Transfusion Medicine最新文献_第9页

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-09-13 DOI: 10.1111/tme.13082

引用次数: 0

Risk factors for red blood cell alloimmunization in patients with hematologic malignancy 血液系统恶性肿瘤患者发生红细胞同种免疫的风险因素

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-09-12 DOI: 10.1111/tme.13096

Pakthipa Pattarakosol, Nattarat Lorucharoen, Phandee Watanaboonyongcharoen, Ponlapat Rojnuckarin

{"title":"Risk factors for red blood cell alloimmunization in patients with hematologic malignancy","authors":"Pakthipa Pattarakosol, Nattarat Lorucharoen, Phandee Watanaboonyongcharoen, Ponlapat Rojnuckarin","doi":"10.1111/tme.13096","DOIUrl":"https://doi.org/10.1111/tme.13096","url":null,"abstract":"IntroductionPatients with hematologic malignancy have a higher risk of developing red blood cell (RBC) alloimmunization which can delay blood transfusion. Information on the risk factors for alloimmunization in this group is still limited. This study aimed to determine the prevalence and predictors of RBC alloimmunization among these patients.Materials and MethodsElectronic medical records of the patients with acute myeloid leukaemia (AML), acute lymphoid leukaemia (ALL), multiple myeloma (MM) and lymphoma from a tertiary care hospital between January 2018 and December 2022 were retrospectively reviewed. Clinical, demographic and transfusion history data of the included patients were analysed.ResultsOf the 983 patients with hematologic malignancy, 798 were included in the study. The prevalence of RBC alloantibodies in this population was 4.8% (38 patients). The alloimmunization rate of each subgroup was as followed: AML 9.1%, ALL 2.9%, MM 3.8% and lymphoma 2.5%. The most common alloantibodies were anti‐Mia, anti‐E and anti‐Lea. The majority (29/38, 76.3%) of alloimmunization had a single alloantibody. RBC autoantibody was detected in 10 patients. The detection of autoantibodies and having AML were independently associated with RBC alloimmunization (adjusted odds ratio [aOR] 13.41, 95% confidence interval [CI] 2.00–89.72, p = 0.007 and aOR 11.44, 95% CI 2.02–64.72, p = 0.006, respectively).ConclusionThe prevalence of RBC alloimmunization in the patients with hematologic malignancy was 4.8%. The alloimmunization rate of the AML subgroup was higher than those of other hematologic malignancies. The detection of autoantibodies and the AML diagnosis were identified as potential risk factors for RBC alloimmunization.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":"27 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142217242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Implementation challenges of electronic blood transfusion safety systems: Lessons from an international, multi‐site comparative case study 输血安全电子系统的实施挑战：国际多站点比较案例研究的经验教训

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-09-10 DOI: 10.1111/tme.13095

Stijn Horck, Nick Fahy, Trisha Greenhalgh

{"title":"Implementation challenges of electronic blood transfusion safety systems: Lessons from an international, multi‐site comparative case study","authors":"Stijn Horck, Nick Fahy, Trisha Greenhalgh","doi":"10.1111/tme.13095","DOIUrl":"https://doi.org/10.1111/tme.13095","url":null,"abstract":"BackgroundSevere transfusion reactions resulting from errors in matching the correct blood with the correct patient are considered never events. Despite the relative technical simplicity of barcode scanning for patient‐blood bag matching, the adoption and universal application of this safety measure are by no means universal. This study highlights the logistical and institutional challenges associated with spreading, scaling up, and sustaining such IT‐supported safety measures in healthcare.Study Design and MethodsWe report findings from a 5‐year, prospective, multi‐site case study conducted across one hospital in England and three hospitals in the Netherlands. Ethnographic methods, including interviews and observations, were used at each site to investigate the implementation of barcode scanning‐supported safety pathways for blood transfusions.ResultsSignificant variation was observed across the sites in the adoption and implementation of barcode scanning‐supported safety pathways. Despite the potential for reducing transfusion errors, the introduction of this innovation was met with varying levels of success in different settings.DiscussionThis study highlights the critical role of inter‐hospital learning and flexible system design in successfully implementing barcode scanning‐supported safety pathways for blood transfusions. A more structured, national‐level network for knowledge sharing could enhance the spread and sustainability of such innovations across healthcare settings.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":"05 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142217244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterising practice patterns of human derived, lyophilized coagulation concentrates within the trauma quality improvement program registry 在创伤质量改进计划登记册中描述人源冻干凝血浓缩物的实践模式

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-09-10 DOI: 10.1111/tme.13094

Chester A. Rosenthal, David J. Douin, Mitch J. Cohen, Julie A. Rizzo, Michael D. April, Steven G. Schauer

{"title":"Characterising practice patterns of human derived, lyophilized coagulation concentrates within the trauma quality improvement program registry","authors":"Chester A. Rosenthal, David J. Douin, Mitch J. Cohen, Julie A. Rizzo, Michael D. April, Steven G. Schauer","doi":"10.1111/tme.13094","DOIUrl":"https://doi.org/10.1111/tme.13094","url":null,"abstract":"ObjectivesWe seek to describe the current practice pattern use of prothrombin complex concentrate (PCC) and fibrinogen concentrate (FC) in trauma patients.BackgroundTrauma‐induced coagulopathy (TIC) and endotheliopathy of trauma (EOT) contribute significantly to mortality from traumatic haemorrhage. FC, and 4‐factor PCC are potential treatments for EOT and TIC, respectively.Materials and MethodsWe obtained data from the Trauma Quality Improvement Program (TQIP) registry and identified patients who received either PCC or FC using procedural codes. We used descriptive statistics to characterise practice patterns of these products.ResultsThere were 6 714 002 total encounters within the TQIP from 2017 to 2022, of which 10 589 received PCC and 3009 received FC. Of the recipients, there were 35 that received both products. There were 44 that received both. The median age of PCC recipients was 77 (69–84) with 19 patients <15 years of age with the youngest being 2 years of age. There was a general upward trend in the number of facilities with documented use of PCC: 155/744, 168/766, 189/764, 206/780, 234/795, and 235/816, respectively. The median age of FC recipients was 57 (32–75) with 48 patients <15 years of age with the youngest being 1 year of age. There was a minor downward trend in the number of facilities that had documented use of FC: 55, 44, 39, 32, 38 and 40.ConclusionsThe administration of PCC and FC remains uncommon, although there appears to be an upward trend of PCC use. Most PCC use appeared to be for anticoagulation reversal in the setting of head trauma. Data guiding the use of these products are necessary as these products become more recognised as adjuncts to traumatic haemorrhage control.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":"13 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142217106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

XLI Annual Scientific Meeting of the British Blood Transfusion Society 17-19 September 2024, SEC, Glasgow, Scotland. 英国输血协会第四十一届科学年会，2024 年 9 月 17-19 日，苏格兰格拉斯哥 SEC。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-09-01 DOI: 10.1111/tme.13089

引用次数: 0

Evaluation of platelet concentrates prepared using different methods after overnight holding (18-24 h) of whole blood at room temperature. 对室温下全血过夜（18-24 小时）后用不同方法制备的血小板浓缩物进行评估。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-08-01 Epub Date: 2024-06-30 DOI: 10.1111/tme.13064

Deviprasanna Mohanty, Rahul Chaurasia, Anand Kumar, Gopal Kumar Patidar, Hem Chandra Pandey, Arulselvi Subramanian

{"title":"Evaluation of platelet concentrates prepared using different methods after overnight holding (18-24 h) of whole blood at room temperature.","authors":"Deviprasanna Mohanty, Rahul Chaurasia, Anand Kumar, Gopal Kumar Patidar, Hem Chandra Pandey, Arulselvi Subramanian","doi":"10.1111/tme.13064","DOIUrl":"10.1111/tme.13064","url":null,"abstract":"Background and objectives: Regulatory requirement of fixed holding time (6 h) of whole blood (WB) at room temperature, that is, 22-24°C (RT) results in sub-optimal component separation. The aim was to evaluate the platelet concentrates (PC) prepared by both platelet rich plasma (PRP) and buffy coat (BC) methods after overnight hold (18-24 h) at RT.Materials and methods: A prospective experimental study was performed. A total of 48 WB units collected were divided into four groups (12 each) control-1 (C1) and test-1 (T1) for PRP and control-2 (C2) and test-2 (T2) for the BC method. Control groups were processed within 6 h, and in test groups, components were prepared after overnight hold, followed by evaluation of quality parameters.Results: Irrespective of the method used, all PCs had similar volume, platelet yield, swirling, no bacterial contamination, RBC contamination, PaO2 and PaCO2 levels. PCs in the T1 group had significant differences in glucose and MPV values on d1, which were resolved by d5 of storage. PCs in T2 has significant differences in pH, glucose, and MPV levels throughout storage. PRBC in test and control groups had similar quality parameters till d42 of storage. FFPs in all tests were noninferior to the concurrent control groups till 3 months of storage.Conclusion: Overnight holding of WB had no lasting deleterious changes. Though a few biochemical parameters in the test groups were significantly different, they can be accepted to improve the logistics of component separation. Overall PRP method seemed to have a better result than the BC method after an overnight hold.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"311-318"},"PeriodicalIF":1.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141470918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Allogenic and autologous nondiluted serum eye drops-validation strategy compliant with good manufacturing practice. 异体和自体非稀释血清滴眼液--符合良好生产规范的验证策略。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-08-01 Epub Date: 2024-07-22 DOI: 10.1111/tme.13068

Frauke Dormann, Viola Hähnel, Viktoria Müller, Ralph Burkhardt, Robert Offner

{"title":"Allogenic and autologous nondiluted serum eye drops-validation strategy compliant with good manufacturing practice.","authors":"Frauke Dormann, Viola Hähnel, Viktoria Müller, Ralph Burkhardt, Robert Offner","doi":"10.1111/tme.13068","DOIUrl":"10.1111/tme.13068","url":null,"abstract":"Background and aims: Serum eye drops alleviate ocular symptoms of diseases such as sicca syndrome, or chronic graft-versus-host disease. This study was designed for good manufacturing practice validation of our standard manufacturing, storage and transport processes for both autologous and allogenic SEDs. Specifications of quality parameters are lacking and were aimed to be defined.Methods: Using sterile collected, coagulated whole blood, serum was separated by centrifugation and filled into single-use eye drop applicator vials. Quality control tests included visual inspection, sterility, leukocyte concentration, pH, vitamin A, TGF-ß and VEGF-A. Samples were collected after manufacture and after 24 h and 6 months of frozen storage (-20°C). Sterility testing was performed after opening the SED applicators at specified intervals. For transport validation, SEDs were packed in insulated transport bags and stored at 20-24°C and 30-32°C for 8 h.Results: Vitamin A, TGF-ß and VEGF-A assays showed no difference in concentration between fresh and 24 h frozen serum. All specifications for pH (aim 7.4) and cellular contamination were met and microbiological contamination tests were negative. Shelf-life was defined as 6 months at -20°C. Once opened, the product must be used within 24 h to avoid bacterial outgrowth. Transporting frozen SEDs from the manufacturer via a local pharmacy to the patient within a maximum of 4 h was demonstrated.Conclusions: The GMP compliance of our production, storage and transport processes for autologous and allogenic SEDs was successfully validated. 100% serum eye drops in single-use applicators can be safely used for up to 24 h after opening.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"319-325"},"PeriodicalIF":1.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141735068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preventing misinterpretation of rare blood types in clinical laboratories: A case study on B3 phenotype. 防止临床实验室对稀有血型的误读：B3 表型案例研究。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-08-01 Epub Date: 2024-07-16 DOI: 10.1111/tme.13065

Ying-Ju Chen, Yung-Che Chou, Tze-Kiong Er

引用次数: 0

Every minute counts: A comparison of thawing times and haemostatic quality of plasma thawed at 37°C and 45°C using four different methods. 分秒必争：采用四种不同方法比较 37°C 和 45°C 解冻血浆的解冻时间和止血质量。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-08-01 Epub Date: 2024-06-23 DOI: 10.1111/tme.13061

J McCullagh, C Booth, J Lancut, S Platton, P Richards, L Green

{"title":"Every minute counts: A comparison of thawing times and haemostatic quality of plasma thawed at 37°C and 45°C using four different methods.","authors":"J McCullagh, C Booth, J Lancut, S Platton, P Richards, L Green","doi":"10.1111/tme.13061","DOIUrl":"10.1111/tme.13061","url":null,"abstract":"Background: Having faster plasma thawing devices could be beneficial for transfusion services, as it may improve the rapid availability of thawed plasma for bleeding patients, and it might remove the need to have extended pre-thawed plasma: thus, reducing unnecessary plasma wastage.Study design and methods: The aims of this study were to assess (a) the thawing times and (b) in vitro haemostatic quality of thawed plasma using Barkey Plasmatherm V (PTV) at 37 and 45°C versus Barkey Plasmatherm Classic (PTC) at 37 and 45°C, Sarstedt Sahara-III Maxitherm (SS-III) at 37°C and Helmer Scientific Thermogenesis Thermoline (TT) at 37°C. Haemostatic quality was assessed using LG-Octaplas at three different time points: baseline (5 min), 24 and 120 h after thawing.Results: The thawing time (SD) of 2 and 4 units was significantly different between different thawers. PTV at 45°C was the fastest method for both 2 and 4 units (7.06 min [0.68], 9.6 min [0.87], respectively). SS-III at 37°C being the slowest method (24.69 min [2.09] and 27.18 min [4.4], respectively) (p = < 0.05). Baseline measurements for all assays showed no significant difference in the prothrombin time, fibrinogen, FII, FV, protein C activity or free protein S antigen between all methods tested. However, at baseline PTV (both 37°C and 45°C) had significantly higher levels of FVII, FVIII and FXI and shortened activated partial thromboplastin time.Discussion: PTV was the quickest method at thawing plasma at both 37 and at 45°C. The haemostatic quality of plasma thawed at 45 versus 37°C was not impaired. Thawing frozen plasma at 45°C should be considered.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"304-310"},"PeriodicalIF":1.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141459511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic profile of RHCE, Kell, Duffy, Kidd, Diego and MNS hybrid glycophorins blood groups in ethnic northeastern Thais: Alleles, genotypes and risk of alloimmunisation. 泰国东北部少数民族中 RHCE、Kell、Duffy、Kidd、Diego 和 MNS 混合糖蛋白血型的遗传概况：等位基因、基因型和同种免疫风险。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-08-01 Epub Date: 2024-05-28 DOI: 10.1111/tme.13055

Piyapong Simtong, Amonrat Jumnainsong, Chanvit Leelayuwat

{"title":"Genetic profile of RHCE, Kell, Duffy, Kidd, Diego and MNS hybrid glycophorins blood groups in ethnic northeastern Thais: Alleles, genotypes and risk of alloimmunisation.","authors":"Piyapong Simtong, Amonrat Jumnainsong, Chanvit Leelayuwat","doi":"10.1111/tme.13055","DOIUrl":"10.1111/tme.13055","url":null,"abstract":"Background: Antibodies against blood group antigens play a key role in the pathophysiology of haemolytic transfusion reactions (HTRs) and haemolytic disease of the fetus and newborn (HDFN). This study aimed to determine the frequencies of alleles, genotypes, and risk of alloimmunisation of clinically significant blood group systems in ethnic northeastern Thais.Methods: In total, 345 unrelated, healthy, ethnic northeastern Thais were tested using the in-house PCR-sequence specific primers (PCR-SSP) method for simultaneously genotyping of RHCE, Kell, Duffy, Kidd, Diego and MNS glycophorin hybrids and results confirmed by Sanger sequencing.Results: In this cohort, the alleles RHCE*C (81.0%) and RHCE*e (84.8%) were more prevalent than RHCE*c (19.0%) and RHCE*E (15.2%). The most common predicted haplotype combinations of the RHCE alleles were C+c-E-e+(R1R1) (59.4%) followed by the C+c+E+e+ (R1R2) (20.6%) and C+c+E-e+ (R1r) (11.3%). The KEL*01 allele was not found in this study. The frequencies of FY*01 and FY*02 were 88.3% and 11.7%, respectively. The genotype FY*02/02 was found in four samples (1.2%). The frequencies of JK*01 and JK*02 were 52.5% and 47.5%, respectively. Homozygous JK*02/02 was found in 81 samples (23.5%). The frequencies of DI*01 and DI*02 were 0.6% and 99.4%, respectively. In total, 64 samples (18.6%) were found to carry the MNS glycophorin hybrids.Conclusions: Our results indicated a possible high risk of c, E, Fyb, Jka, Jkb and Mia alloimmunisation in these populations. Moreover, methods established for genotyping clinically significant blood groups in this study can now be utilised in routine clinical application.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"287-297"},"PeriodicalIF":1.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141158040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0