Transfusion Medicine最新文献_第6页

The infected blood inquiry: Impact on public perceptions of blood supply risk, safety, and donation attitudes. 受感染血液调查：对公众对血液供应风险、安全性和捐献态度看法的影响。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-12-01 Epub Date: 2024-11-12 DOI: 10.1111/tme.13108

Richard Mills, Eva-Maria Merz, Mark Croucher, Barbara Masser, Susan R Brailsford, Robert Smith, Eamonn Ferguson

{"title":"The infected blood inquiry: Impact on public perceptions of blood supply risk, safety, and donation attitudes.","authors":"Richard Mills, Eva-Maria Merz, Mark Croucher, Barbara Masser, Susan R Brailsford, Robert Smith, Eamonn Ferguson","doi":"10.1111/tme.13108","DOIUrl":"10.1111/tme.13108","url":null,"abstract":"Background: The UK's Infected Blood Inquiry (IBI) highlighted a major public health scandal, with at least 30 000 people infected and more than 3000 deaths attributable to infected blood and blood products. This study investigates the impact of the IBI announcement on May 20, 2024, on public perceptions of blood supply risk, safety, and donation intentions in the UK compared to the USA.Methods: A 2 (country: UK vs. USA) × 2 (time: pre-, post-IBI announcement) between-within-subject study was conducted with 1635 participants (888 UK, 747 USA). Pre-IBI data were collected from May 3 to 7, 2024, and post-IBI data from May 30 to June 30, 2024. Key measures were perceived infection risk from transfusion, transfusion safety, willingness to donate and encourage others. The impact was assessed using differences-in-differences (DiD) and reliable-change-indices (RCI).Results: UK participants showed a significant but small decrease in perceived safety compared to USA participants, with 1 in 30 UK individuals perceiving a significant reduction in perceived transfusion safety. Decreases in perceived safety were associated with significant decreases in willingness to donate and encouragement of others in the whole sample and in USA participants and significant decreases in willingness to encourage others in UK participants. Older people reported a greater reduction in safety, and non-donors were more likely to be put off donating and not ask others to donate as a result of their perception that safety had been reduced.Conclusion: Overall, perceived safety decreased marginally in the UK general population. Future research should explore the long-term impacts of the IBI.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"478-490"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11653061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What is best practice for the prevention of anti-D alloimmunisation in D-negative recipients receiving solid organ transplants from D-positive donors. 在接受 D 阳性捐献者实体器官移植的 D 阴性受者中，预防抗 D 免疫的最佳做法是什么？

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-12-01 Epub Date: 2024-10-01 DOI: 10.1111/tme.13097

Thomas Lynes, Anna Mon Ying Li, Deirdre Sexton, David Nasralla, Matthew Hazell

引用次数: 0

A review of immunoglobulin use in a district general hospital setting. 地区综合医院免疫球蛋白使用情况回顾。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-12-01 Epub Date: 2024-06-25 DOI: 10.1111/tme.13059

Julie Gillies, Lorna Robertson, Debbie Tait

引用次数: 0

Charles Waller and Edward Doubleday-Colleagues of James Blundell and early supporters of blood transfusion. 查尔斯-沃勒（Charles Waller）和爱德华-道布尔戴（Edward Doubleday）--詹姆斯-布伦德尔（James Blundell）的同事，输血的早期支持者。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-12-01 Epub Date: 2024-03-22 DOI: 10.1111/tme.13036

Phil Learoyd

引用次数: 0

Validation of pathogen reduced plasmas from maxi-pools combined with fast thawing. 验证最大池与快速解冻相结合减少病原体的等离子体。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-12-01 Epub Date: 2024-11-05 DOI: 10.1111/tme.13106

Marja-Kaisa Auvinen, Folke Knutson, Helena Löf

{"title":"Validation of pathogen reduced plasmas from maxi-pools combined with fast thawing.","authors":"Marja-Kaisa Auvinen, Folke Knutson, Helena Löf","doi":"10.1111/tme.13106","DOIUrl":"10.1111/tme.13106","url":null,"abstract":"Objectives: Fast thawing for emergency situations and reduction of plasma wastage.Background: Evaluation of plasma units, pooled and pathogen reduced (PR) in \"maxi-pools\" with amotosalen and UVA light, and fast thawing.Methods/materials: Per replicate, 10 WB-derived leukocyte depleted plasma units were frozen within 24 h at ≤ -25°C and stored for 7 days. After thawing, a maxi-pool was constituted from the 10 units. After splitting into 4 sub-pools of 650 mL, the sub-pools were PR treated then split into 3 units resulting in 12 PR plasma units at 200 mL. Hundred and twenty PR plasma units were produced in total. The units were frozen at ≤ -25°C for 1 week, then thawed either in a fast plasma thawer for 5 min or in other control devices (17 to 23 min).Fviii: C, Fibrinogen, albumin, IgG, protein S and VWF were measured in plasma units, maxi-pools and plasmas after PR treatment and thawing.Results: There was a statistically significant (p < 0.001) but still clinically acceptable (over the recommended levels of ≥0.5 IU/mL and ≥2 g/L) reduction of FVIII:C and Fibrinogen after PR with 69% and 87% recovery, respectively. Other proteins were not significantly affected by the processes.Conclusion: Pooling 10 plasma units before the PR treatment standardises volume and protein content of plasma units. Besides the economic value of generating 12 products for transfusion, this procedure combined with a thawing time of about 5 min is of value in emergency situations and may reduce plasma wastage.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"537-542"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11653055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating utility of routine ferritin testing in blood donors: A hospital-based blood donor centre experience. 评估献血者铁蛋白常规检测的实用性：医院献血中心的经验。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-12-01 Epub Date: 2024-08-25 DOI: 10.1111/tme.13081

Philip Petersen, Hesamedin Hakimjavadi, Srikar Chamala, Gagan Mathur

{"title":"Evaluating utility of routine ferritin testing in blood donors: A hospital-based blood donor centre experience.","authors":"Philip Petersen, Hesamedin Hakimjavadi, Srikar Chamala, Gagan Mathur","doi":"10.1111/tme.13081","DOIUrl":"10.1111/tme.13081","url":null,"abstract":"Background and objectives: Iron deficiency (ID) poses a prevalent concern among blood donors, especially impacting young donors, premenopausal females and frequent donors. In alignment with recommendations to address ID, routine ferritin testing was implemented in a hospital-based donor centre.Materials and methods: Data set, encompassing 26 164 ferritin values from 16 464 blood donors over 33 months, were analysed retrospectively. Ferritin levels were assessed concerning donor characteristics such as sex, age, ethnicity and donation frequency.Results: Ferritin testing revealed age, sex and ethnicity variations, emphasising the heightened risk of ID in young females meeting all donation criteria under 23 year of age who demonstrated the lowest mean baseline ferritin (41% [CI: 34%-48%] < 26 ng/mL; 20% [CI: 14%-25%] < 15 ng/mL). Postmenopausal females exhibited ferritin levels similar to similarly aged males. Irrespective of sex, donors showcased mean ferritin recovery within 6 months. Analysis of ferritin recovery post-donation showed a five-fold increase in risk (compared with first visit) of ID when donors return at a 2-month interval. 'Regular' donors (≥10 visits) approach a median steady ferritin level (~30-35 ng/mL) by the sixth visit.Conclusion: As reliance on regular blood donors increases, donation policies must strike a balance between blood centre resources and the risks posed to both regular and at-risk donors. Frequent blood donation led to donors attaining a mean steady state ferritin level above the threshold for ID. At-risk groups, particularly premenopausal females, were several times more likely to experience ID after donation but demonstrated recovery rates similar to their group's baseline levels. This valuable information informed the development of new donor deferral policies.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"491-498"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11653056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142056616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk of transfusion-associated malaria in sub-Saharan Africa: The case of Mali. 撒哈拉以南非洲地区输血相关疟疾的风险：马里案例。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-12-01 Epub Date: 2024-11-04 DOI: 10.1111/tme.13101

Ouo-Ouo Loua, Yacouba Cissoko, Seny Chantal Loua, Issa Konaté, Hama Hamidou Issa, Boubacar Maïga, Aden Ibrahim Bouh, Mariam Soumaré, Dramane Sogoba, Oumar Magassouba, Assétou Fofana, Sounkalo Dao

{"title":"Risk of transfusion-associated malaria in sub-Saharan Africa: The case of Mali.","authors":"Ouo-Ouo Loua, Yacouba Cissoko, Seny Chantal Loua, Issa Konaté, Hama Hamidou Issa, Boubacar Maïga, Aden Ibrahim Bouh, Mariam Soumaré, Dramane Sogoba, Oumar Magassouba, Assétou Fofana, Sounkalo Dao","doi":"10.1111/tme.13101","DOIUrl":"10.1111/tme.13101","url":null,"abstract":"Introduction: Malaria is a health threat in sub-Saharan Africa, where Plasmodium is not tested in blood bags. Our objective was to determine the prevalence of plasmodial carriage in blood bags and the associated factors, and the involvement of these bags in the occurrence of malaria in recipients.Methods: From 1st April to 30th November, 2020, we conducted a prospective cross-sectional study of 348 blood bags stored at 4°C in Bamako. Using SPSS 21.0 software, statistical analyses were performed using a binary logistic regression model with a significance threshold of p < 0.05 and the odds ratio (OR) framed by its 95% confidence interval (CI).Results: During this period, 348 blood bags were transfused into 108/152 hospitalised patients, generating a transfusion frequency of 71.1%, with a prevalence of plasmodial carriage of 22%. Among the 54 initially malaria-negative recipients, all 20 (37%) who received malaria-positive blood bags and slept under long-acting insecticide-treated nets (LLINs) developed malaria. We recorded 33.3% deaths. Donor age ≤ 34 years (p = 0.011; OR = 2.55[CI.95% = 1.25-5.23]), replacement donation (p = 0.000; OR = 0.04[CI.95% = 0.0-0.19]) and not regular use of LLINs by donors (p = 0.048; OR = 0.53[CI.95% = 0.29-1]) were factors associated with plasmodial carriage of blood bags. CD4 count<200 cells/mm3 (p = 0.002; OR = 0.2[CI.95% = 0.10-0.52]), severe anaemia (p = 0.034; OR = 0.26[CI.95% = 0.10-0.90]) and decompensated anaemia (p = 0.034; OR = 3.88[CI.95% = 1.11-13.56]) were factors independently associated with recipient death.Conclusion: The prevalence of plasmodial carriage among blood donors is increasing in Mali. Transfusion malaria is a reality to be feared, with the risk increasing with the level of malaria endemicity of the blood donor.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"527-536"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142576654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pitfalls of reasoning in hospital-based transfusion medicine. 医院输血医学中的推理陷阱。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-12-01 Epub Date: 2024-10-15 DOI: 10.1111/tme.13104

Sheharyar Raza, Jeremy W Jacobs, Garrett S Booth, Jeannie Callum

{"title":"Pitfalls of reasoning in hospital-based transfusion medicine.","authors":"Sheharyar Raza, Jeremy W Jacobs, Garrett S Booth, Jeannie Callum","doi":"10.1111/tme.13104","DOIUrl":"10.1111/tme.13104","url":null,"abstract":"Introduction: Hospital-based transfusion involves hundreds of daily medical decisions. Medical decision-making under uncertainty is susceptible to cognitive biases which can lead to systematic errors of reasoning and suboptimal patient care. Here we review common cognitive biases that may be relevant for transfusion practice.Materials and methods: Biases were selected based on categorical diversity, evidence from healthcare contexts, and relevance for transfusion medicine. For each bias, we provide background psychology literature, representative clinical examples, considerations for transfusion medicine, and strategies for mitigation.Results: We report seven cognitive biases relating to memory (availability heuristic, limited memory), interpretation (framing effects, anchoring bias), and incentives (search satisficing, sunk cost fallacy, feedback sanction).Conclusion: Pitfalls of reasoning due to cognitive biases are prominent in medical decision making and relevant for hospital transfusion medicine. An awareness of these phenomena might stimulate further research, encourage corrective measures, and motivate nudge-based interventions to improve transfusion practice.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"543-549"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11653058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blood transfusion in injured older adults: A retrospective cohort study. 受伤老年人的输血情况：一项回顾性队列研究。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-12-01 Epub Date: 2024-09-28 DOI: 10.1111/tme.13099

Zhinan Liu, Zaher Kmail, Mairead Higgins, Lynn G Stansbury, Thitikan Kunapaisal, Kathleen M O'Connell, Itay Bentov, Monica S Vavilala, John R Hess

{"title":"Blood transfusion in injured older adults: A retrospective cohort study.","authors":"Zhinan Liu, Zaher Kmail, Mairead Higgins, Lynn G Stansbury, Thitikan Kunapaisal, Kathleen M O'Connell, Itay Bentov, Monica S Vavilala, John R Hess","doi":"10.1111/tme.13099","DOIUrl":"10.1111/tme.13099","url":null,"abstract":"Objectives: We asked how increasing age interacts with transfusion and mortality among older injured adults at our large regional trauma center.Background: Older adults are increasing proportions of acute trauma care and transfusion, but the specific interactions of increasing age with blood product use are unclear.Methods/materials: Trauma data (age, injury severity, mechanism, etc.) were linked with transfusion service data (type, timing and numbers of units) for all acute trauma patients treated at our center 2011-2022. Subsets of patients aged ≥55 years were identified by age decade and trends assessed statistically, p < 0.01.Results: Of 73 645 patients, 25 409 (34.5%) were aged ≥55. Within increasing 10-year age cohorts, these older patients were increasingly female (32.2%-67.2%), transferred from outside facilities (55.2%-65.9%) and injured in falls (44.4%-90.3%). Overall, patients ≥55, despite roughly equivalent injury severity, were twice as likely to be transfused (24% vs. 12.8%) as younger patients and to die during hospitalisation (7.5% vs. 2.9%). Cohort survival at all ages and levels of transfusion intensity in the first 4 h of care were more than 50%. Through age 94, numbers of red cell and whole blood units given in the first 4 h of care were a function of injury severity, not age cohort.Conclusions: In our trauma resuscitation practice, patients aged ≥55 years are more likely to receive blood products than younger patients, but numbers of units given in the first 4 h appear based on injury severity. Age equity in acute resuscitation is demonstrated.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"506-513"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abstracts for the Australian and New Zealand Society of Blood Transfusion (ANZSBT) Stream of the BLOOD 2023 Meeting, 5th - 8th November 2023, Melbourne, Australia. 澳大利亚和新西兰输血协会（ANZSBT）2023 年 BLOOD 会议流摘要，2023 年 11 月 5-8 日，澳大利亚墨尔本。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-11-01 DOI: 10.1111/tme.13103

引用次数: 0