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Lipidomic changes occurring in platelets during extended cold storage 血小板在长时间冷藏过程中发生的脂质体变化
IF 1.5 4区 医学
Transfusion Medicine Pub Date : 2024-04-29 DOI: 10.1111/tme.13043
Sarah M. Green, Matthew P. Padula, Tyren M. Dodgen, Amani Batarseh, Denese C. Marks, Lacey Johnson
{"title":"Lipidomic changes occurring in platelets during extended cold storage","authors":"Sarah M. Green, Matthew P. Padula, Tyren M. Dodgen, Amani Batarseh, Denese C. Marks, Lacey Johnson","doi":"10.1111/tme.13043","DOIUrl":"https://doi.org/10.1111/tme.13043","url":null,"abstract":"ObjectivesCold storage is being implemented as an alternative to conventional room‐temperature storage for extending the shelf‐life of platelet components beyond 5–7 days. The aim of this study was to characterise the lipid profile of platelets stored under standard room‐temperature or cold (refrigerated) conditions.MethodsMatched apheresis derived platelet components in 60% PAS‐E/40% plasma (<jats:italic>n</jats:italic> = 8) were stored at room‐temperature (20–24°C with agitation) or in the cold (2–6°C without agitation). Platelets were sampled on day 1, 5 and 14. The lipidome was assessed by ultra‐pressure liquid chromatography ion mobility quadrupole time of flight mass spectrometry (UPLC IMS QToF). Changes in bioactive lipid mediators were measured by ELISA.ResultsThe total phospholipid and sphingolipid content of the platelets and supernatant were 44 544 ± 2915 μg/mL and 38 990 ± 10 880 μg/mL, respectively, and was similar over 14 days, regardless of storage temperature. The proportion of the procoagulant lipids, phosphatidylserine (PS) and phosphatidylethanolamine (PE), increased by 2.7% and 12.2%, respectively, during extended cold storage. Cold storage for 14 days increased sphingomyelin (SM) by 4.1% and decreased ceramide by 1.6% compared to day 1. Further, lysophosphatidylcholine (LPC) species remained unchanged during cold storage for 14 days. The concentration of 12‐ and 15‐hydroxyeicosatetraenoic acid (HETE) were lower in the supernatant of cold‐stored platelets than room‐temperature controls stored for 14 days.ConclusionThe lipid profile of platelets was relatively unchanged during storage for 5 days, regardless of temperature. However, during extended cold storage (14 days) the proportion of the procoagulant lipids, PS and PE, increased, while LPC and bioactive lipids were stable.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":"50 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140840723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transfusion Evidence Synopsis: Platelet transfusion before CVC placement in patients with thrombocytopenia (PACER trial) 输血证据概要:血小板减少症患者置入 CVC 前的血小板输注(PACER 试验)
IF 1.5 4区 医学
Transfusion Medicine Pub Date : 2024-04-18 DOI: 10.1111/tme.13040
Asha Aggarwal
{"title":"Transfusion Evidence Synopsis: Platelet transfusion before CVC placement in patients with thrombocytopenia (PACER trial)","authors":"Asha Aggarwal","doi":"10.1111/tme.13040","DOIUrl":"https://doi.org/10.1111/tme.13040","url":null,"abstract":"<div>\u0000<div>\u0000<p><b>Clinical question</b>:</p>\u0000<p>In haematology and intensive care (ICU) patients with a platelet count of 10–50 × 10<sup>9</sup>/L, does withholding platelet transfusion prior to central venous catheter (CVC) insertion increase the incidence of bleeding in comparison to transfusing one unit of platelets?</p>\u0000<p><b>Evidence from study</b>:</p>\u0000<p>Withholding platelet transfusion did not meet the criteria for non-inferiority and resulted in more CVC-related bleeding.</p>\u0000</div>\u0000</div>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":"9 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140623727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and safety of BNT162b2 mRNA vaccine in a cohort of 90 transfusion dependent thalassemia patients BNT162b2 mRNA 疫苗在 90 名输血依赖型地中海贫血患者中的疗效和安全性
IF 1.5 4区 医学
Transfusion Medicine Pub Date : 2024-04-18 DOI: 10.1111/tme.13038
M. Marziali, P. Pugliese, A. A. Losardo, M. Ribersani, E. Anastasi, A. Angeloni, A. Pavan, G. Gentile
{"title":"Efficacy and safety of BNT162b2 mRNA vaccine in a cohort of 90 transfusion dependent thalassemia patients","authors":"M. Marziali, P. Pugliese, A. A. Losardo, M. Ribersani, E. Anastasi, A. Angeloni, A. Pavan, G. Gentile","doi":"10.1111/tme.13038","DOIUrl":"https://doi.org/10.1111/tme.13038","url":null,"abstract":"","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":"21 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140623559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acknowledgements to our reviewers 向审稿人致谢
IF 1.5 4区 医学
Transfusion Medicine Pub Date : 2024-04-05 DOI: 10.1111/tme.13033
{"title":"Acknowledgements to our reviewers","authors":"","doi":"10.1111/tme.13033","DOIUrl":"https://doi.org/10.1111/tme.13033","url":null,"abstract":"","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":"7 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140582961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The feasibility of introducing a whole blood component for traumatic haemorrhage in the UK 在英国引入全血成分治疗创伤性出血的可行性
IF 1.5 4区 医学
Transfusion Medicine Pub Date : 2024-04-05 DOI: 10.1111/tme.13039
Josephine McCullagh, Peter Basham, Jane Davies, Vicky Hicks, Alastair Hunter, Julia Lancut, Laura Green
{"title":"The feasibility of introducing a whole blood component for traumatic haemorrhage in the UK","authors":"Josephine McCullagh, Peter Basham, Jane Davies, Vicky Hicks, Alastair Hunter, Julia Lancut, Laura Green","doi":"10.1111/tme.13039","DOIUrl":"https://doi.org/10.1111/tme.13039","url":null,"abstract":"BackgroundThe interest in re‐introducing whole blood (WB) transfusion for the management of traumatic major haemorrhage is increasing. However, due to the current leucodepletion filters used in the UK a WB component was not readily available. Instead, an alternative but similar component, leucocyte depleted red cell and plasma (LD‐RCP), which provided a unique experience in assessing the feasibility of a WB component was used whilst a WB component was being manufactured.Study Design and MethodsBetween November 2018 and October 2020, LD‐RCP replaced RBC as standard of care for all trauma patients with major haemorrhage in London. The aims of the study were to assess (a) deliverability, (b) component wastage and (c) safety.ResultsOver the study period a total of 1208 LD‐RCP units were delivered, of which 96.5% were delivered ‘On Time In Full’ (OTIF). Of the 1208 units, 733 (60.68%) were transfused and 475 (39.3%) units were wasted. Component wastage reduced significantly throughout the study (<jats:italic>p</jats:italic> = 0.001). A total of 177 patients had a blood group recorded, 86 were group O and 91 were non‐group O. There was no statistically significantly difference between haemoglobin (<jats:italic>p</jats:italic> = 0.422), or bilirubin levels (<jats:italic>p</jats:italic> = 0.084) between group O and non‐group O patients.DiscussionIt was feasible for NHS Blood and Transplant to deliver LD‐RCP on time in full, however component wastage was high due to short shelf life and limited use of the component. Low titre group O LD‐RCP units were not associated with clinical evidence of haemolysis.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":"140 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140582762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of a 5-year, evidenced-based, rational blood utilisation project in a South African regional hospital. 对南非一家地区医院为期 5 年的循证合理用血项目进行分析。
IF 1.5 4区 医学
Transfusion Medicine Pub Date : 2024-04-01 Epub Date: 2023-12-28 DOI: 10.1111/tme.13025
Robert Wise, Kirsten Hood, David Bishop, Gary Sharp, Reitze Rodseth
{"title":"Analysis of a 5-year, evidenced-based, rational blood utilisation project in a South African regional hospital.","authors":"Robert Wise, Kirsten Hood, David Bishop, Gary Sharp, Reitze Rodseth","doi":"10.1111/tme.13025","DOIUrl":"10.1111/tme.13025","url":null,"abstract":"<p><strong>Background: </strong>Blood products are a lifesaving but limited resource, particularly in resource-limited settings. Evidence-based transfusion criteria tailored to local hospitals have shown great promise in reducing costs, minimising shortages, and ameliorating the morbidity and mortality associated with liberal blood product usage. We implemented the \"Saving Blood, Saving Lives\" project to: promote responsible blood product use and reduce blood product ordering inefficiencies and expenditure.</p><p><strong>Methods: </strong>A comprehensive change management programme, preceded by 3 months of clinical department consultation and training, was implemented. A new evidence-based protocol for blood product utilisation was developed, together with an accountability form. This form was used in monthly audit meetings to refine policies, identify new problems, improve communication, and to drive hospital staff accountability and training. The primary measure of the programme's success was the change in the number of red cell concentrate units ordered.</p><p><strong>Results: </strong>Project implementation required minimal time and no additional budget or staff. Annual red cell concentrate usage reduced from 7211 units in year one to 4077 units in year 5 (p < 0.001). Similar reductions were seen in freeze-dried plasma and platelet usage, as well as administrative costs. Total project saving, adjusted to baseline admission numbers, amounted to over R46 million ($2.5 million).</p><p><strong>Conclusions: </strong>As a change management programme centred the \"Saving Blood, Saving Lives\" project, was able to significantly reduce blood product-related administration and expenditure by implementing evidence-based transfusion criteria. The programme is simple, replicable and cost effective, making it ideally suited for use in resource-constrained environments.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"154-164"},"PeriodicalIF":1.5,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139049384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The influence of the COVID-19 pandemic on blood donation and supply in China. COVID-19 大流行对中国献血和血液供应的影响。
IF 1.5 4区 医学
Transfusion Medicine Pub Date : 2024-04-01 Epub Date: 2023-12-27 DOI: 10.1111/tme.13020
Si-Cong Yu, Yun-Tai Yao
{"title":"The influence of the COVID-19 pandemic on blood donation and supply in China.","authors":"Si-Cong Yu, Yun-Tai Yao","doi":"10.1111/tme.13020","DOIUrl":"10.1111/tme.13020","url":null,"abstract":"<p><strong>Introduction: </strong>During the COVID-19 pandemic, there was a sharp decline in blood donation which posed a serious threat to the clinical blood supply worldwide. The aim of this study was to evaluate the influence of the COVID-19 pandemic on blood donation and supply in China on a nationwide level.</p><p><strong>Methods: </strong>A comprehensive review of the published literature was performed using eight databases including PubMed, Web of Science, Cochrane Library, Ovid, Embase, CNKI, WANFANG, and VIP by searching relevant words combinations.</p><p><strong>Results: </strong>Twenty-seven studies were determined to be eligible and included. Among them, 21 studies reported the situation of blood donation during the COVID-19 pandemic in China. The donation of both whole blood and platelet concentrates declined (with a decline of 5%-86% for whole blood and 3%-34% for platelet concentrates), with this especially evident in February 2020. The COVID-19 pandemic changed the pattern of blood donation and the composition of blood donors accordingly. Fifteen articles reported the supply of various blood components during the COVID-19 pandemic. The supply and usage of both packed red blood cell (PRBC) and fresh-frozen plasma (FFP) decreased (with a decrease of 4%-40% for PRBC and 9%-58% for FFP). The proportion of blood transfusions in different departments changed too. Compared to 2019, there was a decrease in surgical blood transfusions, and an increase in that used in treatments performed in emergency and internal medicine departments.</p><p><strong>Conclusion: </strong>The COVID-19 pandemic has led to an overall reduction of blood transfusion activities in most cities in China, in particular blood donations and blood demands.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"124-135"},"PeriodicalIF":1.5,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139049388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Guidelines for the specification, implementation and management of IT systems in hospital transfusion laboratories: A British Society for Haematology Guideline. 医院输血实验室信息技术系统的规范、实施和管理指南。
IF 1.5 4区 医学
Transfusion Medicine Pub Date : 2024-04-01 Epub Date: 2024-01-24 DOI: 10.1111/tme.13027
Julie Staves, Paul Ashford, Tom Bullock, Tony Coates, Linda Lodge, Nishil Patel, Megan Rowley, Nigel Sargant, Chloë E George
{"title":"Guidelines for the specification, implementation and management of IT systems in hospital transfusion laboratories: A British Society for Haematology Guideline.","authors":"Julie Staves, Paul Ashford, Tom Bullock, Tony Coates, Linda Lodge, Nishil Patel, Megan Rowley, Nigel Sargant, Chloë E George","doi":"10.1111/tme.13027","DOIUrl":"10.1111/tme.13027","url":null,"abstract":"","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"83-111"},"PeriodicalIF":1.5,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139542767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of disruptions in O RhD negative donations in Colombia on increasing maternal mortality ratio from haemorrhage. 哥伦比亚的 O 型 RhD 阴性捐献中断对增加产妇大出血死亡率的影响。
IF 1.5 4区 医学
Transfusion Medicine Pub Date : 2024-04-01 Epub Date: 2023-12-27 DOI: 10.1111/tme.13021
María-Isabel Bermúdez-Forero, Diana-Carolina Delgado-López, Diego-Alexander Anzola-Samudio, Fernando Palomino, Michel-Andres Garcia-Otalora
{"title":"Role of disruptions in O RhD negative donations in Colombia on increasing maternal mortality ratio from haemorrhage.","authors":"María-Isabel Bermúdez-Forero, Diana-Carolina Delgado-López, Diego-Alexander Anzola-Samudio, Fernando Palomino, Michel-Andres Garcia-Otalora","doi":"10.1111/tme.13021","DOIUrl":"10.1111/tme.13021","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this work was to evaluate the relationship of the maternal mortality ratio due to obstetric haemorrhage (MMROH) with the national blood donations, particularly O RhD negative (Oneg) before and during COVID-19 pandemic.</p><p><strong>Background: </strong>The maternal mortality ratio is increasing in Colombia, yet little is known regarding the relationship between blood donations and maternal mortality due to obstetric haemorrhage.</p><p><strong>Materials and methods: </strong>A retrospective cross-sectional study between January 1, 2018, and December 31, 2021, was performed, to assess MMROH compared to the blood donations notified to the Colombian National Haemovigilance System, through non-parametric methods. Because a relationship between blood donations and MMROH was identified, the analysis was expanded from 2009 to 2017.</p><p><strong>Results: </strong>In 2020, Colombia increased the MMROH by 32% compared to 2019 which coincided with the lockdown period to contain COVID-19. An inversed relationship (SumD<sup>2</sup> = 631.0; r<sub>s</sub> = -0.7335; p 0.01) between blood donations, particularly Oneg (SumD<sup>2</sup> = 652.0; r<sub>s</sub> = -0.7912; p 0.002) and MMROH was identified. For the years 2015-2019 and 2021, the annual mean MMROH was 8.5 ± 0.5 per 100 000 live births when the annual mean blood donations was 18.2 ± 0.4 donations per 1000 people and the Oneg was 1.0 ± 0.0 donations per 1000 people. In contrast, the years 2009-2014 and 2020 displayed an annual MMROH of 12.6 ± 0.8, when the annual collection of blood was 16.4 ± 0.8 donations and the Oneg was 0.9 ± 0.0, p < 0.001.</p><p><strong>Conclusion: </strong>There was an inverse relationship between blood donation, mainly Oneg, and maternal mortality from obstetric haemorrhage. However, we recognise these deaths could be related to other reasons, especially when they occurred in rural areas with limited access to medical services.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"142-153"},"PeriodicalIF":1.5,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139049387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The importance of need-altruism and kin-altruism to blood donor behaviour for black and white people. 需求-利他主义和亲属-利他主义对黑人和白人献血行为的重要性。
IF 1.5 4区 医学
Transfusion Medicine Pub Date : 2024-04-01 Epub Date: 2024-02-02 DOI: 10.1111/tme.13032
Eamonn Ferguson, Erin Dawe-Lane, Oluwafemi Ajayi, Bodunrin Osikomaiya, Richard Mills, Abiola Okubanjo
{"title":"The importance of need-altruism and kin-altruism to blood donor behaviour for black and white people.","authors":"Eamonn Ferguson, Erin Dawe-Lane, Oluwafemi Ajayi, Bodunrin Osikomaiya, Richard Mills, Abiola Okubanjo","doi":"10.1111/tme.13032","DOIUrl":"10.1111/tme.13032","url":null,"abstract":"<p><strong>Background: </strong>Need-altruism (a preference to help people in need) and kin-altruism (a preference to help kin over non-kin) underlie two hypotheses for voluntary blood donation: (i) Need-altruism underlies motivations for volunteer blood donation and (ii) Black people express a stronger preference for kin-altruism, which is a potential barrier to donation. This paper tests these hypotheses and explores how need- and kin-altruism are associated with wider altruistic motivations, barriers, and strategies to encourage donation.</p><p><strong>Methods: </strong>We assessed need- and kin-altruism, other mechanisms-of-altruism (e.g., reluctant-altruism), barriers, strategies to encourage donation, donor status, and willingness-to-donate across four groups based on ethnicity (Black; White), nationality (British; Nigerian), and country-of-residence: (i) Black-British people (n = 395), and Black-Nigerian people (ii) in the UK (n = 97) or (iii) across the rest of the world (n = 101), and (v) White-British people in the UK (n = 452). We also sampled a Black-Nigerian Expert group (n = 60).</p><p><strong>Results: </strong>Need-altruism was higher in donors and associated with willingness-to-donate in non-donors. Levels of kin-altruism did not differ between Black and White people, but need-altruism was lower in Black-British people. Kin-altruism was associated with a preference for incentives, and need-altruism with a preference for recognition (e.g., a thank you) as well as an increased willingness-to-donate for Black non-donors. Need-altruism underlies a blood-donor-cooperative-phenotype.</p><p><strong>Conclusion: </strong>Need-altruism is central to blood donation, in particular recruitment. Lower need-altruism may be a specific barrier for Black-British people. Kin-altruism is important for Black non-donors. The blood donor cooperative phenotype deserves further consideration. Implications for blood services are discussed.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"112-123"},"PeriodicalIF":1.5,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139672782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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