Transfusion Medicine最新文献_第7页

Hepatitis E virus screening in Irish blood donors: Seven years of individual donation nucleic acid testing reveals a frequent blood donor infection-but what is the risk? 爱尔兰献血者戊型肝炎病毒筛查：7年的个人捐献核酸检测显示献血者经常感染戊型肝炎病毒，但风险是什么？

IF 1.4 4区医学

Transfusion Medicine Pub Date : 2026-06-01 Epub Date: 2025-12-12 DOI: 10.1111/tme.70047

Niamh O'Flaherty, Marice Mullarkey, Lisa Burke, Pádraig Williams, Jonathan Dean, Jola Szulc, Allison Waters

{"title":"Hepatitis E virus screening in Irish blood donors: Seven years of individual donation nucleic acid testing reveals a frequent blood donor infection-but what is the risk?","authors":"Niamh O'Flaherty, Marice Mullarkey, Lisa Burke, Pádraig Williams, Jonathan Dean, Jola Szulc, Allison Waters","doi":"10.1111/tme.70047","DOIUrl":"10.1111/tme.70047","url":null,"abstract":"Background: Screening blood donations for HEV RNA mitigates the risk of transfusion-transmitted HEV infection (TT-HEV), a recognised blood safety issue in Europe. This study reports the findings of government-funded HEV RNA blood donation screening 2016-2022 and includes an estimate of residual risk.Method: Donation samples were universally and individually tested for HEV RNA using the Procleix HEV assay. Repeat reactive samples were referred for further molecular (PCR, viral load, genotyping) and serological analyses. A previously described model was used for the estimation of residual risk.Results: 229 HEV RNA positive donations were identified in 980 690 donations. Serological window period donations accounted for 148 (65%) of cases. HEV RNA donation positivity ranged from 1 in 6153 (0.016%) to 1 in 2314 (0.043%). In the absence of screening and with a residual plasma volume of 10 mL, >19% of the Hepatitis E virus positive Red Cell Concentrates (n = 42/220) could have resulted in transmission. The residual risk, based on a window period of 14 days was estimated at 51 per million donations. At least 15 components with infectious doses of >1 × 106 IU were interdicted.Conclusions: Autochthonous asymptomatic HEV infection continues to occur in Irish donors with relative frequency. As donors with higher viral loads can lead to infectious donations, the value of screening the blood supply for HEV is evident and supported by an absence of reported TT HEV cases. Interventions to control foodborne HEV may reduce the relative benefit of screening in the future.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"279-289"},"PeriodicalIF":1.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145744756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative evaluation of blood component preparation with the top-and-top and top-and-bottom methods: A change in Uruguay. 顶顶法和顶底法制备血液成分的比较评价：乌拉圭的变化。

IF 1.4 4区医学

Transfusion Medicine Pub Date : 2026-06-01 Epub Date: 2025-10-18 DOI: 10.1111/tme.70039

Natalia Méndez Acosta, Gabriela Rivas Alén, Ismael Rodriguez Grecco, Allexandra Díaz, Dalia Moreno, Ludwig R Frontier Ramos

{"title":"Comparative evaluation of blood component preparation with the top-and-top and top-and-bottom methods: A change in Uruguay.","authors":"Natalia Méndez Acosta, Gabriela Rivas Alén, Ismael Rodriguez Grecco, Allexandra Díaz, Dalia Moreno, Ludwig R Frontier Ramos","doi":"10.1111/tme.70039","DOIUrl":"10.1111/tme.70039","url":null,"abstract":"Background: Hospital de Clínicas, in conjunction with the Universidad de la República UDELAR in Uruguay, evaluated the quality of blood components after separation with a top-and-bottom (TB) system, comparing it with the top-and-top (TT) system and verifying compliance with local and international standards.Study design and methods: Whole blood (WB) was collected using TB (n = 150) and TT (n = 130). TB units were processed with MacoPress Smart, obtaining red cell concentrate (RCC), plasma (PL), and buffy coat (BC). After 2 h, BC had a soft spin centrifugation for a single unit of platelet concentrate (SUPC). TT bags were managed on day 0 (up to 8 h of collection) with manual press obtaining RCC and platelet-rich plasma units (PRP). PRP had hard spin centrifugation and was separated again with the manual press to collect PL and SUPC.Results: TB system produced RCC with higher haemoglobin concentration and Haematocrit but with lower volume and Hb/unit (p < 0.001). The TB system produced RCC with lower leukocytes and residual platelet levels (p < 0.001). SUPC showed fewer residual leukocytes and red cell levels with TB (p < 0.001), but TT produced a higher mean platelet count than the TB system (p < 0.001). During this evaluation, there was no significant difference in the mean plasma volume (p = 0.178).Conclusion: The analysis favors the implementation of TB in the HC Blood Bank, improving the quality and safety of the transfusion service.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"260-264"},"PeriodicalIF":1.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The heterogeneity of non-donors: A latent class analysis of demographic, social connection and sexual lifestyle of men who have sex with men who have never donated blood. 非献血者的异质性：与从未献过血的男性发生性关系的男性的人口统计学、社会关系和性生活方式的潜在阶层分析。

IF 1.4 4区医学

Transfusion Medicine Pub Date : 2026-06-01 Epub Date: 2025-12-08 DOI: 10.1111/tme.70050

Koson Tony Sriamporn, Peter J W Saxton, Nathan S Consedine

{"title":"The heterogeneity of non-donors: A latent class analysis of demographic, social connection and sexual lifestyle of men who have sex with men who have never donated blood.","authors":"Koson Tony Sriamporn, Peter J W Saxton, Nathan S Consedine","doi":"10.1111/tme.70050","DOIUrl":"10.1111/tme.70050","url":null,"abstract":"Background: As blood donation policies become more inclusive and men who have sex with men (MSM) become eligible, understanding non-donors will become increasingly important. MSM non-donors are often treated as a homogenous group, despite growing evidence that there is no universal non-donor profile. This oversimplification may obscure variation in behavioural risk parameters and does not optimally inform the development of effective recruitment or retention strategies. We aim to address this gap by identifying subgroups of MSM non-donors and examining how their behaviours and attitudinal profiles may inform targeted recruitment efforts.Methods: We used data from a cross-sectional voluntary online community survey of HIV risk behaviour and blood donation history. Latent Class Analysis (LCA) was used to identify subgroups of MSM who had never donated blood. Attitudes towards the MSM deferral policy, blood service and how civically important they view blood donation were compared across groups.Results: 1339/3838 participants were non-donors. LCA identified four distinct subgroups of non-donors: 'Sexually, but not socially engaged' (16.1%), 'Young and single' (22.1%), 'Monogamous' (28.1%) and 'Socially and sexually engaged' (33.5%). These groups differed in their demographic make-up, social connections, sexual lifestyles and in their attitudes towards blood donation.Conclusion: This study highlights the heterogeneity within MSM non-donors. We propose that the 'Young and single' and 'Monogamous' MSM might be more readily recruited due to their favourable eligibility and attitudinal profile. Furthermore, there is potential need for tailored outreach to maximise future donor engagement and a safe blood supply under individualised donor assessment approaches.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"231-241"},"PeriodicalIF":1.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145701978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 1.4 4区医学

Transfusion Medicine Pub Date : 2026-06-01 Epub Date: 2026-01-06 DOI: 10.1111/tme.70053

Mauro Guariento, Carlos Echecopar, Víctor Galán-Gómez, Isabel Martínez Romera, Berta González Martínez, Sonsoles San Román, Víctor Quintero Calcaño, Luisa Sisinni, Antonio Pérez Martínez, Aurora Viejo Llorente, Ana Kerguelen Fuentes

{"title":"Transfusion-related pulmonary complications in paediatric acute myeloid leukaemia: A case report of transfusion-associated circulatory overload (TACO) and transfusion-related acute lung injury (TRALI).","authors":"Mauro Guariento, Carlos Echecopar, Víctor Galán-Gómez, Isabel Martínez Romera, Berta González Martínez, Sonsoles San Román, Víctor Quintero Calcaño, Luisa Sisinni, Antonio Pérez Martínez, Aurora Viejo Llorente, Ana Kerguelen Fuentes","doi":"10.1111/tme.70053","DOIUrl":"10.1111/tme.70053","url":null,"abstract":"Background: Pulmonary complications of transfusion are a leading cause of morbidity and mortality. Transfusion-associated circulatory overload (TACO) is the most common, whereas transfusion-related acute lung injury (TRALI) is less frequent but potentially fatal.Objective: To describe a pediatric case with overlapping features of TACO and TRALI following platelet transfusion and to highlight diagnostic and management challenges.Methods: We report the case of a 15-year-old patient with acute myeloid leukemia who developed acute respiratory compromise after platelet transfusion. Clinical findings, laboratory data (including pro-BNP), imaging, and immunologic investigations were evaluated.Results: Elevated pro-BNP levels and signs of fluid overload were consistent with TACO. However, chest radiography demonstrated non-cardiogenic pulmonary edema, and pre-existing pulmonary involvement supported a diagnosis of type II TRALI. Management included immediate cessation of transfusion, oxygen therapy, and comprehensive evaluation with cytokine profiling, antibody screening, and advanced immunologic testing.Conclusion: This case illustrates the diagnostic complexity of transfusion-related pulmonary complications, particularly when TACO and TRALI features overlap, and underscores the importance of a multidisciplinary approach to management and investigation.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"295-301"},"PeriodicalIF":1.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145913084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug-induced immune haemolytic anaemia caused by cefamandole sodium: Complete serologic studies and clinical follow-up. 头孢门多尔钠致药物性免疫溶血性贫血：完整的血清学研究和临床随访。

IF 1.4 4区医学

Transfusion Medicine Pub Date : 2026-06-01 Epub Date: 2025-10-09 DOI: 10.1111/tme.70037

Yuanjun Wu, Yinglin Wu, Weifan Xu, Yuanyuan Xu, Ganping Guo

{"title":"Drug-induced immune haemolytic anaemia caused by cefamandole sodium: Complete serologic studies and clinical follow-up.","authors":"Yuanjun Wu, Yinglin Wu, Weifan Xu, Yuanyuan Xu, Ganping Guo","doi":"10.1111/tme.70037","DOIUrl":"10.1111/tme.70037","url":null,"abstract":"Background and objectives: There is limited knowledge regarding cefamandole-related drug-induced immune haemolytic anaemia (DIIHA). We conducted a comprehensive serological and clinical follow-up study of a case of cefamandole-induced DIIHA to improve understanding of this condition.Materials and methods: A patient with advanced hepatocellular carcinoma developed severe haemolytic anaemia along with significant worsening of hepatic and renal function after intravenous cefamandole was administered for a urinary tract infection. Serological testing included the direct antiglobulin tests (DATs), irregular red blood cell (RBC) antibody screening and detection of cefamandole-dependent antibodies using two standard methods for drug-dependent antibodies: 'testing in the presence of soluble drug' and 'testing drug-treated RBCs', which were performed after cefamandole discontinuation. Clinical follow-up was conducted for 41 days after drug cessation.Results: The results of DAT for anti-IgG and anti-C3d were strongly positive, while irregular RBC antibody screening was negative. Plasma samples collected at different points from 13 to 38 days after cefamandole discontinuation were incubated with cefamandole-coated RBCs at 37°C, revealing both IgM and IgG cefamandole-dependent antibodies, with a maximum titre of 16. Following treatment with blood transfusion, intravenous immunoglobulin (IVIG), and methylprednisolone, anaemia and organ dysfunction showed marked improvement. Therefore, the patient was diagnosed with cefamandole-induced DIIHA.Conclusions: This study may be the second serological analysis and the first comprehensive clinical follow-up of cefamandole-induced DIIHA. It demonstrates that cefamandole-dependent antibodies can activate complement, leading to severe haemolytic anaemia and hepatic and renal impairment. The 'testing drug-treated RBCs' method is suitable for detecting cefamandole-dependent antibodies.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"252-259"},"PeriodicalIF":1.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Haemoglobin levels, transfusion patterns, and associated outcomes in children with severe TBI: A secondary analysis from approaches and decisions in acute paediatric traumatic brain injury trial. 严重TBI患儿的血红蛋白水平、输血模式和相关结局：急性儿科创伤性脑损伤试验方法和决策的二次分析

IF 1.4 4区医学

Transfusion Medicine Pub Date : 2026-06-01 Epub Date: 2025-12-07 DOI: 10.1111/tme.70043

Ali B V McMichael, Jaskaran Rakkar, Sandra D W Buttram

{"title":"Haemoglobin levels, transfusion patterns, and associated outcomes in children with severe TBI: A secondary analysis from approaches and decisions in acute paediatric traumatic brain injury trial.","authors":"Ali B V McMichael, Jaskaran Rakkar, Sandra D W Buttram","doi":"10.1111/tme.70043","DOIUrl":"10.1111/tme.70043","url":null,"abstract":"Objective: To evaluate the incidence of haemoglobin (Hgb) values <10 g/dL and transfusion in children with severe traumatic brain injury (TBI).Design: Non-prespecified secondary analysis using the Approaches and Decisions in Acute Paediatric TBI (ADAPT) trial (NCT04077411) that prospectively enrolled consecutive paediatric patients from February 2014 to September 2017.Setting: U.S. and international sites with patient enrollment into ADAPT trial.Patients: Patients less than 18 years old with a Glasgow Coma Scale (GCS) score less than or equal to 8 that had an intracranial (ICP) monitor and had at least one Hgb value recorded in the first 24 hours following ICP monitor placement.Interventions: None.Measurements and main results: Of the 997 patients included in the analysis, 895 (90%) had at least one Hgb value <10 g/dL during the study period. 607 (61%) patients received packed red blood cells (pRBCs) or whole blood transfusion, with 66% of transfusions occurring on ICU Day 1. The median blood transfusion volume (either pRBC or whole blood) in the study population was 15.2 mL/kg (IQR 10-27.1) within the first 7 days of ICU stay. In a multivariable logistic analysis, transfusion was associated with younger age, higher admission GCS score, increased clinical and injury severity at admission, and need for surgical intervention. However, neither nadir Hgb nor transfusion was associated with mortality or unfavorable neurologic outcome.Conclusions: In a secondary analysis of ADAPT, both Hgb value <10 g/dL and transfusion were common in children with severe TBI. Nadir Hgb and transfusion were not associated with mortality or unfavourable neurologic outcomes. The optimal threshold for pRBC transfusion in children with severe TBI requires further study.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"242-251"},"PeriodicalIF":1.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145701958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Are we missing the true impact of ferritin-guided donor management? 我们是否忽略了铁蛋白引导的供体管理的真正影响？

IF 1.4 4区医学

Transfusion Medicine Pub Date : 2026-06-01 Epub Date: 2026-01-27 DOI: 10.1111/tme.70063

Yuko Mishima, Rui Terada

引用次数: 0

Incidence and risk factors of passenger lymphocyte syndrome after ABO minor-incompatible lung transplantation. ABO轻微不相容肺移植术后乘客淋巴细胞综合征的发生率及危险因素分析。

IF 1.4 4区医学

Transfusion Medicine Pub Date : 2026-05-29 DOI: 10.1111/tme.70087

Ci Xuan, Zhu Boping, Huang Junting, Su Xiaoqian, Hu Caiting, Li Qiuhua, Mo Xuyou, Li Yiquan

{"title":"Incidence and risk factors of passenger lymphocyte syndrome after ABO minor-incompatible lung transplantation.","authors":"Ci Xuan, Zhu Boping, Huang Junting, Su Xiaoqian, Hu Caiting, Li Qiuhua, Mo Xuyou, Li Yiquan","doi":"10.1111/tme.70087","DOIUrl":"https://doi.org/10.1111/tme.70087","url":null,"abstract":"Objective: To investigate the incidence and risk factors of Passenger Lymphocyte Syndrome (PLS) following ABO minor-incompatible lung transplantation.Methods: A retrospective analysis was performed on 211 lung transplantations conducted between January 2022 and July 2025, including 58 cases involving ABO minor-incompatibility. The diagnosis of PLS was established based on evidence of haemolysis, a positive direct antiglobulin test (DAT), and confirmation of donor-derived antibodies. Clinical characteristics and outcomes were compared between the PLS and non-PLS groups using statistical analyses.Results: The overall incidence of PLS was 3.32% (7/211), with a markedly higher rate of 12.07% (7/58) observed among ABO minor-incompatible transplants. Of the seven PLS cases, six occurred in O-to-non-O donor-recipient pairs. Risk factor analysis revealed that female sex (p < 0.001), bilateral lung transplantation (p = 0.027), and preoperative anaemia (p < 0.001) were significantly associated with the development of PLS. Furthermore, patients with PLS experienced several adverse postoperative outcomes, including lower nadir haemoglobin levels (43.50 g/L vs. 77.00 g/L in controls, p = 0.001) and platelet counts (29.00 × 109/L vs. 101.00 × 109/L, p = 0.001), substantially higher median red blood cell transfusion requirements (23.25 units vs. 0.00 units in controls, p < 0.001), and prolonged median hospital stays (75.50 days vs. 32.00 days, p = 0.002).Conclusion: PLS occurs at a relatively high frequency following ABO minor-incompatible lung transplantation. It is associated with risk factors such as female sex, bilateral lung transplantation, and preoperative anaemia, and contributes to more pronounced postoperative declines in haemoglobin and platelet levels, increased transfusion requirements, and extended hospitalisation.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148056919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring attitudes and barriers to women donating blood in New Delhi from the perspective of blood bank workers. 从血库工作人员的角度探讨新德里妇女献血的态度和障碍。

IF 1.4 4区医学

Transfusion Medicine Pub Date : 2026-05-22 DOI: 10.1111/tme.70084

Hannah-Marie Culley, Priyansh Nathani, Ricky Kalliecharan, Noel Aruparayil, Anurag Mishra

{"title":"Exploring attitudes and barriers to women donating blood in New Delhi from the perspective of blood bank workers.","authors":"Hannah-Marie Culley, Priyansh Nathani, Ricky Kalliecharan, Noel Aruparayil, Anurag Mishra","doi":"10.1111/tme.70084","DOIUrl":"https://doi.org/10.1111/tme.70084","url":null,"abstract":"Background: In India, approximately 26.2 million units of blood are required annually; however, 5.83 million units were collected in 2021. 18% of blood donors in India are women, demonstrating an untapped donor pool, but their attitudes towards donation have not been explored.Objectives: The objectives of this study are to explore women's attitudes and barriers to blood donation in New Delhi from the perspective of blood bank workers.Methods: This is a qualitative study involving blood bank workers. Twenty-five government blood banks in New Delhi were contacted and three participated. Convenience sampling selected 14 participants and semi-structured face-to-face interviews took place. Inductive thematic analysis was used.Results: Attitudes towards blood donation were classified into two themes: responsibility and fear. Blood bank workers suggested women believed blood donation was harmful and it was not their responsibility. Barriers to women donating blood were classified into two themes: social factors and deferral. Social factors, such as family, patriarchal society, and the role of women, reduced the exposure of women to blood donation; therefore, limiting knowledge and the opportunity to donate. Deferral due to anaemia was another barrier.Conclusion: This study suggests that women's perceived responsibility and fears may stem from inadequate exposure to blood donation due to women's societal roles. Social influences and anaemia can pose barriers to women donating blood. However, these opinions are from blood bank workers and not the general population; therefore, further research is required. Educational campaigns for both sexes could reduce stigma around women donating blood.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147989273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of limited donor phenotyped blood transfusion on alloimmunisation in children with thalassaemia and sickle cell anaemia. 有限供体表现型输血对地中海贫血和镰状细胞贫血儿童同种免疫的影响。

IF 1.4 4区医学

Transfusion Medicine Pub Date : 2026-05-20 DOI: 10.1111/tme.70092

Menna Allah Zakaria Mohammad Ali Abou Elwafa, Deena Mohamed Mohamed Habashy, Alaa Magdy Abdelmordy Zidan, Fatma Soliman Elsayed Ebeid

{"title":"The effect of limited donor phenotyped blood transfusion on alloimmunisation in children with thalassaemia and sickle cell anaemia.","authors":"Menna Allah Zakaria Mohammad Ali Abou Elwafa, Deena Mohamed Mohamed Habashy, Alaa Magdy Abdelmordy Zidan, Fatma Soliman Elsayed Ebeid","doi":"10.1111/tme.70092","DOIUrl":"https://doi.org/10.1111/tme.70092","url":null,"abstract":"Background: Chronic transfusion therapy has improved outcomes in children with Beta-Thalassaemia Major (BTM) and sickle cell disease (SCD). However, exposure to multiple blood transfusions introduces challenges such as alloimmunisation, which hinders further transfusions and makes finding matching units more difficult. As a measure to limit exposure of multi-transfused patients to multiple donors, the limited donor exposure program (LDEP) was introduced, where phenotyped blood from committed voluntary 3-5 donors is donated at intervals to each patient. In this study, we aimed to compare the frequency of alloantibodies in a group of patients in LDEP with those receiving blood from multiple donors.Study design and methods: The study was carried out on 140 randomly selected multi-transfused paediatric BTM and SCD patients from Ain Shams University Paediatrics Hospital (66 of whom were in LDEP). All participants were subjected to full history taking including clinical and transfusion history, antibody screening for alloantibodies, and antibody identification.Results: The studied group of patients had a mean age of 5.8 ± 2.9 years with M/F ratio 1.1:1. Factors like gender (higher in females), splenectomy, frequent transfusions, and history of receiving non-phenotyped blood were significantly associated with higher alloimmunisation. LDEP group showed significantly lower alloimmunisation rates than those receiving blood from multiple donors (7.6% vs. 86.5%, p < 0.001).Conclusion: LDEP applied on a segment of multi-transfused patients at Ain Shams University Paediatric Haematology Clinic was associated with a lower, statistically significant prevalence of red cell alloantibodies.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147975686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0