Transfusion Medicine最新文献_第4页

Exploring barriers and facilitators to blood donation in secondary schools in Malawi. 探索马拉维中学献血的障碍和促进因素。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-12-08 DOI: 10.1111/tme.13110

Effie Chipeta, Princess Kaira, Patani Mhango, Emmanuel Singogo, Victor Mwapasa, Adamson S Muula, Andrew Likaka, Titus Chiwindo, Mina C Hosseinipour, Bridon M'baya

{"title":"Exploring barriers and facilitators to blood donation in secondary schools in Malawi.","authors":"Effie Chipeta, Princess Kaira, Patani Mhango, Emmanuel Singogo, Victor Mwapasa, Adamson S Muula, Andrew Likaka, Titus Chiwindo, Mina C Hosseinipour, Bridon M'baya","doi":"10.1111/tme.13110","DOIUrl":"10.1111/tme.13110","url":null,"abstract":"Background and objective: Despite the Malawi Blood Transfusion Service (MBTS) increasing the amount of blood collected since its inception in 2004, Malawi remains with a 27% deficit in required blood supplies nationally. We sought to understand the facilitators and barriers to blood donation among secondary school students in Malawi.Methods: We utilised a qualitative exploratory design, with a sample of 135 participants purposefully selected from 16 secondary schools across Malawi. Data collection methods included in-depth interviews with 20 participants (inclusive of first-time and repeat donors, lapsed and non-donors), 20 key informant interviews (including community leaders, policy-level stakeholders and MBTS staff), and 16 focus group discussions involving 95 participants (community stakeholders and all donor categories). We used the consolidated framework for implementation research (CFIR) to assess barriers and facilitators of blood donation, focusing only on four CFIR domains: internal and external factors; the implementation process and individual characteristics influencing blood donation.Results: Blood donation among students are facilitated by altruism, incentives including milestone awards, knowledge, motivation, transport, peer pressure and individual health status. Common barriers cited included: negative experiences with the blood donation process, fear, unsupported environment, poor incentives, privacy issues and the donation activities starting late than scheduled.Conclusion: While there have been efforts to motivate students to donate blood, significant barriers to blood donation still exist. Intensifying education and awareness campaigns may help dispel misconceptions and fears surrounding donation experiences and blood usage. Also, continuing with the provision of appropriate incentives including milestone awards may also encourage students.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142795225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transfusing selected RhD negative patients with RhD positive packed red cell concentrates resulted in lower frequency of anti-D development and saved almost two thousand RhD negative concentrates during 5 years. 将选择的RhD阴性患者与RhD阳性填充红细胞浓缩物进行输注，降低了抗d发生的频率，并在5年内节省了近2000个RhD阴性浓缩物。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-12-03 DOI: 10.1111/tme.13118

Inger Margit Alm, Elin Brenna, Çiğdem Akalın Akkök

{"title":"Transfusing selected RhD negative patients with RhD positive packed red cell concentrates resulted in lower frequency of anti-D development and saved almost two thousand RhD negative concentrates during 5 years.","authors":"Inger Margit Alm, Elin Brenna, Çiğdem Akalın Akkök","doi":"10.1111/tme.13118","DOIUrl":"https://doi.org/10.1111/tme.13118","url":null,"abstract":"Background: The Blood Bank at Oslo University Hospital implements restrictions when the stocks of blood groups O and A RhD negative packed red blood cell concentrates (PRBCCs) drop below 60 units due to high demand and low donor availability. Restrictions entail transfusing RhD negative male patients and women >50 years with RhD positive units, to provide RhD negative units to those who should not receive RhD positive units. Earlier studies have reported that up to 50% of RhD negative patients developed anti-D after RhD positive blood transfusion. We aimed to investigate the rate of anti-D alloimmunization using this restriction strategy in our population.Study design and methods: This retrospective study was performed at Oslo University Hospital between 2006 and 2011. Antibody screen results were included throughout 2019 for the patients readmitted to the hospital.Results: 607 RhD negative mostly cancer patients and patients having surgery for cardiovascular conditions received 1926 RhD positive PRBCCs. Post-transfusion antibody screen was available for 401 patients (66.1%), and 76 patients (22.2%) developed anti-D. In 15 of the 76 patients (19.7%), anti-D became evanescent in the follow-up.Discussion: The proportion of anti-D immunisation in RhD negative patients receiving RhD positive PRBCCs in this study was consistent with findings from other reports. To our knowledge, this is the first study reporting a high proportion of evanescence of anti-D. Transfusing selected RhD negative patients with RhD positive PRBCCs when RhD negative stocks are low, contributed saving 1926 RhD negative PRBCCs during the study period of 64 months.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resuscitation of adult shocked trauma patients using major haemorrhage protocol guided by viscoelastic haemostatic assays versus formulaic approach. 使用粘弹性止血测定法指导的大出血方案与公式化方法对成人休克创伤患者进行复苏。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-12-01 Epub Date: 2024-11-08 DOI: 10.1111/tme.13109

Biswadev Mitra, Elizabeth Wake, Carly Talarico, Sarah Czuchwicki, Christine Koolstra, Don Campbell, Simon Hendel, James Winearls

{"title":"Resuscitation of adult shocked trauma patients using major haemorrhage protocol guided by viscoelastic haemostatic assays versus formulaic approach.","authors":"Biswadev Mitra, Elizabeth Wake, Carly Talarico, Sarah Czuchwicki, Christine Koolstra, Don Campbell, Simon Hendel, James Winearls","doi":"10.1111/tme.13109","DOIUrl":"10.1111/tme.13109","url":null,"abstract":"Background: The resuscitation of trauma patients with critical bleeding may follow a formulaic approach using high ratios of blood components or a viscoelastic haemostatic assay (VHA) guided approach. The aim of this study was to compare the two strategies for resuscitation of shocked trauma patients.Methods: This was a registry-based cohort study including shocked trauma patients from two trauma centres-one practising a formulaic approach, with VHA unavailable during trauma resuscitation and the other practicing a VHA-guided resuscitation strategy. The primary outcome was the total units of blood components transfused in 24 h after adjusting for differences in baseline characteristics and time to death.Results: Between 01 Jan 2020 and 31 Dec 2022, 152 eligible patients were categorised to the formulaic group and 40 to the VHA group. Prehospital times were longer in the formulaic group (2.0 vs. 1.4 h), and more patients in the VHA group (38% vs. 17%) were transfused prehospital blood components. Formulaic resuscitation was associated with significantly more blood components transfused (adjusted incidence rate ratio 1.5; 95%CI: 1.4-1.7, p < 0.001). Using a formulaic approach, patients were administered more red blood cells, plasma and platelets, but fewer cryoprecipitate. There was no significant association of the formulaic approach with in-hospital mortality (adjusted odds ratio 2.4; 95%CI: 0.7-8.0, p = 0.17).Conclusions: Given the cost and potential adverse effects of blood component transfusions, VHA-guided transfusion strategies present an attractive option, particularly among centres managing high volumes of shocked patients. Further trials, enrolling the population most likely to benefit from precision transfusion strategies, are indicated.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"514-519"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What is best practice for the prevention of anti-D alloimmunisation in D-negative recipients receiving solid organ transplants from D-positive donors. 在接受 D 阳性捐献者实体器官移植的 D 阴性受者中，预防抗 D 免疫的最佳做法是什么？

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-12-01 Epub Date: 2024-10-01 DOI: 10.1111/tme.13097

Thomas Lynes, Anna Mon Ying Li, Deirdre Sexton, David Nasralla, Matthew Hazell

引用次数: 0

Determining the strength of evidence for an association between sexual indicators and risk of acquiring HIV and sexually transmitted infections: Providing evidence for blood donation policy change. 确定性指标与感染艾滋病毒和性传播疾病风险之间关联的证据强度：为改变献血政策提供证据。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-12-01 Epub Date: 2024-07-22 DOI: 10.1111/tme.13062

Joe Flannagan, Katy L Davison, Claire Reynolds, Susan R Brailsford

{"title":"Determining the strength of evidence for an association between sexual indicators and risk of acquiring HIV and sexually transmitted infections: Providing evidence for blood donation policy change.","authors":"Joe Flannagan, Katy L Davison, Claire Reynolds, Susan R Brailsford","doi":"10.1111/tme.13062","DOIUrl":"10.1111/tme.13062","url":null,"abstract":"In 2019 the For The Assessment Of Individualised Risk (FAIR) project began a review of UK blood donor selection policy to determine if a more individualised approach to donor selection could be safely implemented. An evidence base was required to inform selection policy to move from a population to a more individual based policy, specifically what sexual behaviours/indicators should be considered as screening questions to maintain the safety of the blood supply. Eight sexual behaviours/indicators were reviewed: history of bacterial sexually transmitted infections (STIs), chemsex, number of recent partners, condom use, type of sex, sexual health service (SHS) attendance, new sexual partner and exclusivity. We conducted searches in multiple databases to identify literature looking at the association between these behaviours/indicators and HIV/STI acquisition risk. A scoring system to determine strength of evidence was devised and applied to papers that passed screening. Key studies were identified which achieved the maximum score and more in-depth reviews were conducted for these. We identified 58 studies, including 17 key studies. Strong evidence was found linking a previous bacterial STI, chemsex and increasing numbers of sexual partners to acquisition risk. Condom use, type of sex and new partners were found to have some strength of evidence for this link. SHS attendance and exclusivity had minimal evidence. We recommended that the behaviours/indicators viewed as having strong or some strength of evidence should be considered as screening questions in a more individualised approach to donor selection criteria.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"466-477"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11653059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141749148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The infected blood inquiry: Impact on public perceptions of blood supply risk, safety, and donation attitudes. 受感染血液调查：对公众对血液供应风险、安全性和捐献态度看法的影响。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-12-01 Epub Date: 2024-11-12 DOI: 10.1111/tme.13108

Richard Mills, Eva-Maria Merz, Mark Croucher, Barbara Masser, Susan R Brailsford, Robert Smith, Eamonn Ferguson

{"title":"The infected blood inquiry: Impact on public perceptions of blood supply risk, safety, and donation attitudes.","authors":"Richard Mills, Eva-Maria Merz, Mark Croucher, Barbara Masser, Susan R Brailsford, Robert Smith, Eamonn Ferguson","doi":"10.1111/tme.13108","DOIUrl":"10.1111/tme.13108","url":null,"abstract":"Background: The UK's Infected Blood Inquiry (IBI) highlighted a major public health scandal, with at least 30 000 people infected and more than 3000 deaths attributable to infected blood and blood products. This study investigates the impact of the IBI announcement on May 20, 2024, on public perceptions of blood supply risk, safety, and donation intentions in the UK compared to the USA.Methods: A 2 (country: UK vs. USA) × 2 (time: pre-, post-IBI announcement) between-within-subject study was conducted with 1635 participants (888 UK, 747 USA). Pre-IBI data were collected from May 3 to 7, 2024, and post-IBI data from May 30 to June 30, 2024. Key measures were perceived infection risk from transfusion, transfusion safety, willingness to donate and encourage others. The impact was assessed using differences-in-differences (DiD) and reliable-change-indices (RCI).Results: UK participants showed a significant but small decrease in perceived safety compared to USA participants, with 1 in 30 UK individuals perceiving a significant reduction in perceived transfusion safety. Decreases in perceived safety were associated with significant decreases in willingness to donate and encouragement of others in the whole sample and in USA participants and significant decreases in willingness to encourage others in UK participants. Older people reported a greater reduction in safety, and non-donors were more likely to be put off donating and not ask others to donate as a result of their perception that safety had been reduced.Conclusion: Overall, perceived safety decreased marginally in the UK general population. Future research should explore the long-term impacts of the IBI.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"478-490"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11653061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review of immunoglobulin use in a district general hospital setting. 地区综合医院免疫球蛋白使用情况回顾。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-12-01 Epub Date: 2024-06-25 DOI: 10.1111/tme.13059

Julie Gillies, Lorna Robertson, Debbie Tait

引用次数: 0

Charles Waller and Edward Doubleday-Colleagues of James Blundell and early supporters of blood transfusion. 查尔斯-沃勒（Charles Waller）和爱德华-道布尔戴（Edward Doubleday）--詹姆斯-布伦德尔（James Blundell）的同事，输血的早期支持者。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-12-01 Epub Date: 2024-03-22 DOI: 10.1111/tme.13036

Phil Learoyd

引用次数: 0

Serological investigations on penicillin-induced antibodies in the Thai population. 泰国人群青霉素诱导抗体的血清学调查。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-12-01 DOI: 10.1111/tme.13117

Piyathida Khumsuk, Oytip Nathalang, Tanaporn Choychimplee, Wiradee Sasikarn, Kamphon Intharanut

{"title":"Serological investigations on penicillin-induced antibodies in the Thai population.","authors":"Piyathida Khumsuk, Oytip Nathalang, Tanaporn Choychimplee, Wiradee Sasikarn, Kamphon Intharanut","doi":"10.1111/tme.13117","DOIUrl":"https://doi.org/10.1111/tme.13117","url":null,"abstract":"Objectives: The study aimed to assess the conditions for coating RBCs with penicillin and examine the anti-penicillin reactions of random Thai patients' sera against penicillin-coated RBCs and normal sera from Thai donors testing in the presence of the drug.Background: Penicillin-induced immunologic haemolytic anaemia (IHA) is reportedly related to possessing antipenicillin antibodies, immunoglobulin G (IgG), which has been identified in testing penicillin-coated red blood cells (RBCs). In addition, low titre penicillin antibodies, often IgM, are detected in donors by testing in the presence of a solution of the penicillin.Materials and methods: Penicillin-coated RBCs were produced, and antipenicillin was tested against those penicillin-coated RBCs amongst random Thai patients who had strongly positive direct antiglobulin (≥3+). Additionally, sera from Thai blood donors were tested in the presence of the penicillin. These relationships were determined by comparing the numbers of penicillin-antibody positive patients with their diagnosis, sex, age and blood type.Results: Penicillin requires a high pH to optimally adhere to RBCs that showed validated reactions with controls. Enrolment of 304 random patients, of whom 17 (5.59%) had positive antipenicillin tests using penicillin-coated RBCs. Of the 246 donor samples, 3 (1.22%) displayed positive reactivities in the presence of soluble penicillin. Furthermore, no association was discovered between the patient's characteristics and antipenicillin positivity.Conclusions: This is the first study to develop and report on the low percentage of patients' and donors' sera without IHA. Investigating suspected cases of penicillin-induced IHA requires following our suggested method to identify clinically significant antipenicillin.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validation of pathogen reduced plasmas from maxi-pools combined with fast thawing. 验证最大池与快速解冻相结合减少病原体的等离子体。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-12-01 Epub Date: 2024-11-05 DOI: 10.1111/tme.13106

Marja-Kaisa Auvinen, Folke Knutson, Helena Löf

{"title":"Validation of pathogen reduced plasmas from maxi-pools combined with fast thawing.","authors":"Marja-Kaisa Auvinen, Folke Knutson, Helena Löf","doi":"10.1111/tme.13106","DOIUrl":"10.1111/tme.13106","url":null,"abstract":"Objectives: Fast thawing for emergency situations and reduction of plasma wastage.Background: Evaluation of plasma units, pooled and pathogen reduced (PR) in \"maxi-pools\" with amotosalen and UVA light, and fast thawing.Methods/materials: Per replicate, 10 WB-derived leukocyte depleted plasma units were frozen within 24 h at ≤ -25°C and stored for 7 days. After thawing, a maxi-pool was constituted from the 10 units. After splitting into 4 sub-pools of 650 mL, the sub-pools were PR treated then split into 3 units resulting in 12 PR plasma units at 200 mL. Hundred and twenty PR plasma units were produced in total. The units were frozen at ≤ -25°C for 1 week, then thawed either in a fast plasma thawer for 5 min or in other control devices (17 to 23 min).Fviii: C, Fibrinogen, albumin, IgG, protein S and VWF were measured in plasma units, maxi-pools and plasmas after PR treatment and thawing.Results: There was a statistically significant (p < 0.001) but still clinically acceptable (over the recommended levels of ≥0.5 IU/mL and ≥2 g/L) reduction of FVIII:C and Fibrinogen after PR with 69% and 87% recovery, respectively. Other proteins were not significantly affected by the processes.Conclusion: Pooling 10 plasma units before the PR treatment standardises volume and protein content of plasma units. Besides the economic value of generating 12 products for transfusion, this procedure combined with a thawing time of about 5 min is of value in emergency situations and may reduce plasma wastage.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"537-542"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11653055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0