Transfusion Medicine最新文献

{"title":"Review of transfusion practice for beta thalassaemia major patients in Scotland after removal of age criteria for red cell transfusion.","authors":"Nicole Priddee, Katie Hands, Jennifer Laird, Louisa McIlwaine, Fernando Pinto, Susan Baird","doi":"10.1111/tme.13147","DOIUrl":"https://doi.org/10.1111/tme.13147","url":null,"abstract":"","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pure red cell aplasia after ABO incompatible allogeneic stem cell transplantation treated with therapeutic plasma exchange: A case report.","authors":"Abhijit Baheti, Brinda Kakkar, Sameer Melinkeri, Anusree Prabhakaran, Urmi Sheth, Vijaya Gadage, Sanjiv Ketkar","doi":"10.1111/tme.13153","DOIUrl":"https://doi.org/10.1111/tme.13153","url":null,"abstract":"<p><p>Pure red cell aplasia (PRCA) is a known complication of major/bi-directional ABO incompatible allogeneic stem cell transplantation (ABOi allo-SCT). Persistence of recipient's antibodies against the donor's red blood cells (RBCs) leads to delay in recovery of RBCs which can last up to several months. This complication can result in patients becoming transfusion dependent. There is no standard treatment but a combination of different treatment strategies which includes tapering immunosuppression/discontinuation, steroid, erythropoietin, anti-CD-20 monoclonal antibody, daratumumab and therapeutic plasma exchange (TPE). Here we report a case of PRCA after ABOi allogeneic peripheral blood SCT treated successfully with TPE.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144161204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ferritin-guided management of blood donors with a marginally low pre-donation haemoglobin and its effect on the number of donations in the following 3 years.","authors":"Sandra Cutajar, George Galea, Monique A Debattista, Monique Borg Inguanez","doi":"10.1111/tme.13149","DOIUrl":"https://doi.org/10.1111/tme.13149","url":null,"abstract":"<p><strong>Background: </strong>The handling of donors with a marginally low haemoglobin is difficult and problematic and various methodologies have been applied to address this issue.</p><p><strong>Aims: </strong>The aim of this study was to assess whether measurement of serum ferritin and subsequent management of donors with a marginally low haemoglobin had any impact on the number of subsequent donations.</p><p><strong>Materials and methods: </strong>Such donors were prospectively randomised into an intervention group whereby their serum ferritin was measured and those in the control group where routine assessments were done as per current SOPs. In the intervention group, action was taken depending on how low the serum ferritin was. The comparator in both study arms was the number of donations that were given during the follow-up period of 3 years.</p><p><strong>Results: </strong>We could not find any significant consequence due to this intervention.</p><p><strong>Discussion and conclusion: </strong>The potential reasons are discussed, and we are proposing further studies on subsets of donors who are more prone to iron deficiency.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the appropriateness of fresh frozen plasma transfusions in two tertiary teaching hospitals.","authors":"Jongmin Kim, Kae Lyang Koo, Hyun-Ji Lee, Hyung-Hoi Kim","doi":"10.1111/tme.13142","DOIUrl":"https://doi.org/10.1111/tme.13142","url":null,"abstract":"<p><strong>Background: </strong>Despite efforts to standardise practice using evidence-based guidelines, fresh frozen plasma (FFP) remains the blood component most frequently prescribed inappropriately. This study assessed the appropriateness of FFP transfusion in two tertiary teaching hospitals and analysed the characteristics of appropriate and inappropriate transfusions.</p><p><strong>Methods: </strong>Patients who had undergone FFP transfusion between October and December 2022 at two tertiary teaching hospitals were retrospectively analysed. Only the initial FFP transfusion data were analysed for each patient. Patient characteristics; laboratory test results, including prothrombin time, international normalised ratio, and activated partial thromboplastin time; and the association of FFP transfusion with various factors were examined. Sub-therapeutic dosing was defined as the transfusion of ≤2 units of FFP. FFP transfusions were classified into eight groups based on a classification algorithm to determine their appropriateness.</p><p><strong>Results: </strong>In total, 584 FFP transfusions (2301 units) were analysed, with 42.1% involving subtherapeutic dosing. FFP transfusions were performed in the intensive care unit (ICU; 30.5%), general ward (24.8%), operating room (21.1%), and emergency room (22.9%). Overall, 51.5% of FFP transfusions were deemed appropriate, with significant variations being observed between the hospitals (Hospital B vs. Hospital A: 73.2% vs. 35.3%). Inappropriate FFP transfusions were associated with a higher INR, with 73.4% of them being associated with severe bleeding and/or surgery.</p><p><strong>Conclusions: </strong>In conclusion, 40.6% of FFP transfusions were deemed inappropriate in the present study owing to failure to meet laboratory criteria. The present study provides valuable insights into the optimisation of plasma transfusion practices and emphasises the requirement for institution-specific management.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144161199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy and safety of therapeutic thrombocytapheresis in patients with extreme thrombocytosis.","authors":"Serhat Çelik, Zeynep Tuğba Güven, Muzaffer Keklik, Ali Ünal, Leylagül Kaynar","doi":"10.1111/tme.13150","DOIUrl":"https://doi.org/10.1111/tme.13150","url":null,"abstract":"<p><strong>Introduction: </strong>Therapeutic thrombocytapheresis (TTA) is used to promptly reduce platelet count to prevent thrombohemorrhagic complications that may develop in extreme thrombocytosis. In this study, the efficacy and safety of TTA were investigated in our patients who underwent TTA for extreme thrombocytosis for more than 20 years.</p><p><strong>Materials and methods: </strong>Forty-four patients who underwent TTA due to extreme thrombocytosis between January 2000 and December 2021 in Erciyes University, Faculty of Medicine Therapeutic Apheresis Unit were analysed retrospectively. Extreme thrombocytosis was defined as a platelet count >1000 × 10⁹/L.</p><p><strong>Results: </strong>The median percentage of platelet reduction was 62.2% (28.6%-90.1%). TTA was administered with Spectra Optia in 45.5% (n = 20) and Fresenius in 54.5% (n = 24) of the patients. No statistically significant difference was observed between age, gender, diagnoses, and devices used regarding TTA efficiency. The percentage of platelet reduction was higher in those who had a platelet precount above 1500 × 10⁹/L than those who did not (64.5% ± 9.9% vs. 57.3% ± 12.9%, p = 0.045). No major complications were observed. Mild side effects were observed in five (11.4%) patients.</p><p><strong>Conclusion: </strong>TTA provided prompt, effective, and safe reduction of platelet count in the treatment of extreme thrombocytosis.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reducing allogenic blood exposure in paediatric cellular therapy collections: A conservative prime strategy.","authors":"Andriana Pavlovich, Yamac Akgun","doi":"10.1111/tme.13151","DOIUrl":"https://doi.org/10.1111/tme.13151","url":null,"abstract":"<p><strong>Background and objectives: </strong>Mononuclear cell (MNC) collection is critical for paediatric patients undergoing cellular therapies such as chimeric antigen receptor T-cell and haematopoietic stem cell transplantation. In children, extracorporeal volume (ECV) often exceeds 15% of total blood volume (TBV), traditionally necessitating red blood cell (RBC) priming to reduce the risk of haemodynamic instability. However, RBC priming introduces allogenic blood exposure and related complications. This study evaluated the safety and feasibility of unprimed MNC collection in paediatric patients with ECV/TBV ratios greater than 15%.</p><p><strong>Materials and methods: </strong>We retrospectively reviewed two paediatric patients with B-cell acute lymphoblastic leukaemia (B-ALL) who underwent MNC collection using the Spectra Optia system in continuous mononuclear cell collection mode. Both patients had ECV/TBV ratios of 16% and 17%, respectively. Vital signs and laboratory parameters were monitored throughout and after the procedures to assess for adverse events, haemodynamic instability, and need for transfusion.</p><p><strong>Results: </strong>Both patients completed MNC collection without adverse reactions, interruptions, or clinically significant changes in vital signs. Post-procedural haemoglobin and platelet counts showed no major declines, and neither patient required transfusion. Collection efficiency met institutional standards, and no symptoms of hypovolemia or citrate toxicity were observed.</p><p><strong>Conclusion: </strong>Unprimed MNC collection can be safely performed in paediatric patients even when the ECV/TBV ratio exceeds 15%. With careful monitoring and procedural planning, this conservative strategy may reduce allogenic blood exposure without compromising safety or collection efficiency.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transfusion training for haematology registrars: Results of a UK-wide survey.","authors":"Lorna Cain, Lucy Neave, Shubha Allard, Dora Foukaneli, Suzy Morton, Shruthi Narayan","doi":"10.1111/tme.13146","DOIUrl":"https://doi.org/10.1111/tme.13146","url":null,"abstract":"<p><strong>Objectives: </strong>To understand the current status of transfusion training for haematology specialty registrars in the UK and identify potential solutions for improvement.</p><p><strong>Background: </strong>Transfusion knowledge and experience are essential for all haematologists. There are concerns regarding inconsistencies with the delivery of transfusion training.</p><p><strong>Methods: </strong>A 30-question online survey was distributed using the SurveyMonkey platform to UK haematology specialty trainees in June-July 2023.</p><p><strong>Results: </strong>A total of 150 responses (response rate 24%) were received from trainees at different stages of training in 17 training regions. Forty-four percent (66/150) trainees had undertaken or were expected to undertake a dedicated transfusion post during their training; these were deemed to be educationally useful. Ninety-nine percent (149/150) trainees had managed transfusion queries at work. Most trainees (69%, 103/150) had received teaching in hospitals outside of a dedicated transfusion post. A high proportion (87%, 131/150) had attended a transfusion course provided by a national blood service. Levels of overall satisfaction with the transfusion training provided varied: very satisfied/satisfied (30%), neutral (31%), dissatisfied/very dissatisfied (39%). The most common barriers to training selected were lack of exposure to the transfusion laboratory (75%), clashing clinical commitments taking priority (74%), and lack of provision of dedicated transfusion training (70%).</p><p><strong>Conclusion: </strong>There is mixed satisfaction with the transfusion training received by UK haematology registrars, evident from this survey. Protected time for transfusion training in dedicated transfusion posts and in other hospital posts, including laboratory time, is needed for all haematology trainees.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping the blood transfusion supply in the west region of Cameroon: A cross-sectional study.","authors":"Armand Willy Nguemnang Nguemnang, Ketina Hirma Tchio-Nighie, Carine Mbianda Tchingué, Collins Buh Nkum, Jérôme Ateudjieu","doi":"10.1111/tme.13148","DOIUrl":"https://doi.org/10.1111/tme.13148","url":null,"abstract":"<p><strong>Background: </strong>Blood transfusion is one of the priorities of a health system. However, this topic is poorly documented in under developing countries.</p><p><strong>Objective: </strong>Describe the supply of blood transfusion in the West Region of Cameroon.</p><p><strong>Methods/materials: </strong>This was a descriptive cross-sectional study conducted in health facilities that handles blood transfusion in the West Region of Cameroon from March to May 2022. Data were collected using an observational grid and a questionnaire administered face-to-face to the health personnel involved in blood transfusion to collect informations on blood transfusion practices. These data were analysed using SPSS 20 software for proportions and ArcGIS 10.3.1 for blood transfusion maps.</p><p><strong>Results: </strong>90/877 health facilities of the West Region supplied blood transfusion. Each of the 20 health districts had at least one health facility supplying blood transfusion service. Among the 90 health facilities supplying blood transfusion service, 86 (95.5%) consented to participate in the study. A mean of 4.5 health facilities carried out blood transfusion per health district with 3.8 health facilities per 100,000 occupants. Of the 90 health facilities, 14 (16.3%) had a blood bank, with 03 (21.4%) being non-functional, for a mean of 0.4 blood bank for 10,000 occupants. A total of 18 health facilities supplying blood transfusion were found around a radius of 5 km from a functional blood bank. Among the 86 health facilities, 12 (13.8%) had a blood conservation room; the main source of blood for transfusion was family donors 62 (72%); the type of blood product most frequently administered was whole blood 82 (96.5%); 3 (3.4%) had a plasma extractor/manual separator; 19 (22.1%) performed the ELISA chain, and the Cross match was performed in 57 (66.3%) health facilities.</p><p><strong>Conclusion: </strong>The results of the study reveal limited geographic access of populations to health facilities supply blood transfusion and to blood banks in the West Region of Cameroon.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating a blood warming device for packed red blood cell transfusions to decrease hypothermia in very preterm infants: A randomised control trial protocol.","authors":"Kayla C Everhart, Michael D Wirth, Victor N Iskersky, Robin B Dail","doi":"10.1111/tme.13143","DOIUrl":"https://doi.org/10.1111/tme.13143","url":null,"abstract":"<p><strong>Background: </strong>This protocol describes a study to test a commercial blood warming device in warming blood transfusions to prevent hypothermia associated with packed red blood cell (PRBC) transfusions in very preterm infants.</p><p><strong>Objectives: </strong>Very preterm infants receiving blood transfusions warmed by a commercial blood warmer will have less central body hypothermia post transfusion (abdominal temperatures <36.5°C) and/or a higher mean abdominal temperature for the hour after the transfusion is complete compared to those receiving blood transfusions by standard of care. This trial has been registered with Clinicaltrials.gov (trial number NCT05170633).</p><p><strong>Methods: </strong>In this trial, which is funded by The Gerber Foundation and adhered to the SPIRIT2013 checklist, 140 very preterm infants with an order to receive PRBCs will be randomised into a standard of care group to receive one PRBC transfusion over 3 h with blood in a syringe at room temperature or into the intervention group to receive one PRBC transfusion over 3 h using a Hotline® Blood and Fluid Warmer. Abdominal skin temperatures will be measured every minute through a blood transfusion using a skin thermistor and datalogger.</p><p><strong>Data analysis: </strong>Descriptive statistics will be computed for each group to compare demographics and all infant pre-, during, and post-transfusion body temperatures. A student t-test will be used to compare the groups on mean post-transfusion temperatures as a primary outcome variable. To examine thermal change over time between the two groups, linear mixed models with a random intercept will be utilised.</p><p><strong>Results: </strong>This trial began in January 2022, in a South Carolina neonatal intensive care unit and is ongoing.</p><p><strong>Discussion: </strong>This RCT will determine if warming PRBC transfusions will prevent hypothermia in preterm infants during and after blood transfusions. Results from this trial will be used to design national standards for blood transfusions in preterm infants to decrease morbidity and mortality.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge and practices in transfusion regarding bedside compatibility test: Insights from a monocentric observational study.","authors":"Ikbel Ghachem, Dorra Baccouche, Mohamed Yassine Kaabar, Ichrak Ghachem, Haifa Tounsi, Asma Bachali","doi":"10.1111/tme.13145","DOIUrl":"https://doi.org/10.1111/tme.13145","url":null,"abstract":"<p><strong>Background: </strong>The bedside compatibility test (BCT) is the final barrier to transfusion safety, aiming to prevent ABO-incompatible incidents. This study evaluated the knowledge and practices of BCT and assessed the impact of a training session introducing a new technique of BCT based on Serafol ABO card.</p><p><strong>Methods: </strong>This is an observational study targeting transfusion-qualified staff working at the MTM hospital in Nabeul. It involved an initial knowledge assessment, a training session on BCT principles, and post-assessment using an anonymous questionnaire that included the interpretation of Serafol ABO card examples.</p><p><strong>Results: </strong>Among 93 participants, 18% frequently performed transfusions, and 31% had prior training. Incorrect BCT practices, including unsafe serum methods, were noted in 46%. Only 7.5% completed necessary pre-transfusion checks. The frequency of overall scores (≥50/100) increased significantly from 43% to 90% (p = 0.000) after the training session. Correct interpretation of the Serafol ABO card was achieved by 86% and 81% of participants in isogroup and non-isogroup compatible situations, respectively. However, 20.5% of participants would have transfused an incompatible unit. A significant difference was observed between doctors and paramedics in interpreting non-isogroup compatible and incompatible situations (p = 0.03). The overall mean interpretation score was 7.7/9, with a 77% compatibility accuracy rate. Professional profile parameters did not significantly influence correct responses.</p><p><strong>Conclusion: </strong>This study revealed gaps in BCT practices, significantly improved through training and the introduction of the Serafol ABO card. Continuous training, medical assessments, and procedure monitoring are vital to enhance transfusion safety.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}