Transfusion Medicine最新文献

{"title":"Knowledge and practice towards voluntary blood donation among University of Kerbala students.","authors":"Ghasaq Al-Rubaie, Mustafa Mulla Hasan, Nibras Tareq","doi":"10.1111/tme.70083","DOIUrl":"10.1111/tme.70083","url":null,"abstract":"<p><strong>Background: </strong>Blood donation is a life-saving practice, yet many developing countries face chronic shortages due to a lack of regular donors. This study assessed knowledge and practice of voluntary blood donation among university students, examined associations with socio-demographic factors and academic field, and identified motivators and barriers.</p><p><strong>Methods: </strong>A cross-sectional survey was conducted among third- and fourth-year students in five medical and non-medical colleges at the University of Kerbala using one-stage cluster sampling. A structured Arabic questionnaire assessed demographics, knowledge (19 items), donation history, attitudes, and information sources. Analyses included chi-square tests, univariate and multivariable logistic regression.</p><p><strong>Results: </strong>Of 730 students, 19.7% had good knowledge. Medical students scored higher than non-medical students (29.3% vs. 10.0%, p < 0.001), and females outperformed males (p = 0.04). Only 11.6% had ever donated, with substantially higher rates in males (22% vs. 4%, p < 0.001). Although non-medical students appeared more likely to donate in crude analysis (15.7% vs. 7.9%), this association disappeared after adjustment, indicating gender explained the difference. In multivariable models, medical college enrollment and blood group A independently predicted higher knowledge, while older age, male gender, higher knowledge, and smoking independently predicted donation. Non-medical students more often viewed donation as a humanitarian and religious duty, while medical students more frequently cited academic study as an information source. Altruism was the leading motivator (57.6%), and the most common barrier was never being asked to donate (50.7%).</p><p><strong>Conclusion: </strong>Knowledge and donation rates were modest. Targeted educational initiatives and increased on-campus opportunities may help translate high willingness into actual donation.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"463-474"},"PeriodicalIF":1.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147975530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cryoprecipitate utilisation, shortages and institutional policies in the United States: A survey of practices and policies.","authors":"Chinelo P Onyenekwu, Mariam Ratiani, Jenna Wade, Angela Treml","doi":"10.1111/tme.70079","DOIUrl":"10.1111/tme.70079","url":null,"abstract":"<p><strong>Background: </strong>Since the COVID-19 pandemic, demand for blood products has remained high, while donations have declined. Institutional policies guiding the use of these products may affect their availability, utilisation and waste. We surveyed blood banks (BBs) in the United States (U.S.) to assess policies and practices related to cryoprecipitate compatibility and to characterise experiences with administration, shortages and waste.</p><p><strong>Methods: </strong>An 11-question online survey was distributed to U.S. BBs via Qualtrics. Responses were exported to Excel and analysed using descriptive statistics. Variables are reported as frequencies and percentages.</p><p><strong>Results: </strong>Of 241 BBs, 82 responded (34%). Thirty-seven (45%) served community hospitals, 31 (38%) served academic hospitals and 55 (69%) served both adult and paediatric populations. Thirty (38%) BBs reported preferentially administering ABO type-specific cryoprecipitate when available, although none reported restricting transfusion exclusively to type-specific units under all circumstances. Eighteen (23%) limited the number of out-of-group units per patient within 24 h. Ten (13%) BBs reported shortages occurring at least 3-5 times per year. During shortages, 25 (61%) BBs proactively screened orders, and 14 (34%) used fibrinogen concentrate as an alternative. Annual wastage varied, with 12 (15%) BBs discarding more than 50 pooled units, often because unused units were thawed for massive transfusion protocols (MTPs). Strategies to reduce wastage included thawing units later in the MTP cycle, proactive order screening and supplementation with fibrinogen concentrate.</p><p><strong>Conclusion: </strong>Although a subset of BBs reported substantial shortages of cryoprecipitate, some institutions reported significant waste. Targeted strategies, such as limiting units administered, proactively reviewing orders, offering alternative products and modifying thawing policies for MTPs, may improve efficiency and reduce waste.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"503-510"},"PeriodicalIF":1.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Motives and barriers to blood donation among adults aged over 50 years: A qualitative analysis.","authors":"Melissa K Hyde, Barbara M Masser, Rachel Thorpe, Aaron Akpu Philip, Amanda Salmon, Theresa L Scott, Tanya E Davison","doi":"10.1111/tme.70077","DOIUrl":"10.1111/tme.70077","url":null,"abstract":"<p><strong>Background: </strong>Ageing populations will increase demand for blood-products and donors who supply them. While blood collection agencies (BCAs) typically target younger people to expand supply, recruiting donors aged 50+ is also a potential solution. However, few studies focus exclusively on this group. We aimed to explore motives, barriers, costs, benefits, and BCA support and engagement of donors and non-donors aged 50+.</p><p><strong>Methods/materials: </strong>Semi-structured interviews were conducted with 31 donors who began or returned to donating (after >25 years) aged 50+, and 28 non-donors aged 50+ who had never donated or not donated in >30 years. We used reflexive and codebook thematic analysis of data.</p><p><strong>Results: </strong>Seven themes were generated: awareness of donation, accessibility and ease of donation, health and donation, age or life-stage and donation, helping self and others, social connections, and inspiration and incentives. Donors discussed their growing capacity for donation while others planned donation around busy lifestyles. Awareness of the need for blood motivated donors, alongside their desire to give back (i.e. reciprocity). Donors uniquely discussed their health privilege enabling donation and feeling obligated to help others less healthy. Non-donors lacked information and awareness about donating. Donation sites were viewed as inaccessible and family/work priorities limited capacity. Non-donors uniquely discussed being 'too old' to donate. They felt unwanted by and invisible to BCAs who do not target them in messaging/campaigns.</p><p><strong>Conclusion: </strong>To ensure sustainability of blood supplies and avoid marginalising those aged 50+, BCAs should be more inclusive with greater awareness raising, targeted marketing, and maximising accessible donation opportunities.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"442-462"},"PeriodicalIF":1.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670400/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147475293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abstracts from the SHOT Symposium 2025.","authors":"","doi":"10.1111/tme.70119","DOIUrl":"https://doi.org/10.1111/tme.70119","url":null,"abstract":"","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":"36 Suppl 3 ","pages":"4-22"},"PeriodicalIF":1.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149228722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abstracts from the SHOT Symposium 2024.","authors":"","doi":"10.1111/tme.70118","DOIUrl":"https://doi.org/10.1111/tme.70118","url":null,"abstract":"","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":"36 Suppl 2 ","pages":"4-19"},"PeriodicalIF":1.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149228760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isoagglutinin dynamics and transfusion dependency after ABO-incompatible haematopoietic stem cell transplants.","authors":"C C Archana, Suryatapa Saha, Shashank Ojha, Navin Khattry, Sachin Punatar, Anant Gokarn, Akanksha Chichra, Sumeet Mirgh, Gourav Bain, Libin Mathew, Amol Tirlotkar","doi":"10.1111/tme.70080","DOIUrl":"10.1111/tme.70080","url":null,"abstract":"<p><strong>Background: </strong>ABO incompatibility is common in allogeneic haematopoietic stem cell transplantation (HSCT) and may delay erythroid recovery and prolong transfusion support. Data correlating post-transplant isoagglutinin kinetics with transfusion dependency is limited.</p><p><strong>Methods: </strong>We retrospectively analysed ABO-incompatible allogeneic HSCTs performed between June 2008 and December 2023. Patients were classified as major, minor or bidirectional incompatibility. Serial Immunoglobulin M (IgM) and Immunoglobulin G (IgG) anti-A and anti-B isoagglutinin titres were monitored post-transplant. Time to isoagglutinin disappearance, donor red blood cell (RBC) appearance and associations with packed red blood cell (PRBC) and single donor platelet (SDP) transfusion requirements were evaluated.</p><p><strong>Results: </strong>Among 459 allogeneic HSCTs, 183 (39.9%) were ABO-incompatible. Median isoagglutinin disappearance was 28 days in major and 38.5 days in bidirectional incompatibility, with delayed donor RBC appearance in the latter. Anti-A isoagglutinins persisted longer than anti-B. Persistent isoagglutinins correlated with increased early PRBC and SDP transfusion requirements.</p><p><strong>Conclusions: </strong>Isoagglutinin kinetics vary by ABO incompatibility type and are associated with early transfusion dependency after HSCT.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"492-502"},"PeriodicalIF":1.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Timing of intrapartum transfusion among obstetric patients, stratified by admission and discharge haemoglobin, relative to anaesthesia care: A retrospective cohort study.","authors":"Franklin Dexter, Richard H Epstein, Unyime S Ituk","doi":"10.1111/tme.70082","DOIUrl":"10.1111/tme.70082","url":null,"abstract":"<p><strong>Background: </strong>We previously validated and implemented criteria for auditing anaesthesiologists with intraoperative transfusion based on low median blood loss of the surgical procedure or absence of anaemia before transfusion. However, obstetrical cases were excluded during implementation, as the peripartum blood management protocol does not include haemoglobin determinations, matching American College of Obstetricians and Gynaecologists recommendations. For non-obstetrical surgery, intraoperative transfusion is associated with an increased probability of postpartum transfusion. Because of the obstetrical transfusion approach, we hypothesized the opposite relationship between intrapartum and postpartum transfusion.</p><p><strong>Methods: </strong>The retrospective cohort study included all 30 160 patients who delivered at the University of Iowa January 2013 through March 2025.</p><p><strong>Results: </strong>Any RBC administration during anaesthesia care reduced the odds of later transfusion (odds ratio 0.14, 99% confidence interval (CI) 0.11%-0.18%). Single-unit RBC administration during anaesthesia reduced such odds (0.09, 99% CI 0.06%-0.11%), as did multiple-unit transfusion (0.18, 99% CI 0.13%-0.24%). McNemar tests had Bonferroni-adjusted p-values <0.0001. While antepartum anaemia (haemoglobin <11 g/dL) increased the probability of transfusion by 7.41% (standard error 0.43%) outside of anaesthesia care, the RBC transfusion decision during anaesthesia care was less influenced by anaemia, 1.52% (0.22%), p < 0.0001. Many (59%, 99% CI 50%-69%) RBC units started during anaesthesia care were administered to patients who were not anaemic (haemoglobin ≥11 g/dL) at admission. Most patients with single-unit RBC transfusion and blood loss <2500 mL had stable haemodynamics.</p><p><strong>Conclusions: </strong>Unlike several categories of non-obstetrical procedures, RBC transfusion during anaesthesia care for delivery was associated with a reduced probability of postpartum RBC transfusion. A reasonable approach for blood bank auditing of anaesthesiologists' obstetric RBC transfusion decision-making would be to review cases when RBC were administered, there was blood loss <2500 mL, no subsequent transfusion, and discharge haemoglobin ≥9 g/dL.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"475-483"},"PeriodicalIF":1.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved blood component quality and processing efficiency with a fully automated whole blood preparation system.","authors":"Sinan Demircioğlu, Melda Cömert, Mehtap Yücel, İsmail Yaşar Avcı","doi":"10.1111/tme.70125","DOIUrl":"https://doi.org/10.1111/tme.70125","url":null,"abstract":"<p><strong>Background: </strong>Automation in blood component preparation has emerged as a key strategy to improve standardisation, reduce operator-dependent variability, and enhance product quality and workflow efficiency. However, comparative real-world data between fully automated (FA) and semi-automated (SA) systems remain limited.</p><p><strong>Methods: </strong>In this retrospective study, a total of 699 blood component units, including 400 red blood cell concentrates (RCC), 199 pooled platelet concentrates (PPC), and 100 fresh frozen plasma (FFP) units prepared between June 2024 and June 2025, were analysed. Quality parameters such as volume, haemoglobin (Hb), total Hb content, haematocrit (Hct), hemolysis, potassium, platelet count, leukocyte count, pH, and Factor VIII activity were compared between FA and SA systems. Preparation times were also evaluated.</p><p><strong>Results: </strong>The FA system significantly reduced preparation time for all blood components (p< 0.001). RCC units produced by FA demonstrated higher volume, weight, Hb, and Hct levels, along with lower haemolysis rates and potassium concentrations (p< .05). FA-prepared PPC units showed reduced leukocyte contamination and improved platelet yield, particularly in six-pool concentrates, while maintaining comparable pH values. In FFP analysis, erythrocyte counts, pH, and Factor VIII activity were similar between systems; however, FA units exhibited significantly lower leukocyte levels, whereas SA units had higher volume and weight (p< 0.05).</p><p><strong>Conclusion: </strong>Fully automated whole blood preparation systems significantly enhance operational efficiency and improve key quality parameters of blood components compared with semi-automated methods. The adoption of automation may contribute to improved transfusion safety, better resource utilisation, and greater standardisation in blood component preparation.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative intravenous iron and red blood cell transfusion requirements in elderly intertrochanteric femoral fractures.","authors":"Keong-Hwan Kim, Gill Song, Yeon Sik Heo, Jinwon Jang, Woo Dong Nam","doi":"10.1111/tme.70121","DOIUrl":"https://doi.org/10.1111/tme.70121","url":null,"abstract":"<p><strong>Background: </strong>Intravenous (IV) iron is used in patient blood management for elderly patients with hip fractures, but its effectiveness in reducing red blood cell (RBC) transfusion remains unclear. This study evaluated the effect of preoperative IV iron on perioperative RBC transfusion volume and identified associated factors.</p><p><strong>Methods: </strong>We retrospectively reviewed 307 patients aged ≥65 years who underwent cephalomedullary nailing for intertrochanteric femoral fractures between 2018 and 2021. From November 2020, patients routinely received preoperative IV iron; earlier patients did not (180 non-IV iron and 127 IV iron). Patient, fracture, surgical and transfusion variables were compared. Multiple regression identified factors associated with total perioperative transfusion volume.</p><p><strong>Results: </strong>Total perioperative RBC transfusion volume did not differ between the non-IV iron and IV iron groups (292.1 vs. 272.7 mL, p = 0.868). In multiple regression analysis, significant predictors were AO Foundation/Orthopaedic Trauma Association fracture classification (β = 73.1 mL, 95% confidence interval [CI] 32.4-113.7, p < 0.001), spinal anaesthesia (β = -78.9 mL, 95% CI -144.3 to -13.5, p = 0.018), operative time (β = 2.9 mL/min, 95% CI 0.5-5.2, p = 0.020) and admission haemoglobin level (β = -94.6 mL/g/dL, 95% CI -111.1 to -78.1, p < 0.001). Preoperative IV iron was not independently associated with transfusion volume (β = -49.7 mL, 95% CI -103.1 to 3.7, p = 0.068).</p><p><strong>Conclusion: </strong>Preoperative IV iron did not significantly reduce perioperative RBC transfusion requirements in elderly patients with intertrochanteric femoral fractures. Shorter operative time and spinal anaesthesia were associated with lower transfusion volume.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149040873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing key performance indicators using routinely collected healthcare data in obstetric patient blood management: A multi-stage consensus study.","authors":"Kate Fletcher, Hayley Evans, Asma Tameez-Uddin, Gurman Kaur, Akshay Shah, Robbie Foy, Michael F Murphy, Simon J Stanworth, Susan Robinson","doi":"10.1111/tme.70115","DOIUrl":"https://doi.org/10.1111/tme.70115","url":null,"abstract":"<p><strong>Background: </strong>Patient blood management (PBM) including appropriate red blood cell (RBC) transfusion underpins the management of severe anaemia and haemorrhage during pregnancy, delivery and postpartum. However, there is marked variation in practice despite guidelines and standards. Key performance indicators (KPIs) can identify deviation from agreed standards, support benchmarking and guide efforts to improve outcomes. We aimed to develop a set of obstetric PBM KPIs which may be measured from routinely collected electronic health records.</p><p><strong>Methods: </strong>We undertook a three-stage process. First, we completed a scoping review to identify potential KPIs from relevant literature and clinical guidelines. Second, we conducted a modified RAND consensus process with a multidisciplinary panel of medical professionals. The consensus panel rated potential KPIs according to importance and feasibility. Third, our research team undertook a 'sense check' to refine and make the final selection of the KPIs.</p><p><strong>Results: </strong>Out of 25 candidate KPIs initially identified, we derived a final set of 10 KPIs covering PBM in obstetrics and the RBC transfusion practice. Fifteen candidate KPIs were rejected: 6 KPIs were judged neither important nor feasible, 2 not feasible for further study at the current time, 2 not important to the general obstetric population and 5 represented organisation of care, rather than clinical practice.</p><p><strong>Conclusions: </strong>Using a systematic, stepwise, transparent approach, we have developed a set of 10 KPIs based on routine health data sources to monitor and guide improvement of PBM implementation, particularly RBC transfusion practice in obstetrics. These KPIs now require further field testing using routinely collected data.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148945664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}