Transfusion Medicine最新文献

{"title":"A rare Gerbich-negative (Ge:-2,-3,4) phenotype in a Peruvian patient.","authors":"Jimmy Rinaldo Morales Del Pino, Karla Alexandra Paredes García, Carlos Enrique Penalillo Pimentel, Anita Del Carmen Leyva Carlos, Arturo Ampelio Iii Sagastegui Soto","doi":"10.1111/tme.70090","DOIUrl":"https://doi.org/10.1111/tme.70090","url":null,"abstract":"<p><strong>Objectives: </strong>To describe the serological and molecular characteristics of a rare Gerbich-negative phenotype detected in a Peruvian patient.</p><p><strong>Background: </strong>The Gerbich blood group (Ge) system includes high-prevalence antigens (Ge2, Ge3, Ge4) encoded by the GYPC gene. Absence of these antigens is extremely rare and has been reported mainly in Melanesian and Middle Eastern populations. To our knowledge, no molecularly confirmed cases have been reported in Peru.</p><p><strong>Methods/materials: </strong>A 65-year-old Peruvian man scheduled for orthopaedic surgery underwent pretransfusion testing, including an indirect antiglobulin test, antibody identification using Low Ionic Strength Solution (LISS)/Coombs column agglutination cards at 37°C, papain-treated reagent red cells, a direct antiglobulin test, autocontrol, differential alloadsorptions and neutralization studies. Anti-Ge2 reference serum (IBGRL 4370) and molecular analysis of GYPC were performed.</p><p><strong>Results: </strong>Pretransfusion testing showed panagglutination with 2+ reactions in all reagent red cells; no reaction was observed with papain-treated cells. The direct antiglobulin test, autocontrol and additional serological studies were negative. The antibody titre was 1:8. No reactivity was observed with anti-Ge2, and molecular analysis identified the GE*01.-03.02 allele, responsible for the Gerbich phenotype (Ge:-2,-3,4).</p><p><strong>Conclusion: </strong>This report describes a rare Gerbich-negative phenotype in a Peruvian patient and highlights the importance of molecular typing for transfusion management.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147949638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alternative strategies to promote voluntary blood donation in secondary schools in Malawi: Enhancing participation and impact-Malawi BLOODSAFE program.","authors":"Princess Kaira, Patani Mhango, Effie Chipeta, Emmanuel Singogo, Victor Mwapasa, Adamson Muula, Titus Chiwindo, Mina C Hosseinipour, Bridon Mbaya","doi":"10.1111/tme.70089","DOIUrl":"https://doi.org/10.1111/tme.70089","url":null,"abstract":"<p><strong>Background and objective: </strong>Adequate blood supply remains a challenge in sub-Saharan Africa (SSA). Malawi has a 13% shortfall in required blood supplies. Innovative recruitment and retention strategies are crucial to ensuring a sufficient number of donors and blood supply. We explored alternative approaches to enhance blood donation in Malawi to bridge the gap.</p><p><strong>Methods: </strong>A qualitative exploratory design was utilised with a sample of 135 participants purposively selected in eight districts, in the Northern, Central, Southern and Eastern regions of Malawi. Data were collected using in-depth interviews with 20 participants (first-time and repeat donors, lapsed and non-donors), 20 key informant interviews with community, policy-level stakeholders, Malawi Blood Transfusion Service (MBTS) staff and 16 focus group discussions (involving 95 participants). Thematic content analysis was used to categorise the strategies, and a qualitative software data package (NVivo version 12) was used to organise the qualitative data.</p><p><strong>Results: </strong>Donor education emerged as a key strategy for donor recruitment and retention. Other strategies included the formation of blood donor clubs in secondary schools and for post-secondary students, accountability mechanisms related to blood: its collection and management of blood and blood products, the provision of incentives and youth-friendly motivation strategies, including school competitions (quizzes and sports) and entertainment.</p><p><strong>Conclusion: </strong>The study emphasised the significance of blood donor education in encouraging blood donation. Participants' views suggest that developing innovative approaches for education to increase awareness and understanding of blood-donation processes may help motivate more individuals to donate. In addition, participants suggested other youth-friendly approaches to support blood donor recruitment, including providing incentives preferred by young people, introducing intra-school competitions and incorporating entertainment activities. These insights point to the potential value of developing innovative strategies to support blood donor recruitment efforts.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147933949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential regulation of erythropoiesis-related microRNAs in blood donors: Erythrocyte glutathione predicts miR-142 expression.","authors":"Aziz Karaca, Şenol Çitli, Medeni Arpa, Eda Yılmaz Kutlu","doi":"10.1111/tme.70088","DOIUrl":"https://doi.org/10.1111/tme.70088","url":null,"abstract":"<p><strong>Background: </strong>Repeat blood donation affects erythrocyte health through physiological adaptations. This study examines how repeat donation affects erythrocyte morphology, oxidative stress and erythropoiesis-regulating microRNAs (miRNAs: miR-142, miR-144, miR-451).</p><p><strong>Methods: </strong>A cross-sectional study included 42 male participants: repeat donors (n = 21, ≥3 donations/year) and first-time donors (n = 21). Whole blood miRNA expression was measured by quantitative reverse transcription polymerase chain reaction (qRT-PCR), hemogram parameters by autoanalysers and oxidative markers (malondialdehyde [MDA], glutathione [GSH]) spectrophotometrically. A Directed Acyclic Graph was constructed for variable selection, and separate linear regression models with Gaussian error distribution were fitted for each miRNA in repeat and first-time donor groups, including 2-year donation count, age, body mass index, smoking, erythrocyte morphology (haemoglobin, mean corpuscular volume, red cell distribution width) and oxidative stress parameters (erythrocyte GSH, plasma GSH, erythrocyte MDA, plasma MDA) as predictors.</p><p><strong>Results: </strong>Univariate analysis revealed a significant 3.17-fold upregulation of miR-142 in repeat donors (p = 0.040); miR-144 and miR-451 remained stable. Linear regression analysis identified two key findings: (1) eGSH was a significant predictor of miR-142 expression in first-time donors (β = -0.080, p = 0.041), representing a fundamental redox-miRNA relationship independent of donation status; and (2) smoking approached significance as a predictor of miR-144 in repeat donors (β = 2.819, p = 0.053), approaching significance and suggesting a possible cumulative oxidative stress threshold. No predictor reached significance for miR-451 in either group, confirming its homeostatic stability.</p><p><strong>Conclusions: </strong>Repeat blood donation is associated with significant miR-142-3p upregulation. Linear regression analysis reveals a novel eGSH-miR-142 axis as a fundamental erythrocyte physiological mechanism and provides suggestive evidence for a double-hit hypothesis for miR-144 regulation in smoking donors. miR-451 demonstrates donor-independent homeostatic stability with potential as a blood product quality reference marker.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A retrospective analysis of the antigen-negative red blood cell supply conducted at a single centre in China.","authors":"Aiping Zhao, Xiujiao Jiang, Li An, Yuanfeng Chen, Weidong He, Qun Xu, Wenchao Li, Yingfang Pan","doi":"10.1111/tme.70086","DOIUrl":"10.1111/tme.70086","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to analyse the distribution and demand patterns of antigen-negative red blood cells (RBCs) in Shandong Province, China (2022-2024), with a focus on ABO blood groups and clinically significant antigens. The research was designed to provide rigorous data for advancing precision transfusion protocols and to establish a theoretical basis for optimising regional blood-sharing platforms and facilitating their expansion into a nationwide network. Furthermore, analysis of blood antigen distribution characteristics in broader populations was conducted to validate the feasibility of future expansion plans.</p><p><strong>Methods: </strong>Retrospective data from the Tangshan Qiao 9.5 Modern Blood Management System and clinical transfusion service software (2022-2024) were analysed using Excel 2010 and GraphPad Prism 10. The key metrics included ABO blood type proportions, demand intensity (the ratio of special crossmatched blood to total RBC units) and demographic trends.</p><p><strong>Results: </strong>Type B blood exhibited a 'double-high' pattern (42.76% absolute supply, 1.41% demand intensity), whereas type AB showed elevated demand intensity (1.08%) despite a low total volume supply (10.80%). The Rh (57.90%) and Kidd (22.84%) systems dominated the antigen-negative RBC distribution. Females (63.25%) and patients aged >50 years (65.73%) were the primary recipients, linked to pregnancy-related immune exposure and chronic comorbidities.</p><p><strong>Conclusion: </strong>Routine testing for RhCcEe and Kidd antigens, dynamic inventory strategies for high-demand blood types and regional data-sharing platforms are critical for increasing transfusion safety. Multicentre collaboration and the adoption of international antigen-matching protocols are recommended to address China's ageing population and chronic disease burden.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of fibrinogen concentrate in coagulation testing aids in the diagnosis and management of rare bleeding disorders.","authors":"Yang Yang, Lulu Zhang, Zekai Lei, Ning Tang","doi":"10.1111/tme.70085","DOIUrl":"https://doi.org/10.1111/tme.70085","url":null,"abstract":"<p><strong>Background: </strong>Many clinical laboratories lack the methods or resources to quickly identify rare haemorrhagic diseases, such as genetic/acquired fibrinogen defects and factor XIII deficiency.</p><p><strong>Case report: </strong>This report explored the value of human fibrinogen concentrate in the diagnosis and management of rare bleeding disorders through three case studies. Case 1 involved acquired hypofibrinogenemia caused by snake bite, where the coagulation abnormality was corrected by adding fibrinogen in vitro, confirming the mechanism of snake venom-specific degradation of fibrinogen. Case 2 utilised fibrinogen solution to establish a thromboelastography mixing test for rapid diagnosis of autoimmune factor XIII inhibitors. Case 3 improved platelet aggregation function in patients with congenital abnormal fibrinogenaemia through fibrinogen solution.</p><p><strong>Conclusion: </strong>These case studies showed that fibrinogen concentrate may serve as a specific additive to assist in the rapid identification of coagulation dysfunction and guide precise treatment.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147780946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transfusion management in autoimmune haemolytic anaemia patients: A 5-year experience from a tertiary care referral centre in India.","authors":"Suhasini Sil, Vineet Sharma, Poonam Coshic, Hem Chandra Pandey, Apalak Garg, Chippy C S, Seema Kumari Meena, Suganya Palanisamy, Vidushi Gupta","doi":"10.1111/tme.70033","DOIUrl":"10.1111/tme.70033","url":null,"abstract":"<p><strong>Objectives: </strong>The study aimed to analyse transfusion practices in sensitised autoimmune haemolytic anaemia (AIHA) patients and transfusion outcomes following transfusion of antigen-matched best-matched (AMBM) red cells.</p><p><strong>Background: </strong>Transfusion practices in AIHA patients across resource-poor settings remain a challenge. The outcome of transfusions following the practice of transfusing best-matched (BM) units remains unknown. The data on alloimmunisation rates in sensitised AIHA patients, the utility of adsorption, and transfusion of AMBM red cells from resource-poor settings will enhance the adoption of optimal practices.</p><p><strong>Methods and materials: </strong>Retrospective data on AIHA patients' work-up were collected and analysed for a 5-year interval. Patients were grouped based on the presence or absence of alloimmunisation and whether they received transfusion of AMBM versus BM units based on serological testing. Inter-transfusion interval (ITI) and post-transfusion haemoglobin increment (PTHI) were calculated and compared.</p><p><strong>Results: </strong>Of 368 AIHA patients during the study period, adsorption was performed in 138 patients with a history of a sensitising event. Red cell alloantibodies were identified in 74 patients (53.6%). Shorter ITI was observed in alloimmunised patients when transfused BM red cells versus AMBM red cells [2 (1-3) days vs. 4 (3-5) days; p < 0.001]. Lower PTHI was observed in alloimmunised patients when transfused BM red cells versus AMBM red cells [0.65 (0.45-0.8) g/dl vs. 0.9 (0.7-1.2) g/dL; p < 0.001].</p><p><strong>Conclusion: </strong>High alloimmunisation rates were observed in sensitised AIHA patients. Significantly higher PTHI and longer ITI were observed with transfusion of AMBM units. These findings highlight the benefits of identifying and matching against alloantibodies for better transfusion outcomes.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"142-149"},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145281026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burden of transfusion-transmitted infections among patients with thalassaemia and sickle cell anaemia in India: A systematic review and meta-analysis.","authors":"Vaibhav Shandilya, Savitha Seetharaman, Sahana Parmeswaraiah Geetha, Divjot Singh Lamba, Soumya Das, Bijaya Kumar Padhi, Aravind P Gandhi","doi":"10.1111/tme.70044","DOIUrl":"10.1111/tme.70044","url":null,"abstract":"<p><p>Lifelong blood transfusions, crucial for severe cases of thalassaemia and sickle cell disease (SCD), contribute to a high risk of transfusion-transmitted infections (TTIs). The current systematic review and meta-analysis determined the prevalence of transfusion-transmitted infections (TTIs) among patients with thalassaemia and sickle cell anaemia in India. A systematic search was conducted in PubMed, Scopus, ProQuest, EMBASE and Web of Science for articles published up to September 13, 2025. Title abstract screening followed by full-text review and data extraction was done by two independent reviewers. Risk of bias was assessed for the included studies. Meta-analysis was conducted to estimate the pooled prevalence of TTIs. The systematic review and meta-analysis identified 397 unique articles, with 39 selected for full-text review. After exclusions, 24 studies spanning from 1990 to 2023 were included. All 24 studies included patients with beta thalassaemia, whereas only one study had data on sickle cell anaemia patients, so this review focuses mainly on the prevalence of TTI in patients with beta thalassaemia. The pooled prevalence of Hepatitis C was 22% (95% CI: 14%-30%; I² = 96%), Hepatitis B was 8% (95% CI: 2%-16%; I² = 96%) and HIV was 4% (95% CI: 2%-7%; I² = 77%) in beta-thalassaemia patients, all showing high heterogeneity. Meta-regression revealed a statistically significant decline over time in HBV (Beta = -0.0194, p = <0.01) while Hepatitis C prevalence (Beta = -0.0025, p = 0.6642) and HIV showed no significant trend (Beta = -0.0001, p = 0.9839). Significant burden of TTIs is present among transfusion-dependent thalassaemia and sickle cell anaemia patients in India. Strengthening screening protocols, improving vaccination coverage and implementing targeted healthcare interventions are essential to mitigate this preventable risk.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"121-132"},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145640327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterisation of RHD and RHCE variations in blood donors from Jazan Province, Southwestern Saudi Arabia.","authors":"Maymoon M Madkhali, Mayisah Khormy, Abdullah A Meshi, Bandar Kameli, Khaled Ghazwani, Ohoud Sufyani, Salha Hakami, Yahya Khawaji, Abdullah A Mobarki, Khaled Essawi, Waleed Hakami, Yara Alyahyawi, Aymen M Madkhali, Gasim Dobie, Hassan A Hamali","doi":"10.1111/tme.70040","DOIUrl":"10.1111/tme.70040","url":null,"abstract":"<p><strong>Background and objectives: </strong>Rh is among the most important and highly polymorphic blood group systems due to the proximity of the RHD and RHCE genes, which encode numerous highly immunogenic antigens. However, in areas of Saudi Arabia with a high prevalence of hemoglobinopathy, the molecular characteristics of RHD and RHCE variations are lacking. This study focuses on characterizing the allelic and genotypic distributions of RHD and RHCE blood donors in Jazan, Saudi Arabia.</p><p><strong>Materials and methods: </strong>All blood donors' records between June 2023 and December 2024 were reviewed. ID RHD XT was applied for 60 negative or weak RhD Saudi donors, while 354 Saudi and 110 non-Saudi donors received RHCE genotyping using the ID CORE XT.</p><p><strong>Results: </strong>RHD deletion accounted for 76.7% of the RhD-negative donors. RHCE*Ce (44.1%) was the most common RHCE allele in Saudis, followed by RHCE*ce (31.9%) and RHCE*cE (12.3%). Variant alleles including RHCEce*(733G), RHCEce*(733G,1006T), RHCE*ceAR, RHCE*ce(712G), and RHDr's-RHCE*ce(733G,1006T) were detected in 11.72% in Saudi and 7.73% in non-Saudi, while low- and high-frequency antigens V, hrS, VS, and hrB were observed in Saudis with frequencies of 21.8%, 97.8%, 24.8%, and 93.2%, respectively. RHCE*ce/RHCE*Ce was the most prevalent genotype (26.8%). The non-Saudi group displayed similar profiles, with RHCE*Ce (48.2%), RHCE*ce (30.9%), and RHCE*cE (13.2%). There were no significant differences between Saudi and non-Saudi allele or genotype distributions using Fisher's exact test.</p><p><strong>Conclusion: </strong>The study represents the first molecular characterisation of RHD and RHCE alleles in Saudi Arabia, revealing marked allelic and genotypic diversity, with important implications for transfusion safety in the Jazan region, where hemoglobinopathies are prevalent.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"158-164"},"PeriodicalIF":1.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145378696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heart rate changes after phlebotomy in polycythaemia vera and healthy donors: An observational case-crossover pilot study.","authors":"Rik P B Tonino, Elisabeth M J Huis In 't Veld, Martin R Schipperus, Jaap Jan Zwaginga","doi":"10.1111/tme.70038","DOIUrl":"10.1111/tme.70038","url":null,"abstract":"<p><strong>Background: </strong>Haemoglobin plays a crucial role in oxygen transport, and any acute deviation will trigger compensatory hemodynamic functions. While the consequences of anaemia are well documented, the effects of haemoglobin reduction in individuals without anaemia remain less explored. Patients with polycythaemia vera and healthy blood donors, who both undergo regular phlebotomies, offer a valuable model for studying these effects.</p><p><strong>Methods: </strong>This observational case-crossover study assessed short-term physiological and quality-of-life changes following phlebotomy in five patients with polycythaemia vera and six healthy blood donors. Participants were remotely monitored using a smartwatch and completed daily quality-of-life assessments. The primary outcome was heart rate, while secondary outcomes included step count and quality-of-life measures.</p><p><strong>Results: </strong>Patients with polycythaemia vera exhibited stable heart rates, with only minor variations in physical activity and quality of life after phlebotomy. In contrast, healthy blood donors experienced a significant increase in heart rate, which returned to baseline within a week. Physical activity remained clinically unchanged in both groups, and quality-of-life scores were stable.</p><p><strong>Conclusions: </strong>This pilot study demonstrates that any acute haemoglobin reduction, even within the normal range, induces measurable heart rate changes that are directly related to probably the most optimal oxygen delivery state. Moreover, our studies show that wearable technology is sensitive enough to detect these effects. Hence, this nowadays readily available telemetry allows monitoring of subtle physiological changes in a research setting, but it also offers a path towards optimising QoL for patients with anaemia, polyglobulia and for blood donors.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"150-157"},"PeriodicalIF":1.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145347522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of perioperative erythropoietin-stimulating agents and intravenous iron on patient outcomes following solid organ transplantation: A systematic review.","authors":"Frank Lee, Quentin Eichbaum, Christine Cserti-Gazdewich, Darren Mullane, Frederick W Lombard, Jeremy W Jacobs, Katerina Pavenski, Marina Englesakis, Alexander Dotto, Terry Cho, Andrés Leonard-Reixa, Jacqueline Trudeau, Andrew W Shih, Justyna Bartoszko","doi":"10.1111/tme.70045","DOIUrl":"10.1111/tme.70045","url":null,"abstract":"<p><p>Solid organ transplant is associated with high rates of anaemia and transfusion, but there is little comparative data on interventions such as erythropoietin-stimulating agents (ESAs) and intravenous (IV) iron. We conducted a systematic review examining the association of ESAs and IV iron with outcomes in adults undergoing solid organ transplant. This review was registered with PROSPERO (CRD42023474722). EMBASE and MEDLINE were searched from inception to April 11, 2025. Identified studies included adults (≥18 years of age) undergoing heart, liver, lung, or kidney transplant who received any ESA and/or IV iron before, during, or up to 1 month following solid organ transplant surgery compared to patients who did not. Article screening, full text review and data extraction were performed by two independent reviewers. The primary outcome of interest was transfusion volume, with secondary outcomes including haematological parameters, graft-related outcomes and rates of major morbidity and mortality. Results were analysed descriptively and compiled into tables, and the risk of bias was assessed using the CLARITY framework. From 1693 studies identified, 22 were included (kidney transplant, n = 16; heart transplant or Left Ventricular Assist Device as a bridge to transplant, n = 4; liver transplant, n = 2). Due to heterogeneity in design, interventions and outcomes, meta-analysis was not attempted. The quality of evidence was graded as Very Low. On the whole, a comprehensive strategy implementing ESAs and IV iron may improve haematological parameters and facilitate transfusion avoidance. High-quality prospective studies assessing the impact of protocols for haemoglobin optimisation and transfusion avoidance in solid organ transplant are needed.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"95-120"},"PeriodicalIF":1.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145726392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}