{"title":"Extracorporeal photopheresis-New insights into an old procedure.","authors":"Sabine Seiffert, Janine Kirchberg, Enrica Bach, Victoria Menger, Mandy Brückner, Ulrich Sack, Ulrike Köhl, Uwe Platzbecker, Andreas Boldt, Marco Herling, Vladan Vučinić","doi":"10.1111/tme.13156","DOIUrl":"https://doi.org/10.1111/tme.13156","url":null,"abstract":"Background: Extracorporeal photopheresis (ECP) is a safe immunomodulatory strategy that induces cell-type selective apoptosis through photodynamic processes. Despite decades of use, the mechanisms underlying ECP remain largely unexplored, particularly in studies examining specific immune cell subsets in ex vivo setups.Aims: This proof-of-concept pilot study presents data on apoptosis and proliferation of T-lymphocytes following ex vivo ECP application to leukocyte concentrates (LC) and peripheral blood (PB) samples from healthy donors.Methods: LC and PB were diluted to a haematocrit of 2% and treated with 8-methoxypsoralen, followed by ECP (ECP+) or no ECP (ECP-) in a discontinued system. Apoptosis of mononuclear cells was assessed 48 h post-ECP using annexin V and 7 Aminoactinomycin D (7-AAD) staining with flow-cytometric quantification. The proliferative capacity of non-apoptotic T-lymphocytes was measured after 72 h of post-ECP stimulation with anti-CD3/CD28 cross-linking, using Violet Proliferation Dye 450.Results: ECP exposure significantly reduced the median T-cell receptor-induced proliferation of viable T-lymphocytes from both LC (4.6%, p = 0.02) and PB (4.2%, p = 0.03). However, 7-AAD staining 48 h post-ECP showed no significant differences in the proportions of apoptotic cells in this experimental model.Conclusion: Ex vivo ECP treatment inhibited T-lymphocyte proliferation in both LC and PB from healthy individuals, suggesting this as a key mode of action. Our findings highlight ECP's potential applications, including its implications for modern immune therapies' adverse effects. Further analyses of functional characteristics of remaining vital cells are necessary.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0