Transfusion Medicine最新文献

{"title":"Digital reminders and donor return: A randomised evaluation of short message service, WhatsApp and telephone calls in a Nigerian tertiary hospital.","authors":"Ann A Ogbenna, Mofogofoluwa I Amao, Ademola S Adewoyin, Olufemi A Oyedeji, Oluseyi M Opadeyi, Chika L Uche, Adejoke T Olatinwo, Olusayo O Alao, Vincent O Osunkalu","doi":"10.1111/tme.70131","DOIUrl":"https://doi.org/10.1111/tme.70131","url":null,"abstract":"<p><strong>Background: </strong>Maintaining an adequate and safe blood supply is a major challenge in low- and middle-income countries, where donor lapse and low voluntary donation rates hinder sustainability. Mobile communication technologies such as short message service (SMS), WhatsApp and telephone calls offer scalable approaches to donor outreach, but their comparative effectiveness in re-engaging lapsed and inactive donors in sub-Saharan Africa remains insufficiently studied.</p><p><strong>Objectives: </strong>This study assessed the effectiveness of these communication tools in re-engaging lapsed (no donation within 12 months despite donation within the prior 24 months) and inactive donors (no donation for >24 months) at Lagos University Teaching Hospital (LUTH), using re-donation within 30 days as the primary outcome.</p><p><strong>Study design and methods: </strong>A stratified, randomised interventional study with computer-generated allocation, stratified by age, sex and donor status, was conducted among lapsed and inactive voluntary blood donors at LUTH. Donors were allocated to one of four groups: SMS, WhatsApp message, telephone call or no-intervention control, and followed for 30 days. Secondary outcomes included message delivery and donor response. Sociodemographic variables and self-reported barriers to return were also assessed.</p><p><strong>Results: </strong>Of 3014 donors identified, 2809 met eligibility criteria and were randomised. Among 2107 donors who received attempted contact, 1546 (73.4%) were successfully reached. SMS achieved the highest delivery rate (95.4%), followed by telephone calls (63.8%) and WhatsApp messages (60.8%). Positive responses were recorded in 429 (27.7%) donors, with 421 (98.1%) arising from telephone outreach. SMS generated eight positive responses (1.9%), and WhatsApp produced none. Only one donor, belonging to the telephone group, returned to donate during follow-up, yielding an overall re-donation rate of 0.04%. Reported barriers included time constraints, occupational demands and long distance to the donation centre.</p><p><strong>Conclusion: </strong>Telephone calls elicited the strongest immediate engagement, but single-contact reminders, regardless of modality, were insufficient to generate meaningful short-term donor return. Effective donor retention strategies in Nigeria will require multi-contact outreach, personalised communication and interventions addressing structural barriers such as scheduling and distance.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149167184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microfluidics to assess the impact of transfused blood components.","authors":"E J Sayers, J Nash, E M Davies, C V Saunders, C E George","doi":"10.1111/tme.70124","DOIUrl":"https://doi.org/10.1111/tme.70124","url":null,"abstract":"<p><p>Assessing the function of transfused blood components within the dynamic environment of the vascular system remains challenging, as conventional assays are largely static and poorly represent the dynamic mechanical and biochemical interactions between blood cells and the vessel wall. Microfluidic approaches, which study blood flow within small-scale channels, provide an opportunity to bridge this gap by introducing physiologically relevant flow and shear rates into experimental models. This review synthesises the current literature describing the application of microfluidic technologies to the assessment of transfused blood components, with particular emphasis on platelet concentrates, red cell concentrates and plasma-derived products. Across existing studies, microfluidic models have demonstrated differences in component function related to storage conditions, manufacturing methods and emerging transfusion products that are not always detected using conventional bulk assays. These approaches have provided new insights into platelet haemostasis at defined shear rates, red cell deformability and gas exchange, and plasma-mediated coagulation in trauma and critical illness. However, substantial diversity in device design, experimental conditions and analytical endpoints limits direct comparison between studies and constrains translation into routine practice. The development of more standardised platforms, alongside integration with endothelialised and organ-on-a-chip models, may help to overcome these challenges. Overall, microfluidics represents a promising tool for improving functional assessment of blood components and supporting future advances in transfusion medicine research and personalised transfusion strategies.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149148263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravenous immunoglobulin as an adjunct to phototherapy in neonatal haemolytic disease: A systematic review and meta-analysis.","authors":"Megan Roberts, James W F Burns, Alma Sato, Dafni-Stravroula Grammenou, Emily E Lugard, May Y Hajeir, Lamees M Al Darwashi, David Riese, Eleanor Froneman, Christian A Than, Hayato Nakanishi, Sandeep Potluri","doi":"10.1111/tme.70123","DOIUrl":"https://doi.org/10.1111/tme.70123","url":null,"abstract":"<p><p>Phototherapy remains the first-line treatment of haemolytic disease of the newborn (HDN), a potentially life-threatening condition caused by maternal alloimmunisation. Intravenous immunoglobulin (IVIG) has been proposed as an adjunct to reduce the need for exchange transfusion (ET), a procedure associated with significant risks. This meta-analysis aims to evaluate the safety and efficacy of IVIG combined with phototherapy versus phototherapy alone in neonates with HDN. A comprehensive search of MEDLINE, EMBASE, CINAHL and the Cochrane Library was conducted up to 24 April 2025. Eligible studies included randomised controlled trials and observational cohorts evaluating IVIG in HDN. Data were pooled using random-effects models. This study was prospectively registered in Prospective Register of Systematic Reviews (CRD420251025766). Nineteen studies involving 3673 neonates met the inclusion criteria. IVIG reduced the need for ET (odd ratio [OR] = 0.34; confidence interval [CI]: 0.2-0.8; I² = 88%) when used as an adjunct to phototherapy compared to phototherapy alone. Subgroup analysis suggested that the reduction in ET was more consistent in Rh-mediated HDN (OR = 0.2; CI: 0.1-0.8; I² = 81%) than in ABO-mediated HDN (OR = 0.76; CI: 0.1-4.1; I² = 89%). There were no differences in the length of hospital stay (mean difference [MD] = -0.1 days; CI: -0.8 to 0.6; I² = 98%), duration of phototherapy (MD = -5.1 h; CI: -15.7 to 5.4; I² = 98%) or incidence of adverse events (OR = 1.32; CI: 0.2-10.5; I² = 91%) between groups. Despite reducing ET requirements, adjunctive IVIG with phototherapy may not provide additional clinical benefits compared with phototherapy alone. Further high-quality trials are needed to clarify optimal timing, dosing and patient selection.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149138199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Convolutional neural network for red blood cell transfusion prediction: A machine learning based study.","authors":"Liyun Zheng, Jiyuan Ma, Mengyun Deng, Yiming Ma, Yuan Zhang, Lihua Wang, Xiaofei Li","doi":"10.1111/tme.70126","DOIUrl":"https://doi.org/10.1111/tme.70126","url":null,"abstract":"<p><strong>Background: </strong>Subjective, inconsistent clinician judgement on red blood cell (RBC) transfusion demand causes unnecessary blood wastage, increased perioperative safety risks, and poorly balanced hospital blood inventory. To tackle these persistent clinical limitations, we developed a workflow-adapted clinical decision support tool: a one-dimensional convolutional neural network (1D CNN) trained on routinely acquired haematological and clinical variables to stratify inpatient RBC transfusion volume categories.</p><p><strong>Methods: </strong>Using a retrospective cohort of 7,250 patients from Beijing Friendship Hospital (April 2024-June 2025), we trained a 1D CNN on 19 standardised pre-transfusion variables to predict transfusion volume categories (1, 2, 3, 4, ≥5 units). The model was optimised with Adam and evaluated on a 30% hold-out test set. Comprehensive characterisation of the cohort's baseline clinical features was also performed to clearly define the transfusion contexts and clinical indications of the study population.</p><p><strong>Results: </strong>On the 30% hold-out test set, the 1D CNN reached an overall accuracy of 0.7314 and converged without overfitting. The model accurately identified the predominant 2 units transfusion class (68.03% of cases, precision 0.7314). However, performance was limited in minority classes (≥5 units and 3 units), which showed low prevalence (< 5%) and overlapping haemoglobin values (60-80 g/L), indicating a critical safety limitation.</p><p><strong>Conclusions: </strong>The 1D CNN reliably forecasts routine transfusion requirements in a single-center setting but under-detects high-volume transfusion events. External validation across diverse clinical centers, targeted data enrichment for minority classes, and development of indication-specific sub-models are mandatory to improve the model's generalizability and clinical utility.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149115168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Viscoelastic testing versus conventional coagulation tests in trauma-induced coagulopathy: Barriers to implementation in low- and middle-income countries.","authors":"Vaidehi Prasanth","doi":"10.1111/tme.70093","DOIUrl":"10.1111/tme.70093","url":null,"abstract":"","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"521-523"},"PeriodicalIF":1.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147983450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BSH guideline for the estimation of fetomaternal haemorrhage.","authors":"L Porter, M Hazell, J Eggington, K Veale, D Howarth, L Jappy, S Armstrong-Fisher, C George, S Robinson","doi":"10.1111/tme.70076","DOIUrl":"10.1111/tme.70076","url":null,"abstract":"","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"419-441"},"PeriodicalIF":1.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148240340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimising the workflow for infant ABO blood typing: The role of automated analyser and a manual reflex protocol.","authors":"Eunhui Ji, Seung Hwan Oh, Sun Min Lee, In-Suk Kim, Hyun Ji Lee","doi":"10.1111/tme.70081","DOIUrl":"10.1111/tme.70081","url":null,"abstract":"<p><strong>Objectives: </strong>We aimed to optimise the infant ABO typing workflow by evaluating the performance of the ORTHO VISION analyser (VISION; QuidelOrtho, San Diego, CA, USA) and establishing a targeted manual reflex protocol.</p><p><strong>Background: </strong>The application of automated analysers in infants poses challenges due to weak antigen and antibody expression.</p><p><strong>Methods and materials: </strong>We reviewed ABO blood typing results from 1178 infants who underwent routine dual testing using both the VISION and the manual tube method at our centre. Samples were grouped by age: Group 1 (under 4 months, N = 898, forward typing only) and Group 2 (4 months to under 1 year, N = 280, both forward and reverse typing).</p><p><strong>Results: </strong>The VISION showed almost perfect agreement with the manual method (weighted kappa >0.94). In Group 1, the manual method showed a higher conclusive rate (100% vs. 98.7%; p < 0.001), resolving 12 technical flags. In Group 2, the VISION demonstrated a higher conclusive rate (71.4% vs. 66.4%, p = 0.006) due to superior sensitivity in detecting early anti-A antibodies (p < 0.001). Inconclusive results in Group 2 correlated significantly with younger age (p < 0.001) but not sex or diagnosis. The proposed algorithm is estimated to reduce the manual workload by 92.2% compared to the previous dual-protocol.</p><p><strong>Conclusion: </strong>The VISION is a reliable alternative to manual testing for infant ABO blood typing. Our proposed targeted reflex algorithm can minimise operational fragmentation and systemic human error, thereby optimising laboratory efficiency while maintaining patient safety.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"484-491"},"PeriodicalIF":1.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liberal versus restrictive transfusion in haemato-oncological patients undergoing autologous stem cell transplantation: A single-centre experience.","authors":"Ayman El Idrissi, Irene M L W Körver-Keularts, Ron J M H E Straat, Erik A M Beckers","doi":"10.1111/tme.70078","DOIUrl":"10.1111/tme.70078","url":null,"abstract":"<p><strong>Objectives: </strong>Assess the safety and efficacy of restrictive transfusion in haemato-oncological patients undergoing autologous haematopoietic stem cell transplantation (AHSCT).</p><p><strong>Background: </strong>Restrictive transfusion is increasingly advocated within transfusion medicine to prevent over-treatment, lower transfusion-related adverse events and decrease healthcare costs. Yet there is a paucity of evidence regarding safe restrictive transfusion strategies in AHSCT patients.</p><p><strong>Methods: </strong>Double-unit transfusion at a haemoglobin threshold of 8 g/dL (i.e., liberal transfusion) is compared to single-unit transfusion at a haemoglobin threshold of 7 g/dL (i.e., restrictive transfusion) by means of an interrupted time series study. RBC utilisation, survival and the occurrence of complications were assessed for the initial hospitalisation period and at the hundredth day following AHSCT.</p><p><strong>Results: </strong>A group of 28 liberally transfused patients is compared to 18 restrictively transfused patients. Restrictively transfused patients received a median of 0.0 RBC units (IQR 0.0-1.0) and liberally transfused patients 2.0 RBC units (IQR 0.0-4.0) during hospitalisation (U = 127.5, p = 0.002). The number of RBC concentrates administered by day +100 remained significantly lower for restrictively (0.0 units, IQR 0.0-3.0) as opposed to liberally (2.0 units, IQR 0.0-4.0) transfused patients (U = 168.5, p = 0.026). Survival and readmission rates did not differ significantly between both groups. The most prevalent complications, regardless of the applied transfusion protocol, included mucositis, fever of unknown origin and various infections.</p><p><strong>Conclusion: </strong>Restrictive transfusion through combined lowering of the haemoglobin trigger to 7 g/dL and single-unit transfusion effectively decreases RBC utilisation in a homogenous cohort of haemato-oncology patients undergoing AHSCT without hampering safety.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"511-520"},"PeriodicalIF":1.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147628765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abstracts from the SHOT Symposium 2026.","authors":"","doi":"10.1111/tme.70120","DOIUrl":"https://doi.org/10.1111/tme.70120","url":null,"abstract":"","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":"36 Suppl 4 ","pages":"4-22"},"PeriodicalIF":1.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149228697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Red blood cell transfusion in sickle cell disease: From clinical necessity to immunological complexity.","authors":"Mohamed Eltaib Elmobark, Mohamd Z Sayed-Ahmed, Mohammed Al-Rasheed, Mohamed Marzok, Sivakumar S Moni, Mahmoud Elalfy, Siddig Ibrahim Abdelwahab, Mohamed Abdo Rizk","doi":"10.1111/tme.70122","DOIUrl":"https://doi.org/10.1111/tme.70122","url":null,"abstract":"<p><p>Sickle cell disease (SCD) is one of the most common inherited haemoglobin disorders worldwide and is associated with substantial morbidity, premature mortality and lifelong healthcare utilisation. Red blood cell (RBC) transfusion remains a cornerstone of SCD management and is indispensable for the treatment and prevention of life-threatening complications, including acute chest syndrome, ischaemic stroke, severe anaemia and perioperative complications. Despite its undeniable therapeutic benefits, repeated transfusions are accompanied by important adverse consequences, including alloimmunisation, iron overload, delayed haemolytic transfusion reactions and transfusion-transmitted infections. Beyond haemoglobin S dilution, transfusion therapy interacts with the chronic inflammatory and immune-activated milieu characteristic of SCD. Persistent haemolysis, endothelial dysfunction, nitric oxide depletion, leukocyte and platelet activation collectively influence both disease severity and transfusion-related immune responses, thereby contributing to alloantibody formation and other immunological complications. This review provides a comprehensive overview of the clinical indications, transfusion strategies, immunological mechanisms and transfusion-related complications in patients with SCD. Particular emphasis is placed on the cellular and molecular mechanisms underlying alloimmunisation, including the roles of antigen-presenting cells, CD4⁺ T lymphocytes, B cells and regulatory T cells. Contemporary approaches to minimising transfusion-related complications-including extended antigen matching, molecular RBC genotyping, routine alloantibody screening, iron chelation therapy and emerging immunomodulatory strategies-are critically discussed. In addition, the review highlights regional challenges and evolving transfusion practices in Saudi Arabia, including newborn screening programmes, comprehensive care initiatives, donor-recipient antigen mismatch and implementation of national transfusion strategies. By integrating current evidence from clinical medicine, immunology and transfusion science, this review provides clinicians with an updated framework for optimising transfusion therapy while minimising preventable complications and improving long-term outcomes in patients with SCD.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149115164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}