Transfusion Medicine最新文献_第6页

Plenary session III 全体会议 III

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-09-13 DOI: 10.1111/tme.13083

引用次数: 0

Thursday 19 September 2024 Simultaneous Sessions 2024 年 9 月 19 日星期四同时举行的会议

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-09-13 DOI: 10.1111/tme.13088

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Plenary session II 第二次全体会议

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-09-13 DOI: 10.1111/tme.13082

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Risk factors for red blood cell alloimmunization in patients with hematologic malignancy 血液系统恶性肿瘤患者发生红细胞同种免疫的风险因素

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-09-12 DOI: 10.1111/tme.13096

Pakthipa Pattarakosol, Nattarat Lorucharoen, Phandee Watanaboonyongcharoen, Ponlapat Rojnuckarin

{"title":"Risk factors for red blood cell alloimmunization in patients with hematologic malignancy","authors":"Pakthipa Pattarakosol, Nattarat Lorucharoen, Phandee Watanaboonyongcharoen, Ponlapat Rojnuckarin","doi":"10.1111/tme.13096","DOIUrl":"https://doi.org/10.1111/tme.13096","url":null,"abstract":"IntroductionPatients with hematologic malignancy have a higher risk of developing red blood cell (RBC) alloimmunization which can delay blood transfusion. Information on the risk factors for alloimmunization in this group is still limited. This study aimed to determine the prevalence and predictors of RBC alloimmunization among these patients.Materials and MethodsElectronic medical records of the patients with acute myeloid leukaemia (AML), acute lymphoid leukaemia (ALL), multiple myeloma (MM) and lymphoma from a tertiary care hospital between January 2018 and December 2022 were retrospectively reviewed. Clinical, demographic and transfusion history data of the included patients were analysed.ResultsOf the 983 patients with hematologic malignancy, 798 were included in the study. The prevalence of RBC alloantibodies in this population was 4.8% (38 patients). The alloimmunization rate of each subgroup was as followed: AML 9.1%, ALL 2.9%, MM 3.8% and lymphoma 2.5%. The most common alloantibodies were anti‐Mia, anti‐E and anti‐Lea. The majority (29/38, 76.3%) of alloimmunization had a single alloantibody. RBC autoantibody was detected in 10 patients. The detection of autoantibodies and having AML were independently associated with RBC alloimmunization (adjusted odds ratio [aOR] 13.41, 95% confidence interval [CI] 2.00–89.72, p = 0.007 and aOR 11.44, 95% CI 2.02–64.72, p = 0.006, respectively).ConclusionThe prevalence of RBC alloimmunization in the patients with hematologic malignancy was 4.8%. The alloimmunization rate of the AML subgroup was higher than those of other hematologic malignancies. The detection of autoantibodies and the AML diagnosis were identified as potential risk factors for RBC alloimmunization.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":"27 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142217242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Implementation challenges of electronic blood transfusion safety systems: Lessons from an international, multi‐site comparative case study 输血安全电子系统的实施挑战：国际多站点比较案例研究的经验教训

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-09-10 DOI: 10.1111/tme.13095

Stijn Horck, Nick Fahy, Trisha Greenhalgh

{"title":"Implementation challenges of electronic blood transfusion safety systems: Lessons from an international, multi‐site comparative case study","authors":"Stijn Horck, Nick Fahy, Trisha Greenhalgh","doi":"10.1111/tme.13095","DOIUrl":"https://doi.org/10.1111/tme.13095","url":null,"abstract":"BackgroundSevere transfusion reactions resulting from errors in matching the correct blood with the correct patient are considered never events. Despite the relative technical simplicity of barcode scanning for patient‐blood bag matching, the adoption and universal application of this safety measure are by no means universal. This study highlights the logistical and institutional challenges associated with spreading, scaling up, and sustaining such IT‐supported safety measures in healthcare.Study Design and MethodsWe report findings from a 5‐year, prospective, multi‐site case study conducted across one hospital in England and three hospitals in the Netherlands. Ethnographic methods, including interviews and observations, were used at each site to investigate the implementation of barcode scanning‐supported safety pathways for blood transfusions.ResultsSignificant variation was observed across the sites in the adoption and implementation of barcode scanning‐supported safety pathways. Despite the potential for reducing transfusion errors, the introduction of this innovation was met with varying levels of success in different settings.DiscussionThis study highlights the critical role of inter‐hospital learning and flexible system design in successfully implementing barcode scanning‐supported safety pathways for blood transfusions. A more structured, national‐level network for knowledge sharing could enhance the spread and sustainability of such innovations across healthcare settings.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":"05 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142217244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterising practice patterns of human derived, lyophilized coagulation concentrates within the trauma quality improvement program registry 在创伤质量改进计划登记册中描述人源冻干凝血浓缩物的实践模式

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-09-10 DOI: 10.1111/tme.13094

Chester A. Rosenthal, David J. Douin, Mitch J. Cohen, Julie A. Rizzo, Michael D. April, Steven G. Schauer

{"title":"Characterising practice patterns of human derived, lyophilized coagulation concentrates within the trauma quality improvement program registry","authors":"Chester A. Rosenthal, David J. Douin, Mitch J. Cohen, Julie A. Rizzo, Michael D. April, Steven G. Schauer","doi":"10.1111/tme.13094","DOIUrl":"https://doi.org/10.1111/tme.13094","url":null,"abstract":"ObjectivesWe seek to describe the current practice pattern use of prothrombin complex concentrate (PCC) and fibrinogen concentrate (FC) in trauma patients.BackgroundTrauma‐induced coagulopathy (TIC) and endotheliopathy of trauma (EOT) contribute significantly to mortality from traumatic haemorrhage. FC, and 4‐factor PCC are potential treatments for EOT and TIC, respectively.Materials and MethodsWe obtained data from the Trauma Quality Improvement Program (TQIP) registry and identified patients who received either PCC or FC using procedural codes. We used descriptive statistics to characterise practice patterns of these products.ResultsThere were 6 714 002 total encounters within the TQIP from 2017 to 2022, of which 10 589 received PCC and 3009 received FC. Of the recipients, there were 35 that received both products. There were 44 that received both. The median age of PCC recipients was 77 (69–84) with 19 patients <15 years of age with the youngest being 2 years of age. There was a general upward trend in the number of facilities with documented use of PCC: 155/744, 168/766, 189/764, 206/780, 234/795, and 235/816, respectively. The median age of FC recipients was 57 (32–75) with 48 patients <15 years of age with the youngest being 1 year of age. There was a minor downward trend in the number of facilities that had documented use of FC: 55, 44, 39, 32, 38 and 40.ConclusionsThe administration of PCC and FC remains uncommon, although there appears to be an upward trend of PCC use. Most PCC use appeared to be for anticoagulation reversal in the setting of head trauma. Data guiding the use of these products are necessary as these products become more recognised as adjuncts to traumatic haemorrhage control.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":"13 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142217106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An evaluation of diethylhexyl phthalate free top & bottom in-line blood collection set with a new soft housing filter. 不含邻苯二甲酸二乙基己酯的顶部和底部在线采血装置与新型软外壳过滤器的评估。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-09-07 DOI: 10.1111/tme.13091

Elena Danilova, Farshid Ezligini, Connie Stöckel, Masafumi Asakawa, Geir Hetland

{"title":"An evaluation of diethylhexyl phthalate free top & bottom in-line blood collection set with a new soft housing filter.","authors":"Elena Danilova, Farshid Ezligini, Connie Stöckel, Masafumi Asakawa, Geir Hetland","doi":"10.1111/tme.13091","DOIUrl":"https://doi.org/10.1111/tme.13091","url":null,"abstract":"Background and objectives: Di (2-ethylhexyl) phthalate (DEHP) plasticizer must be removed from polyvinylchloride (PVC) medical devices due to toxicity. DEHP/PVC blood bags were shown to provide stable quality under blood component production and to create good storage conditions for red blood cells concentrate (RBC). It is important that substitution of the DEHP maintains the RBC quality during storage, which should be achieved with Di (isononyl) cyclohexane-1,2-dicarboxylate (DINCH), although substitution of the plasticizer has been challenging.Materials and methods: A DEHP-free Top & Bottom in-line RBC set was validated in a tertiary hospital blood bank facility. Volunteer blood donors were randomly allocated for blood collection into DINCH/PVC or DEHP/PVC set. The groups were additionally divided according to additive solution/filter combination: PAGGS-M + DINCH/PVC filter (only with DINCH/PVC set), and SAG-M + DINCH/PVC filter and SAG-M + DEHP/PVC filter (only with DEHP/PVC set). Processing and storage effects were assessed in all components.Results: RBC concentrates, platelet concentrates and plasma that was processed and stored in DEHP-free set fulfilled European requirements for quality. The cells stored in PAGGS-M after filtration through DEHP-free PVC filter showed the same low haemolysis compared with conventional set at 49 days of storage. Platelets stored in DINCH/PVC bag provided a sufficient quality of platelets after 7 days of storage. Plasma maintained the coagulation factors during 12 months of storage.Conclusion: A new DINCH/PVC set allows production of blood components of satisfactory quality in DEHP-free environment.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

XLI Annual Scientific Meeting of the British Blood Transfusion Society 17-19 September 2024, SEC, Glasgow, Scotland. 英国输血协会第四十一届科学年会，2024 年 9 月 17-19 日，苏格兰格拉斯哥 SEC。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-09-01 DOI: 10.1111/tme.13089

引用次数: 0

Myoglobin saturation as an intracellular indicator for transfusion need in oncology patients. 肌红蛋白饱和度作为肿瘤患者输血需求的细胞内指标。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-08-27 DOI: 10.1111/tme.13090

Kenneth A Schenkman, Wayne A Ciesielski, Terry B Gernsheimer, Lorilee S L Arakaki

{"title":"Myoglobin saturation as an intracellular indicator for transfusion need in oncology patients.","authors":"Kenneth A Schenkman, Wayne A Ciesielski, Terry B Gernsheimer, Lorilee S L Arakaki","doi":"10.1111/tme.13090","DOIUrl":"https://doi.org/10.1111/tme.13090","url":null,"abstract":"Objectives: This study aims to demonstrate the potential of myoglobin saturation as an indicator of oxygen delivery adequacy to help determine the need for red cell transfusion.Background: Modern blood management approaches have been established to optimise use of red blood cells for transfusions in patients with anaemia. However, most approaches make recommendations to transfuse based on haemoglobin or haematocrit levels and do not directly address adequacy of oxygen delivery. Intracellular oxygen determined by myoglobin saturation directly measures oxygen delivery at the tissue level.Methods/materials: A custom built spectrometer system with an optical fibre probe was used in this pilot study to measure muscle cell myoglobin saturation noninvasively from the first digital interosseous muscles in patients undergoing planned red blood cell transfusion. Patients were recruited from both the in-patient and out-patient oncology service at a major university medical centre. Measurements were made immediately before, immediately after, and 24 h following transfusion. Clinical data and tissue oxygen values from the Somanetics INVOS system were also collected.Results: Myoglobin saturation, and thus cellular oxygen increased in some, but not all patients receiving a transfusion, and was most pronounced in patients who initially had low myoglobin saturation compared with the group as a whole.Conclusion: Clinical decisions to transfuse based on haemoglobin or haematocrit thresholds alone are likely insufficient to optimise use of red blood cell transfusions. The combination of haemoglobin or haematocrit with myoglobin saturation may optimally determine who will benefit physiologically from a transfusion.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142081714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Transfusion sample mislabelling and wrong blood in tube in the UK: Insights from the national comparative audits of blood transfusion in 2012 and 2022. 英国输血样本贴错标签和输错血液：2012年和2022年全国输血比较审计的启示。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-08-27 DOI: 10.1111/tme.13092

Catherine Booth, Paul Davies

{"title":"Transfusion sample mislabelling and wrong blood in tube in the UK: Insights from the national comparative audits of blood transfusion in 2012 and 2022.","authors":"Catherine Booth, Paul Davies","doi":"10.1111/tme.13092","DOIUrl":"https://doi.org/10.1111/tme.13092","url":null,"abstract":"Background: Samples for transfusion rejected due to mislabelling can lead to harm when a patient has to be re-bled or has a transfusion or procedure delayed. Electronic labelling systems which scan the patient's identification band and generate a label at their side aim to reduce mislabelling and misidentification leading to wrong blood in tube (WBIT) errors. The 2022 National Comparative audit of sample collection aimed to compare national rates of sample mislabelling and WBIT to the 2012 audit and to examine the impact of electronic systems.Method: All UK hospitals were invited to provide data on rejected transfusion samples and WBIT incidents in 1 month (October 2022) and were asked if they had electronic labelling.Results: Twenty-three thousand five hundred and eighty-four rejected samples were reported by 179 sites in 1 month. The rejection rate of 4.4% represents a 47% increase compared to 2012 (2.99%). There were 92 WBIT incidents, an incidence of 1 in 5882 samples-a 45% increase compared to 1 in 8547 in 2012. Twenty-three percent of sites can print a sample label at the patient's side, up by 224%. The six sites using only electronic sample labelling had a 46.9% lower rejection rate than sites using only hand-labelling but still reported WBIT.Conclusions: The increase in sample rejection and WBIT may reflect pressures facing clinical staff, zero tolerance policies and the two-sample rule. A human factors approach to understanding and tackling underlying reasons locally is recommended. Electronic systems are associated with fewer labelling errors, but careful implementation and training is needed to maximise their safety benefits.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142081715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0