Transfusion Medicine最新文献

{"title":"Two novel variant allele of the RHD gene detected in two Chinese blood donors with the RHD negative phenotype.","authors":"Qiuhong Mo, Xuejun Liu, Mingshuang Lai, Rongji Lai, Limin Chen, Baoren He","doi":"10.1111/tme.70001","DOIUrl":"10.1111/tme.70001","url":null,"abstract":"<p><strong>Background: </strong>The D antigen is the most clinically important antigen in the Rh system due to its high immunogenicity and being the main cause of hemolytic disease of the foetus and newborns (HDFN). High polymorphism of the RHD gene implicates that new RHD variant alleles may be regularly identified.</p><p><strong>Study design and methods: </strong>D antigen status was examined using saline tubes with IgM anti-D (clone RUM-1). If a negative result was observed, indirect antiglobulin test (IAT) and adsorption-elution test were performed with four monoclonal anti-D reagents. A D-screen identification kit was used for partial D identification. All 10 exons of the RHD gene plus flanking intronic regions were amplified and sequenced.</p><p><strong>Results: </strong>The serological investigation showed clearly negative results with all anti-D reagents used when testing against both probands RBCs. The sequencing results of probands revealed c.802-1G>C mutation in proband 1 and c.1154-2A>T mutation in proband 2. These mutations resulted in the change of 3' splice site in the intron-exon junction of intron 5 or intron 8 of the RHD gene from AG to AC or TG, abolishing the splicing effect.</p><p><strong>Conclusions: </strong>We identified two novel splicing variants resulting from c.802-1G>C and c.1154-2A>T mutations in the RHD gene. Both mutations may abolish the splicing effect of the involved exons, leading to the D-negative phenotype.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":"35 5","pages":"494-497"},"PeriodicalIF":1.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12499640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Clinical Significance of Warm Autoantibodies during Pregnancy.","authors":"Emmanuel A Fadeyi, Joshua Cox-Jones, Amit K Saha, Daniel Katz, Bettina Turner, Christina S Warren, Gregory J Pomper","doi":"10.1111/tme.70008","DOIUrl":"10.1111/tme.70008","url":null,"abstract":"<p><strong>Objectives: </strong>The objective of the current study is to determine the clinical significance of a warm autoantibody detected in patients during pregnancy.</p><p><strong>Background: </strong>There are few published studies concerning the clinical significance of warm autoantibodies during pregnancy. The risk to the fetus is determined by the IgG autoantibody's ability to cross the placental barrier.</p><p><strong>Materials and methods: </strong>Existing data of all obstetric patients who had a positive antibody screen with a warm autoantibody diagnosis during their pregnancy in the last 7 years from August 2016 to October 2023 were reviewed. If positive, a direct antiglobulin test (DAT) and an eluate were performed. Statistical analysis was performed to determine the clinical significance of warm autoantibody in pregnant patients. Data collected included blood type, race, age, BMI, the most recent hemoglobin before delivery, and gestation in weeks.</p><p><strong>Results: </strong>Between August 2016 and October 2023, 23 510 pregnant patients had blood type and antibody screen completed at our institution. A total of 812 (3.5%) patients had a positive antibody screen. Only 16 (<2.0%) patients had a positive DAT and eluate confirmation of a warm autoantibody. None of the 16 patients had a previous history of warm autoantibody. 14/16 mothers did not experience an AIHA or HDFN in the newborns.</p><p><strong>Conclusion: </strong>Pregnancy-induced warm autoantibody appears to be harmless for most mothers and their babies. The detection of a warm autoantibody in pregnancy may reflect a potential risk for both the mother and the child; however, on follow up, there were no clinical complications associated with warm autoantibodies in our patient cohort.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"470-475"},"PeriodicalIF":1.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12499641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The hemolytic activity of ABO antibodies: Correlation between quantitative tests, complement-mediated hemolysis assay (CHUHE-P), and IgG subclasses.","authors":"Sidneia Sanches de Menezes Costa, Beatriz Girardo, Thamy Caroline Silva, Karen Ziza, Glaciano Ribeiro, Dante M Langhi, Carla Luana Dinardo, José O Bordin","doi":"10.1111/tme.70005","DOIUrl":"10.1111/tme.70005","url":null,"abstract":"<p><strong>Background: </strong>ABO antibodies can activate complement and cause hemolysis, sometimes with ABO minor incompatible platelet or plasma transfusions. Donor low titres of anti-ABO are used to assess transfusion safety. However, the correlation between antibody titres (measured semi-quantitatively or quantitatively) and their ability to activate complement is unclear.</p><p><strong>Objectives: </strong>This study aimed to correlate ABO antibody (IgM/IgG) titres and the presence of IgG1/IgG3 subclasses with complement-mediated haemolysis using the CHUHE-P assay (Complement Hemolysis Using Human Erythrocytes).</p><p><strong>Methods: </strong>Single-center blood group O donor samples were tested with semi-quantitative methods and classified in group 1 as low ABO titres if titre <100 and into group 2 as high ABO titre if titre >100. Testing included IgM/IgG antibody titration, the CHUHE-P assay, haemolysin test, and determination of IgG1/IgG3 subclasses.</p><p><strong>Results: </strong>Group 1 had 21 and Group 2 had 56 blood donors. In Group 2, CHUHE-P positivity was not associated with IgM or IgG anti-A/B titres or haemolysin test results. IgG1 and IgG3 subclasses of anti-A were significantly associated with positive CHUHE-P. Significant differences between groups included CHUHE-P positivity (p < 0.001), IgG titres (p < 0.01) for anti-A, and CHUHE-P positivity (p < 0.001), IgM titres (p = 0.04), and haemolysin test (p = 0.02) for anti-B. In Group 1, 33% of anti-A and 23.8% of anti-B had positive CHUHE-P.</p><p><strong>Conclusions: </strong>This study aimed to compare the ability of anti-ABO antibodies to cause complement-mediated hemolysis measured by the CHUHE-P test and the results of semi-quantitative/quantitative titration assays, the presence of IgG1 and/or IgG3, and hemolysin test results, where we highlighted an inconsistent association between the methods; the positivity for CHUHE-P was associated with the subclasses of antibodies IgG1 and IgG3.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"458-469"},"PeriodicalIF":1.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144804934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation of a patient blood management programme for platelet therapy among haemato-oncology patients-A quasi-experimental study.","authors":"Vaidehi Prasanth, Daljit Kaur, Gita Negi, Gaurav Dhingra, Ashish Jain, Xavier Belsiyal, Chanchi B Khiamniungan","doi":"10.1111/tme.70016","DOIUrl":"https://doi.org/10.1111/tme.70016","url":null,"abstract":"<p><strong>Background: </strong>The paucity of data pertaining to the implementation of the patient blood management (PBM) programme for platelet transfusion for improved patient outcomes with minimal risks motivated this study. The study aimed to implement an effective PBM programme for platelet transfusion therapy among haemato-oncology patients evaluating transfusion appropriateness and educational intervention for dedicated platelet transfusion practitioners (PtP).</p><p><strong>Study designs and methods: </strong>A quasi-experimental study was conducted for 1 year after Institutional ethics committee (IEC) (as shown in Annexure I) which included pre-intervention, intervention and post-intervention phases for four months each. The study involved platelet auditing, online survey questionnaires, educational intervention for the platelet transfusion practitioners (PtP) and feedback for user satisfaction.</p><p><strong>Results: </strong>The platelet audit showed statistically significant improvement (chi-square test, p < 0.05) in transfusion appropriateness, completeness of the forms filled, number of single donor apheresis procedures, ABO compatible transfusions and thereby reduction in platelet refractory cases during the post-intervention phase compared to the pre-intervention. The online survey showed improvement in self perceived knowledge and practice for all the stakeholders during the post-intervention period.</p><p><strong>Conclusion: </strong>The introduction of platelet transfusion practitioners and the educational sessions they underwent, had a significant impact in achieving transfusion appropriateness for platelet therapy and they gained the ability to prioritise medical emergencies, optimise platelet inventory management and minimise wastage. Educational interventions have enhanced practitioners knowledge and sensitised them to adhere to standard evidence-based platelet transfusion guidelines.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145178923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Guideline for the investigation and management of red cell antibodies in pregnancy: A British Society for Haematology guideline\".","authors":"","doi":"10.1111/tme.70013","DOIUrl":"https://doi.org/10.1111/tme.70013","url":null,"abstract":"","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145150612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytomegalovirus-selected blood components in allogeneic stem cell transplantation: A follow-up survey of English transplant centre practices.","authors":"Oliver Firth, Suzy Morton","doi":"10.1111/tme.70014","DOIUrl":"https://doi.org/10.1111/tme.70014","url":null,"abstract":"<p><strong>Background: </strong>Cytomegalovirus (CMV) infection remains a major cause of morbidity and mortality after allogeneic stem cell transplantation (aSCT). In 2012, the UK Advisory Committee for the Safety of Tissues and Organs (SaBTO) recommended that CMV-unselected (CMV-U) blood components could be safely transfused to this population without increasing the risk of transfusion-transmitted CMV (TTI-CMV). A 2015 survey of UK transplant centres found that 22.7% of aSCT centres did not follow this recommendation. In response, a subsequent good practice paper addressed concerns regarding the determination of pre-transplant CMV serostatus. Annual Serious Hazards of Transfusion (SHOT) reports continue to reassure, with no emerging safety concerns linked to the increased use of CMV-U blood components in this setting.</p><p><strong>Objectives: </strong>To clarify changes in English practice regarding the provision of CMV-U blood components for potential allogeneic stem cell recipients and to identify factors contributing to the continued use of CMV-seronegative (CMV-N) blood components outside SaBTO recommendations.</p><p><strong>Methods: </strong>We surveyed English aSCT centres to establish current practices and perceptions.</p><p><strong>Results: </strong>Of the 32 English transplant centres, 28 responded (88%), 19 adult and nine paediatric centres; 10.7% continue to provide CMV-N components to all CMV-N potential aSCT recipients. Cited reasons include concerns for patients with primary immunodeficiency syndromes and a misperception that TTI-CMV is a 'never event'. Furthermore, 17.9% of centres continue to provide CMV-N components contrary to SaBTO recommendations, citing risks of CMV disease in primary immunodeficiency syndromes, resolution of ambiguous CMV serostatus, and HIV infection.</p><p><strong>Conclusion: </strong>Adherence to SaBTO guidance on transfusion of CMV-U blood components to aSCT recipients continues to improve, but further changes are likely to be challenging, based on the survey responses received and may require international collaboration.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reducing blood component wastage through targeted interventions: A four-year retrospective study at a Saudi tertiary hospital.","authors":"Wajnat A Tounsi, Osama A Alzahrani, Ahmed G Bukhari, Raed M Garout, Raed I Felimban, Ruqaia H Al-Musallam, Waleed M Bawazir, Hadeel Al Sadoun, Majed R Algarni, Walaa H AlAmoudi, Nawaf M Alomayri, Mohammed A Labban, Sara S Alghamdi, Nora Y Hakami","doi":"10.1111/tme.70015","DOIUrl":"10.1111/tme.70015","url":null,"abstract":"<p><strong>Background: </strong>Blood transfusion services are vital to healthcare; however, blood component wastage remains a persistent challenge for transfusion facilities, impacting resource efficiency and patient care. In this four-year retrospective before-and-after study, we investigated blood component wastage at a tertiary hospital in Saudi Arabia to identify key causes of wastage and evaluate the impact of targeted interventions introduced in 2024.</p><p><strong>Methods: </strong>Statistical analyses included z-tests for rate comparisons, effect size estimation using Cohen's h, and 95% confidence intervals (CIs) to assess the impact of the interventions.</p><p><strong>Results: </strong>From 2021 to 2024, 83,185 components were prepared and 13,954 units were discarded. Between 2021 and 2023, the average waste rate was 19.44%. Leading causes included expiration (28.40%), TTI screening reactivity (20.11%), and low platelet yield (18.39%). Following the 2024 implementation of targeted measures-including improved inventory policies, donor screening, and transfusion practices-total waste declined by 35.71% (p < 0.001, 95% CI: 0.016 to 0.024), with a moderate effect size (Cohen's h = 0.20). Total monthly waste rates were also significantly reduced (mean difference of 7.73 percentage points; p < 0.001, 95% CI: 4.87% to 10.59%, Cohen's d = 2.29). The WAPI scores improved across all components, and associated costs were reduced by 15.9%, saving approximately SAR 171366 (US$45856).</p><p><strong>Conclusion: </strong>These findings demonstrate the effectiveness of interventions for reducing blood component wastage and enhancing transfusion service efficiency. Ongoing monitoring and continuous quality improvement are essential to sustain these outcomes and further optimize transfusion practices.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Red blood cell ordering pattern following the introduction of a transfusion procedure based on haemoglobin concentration and anaemia symptoms: A retrospective study.","authors":"Julia Lipina, Piotr F Czempik","doi":"10.1111/tme.70019","DOIUrl":"https://doi.org/10.1111/tme.70019","url":null,"abstract":"<p><strong>Introduction: </strong>Implementation of transfusion guidelines might be poor due to a lack of awareness and strong practice habits. The study aimed to evaluate the impact of a new guideline-based, locally adjusted transfusion procedure on physicians' ordering patterns in a large academic medical centre.</p><p><strong>Materials and methods: </strong>The study was a single-centre, retrospective study, analyzing period between January 2022 and December 2023. The study period was divided into three phases according to the procedure introduction: pre-introduction (January 2022-June 2022), introduction (July 2022-December 2022) and post-introduction (January 2023-December 2023, subdivided into 6-month periods). The new procedure was aimed at adult non-bleeding patients. Data on red blood cell (RBC) transfusions were obtained from a blood bank inventory and electronic health records. The appropriateness of transfusions was assessed against the newly introduced RBC procedure.</p><p><strong>Results: </strong>During the study period, 2413 out of 3686 (65.5%) RBCs were transfused for the indication of \"anaemia\". The number of transfused RBCs between 2022 and 2023 decreased by 467 (32.4%) units. The appropriateness of RBC transfusions increased from 53.6% in the pre-introduction phase to 79.1% by the end of the post-introduction phase. There was a decrease in median pre- and post-transfusion haemoglobin (Hb) concentration, from 73 (IQR 66-78) and 91 (IQR 80-99) to 67 (IQR 60-73) and 84 (IQR 75-93) g L^-1, respectively. The post-introduction phase showed sustained improvement in the appropriateness of RBC transfusions.</p><p><strong>Conclusions: </strong>The newly implemented RBC transfusion procedure, based on haemoglobin concentration and anaemia symptoms, supported by specific transfusion indications integrated into the computerised physician order entry system, resulted in a significant decrease in transfusions and an increase in appropriate transfusions. This improvement was sustained in the long term.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145070528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the effects of a hospital utilisation improvement program on platelet transfusions: A pre-post study.","authors":"Piotr F Czempik, Jakub Rudzki, Michał Porada","doi":"10.1111/tme.70017","DOIUrl":"https://doi.org/10.1111/tme.70017","url":null,"abstract":"<p><strong>Background: </strong>Annually millions of platelet concentrate (PC) are transfused worldwide. The decision regarding PC transfusion is often complex; therefore, the implementation of a hospital programme designed to streamline and facilitate the decision-making process is beneficial. Such a programme helps standardise transfusion practices, ensures that PCs are used appropriately, while also optimising patient outcomes.</p><p><strong>Objectives: </strong>The study aimed to analyse the impact of a new hospital utilisation improvement programme on PC transfusions.</p><p><strong>Methods/materials: </strong>We performed a retrospective analysis of all PC transfusions in adult patients hospitalised in our large academic medical centre. The analysed time covered 12-month periods before and after the introduction of the program, which was based on the most recent clinical practice guidelines from the Association for the Advancement of Blood and Biotherapies. Indications for PC transfusion were divided into prophylactic and therapeutic. The new program was made available on the hospital intranet, obligatory e-learning was required from all clinical and laboratory personnel, and a computerised physician order entry was modified.</p><p><strong>Results: </strong>The transfusion rate in the whole analysed period was 0.17%. The median pre-transfusion platelet count before and after implementation of the programme was 28 (IQR 15.0-50.0) and 24 (IQR 12.0-42.0) × 10⁹/L, respectively. Percentage of therapeutic transfusions increased from 46.7% to 57.7%. Overall the appropriateness of transfusions went up from 48.4% to 59.9%, and was higher for therapeutic (70.2% vs. 60.0%) than prophylactic (45.8% vs. 38.3%) transfusions.</p><p><strong>Conclusion: </strong>Simple hospital utilisation improvement programme, adjusted to the local population and backed by e-learning and modification of a computerised physician order entry, can lead to a more restrictive use of PC transfusions in patients with thrombocytopenia.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145065408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, attitude, and practice studies on hemovigilance in India: A critical appraisal.","authors":"Radheshyam Meher, Aparna Krishna, Gopal Patidar","doi":"10.1111/tme.70011","DOIUrl":"10.1111/tme.70011","url":null,"abstract":"<p><p>Hemovigilance is essential for monitoring, analysing, and preventing adverse transfusion reactions. Hemovigilance Programme of India (HvPI), launched in 2012, aims to improve transfusion safety. However, challenges such as limited knowledge and underreporting persist, necessitating a critical appraisal of existing Knowledge, Attitude, and Practice (KAP) studies to guide future interventions. A systematic literature search was conducted using Google, PubMed, Scopus, Web of Science, and Google Scholar, focusing on KAP studies on hemovigilance in India published post-2012. Keywords included \"hemovigilance,\" \"blood transfusion safety,\" \"adverse transfusion reactions,\" and \"KAP studies,\" combined with \"India\" and \"healthcare professionals.\" Filters for peer-reviewed, English-language studies were applied, and references were reviewed. Studies were appraised using the AXIS tool. Thirteen studies, with 1684 participants from teaching hospitals and tertiary care centres, were included. Most studies were conducted by pharmacology departments (84.6%), predominantly in western India (79.8%). While awareness of transfusion reactions was high, knowledge of reporting mechanisms and hemovigilance programmes was poor. Barriers included lack of training, time constraints, and fear of legal repercussions. Only one study met an acceptable quality score (≥16/20) on AXIS tool, while others demonstrated methodological weaknesses, inadequate sample size justification, lack of non-responder analysis, and insufficient statistical rigour. Despite highlighting the importance of KAP assessments in hemovigilance, the studies' geographical limitations and methodological constraints hinder generalisability. Future research should employ robust methodologies, expand geographical representation, and include diverse populations to enhance hemovigilance practices in India. Strengthening hemovigilance systems through coordinated efforts is essential for improving transfusion safety nationwide.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}