Transfusion Medicine最新文献_第8页

Characterising practice patterns of human derived, lyophilized coagulation concentrates within the trauma quality improvement program registry 在创伤质量改进计划登记册中描述人源冻干凝血浓缩物的实践模式

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-09-10 DOI: 10.1111/tme.13094

Chester A. Rosenthal, David J. Douin, Mitch J. Cohen, Julie A. Rizzo, Michael D. April, Steven G. Schauer

{"title":"Characterising practice patterns of human derived, lyophilized coagulation concentrates within the trauma quality improvement program registry","authors":"Chester A. Rosenthal, David J. Douin, Mitch J. Cohen, Julie A. Rizzo, Michael D. April, Steven G. Schauer","doi":"10.1111/tme.13094","DOIUrl":"https://doi.org/10.1111/tme.13094","url":null,"abstract":"ObjectivesWe seek to describe the current practice pattern use of prothrombin complex concentrate (PCC) and fibrinogen concentrate (FC) in trauma patients.BackgroundTrauma‐induced coagulopathy (TIC) and endotheliopathy of trauma (EOT) contribute significantly to mortality from traumatic haemorrhage. FC, and 4‐factor PCC are potential treatments for EOT and TIC, respectively.Materials and MethodsWe obtained data from the Trauma Quality Improvement Program (TQIP) registry and identified patients who received either PCC or FC using procedural codes. We used descriptive statistics to characterise practice patterns of these products.ResultsThere were 6 714 002 total encounters within the TQIP from 2017 to 2022, of which 10 589 received PCC and 3009 received FC. Of the recipients, there were 35 that received both products. There were 44 that received both. The median age of PCC recipients was 77 (69–84) with 19 patients <15 years of age with the youngest being 2 years of age. There was a general upward trend in the number of facilities with documented use of PCC: 155/744, 168/766, 189/764, 206/780, 234/795, and 235/816, respectively. The median age of FC recipients was 57 (32–75) with 48 patients <15 years of age with the youngest being 1 year of age. There was a minor downward trend in the number of facilities that had documented use of FC: 55, 44, 39, 32, 38 and 40.ConclusionsThe administration of PCC and FC remains uncommon, although there appears to be an upward trend of PCC use. Most PCC use appeared to be for anticoagulation reversal in the setting of head trauma. Data guiding the use of these products are necessary as these products become more recognised as adjuncts to traumatic haemorrhage control.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":"13 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142217106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

XLI Annual Scientific Meeting of the British Blood Transfusion Society 17-19 September 2024, SEC, Glasgow, Scotland. 英国输血协会第四十一届科学年会，2024 年 9 月 17-19 日，苏格兰格拉斯哥 SEC。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-09-01 DOI: 10.1111/tme.13089

引用次数: 0

Evaluation of platelet concentrates prepared using different methods after overnight holding (18-24 h) of whole blood at room temperature. 对室温下全血过夜（18-24 小时）后用不同方法制备的血小板浓缩物进行评估。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-08-01 Epub Date: 2024-06-30 DOI: 10.1111/tme.13064

Deviprasanna Mohanty, Rahul Chaurasia, Anand Kumar, Gopal Kumar Patidar, Hem Chandra Pandey, Arulselvi Subramanian

{"title":"Evaluation of platelet concentrates prepared using different methods after overnight holding (18-24 h) of whole blood at room temperature.","authors":"Deviprasanna Mohanty, Rahul Chaurasia, Anand Kumar, Gopal Kumar Patidar, Hem Chandra Pandey, Arulselvi Subramanian","doi":"10.1111/tme.13064","DOIUrl":"10.1111/tme.13064","url":null,"abstract":"Background and objectives: Regulatory requirement of fixed holding time (6 h) of whole blood (WB) at room temperature, that is, 22-24°C (RT) results in sub-optimal component separation. The aim was to evaluate the platelet concentrates (PC) prepared by both platelet rich plasma (PRP) and buffy coat (BC) methods after overnight hold (18-24 h) at RT.Materials and methods: A prospective experimental study was performed. A total of 48 WB units collected were divided into four groups (12 each) control-1 (C1) and test-1 (T1) for PRP and control-2 (C2) and test-2 (T2) for the BC method. Control groups were processed within 6 h, and in test groups, components were prepared after overnight hold, followed by evaluation of quality parameters.Results: Irrespective of the method used, all PCs had similar volume, platelet yield, swirling, no bacterial contamination, RBC contamination, PaO2 and PaCO2 levels. PCs in the T1 group had significant differences in glucose and MPV values on d1, which were resolved by d5 of storage. PCs in T2 has significant differences in pH, glucose, and MPV levels throughout storage. PRBC in test and control groups had similar quality parameters till d42 of storage. FFPs in all tests were noninferior to the concurrent control groups till 3 months of storage.Conclusion: Overnight holding of WB had no lasting deleterious changes. Though a few biochemical parameters in the test groups were significantly different, they can be accepted to improve the logistics of component separation. Overall PRP method seemed to have a better result than the BC method after an overnight hold.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"311-318"},"PeriodicalIF":1.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141470918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Allogenic and autologous nondiluted serum eye drops-validation strategy compliant with good manufacturing practice. 异体和自体非稀释血清滴眼液--符合良好生产规范的验证策略。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-08-01 Epub Date: 2024-07-22 DOI: 10.1111/tme.13068

Frauke Dormann, Viola Hähnel, Viktoria Müller, Ralph Burkhardt, Robert Offner

{"title":"Allogenic and autologous nondiluted serum eye drops-validation strategy compliant with good manufacturing practice.","authors":"Frauke Dormann, Viola Hähnel, Viktoria Müller, Ralph Burkhardt, Robert Offner","doi":"10.1111/tme.13068","DOIUrl":"10.1111/tme.13068","url":null,"abstract":"Background and aims: Serum eye drops alleviate ocular symptoms of diseases such as sicca syndrome, or chronic graft-versus-host disease. This study was designed for good manufacturing practice validation of our standard manufacturing, storage and transport processes for both autologous and allogenic SEDs. Specifications of quality parameters are lacking and were aimed to be defined.Methods: Using sterile collected, coagulated whole blood, serum was separated by centrifugation and filled into single-use eye drop applicator vials. Quality control tests included visual inspection, sterility, leukocyte concentration, pH, vitamin A, TGF-ß and VEGF-A. Samples were collected after manufacture and after 24 h and 6 months of frozen storage (-20°C). Sterility testing was performed after opening the SED applicators at specified intervals. For transport validation, SEDs were packed in insulated transport bags and stored at 20-24°C and 30-32°C for 8 h.Results: Vitamin A, TGF-ß and VEGF-A assays showed no difference in concentration between fresh and 24 h frozen serum. All specifications for pH (aim 7.4) and cellular contamination were met and microbiological contamination tests were negative. Shelf-life was defined as 6 months at -20°C. Once opened, the product must be used within 24 h to avoid bacterial outgrowth. Transporting frozen SEDs from the manufacturer via a local pharmacy to the patient within a maximum of 4 h was demonstrated.Conclusions: The GMP compliance of our production, storage and transport processes for autologous and allogenic SEDs was successfully validated. 100% serum eye drops in single-use applicators can be safely used for up to 24 h after opening.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"319-325"},"PeriodicalIF":1.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141735068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preventing misinterpretation of rare blood types in clinical laboratories: A case study on B3 phenotype. 防止临床实验室对稀有血型的误读：B3 表型案例研究。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-08-01 Epub Date: 2024-07-16 DOI: 10.1111/tme.13065

Ying-Ju Chen, Yung-Che Chou, Tze-Kiong Er

引用次数: 0

Every minute counts: A comparison of thawing times and haemostatic quality of plasma thawed at 37°C and 45°C using four different methods. 分秒必争：采用四种不同方法比较 37°C 和 45°C 解冻血浆的解冻时间和止血质量。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-08-01 Epub Date: 2024-06-23 DOI: 10.1111/tme.13061

J McCullagh, C Booth, J Lancut, S Platton, P Richards, L Green

{"title":"Every minute counts: A comparison of thawing times and haemostatic quality of plasma thawed at 37°C and 45°C using four different methods.","authors":"J McCullagh, C Booth, J Lancut, S Platton, P Richards, L Green","doi":"10.1111/tme.13061","DOIUrl":"10.1111/tme.13061","url":null,"abstract":"Background: Having faster plasma thawing devices could be beneficial for transfusion services, as it may improve the rapid availability of thawed plasma for bleeding patients, and it might remove the need to have extended pre-thawed plasma: thus, reducing unnecessary plasma wastage.Study design and methods: The aims of this study were to assess (a) the thawing times and (b) in vitro haemostatic quality of thawed plasma using Barkey Plasmatherm V (PTV) at 37 and 45°C versus Barkey Plasmatherm Classic (PTC) at 37 and 45°C, Sarstedt Sahara-III Maxitherm (SS-III) at 37°C and Helmer Scientific Thermogenesis Thermoline (TT) at 37°C. Haemostatic quality was assessed using LG-Octaplas at three different time points: baseline (5 min), 24 and 120 h after thawing.Results: The thawing time (SD) of 2 and 4 units was significantly different between different thawers. PTV at 45°C was the fastest method for both 2 and 4 units (7.06 min [0.68], 9.6 min [0.87], respectively). SS-III at 37°C being the slowest method (24.69 min [2.09] and 27.18 min [4.4], respectively) (p = < 0.05). Baseline measurements for all assays showed no significant difference in the prothrombin time, fibrinogen, FII, FV, protein C activity or free protein S antigen between all methods tested. However, at baseline PTV (both 37°C and 45°C) had significantly higher levels of FVII, FVIII and FXI and shortened activated partial thromboplastin time.Discussion: PTV was the quickest method at thawing plasma at both 37 and at 45°C. The haemostatic quality of plasma thawed at 45 versus 37°C was not impaired. Thawing frozen plasma at 45°C should be considered.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"304-310"},"PeriodicalIF":1.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141459511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic profile of RHCE, Kell, Duffy, Kidd, Diego and MNS hybrid glycophorins blood groups in ethnic northeastern Thais: Alleles, genotypes and risk of alloimmunisation. 泰国东北部少数民族中 RHCE、Kell、Duffy、Kidd、Diego 和 MNS 混合糖蛋白血型的遗传概况：等位基因、基因型和同种免疫风险。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-08-01 Epub Date: 2024-05-28 DOI: 10.1111/tme.13055

Piyapong Simtong, Amonrat Jumnainsong, Chanvit Leelayuwat

{"title":"Genetic profile of RHCE, Kell, Duffy, Kidd, Diego and MNS hybrid glycophorins blood groups in ethnic northeastern Thais: Alleles, genotypes and risk of alloimmunisation.","authors":"Piyapong Simtong, Amonrat Jumnainsong, Chanvit Leelayuwat","doi":"10.1111/tme.13055","DOIUrl":"10.1111/tme.13055","url":null,"abstract":"Background: Antibodies against blood group antigens play a key role in the pathophysiology of haemolytic transfusion reactions (HTRs) and haemolytic disease of the fetus and newborn (HDFN). This study aimed to determine the frequencies of alleles, genotypes, and risk of alloimmunisation of clinically significant blood group systems in ethnic northeastern Thais.Methods: In total, 345 unrelated, healthy, ethnic northeastern Thais were tested using the in-house PCR-sequence specific primers (PCR-SSP) method for simultaneously genotyping of RHCE, Kell, Duffy, Kidd, Diego and MNS glycophorin hybrids and results confirmed by Sanger sequencing.Results: In this cohort, the alleles RHCE*C (81.0%) and RHCE*e (84.8%) were more prevalent than RHCE*c (19.0%) and RHCE*E (15.2%). The most common predicted haplotype combinations of the RHCE alleles were C+c-E-e+(R1R1) (59.4%) followed by the C+c+E+e+ (R1R2) (20.6%) and C+c+E-e+ (R1r) (11.3%). The KEL*01 allele was not found in this study. The frequencies of FY*01 and FY*02 were 88.3% and 11.7%, respectively. The genotype FY*02/02 was found in four samples (1.2%). The frequencies of JK*01 and JK*02 were 52.5% and 47.5%, respectively. Homozygous JK*02/02 was found in 81 samples (23.5%). The frequencies of DI*01 and DI*02 were 0.6% and 99.4%, respectively. In total, 64 samples (18.6%) were found to carry the MNS glycophorin hybrids.Conclusions: Our results indicated a possible high risk of c, E, Fyb, Jka, Jkb and Mia alloimmunisation in these populations. Moreover, methods established for genotyping clinically significant blood groups in this study can now be utilised in routine clinical application.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"287-297"},"PeriodicalIF":1.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141158040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Healthcare provider's perceptions of bleeding in patients with acute leukaemia undergoing induction chemotherapy: A qualitative study. 医护人员对接受诱导化疗的急性白血病患者出血的看法：定性研究。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-08-01 Epub Date: 2024-07-20 DOI: 10.1111/tme.13070

Shipra Taneja, Nancy M Heddle, Christopher Hillis, Shannon Lane, Meera Karunakaran, Dawn Maze, Dimpy Modi, Dina Khalaf, Donald M Arnold, Hassan Zahreddine, Kathryn Webert, Laura Hess, Richard Cook, Simon Stanworth, Terry Gernsheimer, Meredith Vanstone

{"title":"Healthcare provider's perceptions of bleeding in patients with acute leukaemia undergoing induction chemotherapy: A qualitative study.","authors":"Shipra Taneja, Nancy M Heddle, Christopher Hillis, Shannon Lane, Meera Karunakaran, Dawn Maze, Dimpy Modi, Dina Khalaf, Donald M Arnold, Hassan Zahreddine, Kathryn Webert, Laura Hess, Richard Cook, Simon Stanworth, Terry Gernsheimer, Meredith Vanstone","doi":"10.1111/tme.13070","DOIUrl":"10.1111/tme.13070","url":null,"abstract":"Background: Bleeding is a primary outcome for many transfusion-related trials in acute leukaemia (AL) patients, typically graded using the World Health Organisation (WHO) bleeding scale (clinically significant bleed (CSB) is ≥grade 2). This composite outcome fails to differentiate minor bleeds that may not be significant, poorly represents the total burden of bleeding and lacks input from healthcare providers (HCPs) and patients. As part of a multi-step project to create a better bleeding tool for trials, our objective was to identify HCPs' perspectives on the components of CSB in AL patients.Study design and methods: Using qualitative description, we interviewed 19 physicians and nurses who care for AL patients undergoing induction chemotherapy. Participants were recruited from professional organisations, networks and social media. An inductive approach to conventional content analysis was used.Results: HCPs identified features of CSB as the anatomical site of bleeding, amount of bleeding, need for intervention and changes in vital signs. Using these characteristics, bleeding events were categorised into three groups: clinically significant, could evolve into a CSB and not clinically significant. HCPs considered the patient's condition, bleeding history and clinical intuitions when deciding whether a bleed could escalate into serious bleeding.Discussion: Using data from HCPs, we categorised bleeds as clinically significant, could evolve into a CSB, and not significant. A study of patients' perspectives on the importance of different kinds of bleeding is the next step to creating a bleeding definition that is informed by evidence, clinicians and patients.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"268-277"},"PeriodicalIF":1.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141731427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BNT162b2 mRNA vaccine in transfusion dependent thalassemia patients. 为输血依赖型地中海贫血患者注射 BNT162b2 mRNA 疫苗。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-08-01 Epub Date: 2024-05-25 DOI: 10.1111/tme.13054

Hinpetch Daungsupawong, Viroj Wiwanitkit

引用次数: 0

Impact of introduction of a goal directed transfusion strategy in a patient blood management program: A single cardiac surgery centre experience. 在患者血液管理计划中引入目标导向输血策略的影响：单个心脏外科中心的经验。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-08-01 Epub Date: 2024-06-30 DOI: 10.1111/tme.13063

Riccardo Fiameni, Matteo Lucchelli, Chiara Novelli, Valentina Salice, Francesca Orsenigo, Mattia Gomarasca, Bedrana MoroSalihovic, Federico Mondin, Giovanni Mistraletti, Ivo Beverina

{"title":"Impact of introduction of a goal directed transfusion strategy in a patient blood management program: A single cardiac surgery centre experience.","authors":"Riccardo Fiameni, Matteo Lucchelli, Chiara Novelli, Valentina Salice, Francesca Orsenigo, Mattia Gomarasca, Bedrana MoroSalihovic, Federico Mondin, Giovanni Mistraletti, Ivo Beverina","doi":"10.1111/tme.13063","DOIUrl":"10.1111/tme.13063","url":null,"abstract":"Background: The aim of this retrospective and observational study was to analyse the impact of the introduction of a goal directed transfusion (GDT) strategy based on a viscoelastic test (ROTEM®) and specific procoagulant products in a patient blood management (PBM) Program on blood product use and perioperative bleeding in a single cardiac surgery centre.Study design and methods: Patient population underwent cardiac surgery from 2011 to 2021 was divided in two groups based on PBM protocol used (G#11-14, years 2011-2014, G#15-21, years 2015-2021) and compared for the following variables: intraoperative and postoperative transfusions of packed red blood cell and any procoagulant products, postoperative drain blood loss volume and rate of re-exploration surgery. The second program was defined after the introduction of a GDT protocol based on viscoelastic tests and specific procoagulant products.Results: After the introduction of a GDT protocol, about 80% less amongst patients were transfused with fresh frozen plasma and any procoagulant product (p < 0.001 for both phases). Moreover, similar results were obtained with PRBC transfusions (p < 0.001) and drain blood loss volume (p = 0.006) in the postoperative phase. The main factors affecting the use of any procoagulant and PBRC transfusion in the multivariate logistic regression analysis was Group (2 versus 1, OR 0.207, p < 0.001) and preoperative haemoglobin (OR 0.728, p < 0.001), respectively.Discussion: In our experience, a GDT strategy for the diagnosis and treatment of the coagulopathy in patients undergone cardiac surgery led to a significant reduction in bleeding and transfusion.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"257-267"},"PeriodicalIF":1.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141470919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0