Transfusion Medicine最新文献_第10页

Allogenic and autologous nondiluted serum eye drops-validation strategy compliant with good manufacturing practice. 异体和自体非稀释血清滴眼液--符合良好生产规范的验证策略。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-08-01 Epub Date: 2024-07-22 DOI: 10.1111/tme.13068

Frauke Dormann, Viola Hähnel, Viktoria Müller, Ralph Burkhardt, Robert Offner

{"title":"Allogenic and autologous nondiluted serum eye drops-validation strategy compliant with good manufacturing practice.","authors":"Frauke Dormann, Viola Hähnel, Viktoria Müller, Ralph Burkhardt, Robert Offner","doi":"10.1111/tme.13068","DOIUrl":"10.1111/tme.13068","url":null,"abstract":"Background and aims: Serum eye drops alleviate ocular symptoms of diseases such as sicca syndrome, or chronic graft-versus-host disease. This study was designed for good manufacturing practice validation of our standard manufacturing, storage and transport processes for both autologous and allogenic SEDs. Specifications of quality parameters are lacking and were aimed to be defined.Methods: Using sterile collected, coagulated whole blood, serum was separated by centrifugation and filled into single-use eye drop applicator vials. Quality control tests included visual inspection, sterility, leukocyte concentration, pH, vitamin A, TGF-ß and VEGF-A. Samples were collected after manufacture and after 24 h and 6 months of frozen storage (-20°C). Sterility testing was performed after opening the SED applicators at specified intervals. For transport validation, SEDs were packed in insulated transport bags and stored at 20-24°C and 30-32°C for 8 h.Results: Vitamin A, TGF-ß and VEGF-A assays showed no difference in concentration between fresh and 24 h frozen serum. All specifications for pH (aim 7.4) and cellular contamination were met and microbiological contamination tests were negative. Shelf-life was defined as 6 months at -20°C. Once opened, the product must be used within 24 h to avoid bacterial outgrowth. Transporting frozen SEDs from the manufacturer via a local pharmacy to the patient within a maximum of 4 h was demonstrated.Conclusions: The GMP compliance of our production, storage and transport processes for autologous and allogenic SEDs was successfully validated. 100% serum eye drops in single-use applicators can be safely used for up to 24 h after opening.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"319-325"},"PeriodicalIF":1.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141735068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preventing misinterpretation of rare blood types in clinical laboratories: A case study on B3 phenotype. 防止临床实验室对稀有血型的误读：B3 表型案例研究。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-08-01 Epub Date: 2024-07-16 DOI: 10.1111/tme.13065

Ying-Ju Chen, Yung-Che Chou, Tze-Kiong Er

引用次数: 0

Every minute counts: A comparison of thawing times and haemostatic quality of plasma thawed at 37°C and 45°C using four different methods. 分秒必争：采用四种不同方法比较 37°C 和 45°C 解冻血浆的解冻时间和止血质量。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-08-01 Epub Date: 2024-06-23 DOI: 10.1111/tme.13061

J McCullagh, C Booth, J Lancut, S Platton, P Richards, L Green

{"title":"Every minute counts: A comparison of thawing times and haemostatic quality of plasma thawed at 37°C and 45°C using four different methods.","authors":"J McCullagh, C Booth, J Lancut, S Platton, P Richards, L Green","doi":"10.1111/tme.13061","DOIUrl":"10.1111/tme.13061","url":null,"abstract":"Background: Having faster plasma thawing devices could be beneficial for transfusion services, as it may improve the rapid availability of thawed plasma for bleeding patients, and it might remove the need to have extended pre-thawed plasma: thus, reducing unnecessary plasma wastage.Study design and methods: The aims of this study were to assess (a) the thawing times and (b) in vitro haemostatic quality of thawed plasma using Barkey Plasmatherm V (PTV) at 37 and 45°C versus Barkey Plasmatherm Classic (PTC) at 37 and 45°C, Sarstedt Sahara-III Maxitherm (SS-III) at 37°C and Helmer Scientific Thermogenesis Thermoline (TT) at 37°C. Haemostatic quality was assessed using LG-Octaplas at three different time points: baseline (5 min), 24 and 120 h after thawing.Results: The thawing time (SD) of 2 and 4 units was significantly different between different thawers. PTV at 45°C was the fastest method for both 2 and 4 units (7.06 min [0.68], 9.6 min [0.87], respectively). SS-III at 37°C being the slowest method (24.69 min [2.09] and 27.18 min [4.4], respectively) (p = < 0.05). Baseline measurements for all assays showed no significant difference in the prothrombin time, fibrinogen, FII, FV, protein C activity or free protein S antigen between all methods tested. However, at baseline PTV (both 37°C and 45°C) had significantly higher levels of FVII, FVIII and FXI and shortened activated partial thromboplastin time.Discussion: PTV was the quickest method at thawing plasma at both 37 and at 45°C. The haemostatic quality of plasma thawed at 45 versus 37°C was not impaired. Thawing frozen plasma at 45°C should be considered.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"304-310"},"PeriodicalIF":1.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141459511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic profile of RHCE, Kell, Duffy, Kidd, Diego and MNS hybrid glycophorins blood groups in ethnic northeastern Thais: Alleles, genotypes and risk of alloimmunisation. 泰国东北部少数民族中 RHCE、Kell、Duffy、Kidd、Diego 和 MNS 混合糖蛋白血型的遗传概况：等位基因、基因型和同种免疫风险。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-08-01 Epub Date: 2024-05-28 DOI: 10.1111/tme.13055

Piyapong Simtong, Amonrat Jumnainsong, Chanvit Leelayuwat

{"title":"Genetic profile of RHCE, Kell, Duffy, Kidd, Diego and MNS hybrid glycophorins blood groups in ethnic northeastern Thais: Alleles, genotypes and risk of alloimmunisation.","authors":"Piyapong Simtong, Amonrat Jumnainsong, Chanvit Leelayuwat","doi":"10.1111/tme.13055","DOIUrl":"10.1111/tme.13055","url":null,"abstract":"Background: Antibodies against blood group antigens play a key role in the pathophysiology of haemolytic transfusion reactions (HTRs) and haemolytic disease of the fetus and newborn (HDFN). This study aimed to determine the frequencies of alleles, genotypes, and risk of alloimmunisation of clinically significant blood group systems in ethnic northeastern Thais.Methods: In total, 345 unrelated, healthy, ethnic northeastern Thais were tested using the in-house PCR-sequence specific primers (PCR-SSP) method for simultaneously genotyping of RHCE, Kell, Duffy, Kidd, Diego and MNS glycophorin hybrids and results confirmed by Sanger sequencing.Results: In this cohort, the alleles RHCE*C (81.0%) and RHCE*e (84.8%) were more prevalent than RHCE*c (19.0%) and RHCE*E (15.2%). The most common predicted haplotype combinations of the RHCE alleles were C+c-E-e+(R1R1) (59.4%) followed by the C+c+E+e+ (R1R2) (20.6%) and C+c+E-e+ (R1r) (11.3%). The KEL*01 allele was not found in this study. The frequencies of FY*01 and FY*02 were 88.3% and 11.7%, respectively. The genotype FY*02/02 was found in four samples (1.2%). The frequencies of JK*01 and JK*02 were 52.5% and 47.5%, respectively. Homozygous JK*02/02 was found in 81 samples (23.5%). The frequencies of DI*01 and DI*02 were 0.6% and 99.4%, respectively. In total, 64 samples (18.6%) were found to carry the MNS glycophorin hybrids.Conclusions: Our results indicated a possible high risk of c, E, Fyb, Jka, Jkb and Mia alloimmunisation in these populations. Moreover, methods established for genotyping clinically significant blood groups in this study can now be utilised in routine clinical application.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"287-297"},"PeriodicalIF":1.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141158040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Healthcare provider's perceptions of bleeding in patients with acute leukaemia undergoing induction chemotherapy: A qualitative study. 医护人员对接受诱导化疗的急性白血病患者出血的看法：定性研究。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-08-01 Epub Date: 2024-07-20 DOI: 10.1111/tme.13070

Shipra Taneja, Nancy M Heddle, Christopher Hillis, Shannon Lane, Meera Karunakaran, Dawn Maze, Dimpy Modi, Dina Khalaf, Donald M Arnold, Hassan Zahreddine, Kathryn Webert, Laura Hess, Richard Cook, Simon Stanworth, Terry Gernsheimer, Meredith Vanstone

{"title":"Healthcare provider's perceptions of bleeding in patients with acute leukaemia undergoing induction chemotherapy: A qualitative study.","authors":"Shipra Taneja, Nancy M Heddle, Christopher Hillis, Shannon Lane, Meera Karunakaran, Dawn Maze, Dimpy Modi, Dina Khalaf, Donald M Arnold, Hassan Zahreddine, Kathryn Webert, Laura Hess, Richard Cook, Simon Stanworth, Terry Gernsheimer, Meredith Vanstone","doi":"10.1111/tme.13070","DOIUrl":"10.1111/tme.13070","url":null,"abstract":"Background: Bleeding is a primary outcome for many transfusion-related trials in acute leukaemia (AL) patients, typically graded using the World Health Organisation (WHO) bleeding scale (clinically significant bleed (CSB) is ≥grade 2). This composite outcome fails to differentiate minor bleeds that may not be significant, poorly represents the total burden of bleeding and lacks input from healthcare providers (HCPs) and patients. As part of a multi-step project to create a better bleeding tool for trials, our objective was to identify HCPs' perspectives on the components of CSB in AL patients.Study design and methods: Using qualitative description, we interviewed 19 physicians and nurses who care for AL patients undergoing induction chemotherapy. Participants were recruited from professional organisations, networks and social media. An inductive approach to conventional content analysis was used.Results: HCPs identified features of CSB as the anatomical site of bleeding, amount of bleeding, need for intervention and changes in vital signs. Using these characteristics, bleeding events were categorised into three groups: clinically significant, could evolve into a CSB and not clinically significant. HCPs considered the patient's condition, bleeding history and clinical intuitions when deciding whether a bleed could escalate into serious bleeding.Discussion: Using data from HCPs, we categorised bleeds as clinically significant, could evolve into a CSB, and not significant. A study of patients' perspectives on the importance of different kinds of bleeding is the next step to creating a bleeding definition that is informed by evidence, clinicians and patients.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"268-277"},"PeriodicalIF":1.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141731427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BNT162b2 mRNA vaccine in transfusion dependent thalassemia patients. 为输血依赖型地中海贫血患者注射 BNT162b2 mRNA 疫苗。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-08-01 Epub Date: 2024-05-25 DOI: 10.1111/tme.13054

Hinpetch Daungsupawong, Viroj Wiwanitkit

引用次数: 0

Impact of introduction of a goal directed transfusion strategy in a patient blood management program: A single cardiac surgery centre experience. 在患者血液管理计划中引入目标导向输血策略的影响：单个心脏外科中心的经验。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-08-01 Epub Date: 2024-06-30 DOI: 10.1111/tme.13063

Riccardo Fiameni, Matteo Lucchelli, Chiara Novelli, Valentina Salice, Francesca Orsenigo, Mattia Gomarasca, Bedrana MoroSalihovic, Federico Mondin, Giovanni Mistraletti, Ivo Beverina

{"title":"Impact of introduction of a goal directed transfusion strategy in a patient blood management program: A single cardiac surgery centre experience.","authors":"Riccardo Fiameni, Matteo Lucchelli, Chiara Novelli, Valentina Salice, Francesca Orsenigo, Mattia Gomarasca, Bedrana MoroSalihovic, Federico Mondin, Giovanni Mistraletti, Ivo Beverina","doi":"10.1111/tme.13063","DOIUrl":"10.1111/tme.13063","url":null,"abstract":"Background: The aim of this retrospective and observational study was to analyse the impact of the introduction of a goal directed transfusion (GDT) strategy based on a viscoelastic test (ROTEM®) and specific procoagulant products in a patient blood management (PBM) Program on blood product use and perioperative bleeding in a single cardiac surgery centre.Study design and methods: Patient population underwent cardiac surgery from 2011 to 2021 was divided in two groups based on PBM protocol used (G#11-14, years 2011-2014, G#15-21, years 2015-2021) and compared for the following variables: intraoperative and postoperative transfusions of packed red blood cell and any procoagulant products, postoperative drain blood loss volume and rate of re-exploration surgery. The second program was defined after the introduction of a GDT protocol based on viscoelastic tests and specific procoagulant products.Results: After the introduction of a GDT protocol, about 80% less amongst patients were transfused with fresh frozen plasma and any procoagulant product (p < 0.001 for both phases). Moreover, similar results were obtained with PRBC transfusions (p < 0.001) and drain blood loss volume (p = 0.006) in the postoperative phase. The main factors affecting the use of any procoagulant and PBRC transfusion in the multivariate logistic regression analysis was Group (2 versus 1, OR 0.207, p < 0.001) and preoperative haemoglobin (OR 0.728, p < 0.001), respectively.Discussion: In our experience, a GDT strategy for the diagnosis and treatment of the coagulopathy in patients undergone cardiac surgery led to a significant reduction in bleeding and transfusion.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"257-267"},"PeriodicalIF":1.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141470919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accuracy of RHC/c genotyping in Chinese Han population. 中国汉族人群中 RHC/c 基因分型的准确性。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-08-01 Epub Date: 2024-05-29 DOI: 10.1111/tme.13056

Shihang Zhou, Ming Liu, Linnan Shao, Wenqian Song, Liying Wang, Yaxin Fan

{"title":"Accuracy of RHC/c genotyping in Chinese Han population.","authors":"Shihang Zhou, Ming Liu, Linnan Shao, Wenqian Song, Liying Wang, Yaxin Fan","doi":"10.1111/tme.13056","DOIUrl":"10.1111/tme.13056","url":null,"abstract":"Background and objectives: The RHCE gene plays an important role in the complex and polymorphic Rh blood group system. RHCE genotyping holds significant clinical and transfusion-related implications. The objective of this study was to evaluate the accuracy of RHC/c genotyping in the Chinese Han population.Materials and methods: Blood samples were obtained from 653 Chinese Han blood donors. The serological RhD and RhCcEe types were determined using monoclonal antibodies. Subsequently, multiplex real-time polymerase chain reaction (PCR) analysis was performed for RHC and RHc genotyping. Additionally, exon 2 of RHCE and exon 1 of RHD were sequenced.Results: The analysis in this study found 443 RhD-positive donors and 210 RhD-negative donors. Among the 653 total donors, discrepancies between the RHC genotyping results and the serological results were found in 37 individuals. Specifically, 6 false-positive RhC results in RhD-positive donors and 28 false-positive RhC results in RhD-negative donors were identified based on c.48C in RHCE exon 1. Additionally, 3 false-negative RhC results were observed in the RhD-positive donors due to a 109 bp insertion in RHCE intron 2. RHc typing demonstrated complete consistency between the real-time PCR and the serological results.Conclusion: In the Chinese Han population, RHC genotyping was reliable when consistent results were achieved by both c.48C-based and 109 bp insertion-based genotyping. Moreover, RHc genotyping based on c.203A and c.307C polymorphic loci demonstrated dependable performance.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"298-303"},"PeriodicalIF":1.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141162361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

'Old is gold' does conventional test tube method still reign supreme? An immuno-haematological survey of anti-D detection and titration in ante-natal cases among major hospitals across India. 传统试管法是否仍是 "金科玉律"？印度各大医院产前病例抗 D 检测和滴定的免疫血液学调查。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-08-01 Epub Date: 2024-06-18 DOI: 10.1111/tme.13057

Prashant Pandey, Arghyadeep Marik, Aseem Tiwari, Sudipta Shekhar Das, Shamee Shastry, Mohit Chowdhry, Supriya Kumari

{"title":"'Old is gold' does conventional test tube method still reign supreme? An immuno-haematological survey of anti-D detection and titration in ante-natal cases among major hospitals across India.","authors":"Prashant Pandey, Arghyadeep Marik, Aseem Tiwari, Sudipta Shekhar Das, Shamee Shastry, Mohit Chowdhry, Supriya Kumari","doi":"10.1111/tme.13057","DOIUrl":"10.1111/tme.13057","url":null,"abstract":"Introduction: Anti-D detection and titration plays a major role in RhD negative antenatal cases both, for monitoring maternal as well as fetal status as well as initiation of early therapeutic interventions, such as intra-uterine transfusions (IUT) to improve maternal as well as fetal morbidity and mortality and reduce the adverse effects of haemolytic disease of fetus and newborn (HDFN). We conducted a survey focusing on the policies and procedures of anti-D detection and titration among major tertiary care centres across India.Methodology: The survey was drafted by a working group of transfusion medicine and immunohematology specialists from six different centres in India. Data were obtained via the use of an online questionnaire.Results: Results were categorised into four categories, Hospital information, immuno-haematological testing methodology, clinical significance of anti-D testing and the role of transfusion medicine specialists. The survey highlighted the modalities as well as the methodologies of anti-D detection and titration in antenatal women across different major tertiary care centres in India.Conclusion: This survey provided a unique snapshot of the prevalent methodologies being employed by major tertiary care centres across the country for detection and titration of anti-D levels as well as the important role it plays in the therapy of affected antenatal women to minimise adverse effects on the fetus.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"278-286"},"PeriodicalIF":1.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141421091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rapid review of strategies to manage low iron levels in adults donating whole‐blood: A focus on donor behaviour 对成人全血捐献者低铁含量管理策略的快速审查：关注捐献者行为

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-06-21 DOI: 10.1111/tme.13060

Amanda Thijsen, Carley N. Gemelli, Melissa K. Hyde, Rachel Thorpe, Barbara M. Masser

{"title":"A rapid review of strategies to manage low iron levels in adults donating whole‐blood: A focus on donor behaviour","authors":"Amanda Thijsen, Carley N. Gemelli, Melissa K. Hyde, Rachel Thorpe, Barbara M. Masser","doi":"10.1111/tme.13060","DOIUrl":"https://doi.org/10.1111/tme.13060","url":null,"abstract":"In recognition of the impact of whole‐blood donation on body iron stores, there has been an increased focus assessing the efficacy of strategies to minimise the risk of iron deficiency (ID). Whilst donor behaviour is an important determinant of success, this literature is yet to be fully synthesised to help guide blood collection agencies when implementing these strategies into routine practice. This rapid review identifies strategies for management of low iron, how they have been communicated to donors, donor compliance with advice, donor use of external health services and their effect on donor retention. Web of Science, Medline, CINAHL and Wiley online library databases were searched from 2012 to November 2023, with 29 studies meeting inclusion criteria. Five iron management strategies were identified: oral iron supplementation (IS), education, dietary advice, lengthening inter‐donation interval and switching donation type. Most studies (n = 16) focused on IS, with only four reporting how they communicated this to donors. Donor use of IS was high in controlled research environments but has not been evaluated when implemented into routine practice. None of the four studies on dietary advice included findings on donor acceptability. The proportion of donors consulting their doctor about a low iron result or their risk of ID was found to be suboptimal. However, in general, the identified strategies and communications had a positive effect on donor retention. More evidence is needed on how to increase donor knowledge and awareness of donation‐related risk of ID as well as to identify how to effectively communicate strategies to donors to ensure optimal acceptability and use.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":"4 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141505839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0