Transfusion Medicine最新文献

{"title":"Systematic literature review and meta-analysis of concordance and accuracy of pretransfusion immunohematology routine tests.","authors":"Christopher Elliott, Stephanie Kelham, Liu Zhang, Stacy Grieve, Tommy Lan, Hoora Moradian, Cristina Coll-Ortega, David Gómez-Ulloa","doi":"10.1111/tme.70010","DOIUrl":"https://doi.org/10.1111/tme.70010","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to assess the concordance and comparative accuracy of commercially available immunohematology (IH) tests for pretransfusion testing.</p><p><strong>Background: </strong>Pretransfusion tests are intended to ensure donor blood is matched with a compatible recipient. Automated testing has become the mainstay since the commercialisation of IH analysers, because of their reduced risk of human error and increased efficiency.</p><p><strong>Methods/materials: </strong>A systematic literature review (SLR) was performed to identify studies evaluating the concordance and sensitivity/specificity of IH tests for ABO/RhD typing, antibody screening, or antibody identification. Pairwise meta-analysis of concordance and sensitivity/specificity of IH tests was conducted when feasible.</p><p><strong>Results: </strong>The SLR identified 48 publications, of which 30 were included for meta-analysis. ID/IH gel (Bio-Rad), DG gel (Grifols), MTS/BioVue gel (Ortho Clinical Diagnostics), and Capture R (Immucor/Werfen) all had almost 100% pooled concordance with each other in ABO/RhD typing and antibody screening. Antibody identification results varied across studies, and pooled concordance rates were lower: 97.53% for DG gel versus ID/IH gel, 85.26% for ID/IH gel vs. MTS/BioVue gel, 85.54% for DG gel versus MTS/BioVue gel, and 71.19% for Capture R versus MTS/BioVue gel. For antibody screening, ID/IH gel, DG gel, and MTS/BioVue gel had pooled sensitivities of 94.23%, 96.31%, and 97.27%, respectively, with a pooled specificity of ~100% for all three tests.</p><p><strong>Conclusion: </strong>All tests had good concordance in ABO/RhD typing and antibody screening, and lower pooled concordance rates for antibody identification. For antibody screening, 95% pooled sensitivity and ~100% specificity were estimated for DG gel, MTS/BioVue gel, and ID/IH gel.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"It is not all anti-policy attitudes: Viewing blood donation as a means to belong predicts blood donation among men who have sex with men.","authors":"Koson Tony Sriamporn, Peter J W Saxton, Nathan S Consedine","doi":"10.1111/tme.70012","DOIUrl":"https://doi.org/10.1111/tme.70012","url":null,"abstract":"<p><strong>Objective: </strong>To examine whether specific attitudes towards blood donation vary across MSM demographic groups; and preliminarily test whether these attitudes predict prior donation behaviour.</p><p><strong>Background: </strong>Insights into blood donors' attitudes facilitate effective donor management, especially as policies for men who have sex with men (MSM) become more inclusive. While attitudes towards donating blood can predict donor decisions, it is unclear whether attitudinal factors specific to MSM groups will be important considerations for blood service providers engaging with this newly eligible donor group.</p><p><strong>Methods: </strong>Data were drawn from a large (N = 3157) online cross-sectional survey of MSM in New Zealand. New items were developed to assess three attitudinal constructs: negative attitudes towards the MSM deferral policy, favourable attitudes towards blood services, and the tendency to view blood donation as a form of civic participation and belonging. Univariate analyses descriptively characterised demographic factors associated with those various attitudes, and multivariate logistic regressions were used to predict self-reported donation histories.</p><p><strong>Results: </strong>Negative views of deferral policies and blood services varied across sample characteristics in univariate analyses, but did not systematically differ between donors and nondonors. However, a perception of blood donation as a means of civic belonging was consistently associated with greater donation, including 1.46 times the odds of having ever donated (p < 0.001) and 1.40 times the odds of having donated recently under the current 3-month deferral policy (p = 0.017).</p><p><strong>Conclusion: </strong>These findings highlight the importance of recognising broader civic-related attitudes in MSM donor research and engagement strategies.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementing bedside electronic transfusion checks at Barts Health NHS Trust: A study protocol for evaluating the effectiveness and value for money.","authors":"Montasir Ahmed, Laura Green, Iram Bhatti, Catherine Booth, Louise Bowles, Ollie Djurdjevic, Helinor McAleese, Josephine McCullagh, Michael F Murphy, Florence Oyekan, Nathan Proudlove, Florian Tomini, Yan Feng","doi":"10.1111/tme.70002","DOIUrl":"10.1111/tme.70002","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the benefits of implementing Bedside Electronic Transfusion Checks (BETC) to patients and value for money at four hospitals at Barts Health NHS Trust.</p><p><strong>Background: </strong>BETC aims to enhance transfusion safety by reducing errors associated with positive patient identification checks for compatibility, blood sample labelling, and blood component administration. There is limited evidence on the potential benefits to patients and healthcare professionals as well as value for money for implementing BETC.</p><p><strong>Methods: </strong>The BETC implementation at four hospitals adopted a non-randomised, staggered, multi-phase strategy. Alongside the implementation, an evaluation study was conducted. The intervention consists of a portable handheld scanning device and a mobile printer used for printing labels that are attached to the compatibility blood bottles and for verifying the patient's details against blood units prior to blood administration. Eligible patients are those who received blood transfusions or had compatibility tests performed during the evaluation period. The outcomes for evaluation include transfusion-related errors and cost savings from an NHS perspective. Regression-based time-series intervention analyses will be applied to evaluate the impacts of BETC implementation.</p><p><strong>Expected results: </strong>The three-year evaluation includes a 12-month pre-implementation period (May 2022 to April 2023) and a 24-month implementation period (May 2023 to April 2025). All staff involved with bedside transfusion were trained on the new system. Data were collected from different transfusion datasets, process mapping dataset, and Health Economics Inventory dataset.</p><p><strong>Discussion: </strong>Findings from this evaluation study will provide empirical evidence on the effectiveness and value for money of implementing BETC and will support decision-making for its wider roll-out in the UK.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Storage of thawed cryoprecipitate for 5 days at refrigerated temperatures: A systematic review and meta-analysis.","authors":"Shuhong Xie, Longhai Tang, Qi Xiao, Qungang Zhou, Mingyuan Wang","doi":"10.1111/tme.70009","DOIUrl":"10.1111/tme.70009","url":null,"abstract":"<p><p>This systematic review and meta-analysis aim to evaluate the changes in coagulation factor and bacterial contamination by extending the preservation period of thawed cryoprecipitate for 5 days at refrigerated temperatures. Literature searches were conducted from three different databases, and the literature was screened according to the inclusion criteria. The quality of the literature was assessed using the Risk of Bias in Non-randomised Studies-of Interventions (ROBINS-I) tool, and a meta-analysis was conducted using RevMan5.3 software. Finally, five studies met the inclusion criteria. The meta-analysis results show that fibrinogen concentration remains stable after storing the thawed cryoprecipitate at refrigerated temperatures for 5 days Mean Difference (MD) = -0.0802, 95% Confidence Interval (CI) = -0.4220, 0.2616, p = 0.65. The systematic review showed that thawed cryoprecipitate stored at refrigerated temperatures for 120 h had a slight decrease in factor VIII activity but still met the current standard, von Willebrand factor content level remained relatively stable, factor XIII activity showed no significant decrease, and no bacterial contamination was detected. Overall, the available data suggest that fibrinogen concentration remained stable and no bacterial contamination was detected after storing the thawed cryoprecipitate at refrigerated temperatures for 5 days. The lack of assessment of aggregate formation is an important limitation of this review. In addition, the number of relevant studies is still relatively limited, and further extensive studies are necessary to confirm this conclusion.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144883838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, attitude, and practice studies on hemovigilance in India: A critical appraisal.","authors":"Radheshyam Meher, Aparna Krishna, Gopal Patidar","doi":"10.1111/tme.70011","DOIUrl":"10.1111/tme.70011","url":null,"abstract":"<p><p>Hemovigilance is essential for monitoring, analysing, and preventing adverse transfusion reactions. Hemovigilance Programme of India (HvPI), launched in 2012, aims to improve transfusion safety. However, challenges such as limited knowledge and underreporting persist, necessitating a critical appraisal of existing Knowledge, Attitude, and Practice (KAP) studies to guide future interventions. A systematic literature search was conducted using Google, PubMed, Scopus, Web of Science, and Google Scholar, focusing on KAP studies on hemovigilance in India published post-2012. Keywords included \"hemovigilance,\" \"blood transfusion safety,\" \"adverse transfusion reactions,\" and \"KAP studies,\" combined with \"India\" and \"healthcare professionals.\" Filters for peer-reviewed, English-language studies were applied, and references were reviewed. Studies were appraised using the AXIS tool. Thirteen studies, with 1684 participants from teaching hospitals and tertiary care centres, were included. Most studies were conducted by pharmacology departments (84.6%), predominantly in western India (79.8%). While awareness of transfusion reactions was high, knowledge of reporting mechanisms and hemovigilance programmes was poor. Barriers included lack of training, time constraints, and fear of legal repercussions. Only one study met an acceptable quality score (≥16/20) on AXIS tool, while others demonstrated methodological weaknesses, inadequate sample size justification, lack of non-responder analysis, and insufficient statistical rigour. Despite highlighting the importance of KAP assessments in hemovigilance, the studies' geographical limitations and methodological constraints hinder generalisability. Future research should employ robust methodologies, expand geographical representation, and include diverse populations to enhance hemovigilance practices in India. Strengthening hemovigilance systems through coordinated efforts is essential for improving transfusion safety nationwide.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Red cell special interest group 2024.","authors":"Vanja Karamatic Crew, Christian Jannete Stevens-Hernandez, Lesley J Bruce","doi":"10.1111/tme.70007","DOIUrl":"https://doi.org/10.1111/tme.70007","url":null,"abstract":"","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144849182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The hemolytic activity of abo antibodies: Correlation between quantitative tests, complement-mediated hemolysis assay (CHUHE-P), and IgG subclasses.","authors":"Sidneia Sanches de Menezes Costa, Beatriz Girardo, Thamy Caroline Silva, Karen Ziza, Glaciano Ribeiro, Dante M Langhi, Carla Luana Dinardo, José O Bordin","doi":"10.1111/tme.70005","DOIUrl":"https://doi.org/10.1111/tme.70005","url":null,"abstract":"<p><strong>Background: </strong>ABO antibodies can activate complement and cause hemolysis, sometimes with ABO minor incompatible platelet or plasma transfusions. Donor low titres of anti-ABO are used to assess transfusion safety. However, the correlation between antibody titres (measured semi-quantitatively or quantitatively) and their ability to activate complement is unclear.</p><p><strong>Objectives: </strong>This study aimed to correlate ABO antibody (IgM/IgG) titres and the presence of IgG1/IgG3 subclasses with complement-mediated haemolysis using the CHUHE-P assay (Complement Hemolysis Using Human Erythrocytes).</p><p><strong>Methods: </strong>Single-center blood group O donor samples were tested with semi-quantitative methods and classified in group 1 as low ABO titres if titre <100 and into group 2 as high ABO titre if titre >100. Testing included IgM/IgG antibody titration, the CHUHE-P assay, haemolysin test, and determination of IgG1/IgG3 subclasses.</p><p><strong>Results: </strong>Group 1 had 21 and Group 2 had 56 blood donors. In Group 2, CHUHE-P positivity was not associated with IgM or IgG anti-A/B titres or haemolysin test results. IgG1 and IgG3 subclasses of anti-A were significantly associated with positive CHUHE-P. Significant differences between groups included CHUHE-P positivity (p < 0.001), IgG titres (p < 0.01) for anti-A, and CHUHE-P positivity (p < 0.001), IgM titres (p = 0.04), and haemolysin test (p = 0.02) for anti-B. In Group 1, 33% of anti-A and 23.8% of anti-B had positive CHUHE-P.</p><p><strong>Conclusions: </strong>This study aimed to compare the ability of anti-ABO antibodies to cause complement-mediated hemolysis measured by the CHUHE-P test and the results of semi-quantitative/quantitative titration assays, the presence of IgG1 and/or IgG3, and hemolysin test results, where we highlighted an inconsistent association between the methods; the positivity for CHUHE-P was associated with the subclasses of antibodies IgG1 and IgG3.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144804934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of D antigen blocking in a weak D individual with autoanti-D.","authors":"Mark Dwight, Emma Taylor, Abigail McNeill, Becky-Lee Halls, Melissa Bullard, Sarah Thorpe, Edyta Dzialach","doi":"10.1111/tme.70006","DOIUrl":"https://doi.org/10.1111/tme.70006","url":null,"abstract":"","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Clinical Significance of Warm Autoantibodies during Pregnancy.","authors":"Emmanuel A Fadeyi, Joshua Cox-Jones, Amit K Saha, Daniel Katz, Bettina Turner, Christina S Warren, Gregory J Pomper","doi":"10.1111/tme.70008","DOIUrl":"https://doi.org/10.1111/tme.70008","url":null,"abstract":"<p><strong>Objectives: </strong>The objective of the current study is to determine the clinical significance of a warm autoantibody detected in patients during pregnancy.</p><p><strong>Background: </strong>There are few published studies concerning the clinical significance of warm autoantibodies during pregnancy. The risk to the fetus is determined by the IgG autoantibody's ability to cross the placental barrier.</p><p><strong>Materials and methods: </strong>Existing data of all obstetric patients who had a positive antibody screen with a warm autoantibody diagnosis during their pregnancy in the last 7 years from August 2016 to October 2023 were reviewed. If positive, a direct antiglobulin test (DAT) and an eluate were performed. Statistical analysis was performed to determine the clinical significance of warm autoantibody in pregnant patients. Data collected included blood type, race, age, BMI, the most recent hemoglobin before delivery, and gestation in weeks.</p><p><strong>Results: </strong>Between August 2016 and October 2023, 23 510 pregnant patients had blood type and antibody screen completed at our institution. A total of 812 (3.5%) patients had a positive antibody screen. Only 16 (<2.0%) patients had a positive DAT and eluate confirmation of a warm autoantibody. None of the 16 patients had a previous history of warm autoantibody. 14/16 mothers did not experience an AIHA or HDFN in the newborns.</p><p><strong>Conclusion: </strong>Pregnancy-induced warm autoantibody appears to be harmless for most mothers and their babies. The detection of a warm autoantibody in pregnancy may reflect a potential risk for both the mother and the child; however, on follow up, there were no clinical complications associated with warm autoantibodies in our patient cohort.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serologic investigation and management of an antibody screen negative para-Bombay phenotype during pregnancy.","authors":"Yaseen Ali Jamal, Joshua Alston Nicholas, Tong Wang, Mohamed Abdelmonem, Suchitra Pandey, Mrigender Singh Virk","doi":"10.1111/tme.70000","DOIUrl":"10.1111/tme.70000","url":null,"abstract":"<p><strong>Background: </strong>Individuals with Bombay and para-Bombay red blood cell (RBC) phenotypes produce anti-H antibodies associated with acute haemolytic transfusion reactions. The rarity of compatible donor units creates unique logistical challenges, especially during pregnancy as the onset of labour and fetal distress can occur without warning.</p><p><strong>Case report: </strong>A 24-year-old female at 38 weeks gestation presented with breech fetal position and reported anti-H antibodies. Critically, the in-house antibody screen was negative by automated solid-phase red cell adherence (SPRCA), while manual testing subsequently demonstrated anti-H antibodies. Forward typing with Ulex europaeus lectin confirmed the absence of H-antigen on RBCs, while Lewis phenotyping and saliva neutralisation revealed H-antigen in secretions, consistent with the para-Bombay phenotype. Three frozen Bombay RBC units were obtained from a nationwide search, and four cross-match compatible non-Bombay (O-positive) units were also prepared. An external cephalic version (ECV) was originally planned since vaginal delivery carries lower bleeding risk than caesarean section (CS). However, acknowledging the unpredictability of ECV, the challenge of timing thawed units, and the possibilities of massive haemorrhage versus wasting rare donor blood, an elective CS was ultimately preferred. Delivery was uneventful without transfusion needs.</p><p><strong>Conclusion: </strong>This case highlights key considerations regarding serologic identification, blood product management, and interdisciplinary clinical decision-making for patients with Bombay and para-Bombay phenotypes. First, automated SPRCA testing may provide false negative results for anti-H antibodies. Second, backup transfusion strategies for para-Bombay patients may include non-Bombay RBCs. Finally, the procurement, preparation, and use of rare blood products requires thoughtful deliberation between multiple care providers.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"399-402"},"PeriodicalIF":1.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144627171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}