Transfusion Medicine最新文献_第8页

CEBPA and GATA2 mutation and a transient blood group discrepancy in a patient with acute myeloid leukaemia. 一名急性髓性白血病患者的 CEBPA 和 GATA2 基因突变及一过性血型差异。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-10-01 Epub Date: 2024-08-25 DOI: 10.1111/tme.13079

Marie Solange Flores-Morán, Enric Fuste

引用次数: 0

Genetic variation of FUT3 gene in the Han population from Northern China. 中国北方汉族人群中 FUT3 基因的遗传变异。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-10-01 Epub Date: 2024-07-19 DOI: 10.1111/tme.13066

Shihang Zhou, Ziwei Zheng, Liying Wang, Wenqian Song, Yuexin Xia, Linnan Shao, Xiaohua Liang

{"title":"Genetic variation of FUT3 gene in the Han population from Northern China.","authors":"Shihang Zhou, Ziwei Zheng, Liying Wang, Wenqian Song, Yuexin Xia, Linnan Shao, Xiaohua Liang","doi":"10.1111/tme.13066","DOIUrl":"10.1111/tme.13066","url":null,"abstract":"Background and objectives: The FUT3 gene encodes α(1,3/1,4)-fucosyltransferase, which is a crucial enzyme in the synthesis of Lewis antigens. FUT3 gene variants show race-specific differences. In this study, we conducted a systematic sequence analysis of the FUT3 coding sequence. The objective was to explore genetic variations of the FUT3 gene within the Han population of Northern China.Materials and methods: A cohort of 313 blood donors was recruited for the study. The coding sequence of the FUT3 gene was amplified using polymerase chain reaction, followed by sequencing and haplotype construction.Results: Twelve single nucleotide variations (SNVs) were identified within the coding sequence of the FUT3 gene. Notably, the c.59 T > G site exhibited the highest mutation frequency of 43.13%, followed by the c.508G > A and c.1067 T > A sites with mutation frequencies of 27.48% and 16.93%, respectively. Le was the most common haplotype, accounting for 67.57% of the cases, and Le/Le was the most common diplotype, accounting for 46.33% of the cases. The study also highlighted a significant difference in mutation frequencies of FUT3 gene between the Han Chinese of Northern China and the Dai of Xishuangbanna, China, but not the Han Chinese in Beijing in the North and the Southern Han Chinese, emphasising that Han Chinese in Northern China are genetically most distant from Europeans and closest to East Asians.Conclusions: Our study characterises FUT3 gene variations in Han Chinese from Northern China, and provides basic genetic data for genetics, forensic medicine, and genotyping of Lewis blood groups.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"437-444"},"PeriodicalIF":1.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141731426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transfusion Camp: The UK experience and its value in improving knowledge of transfusion medicine among postgraduate trainees. 输血训练营：英国的经验及其在提高研究生学员输血医学知识方面的价值。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-10-01 Epub Date: 2024-08-08 DOI: 10.1111/tme.13075

Asha Aggarwal, Kunaal Kaushik, Suzy Morton, Anicee Danaee, Kamala Gurung, Susan Robinson, Casey Kapitany, Sophie Charge, Yulia Lin, Mike Desborough, Michael F Murphy

{"title":"Transfusion Camp: The UK experience and its value in improving knowledge of transfusion medicine among postgraduate trainees.","authors":"Asha Aggarwal, Kunaal Kaushik, Suzy Morton, Anicee Danaee, Kamala Gurung, Susan Robinson, Casey Kapitany, Sophie Charge, Yulia Lin, Mike Desborough, Michael F Murphy","doi":"10.1111/tme.13075","DOIUrl":"10.1111/tme.13075","url":null,"abstract":"Objectives: To report the UK experience of rolling out Transfusion Camp.Background: Transfusion Camp is a structured education programme developed in Toronto, with the aim of reducing knowledge gaps in transfusion medicine in postgraduate trainees. It consists of didactic lectures viewed online by the participants, then interactive, locally delivered seminars. Since 2015, it has been rolled out in the United Kingdom, and is now available in four centres. Here, we report the UK experience of Transfusion Camp and outcomes.Methods: Trainees are recruited via the training programme directors in each region. Pre- and post-course assessments are administered using the validated BEST (Biomedical Excellence for Safer Transfusion) test, with possible scores 0-20, and confidence measured on an A-E Likert scale.Results: Since 2015, 130 trainees have participated in Transfusion Camp in the United Kingdom. Trainees from all specialties significantly improved their BEST-test scores after attending the course (mean score 11.6/20 before the course, compared with 14.3/20 after the course), and confidence in managing transfusion-related issues was also significantly improved.Conclusion: We recommend that all centres consider offering Transfusion Camp to trainees in haematology and other specialties that frequently use blood transfusions, such as anaesthesia/ICU, Internal Medicine and others.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"450-454"},"PeriodicalIF":1.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141907815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tuesday 17 September 2024 SIG session 2024 年 9 月 17 日星期二特别小组会议

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-09-13 DOI: 10.1111/tme.13086

引用次数: 0

Poster session 海报会议

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-09-13 DOI: 10.1111/tme.13084

引用次数: 0

Wednesday 18 September 2024 Simultaneous Sessions 2024 年 9 月 18 日星期三同时举行的会议

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-09-13 DOI: 10.1111/tme.13087