Transfusion Medicine最新文献_第6页

An evaluation of diethylhexyl phthalate free top & bottom in-line blood collection set with a new soft housing filter. 不含邻苯二甲酸二乙基己酯的顶部和底部在线采血装置与新型软外壳过滤器的评估。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2025-02-01 Epub Date: 2024-09-07 DOI: 10.1111/tme.13091

Elena Danilova, Farshid Ezligini, Connie Stöckel, Masafumi Asakawa, Geir Hetland

{"title":"An evaluation of diethylhexyl phthalate free top & bottom in-line blood collection set with a new soft housing filter.","authors":"Elena Danilova, Farshid Ezligini, Connie Stöckel, Masafumi Asakawa, Geir Hetland","doi":"10.1111/tme.13091","DOIUrl":"10.1111/tme.13091","url":null,"abstract":"Background and objectives: Di (2-ethylhexyl) phthalate (DEHP) plasticizer must be removed from polyvinylchloride (PVC) medical devices due to toxicity. DEHP/PVC blood bags were shown to provide stable quality under blood component production and to create good storage conditions for red blood cells concentrate (RBC). It is important that substitution of the DEHP maintains the RBC quality during storage, which should be achieved with Di (isononyl) cyclohexane-1,2-dicarboxylate (DINCH), although substitution of the plasticizer has been challenging.Materials and methods: A DEHP-free Top & Bottom in-line RBC set was validated in a tertiary hospital blood bank facility. Volunteer blood donors were randomly allocated for blood collection into DINCH/PVC or DEHP/PVC set. The groups were additionally divided according to additive solution/filter combination: PAGGS-M + DINCH/PVC filter (only with DINCH/PVC set), and SAG-M + DINCH/PVC filter and SAG-M + DEHP/PVC filter (only with DEHP/PVC set). Processing and storage effects were assessed in all components.Results: RBC concentrates, platelet concentrates and plasma that was processed and stored in DEHP-free set fulfilled European requirements for quality. The cells stored in PAGGS-M after filtration through DEHP-free PVC filter showed the same low haemolysis compared with conventional set at 49 days of storage. Platelets stored in DINCH/PVC bag provided a sufficient quality of platelets after 7 days of storage. Plasma maintained the coagulation factors during 12 months of storage.Conclusion: A new DINCH/PVC set allows production of blood components of satisfactory quality in DEHP-free environment.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"82-90"},"PeriodicalIF":1.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11833214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A prospective, multi-centric study on the prevalence of dengue, zika and chikungunya in asymptomatic blood donors from different geographical regions of Brazil. 一项关于巴西不同地理区域无症状献血者中登革热、寨卡和基孔肯雅热流行的前瞻性多中心研究。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2025-02-01 Epub Date: 2024-12-12 DOI: 10.1111/tme.13119

Dante M Langhi, José E Levi, Sidneia Sanches, Renato S Cerqueira, Alvina Clara Felix, Glaciano Ribeiro, José O Bordin

{"title":"A prospective, multi-centric study on the prevalence of dengue, zika and chikungunya in asymptomatic blood donors from different geographical regions of Brazil.","authors":"Dante M Langhi, José E Levi, Sidneia Sanches, Renato S Cerqueira, Alvina Clara Felix, Glaciano Ribeiro, José O Bordin","doi":"10.1111/tme.13119","DOIUrl":"10.1111/tme.13119","url":null,"abstract":"Background and objectives: Arboviruses outbreaks are increasing in their frequency, geographical area and extension. Brazil is one of the most affected countries in the world, due to its tropical weather and favourable mosquito proliferation conditions. During outbreaks, the safety of the blood supply is a concern, in spite of the low number of transfusion-transmitted cases with clinical impact. The aim of this study was to evaluate the use of NAT for Dengue, Zika and Chikungunya RNA in actual screening.Materials and methods: Blood donors from services located in 4 Brazilian regions were invited to participate in the study and provide an extra blood sample during the collection period between February 7, 2020, and April 4, 2020. Plasma from 21 341 donations was tested in mini pools of 6 by a duplex NAT for Dengue and Chikungunya, in addition to a Zika single assay. Confirmed viremic samples were submitted to an alternative NAT and serological assays.Results: There were 33 (0.15%) Dengue RNA+ and 5 (0.02%) Chikungunya RNA+ donations. The South region showed the highest prevalence of Dengue-infected donors (0.29%). These results are in line with the incidence of these arboviruses on the respective geographical regions. Viremic units were discarded and blood services notified.Conclusion: Screening blood donors for arboviruses during the outbreak season in Brazil reveals a significant number of viremic individuals. Arbovirus NAT testing is feasible and may be incorporated to the current screening policy.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"91-96"},"PeriodicalIF":1.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transfusion sample mislabelling and wrong blood in tube in the UK: Insights from the national comparative audits of blood transfusion in 2012 and 2022. 英国输血样本贴错标签和输错血液：2012年和2022年全国输血比较审计的启示。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2025-02-01 Epub Date: 2024-08-27 DOI: 10.1111/tme.13092

Catherine Booth, Paul Davies

{"title":"Transfusion sample mislabelling and wrong blood in tube in the UK: Insights from the national comparative audits of blood transfusion in 2012 and 2022.","authors":"Catherine Booth, Paul Davies","doi":"10.1111/tme.13092","DOIUrl":"10.1111/tme.13092","url":null,"abstract":"Background: Samples for transfusion rejected due to mislabelling can lead to harm when a patient has to be re-bled or has a transfusion or procedure delayed. Electronic labelling systems which scan the patient's identification band and generate a label at their side aim to reduce mislabelling and misidentification leading to wrong blood in tube (WBIT) errors. The 2022 National Comparative audit of sample collection aimed to compare national rates of sample mislabelling and WBIT to the 2012 audit and to examine the impact of electronic systems.Method: All UK hospitals were invited to provide data on rejected transfusion samples and WBIT incidents in 1 month (October 2022) and were asked if they had electronic labelling.Results: Twenty-three thousand five hundred and eighty-four rejected samples were reported by 179 sites in 1 month. The rejection rate of 4.4% represents a 47% increase compared to 2012 (2.99%). There were 92 WBIT incidents, an incidence of 1 in 5882 samples-a 45% increase compared to 1 in 8547 in 2012. Twenty-three percent of sites can print a sample label at the patient's side, up by 224%. The six sites using only electronic sample labelling had a 46.9% lower rejection rate than sites using only hand-labelling but still reported WBIT.Conclusions: The increase in sample rejection and WBIT may reflect pressures facing clinical staff, zero tolerance policies and the two-sample rule. A human factors approach to understanding and tackling underlying reasons locally is recommended. Electronic systems are associated with fewer labelling errors, but careful implementation and training is needed to maximise their safety benefits.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"41-47"},"PeriodicalIF":1.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142081715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resuscitation of adult shocked trauma patients using major haemorrhage protocol guided by viscoelastic haemostatic assays versus formulaic approach. 使用粘弹性止血测定法指导的大出血方案与公式化方法对成人休克创伤患者进行复苏。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-12-01 Epub Date: 2024-11-08 DOI: 10.1111/tme.13109

Biswadev Mitra, Elizabeth Wake, Carly Talarico, Sarah Czuchwicki, Christine Koolstra, Don Campbell, Simon Hendel, James Winearls

{"title":"Resuscitation of adult shocked trauma patients using major haemorrhage protocol guided by viscoelastic haemostatic assays versus formulaic approach.","authors":"Biswadev Mitra, Elizabeth Wake, Carly Talarico, Sarah Czuchwicki, Christine Koolstra, Don Campbell, Simon Hendel, James Winearls","doi":"10.1111/tme.13109","DOIUrl":"10.1111/tme.13109","url":null,"abstract":"Background: The resuscitation of trauma patients with critical bleeding may follow a formulaic approach using high ratios of blood components or a viscoelastic haemostatic assay (VHA) guided approach. The aim of this study was to compare the two strategies for resuscitation of shocked trauma patients.Methods: This was a registry-based cohort study including shocked trauma patients from two trauma centres-one practising a formulaic approach, with VHA unavailable during trauma resuscitation and the other practicing a VHA-guided resuscitation strategy. The primary outcome was the total units of blood components transfused in 24 h after adjusting for differences in baseline characteristics and time to death.Results: Between 01 Jan 2020 and 31 Dec 2022, 152 eligible patients were categorised to the formulaic group and 40 to the VHA group. Prehospital times were longer in the formulaic group (2.0 vs. 1.4 h), and more patients in the VHA group (38% vs. 17%) were transfused prehospital blood components. Formulaic resuscitation was associated with significantly more blood components transfused (adjusted incidence rate ratio 1.5; 95%CI: 1.4-1.7, p < 0.001). Using a formulaic approach, patients were administered more red blood cells, plasma and platelets, but fewer cryoprecipitate. There was no significant association of the formulaic approach with in-hospital mortality (adjusted odds ratio 2.4; 95%CI: 0.7-8.0, p = 0.17).Conclusions: Given the cost and potential adverse effects of blood component transfusions, VHA-guided transfusion strategies present an attractive option, particularly among centres managing high volumes of shocked patients. Further trials, enrolling the population most likely to benefit from precision transfusion strategies, are indicated.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"514-519"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determining the strength of evidence for an association between sexual indicators and risk of acquiring HIV and sexually transmitted infections: Providing evidence for blood donation policy change. 确定性指标与感染艾滋病毒和性传播疾病风险之间关联的证据强度：为改变献血政策提供证据。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-12-01 Epub Date: 2024-07-22 DOI: 10.1111/tme.13062

Joe Flannagan, Katy L Davison, Claire Reynolds, Susan R Brailsford

{"title":"Determining the strength of evidence for an association between sexual indicators and risk of acquiring HIV and sexually transmitted infections: Providing evidence for blood donation policy change.","authors":"Joe Flannagan, Katy L Davison, Claire Reynolds, Susan R Brailsford","doi":"10.1111/tme.13062","DOIUrl":"10.1111/tme.13062","url":null,"abstract":"In 2019 the For The Assessment Of Individualised Risk (FAIR) project began a review of UK blood donor selection policy to determine if a more individualised approach to donor selection could be safely implemented. An evidence base was required to inform selection policy to move from a population to a more individual based policy, specifically what sexual behaviours/indicators should be considered as screening questions to maintain the safety of the blood supply. Eight sexual behaviours/indicators were reviewed: history of bacterial sexually transmitted infections (STIs), chemsex, number of recent partners, condom use, type of sex, sexual health service (SHS) attendance, new sexual partner and exclusivity. We conducted searches in multiple databases to identify literature looking at the association between these behaviours/indicators and HIV/STI acquisition risk. A scoring system to determine strength of evidence was devised and applied to papers that passed screening. Key studies were identified which achieved the maximum score and more in-depth reviews were conducted for these. We identified 58 studies, including 17 key studies. Strong evidence was found linking a previous bacterial STI, chemsex and increasing numbers of sexual partners to acquisition risk. Condom use, type of sex and new partners were found to have some strength of evidence for this link. SHS attendance and exclusivity had minimal evidence. We recommended that the behaviours/indicators viewed as having strong or some strength of evidence should be considered as screening questions in a more individualised approach to donor selection criteria.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"466-477"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11653059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141749148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The infected blood inquiry: Impact on public perceptions of blood supply risk, safety, and donation attitudes. 受感染血液调查：对公众对血液供应风险、安全性和捐献态度看法的影响。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-12-01 Epub Date: 2024-11-12 DOI: 10.1111/tme.13108

Richard Mills, Eva-Maria Merz, Mark Croucher, Barbara Masser, Susan R Brailsford, Robert Smith, Eamonn Ferguson

{"title":"The infected blood inquiry: Impact on public perceptions of blood supply risk, safety, and donation attitudes.","authors":"Richard Mills, Eva-Maria Merz, Mark Croucher, Barbara Masser, Susan R Brailsford, Robert Smith, Eamonn Ferguson","doi":"10.1111/tme.13108","DOIUrl":"10.1111/tme.13108","url":null,"abstract":"Background: The UK's Infected Blood Inquiry (IBI) highlighted a major public health scandal, with at least 30 000 people infected and more than 3000 deaths attributable to infected blood and blood products. This study investigates the impact of the IBI announcement on May 20, 2024, on public perceptions of blood supply risk, safety, and donation intentions in the UK compared to the USA.Methods: A 2 (country: UK vs. USA) × 2 (time: pre-, post-IBI announcement) between-within-subject study was conducted with 1635 participants (888 UK, 747 USA). Pre-IBI data were collected from May 3 to 7, 2024, and post-IBI data from May 30 to June 30, 2024. Key measures were perceived infection risk from transfusion, transfusion safety, willingness to donate and encourage others. The impact was assessed using differences-in-differences (DiD) and reliable-change-indices (RCI).Results: UK participants showed a significant but small decrease in perceived safety compared to USA participants, with 1 in 30 UK individuals perceiving a significant reduction in perceived transfusion safety. Decreases in perceived safety were associated with significant decreases in willingness to donate and encouragement of others in the whole sample and in USA participants and significant decreases in willingness to encourage others in UK participants. Older people reported a greater reduction in safety, and non-donors were more likely to be put off donating and not ask others to donate as a result of their perception that safety had been reduced.Conclusion: Overall, perceived safety decreased marginally in the UK general population. Future research should explore the long-term impacts of the IBI.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"478-490"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11653061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What is best practice for the prevention of anti-D alloimmunisation in D-negative recipients receiving solid organ transplants from D-positive donors. 在接受 D 阳性捐献者实体器官移植的 D 阴性受者中，预防抗 D 免疫的最佳做法是什么？

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-12-01 Epub Date: 2024-10-01 DOI: 10.1111/tme.13097

Thomas Lynes, Anna Mon Ying Li, Deirdre Sexton, David Nasralla, Matthew Hazell

引用次数: 0

A review of immunoglobulin use in a district general hospital setting. 地区综合医院免疫球蛋白使用情况回顾。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-12-01 Epub Date: 2024-06-25 DOI: 10.1111/tme.13059

Julie Gillies, Lorna Robertson, Debbie Tait

引用次数: 0

Charles Waller and Edward Doubleday-Colleagues of James Blundell and early supporters of blood transfusion. 查尔斯-沃勒（Charles Waller）和爱德华-道布尔戴（Edward Doubleday）--詹姆斯-布伦德尔（James Blundell）的同事，输血的早期支持者。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-12-01 Epub Date: 2024-03-22 DOI: 10.1111/tme.13036

Phil Learoyd

引用次数: 0

Validation of pathogen reduced plasmas from maxi-pools combined with fast thawing. 验证最大池与快速解冻相结合减少病原体的等离子体。

IF 1.5 4区医学

Transfusion Medicine Pub Date : 2024-12-01 Epub Date: 2024-11-05 DOI: 10.1111/tme.13106

Marja-Kaisa Auvinen, Folke Knutson, Helena Löf

{"title":"Validation of pathogen reduced plasmas from maxi-pools combined with fast thawing.","authors":"Marja-Kaisa Auvinen, Folke Knutson, Helena Löf","doi":"10.1111/tme.13106","DOIUrl":"10.1111/tme.13106","url":null,"abstract":"Objectives: Fast thawing for emergency situations and reduction of plasma wastage.Background: Evaluation of plasma units, pooled and pathogen reduced (PR) in \"maxi-pools\" with amotosalen and UVA light, and fast thawing.Methods/materials: Per replicate, 10 WB-derived leukocyte depleted plasma units were frozen within 24 h at ≤ -25°C and stored for 7 days. After thawing, a maxi-pool was constituted from the 10 units. After splitting into 4 sub-pools of 650 mL, the sub-pools were PR treated then split into 3 units resulting in 12 PR plasma units at 200 mL. Hundred and twenty PR plasma units were produced in total. The units were frozen at ≤ -25°C for 1 week, then thawed either in a fast plasma thawer for 5 min or in other control devices (17 to 23 min).Fviii: C, Fibrinogen, albumin, IgG, protein S and VWF were measured in plasma units, maxi-pools and plasmas after PR treatment and thawing.Results: There was a statistically significant (p < 0.001) but still clinically acceptable (over the recommended levels of ≥0.5 IU/mL and ≥2 g/L) reduction of FVIII:C and Fibrinogen after PR with 69% and 87% recovery, respectively. Other proteins were not significantly affected by the processes.Conclusion: Pooling 10 plasma units before the PR treatment standardises volume and protein content of plasma units. Besides the economic value of generating 12 products for transfusion, this procedure combined with a thawing time of about 5 min is of value in emergency situations and may reduce plasma wastage.","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"537-542"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11653055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0