Transfusion Medicine最新文献

{"title":"Evaluating the effects of a hospital utilisation improvement program on platelet transfusions: A pre-post study.","authors":"Piotr F Czempik, Jakub Rudzki, Michał Porada","doi":"10.1111/tme.70017","DOIUrl":"https://doi.org/10.1111/tme.70017","url":null,"abstract":"<p><strong>Background: </strong>Annually millions of platelet concentrate (PC) are transfused worldwide. The decision regarding PC transfusion is often complex; therefore, the implementation of a hospital programme designed to streamline and facilitate the decision-making process is beneficial. Such a programme helps standardise transfusion practices, ensures that PCs are used appropriately, while also optimising patient outcomes.</p><p><strong>Objectives: </strong>The study aimed to analyse the impact of a new hospital utilisation improvement programme on PC transfusions.</p><p><strong>Methods/materials: </strong>We performed a retrospective analysis of all PC transfusions in adult patients hospitalised in our large academic medical centre. The analysed time covered 12-month periods before and after the introduction of the program, which was based on the most recent clinical practice guidelines from the Association for the Advancement of Blood and Biotherapies. Indications for PC transfusion were divided into prophylactic and therapeutic. The new program was made available on the hospital intranet, obligatory e-learning was required from all clinical and laboratory personnel, and a computerised physician order entry was modified.</p><p><strong>Results: </strong>The transfusion rate in the whole analysed period was 0.17%. The median pre-transfusion platelet count before and after implementation of the programme was 28 (IQR 15.0-50.0) and 24 (IQR 12.0-42.0) × 10⁹/L, respectively. Percentage of therapeutic transfusions increased from 46.7% to 57.7%. Overall the appropriateness of transfusions went up from 48.4% to 59.9%, and was higher for therapeutic (70.2% vs. 60.0%) than prophylactic (45.8% vs. 38.3%) transfusions.</p><p><strong>Conclusion: </strong>Simple hospital utilisation improvement programme, adjusted to the local population and backed by e-learning and modification of a computerised physician order entry, can lead to a more restrictive use of PC transfusions in patients with thrombocytopenia.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145065408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, attitude, and practice studies on hemovigilance in India: A critical appraisal.","authors":"Radheshyam Meher, Aparna Krishna, Gopal Patidar","doi":"10.1111/tme.70011","DOIUrl":"10.1111/tme.70011","url":null,"abstract":"<p><p>Hemovigilance is essential for monitoring, analysing, and preventing adverse transfusion reactions. Hemovigilance Programme of India (HvPI), launched in 2012, aims to improve transfusion safety. However, challenges such as limited knowledge and underreporting persist, necessitating a critical appraisal of existing Knowledge, Attitude, and Practice (KAP) studies to guide future interventions. A systematic literature search was conducted using Google, PubMed, Scopus, Web of Science, and Google Scholar, focusing on KAP studies on hemovigilance in India published post-2012. Keywords included \"hemovigilance,\" \"blood transfusion safety,\" \"adverse transfusion reactions,\" and \"KAP studies,\" combined with \"India\" and \"healthcare professionals.\" Filters for peer-reviewed, English-language studies were applied, and references were reviewed. Studies were appraised using the AXIS tool. Thirteen studies, with 1684 participants from teaching hospitals and tertiary care centres, were included. Most studies were conducted by pharmacology departments (84.6%), predominantly in western India (79.8%). While awareness of transfusion reactions was high, knowledge of reporting mechanisms and hemovigilance programmes was poor. Barriers included lack of training, time constraints, and fear of legal repercussions. Only one study met an acceptable quality score (≥16/20) on AXIS tool, while others demonstrated methodological weaknesses, inadequate sample size justification, lack of non-responder analysis, and insufficient statistical rigour. Despite highlighting the importance of KAP assessments in hemovigilance, the studies' geographical limitations and methodological constraints hinder generalisability. Future research should employ robust methodologies, expand geographical representation, and include diverse populations to enhance hemovigilance practices in India. Strengthening hemovigilance systems through coordinated efforts is essential for improving transfusion safety nationwide.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serologic investigation and management of an antibody screen negative para-Bombay phenotype during pregnancy.","authors":"Yaseen Ali Jamal, Joshua Alston Nicholas, Tong Wang, Mohamed Abdelmonem, Suchitra Pandey, Mrigender Singh Virk","doi":"10.1111/tme.70000","DOIUrl":"10.1111/tme.70000","url":null,"abstract":"<p><strong>Background: </strong>Individuals with Bombay and para-Bombay red blood cell (RBC) phenotypes produce anti-H antibodies associated with acute haemolytic transfusion reactions. The rarity of compatible donor units creates unique logistical challenges, especially during pregnancy as the onset of labour and fetal distress can occur without warning.</p><p><strong>Case report: </strong>A 24-year-old female at 38 weeks gestation presented with breech fetal position and reported anti-H antibodies. Critically, the in-house antibody screen was negative by automated solid-phase red cell adherence (SPRCA), while manual testing subsequently demonstrated anti-H antibodies. Forward typing with Ulex europaeus lectin confirmed the absence of H-antigen on RBCs, while Lewis phenotyping and saliva neutralisation revealed H-antigen in secretions, consistent with the para-Bombay phenotype. Three frozen Bombay RBC units were obtained from a nationwide search, and four cross-match compatible non-Bombay (O-positive) units were also prepared. An external cephalic version (ECV) was originally planned since vaginal delivery carries lower bleeding risk than caesarean section (CS). However, acknowledging the unpredictability of ECV, the challenge of timing thawed units, and the possibilities of massive haemorrhage versus wasting rare donor blood, an elective CS was ultimately preferred. Delivery was uneventful without transfusion needs.</p><p><strong>Conclusion: </strong>This case highlights key considerations regarding serologic identification, blood product management, and interdisciplinary clinical decision-making for patients with Bombay and para-Bombay phenotypes. First, automated SPRCA testing may provide false negative results for anti-H antibodies. Second, backup transfusion strategies for para-Bombay patients may include non-Bombay RBCs. Finally, the procurement, preparation, and use of rare blood products requires thoughtful deliberation between multiple care providers.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"399-402"},"PeriodicalIF":1.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144627171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge and practices in transfusion regarding bedside compatibility test: Insights from a monocentric observational study.","authors":"Ikbel Ghachem, Dorra Baccouche, Mohamed Yassine Kaabar, Ichrak Ghachem, Haifa Tounsi, Asma Bachali","doi":"10.1111/tme.13145","DOIUrl":"10.1111/tme.13145","url":null,"abstract":"<p><strong>Background: </strong>The bedside compatibility test (BCT) is the final barrier to transfusion safety, aiming to prevent ABO-incompatible incidents. This study evaluated the knowledge and practices of BCT and assessed the impact of a training session introducing a new technique of BCT based on Serafol ABO card.</p><p><strong>Methods: </strong>This is an observational study targeting transfusion-qualified staff working at the MTM hospital in Nabeul. It involved an initial knowledge assessment, a training session on BCT principles, and post-assessment using an anonymous questionnaire that included the interpretation of Serafol ABO card examples.</p><p><strong>Results: </strong>Among 93 participants, 18% frequently performed transfusions, and 31% had prior training. Incorrect BCT practices, including unsafe serum methods, were noted in 46%. Only 7.5% completed necessary pre-transfusion checks. The frequency of overall scores (≥50/100) increased significantly from 43% to 90% (p = 0.000) after the training session. Correct interpretation of the Serafol ABO card was achieved by 86% and 81% of participants in isogroup and non-isogroup compatible situations, respectively. However, 20.5% of participants would have transfused an incompatible unit. A significant difference was observed between doctors and paramedics in interpreting non-isogroup compatible and incompatible situations (p = 0.03). The overall mean interpretation score was 7.7/9, with a 77% compatibility accuracy rate. Professional profile parameters did not significantly influence correct responses.</p><p><strong>Conclusion: </strong>This study revealed gaps in BCT practices, significantly improved through training and the introduction of the Serafol ABO card. Continuous training, medical assessments, and procedure monitoring are vital to enhance transfusion safety.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"322-329"},"PeriodicalIF":1.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case report of a rare p phenotype individual and a review of molecular biological analysis of p phenotype in the Chinese population.","authors":"Xiaoxiang Wei, Dong Xiang, Liangfeng Fan, Zhonghui Guo, Dong Ran, Shengdi Bu, Xiaojie Tan, Qin Li","doi":"10.1111/tme.13158","DOIUrl":"10.1111/tme.13158","url":null,"abstract":"<p><strong>Objectives: </strong>To explore the serological characteristics and molecular mechanisms of an individual with the p phenotype in the Chinese population by analysing the serological and genetic background.</p><p><strong>Background: </strong>The p phenotype, which lacks all antigens in the P1PK blood group system, is extremely rare in the Chinese population. Individuals with the p phenotype typically produce anti-PP1P^k antibodies. The P1, P^k antigens belong to the P1PK blood group system, while the P antigen is part of the GLOB blood group system. The antigens in the P1PK system are synthesised by α1,4-galactosyltransferase (α4Gal-T), while the antigens in the GLOB system are produced by 3-𝛽-N-acetylgalactosaminyl-transferase (β3GalNAc-T1). These glycosyltransferases are encoded by the A4GALT and B3GALNT1 genes.</p><p><strong>Materials and methods: </strong>Serological techniques were employed to determine the blood types and antibodies of an individual with the p phenotype. Additionally, first- and third-generation sequencing methods were used to analyse the A4GALT and B3GALNT1 genes in the sample.</p><p><strong>Results: </strong>The serum from the tested individual showed positive reactions with all red blood cells (RBCs) from two sets of panel RBC reagents, while it reacted negatively with a confirmed p phenotype red blood cell. The antibodies in the serum exhibited IgM + IgG properties, with IgG being the predominant type. The antibody titers at room temperature, 37°C, and 4°C were 128, 64, and 256, respectively. Sequencing analysis revealed a homozygous mutation in the A4GALT gene at rs5751348: G > T; c.343A > T; c.903C > G, while no mutation was detected in the B3GALNT1 gene.</p><p><strong>Conclusions: </strong>The tested individual exhibited the p phenotype and likely produces anti-PP1P^k antibodies. The allele carrying rs5751348: G > T; c.343A > T; c.903C > G in the A4GALT gene has been provisionally designated A4GALT*02 N.28 (pending official recognition by ISBT).</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"359-365"},"PeriodicalIF":1.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ferritin-guided management of blood donors with a marginally low pre-donation haemoglobin and its effect on the number of donations in the following 3 years.","authors":"Sandra Cutajar, George Galea, Monique A Debattista, Monique Borg Inguanez","doi":"10.1111/tme.13149","DOIUrl":"10.1111/tme.13149","url":null,"abstract":"<p><strong>Background: </strong>The handling of donors with a marginally low haemoglobin is difficult and problematic and various methodologies have been applied to address this issue.</p><p><strong>Aims: </strong>The aim of this study was to assess whether measurement of serum ferritin and subsequent management of donors with a marginally low haemoglobin had any impact on the number of subsequent donations.</p><p><strong>Materials and methods: </strong>Such donors were prospectively randomised into an intervention group whereby their serum ferritin was measured and those in the control group where routine assessments were done as per current SOPs. In the intervention group, action was taken depending on how low the serum ferritin was. The comparator in both study arms was the number of donations that were given during the follow-up period of 3 years.</p><p><strong>Results: </strong>We could not find any significant consequence due to this intervention.</p><p><strong>Discussion and conclusion: </strong>The potential reasons are discussed, and we are proposing further studies on subsets of donors who are more prone to iron deficiency.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"307-311"},"PeriodicalIF":1.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A nationwide retrospective study of the seroprevalence and risk factors of transfusion-transmissible infections among blood donors in Nigeria.","authors":"Adaeze Oreh, Felix Biyama, Tariere Bozegha, Joshua Fapohunda, Ifeanyi Mgbachi, Victoria Dalyop, Joy Elisha, Folashade Olupitan, Audu Isaiah, Catherine Babalola, Abdullahi Malammadori, Emmanuel Agahiu, Deborah Kure, Caroline Imonikhe, Chinonso Elesie, Ajoke E Ogedegbe, Ukinebo Omokaro, Jerry Egbeaso, Chika Oparah, Omale Amedu, Maarten Postma, Theresa Nwagha, Marinus van Hulst","doi":"10.1111/tme.13160","DOIUrl":"10.1111/tme.13160","url":null,"abstract":"<p><strong>Background: </strong>Blood transfusion's life-saving potential is often marred by the risks of transfusion-transmissible infections (TTIs) from blood donors, for which sub-Saharan African countries record some of the highest burdens.</p><p><strong>Aims: </strong>We aimed to assess the seroprevalence of HBV, HCV, HIV, and Treponema pallidum among blood donors in Nigeria, and determine the association of seropositivity with particular blood donor characteristics.</p><p><strong>Methods: </strong>A retrospective cross-sectional study was conducted to determine the seroprevalence of HBV, HCV, HIV, and Treponema pallidum among blood donors in 13 blood establishments in Nigeria's six geopolitical zones from January 2018 to December 2019 following screening with highly sensitive Enzyme-Linked Immunosorbent Assays. Data was collected from the country's web-based software District Health Information System, Version 2 and analysed using R Studio.</p><p><strong>Results: </strong>The overall TTI seroprevalence was 10.1%, and declined from 10.9% in 2018 to 9.4% in 2019. Male donors (AOR = 0.1; 95% CI: 0.1-0.2, p < 0.001), those aged 46-55 years (AOR = 0.8, 95% CI: 0.7-0.9, p < 0.001), and first-time donors (AOR = 0.1, 95% CI: 0.10-0.12, p < 0.001) were less likely to be seropositive; whereas paid donors (AOR = 2.3, 95% CI: 2.1-2.6, p < 0.001) and mobile blood drive donors (AOR = 1.4; 95% CI: 1.3-1.5, p < 0.001) were more likely to be seropositive.</p><p><strong>Conclusion: </strong>The seroprevalence of TTIs in Nigerian blood donors is high, especially among females, paid donors, and those at mobile donation sites, emphasising the importance of targeted continuous population health education and quality donor selection towards enhancing blood safety.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"374-384"},"PeriodicalIF":1.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12361840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of pressure and temperature on the quality of suspended red blood cells: An ex vivo simulation study.","authors":"Chunyu Feng, Rui Fan, Haimei Ma, Huan Zhang","doi":"10.1111/tme.13141","DOIUrl":"10.1111/tme.13141","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to explore the impact of pressurisation and simultaneous warming at a combination of 50 kPa and 46°C on the quality of suspended red blood cells in an ex vivo environment.</p><p><strong>Background: </strong>During massive rapid blood transfusion, pressure and temperature-controlled blood warming devices are often used to prevent hypothermia caused by the infusion of large amounts of cold blood. If the pressure and temperature are not properly applied during this process, it can endanger the patient's life safety.</p><p><strong>Methods/materials: </strong>400 mL of human suspended red blood cells stored at 2-6°C were subjected to pressure and simultaneous warming at a combination of 50 kPa and 46°C. Changes in blood temperature and blood quality-related indicators before and after warming under pressure were detected, with the procedure repeated six times.</p><p><strong>Results: </strong>In the ex vivo simulated test environment, there were no statistically significant differences in routine blood indicators, biochemical indicators, and hemolysis rates of suspended red blood cells before and after pressure and warming transfusion at 50 kPa pressure and 46°C temperature (P>0.05). There were no significant changes in osmotic fragility after pressure and warming transfusion, and no obvious hemolysis was observed in the morphology of suspended red blood cells under an electron microscope.</p><p><strong>Conclusion: </strong>In the ex vivo simulated test environment, pressure and warming transfusion at 50 kPa pressure and 46°C temperature had no significant impact on blood quality, and the blood quality met the standards for the use of blood products.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"366-373"},"PeriodicalIF":1.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12361830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review of transfusion practice for beta thalassaemia major patients in Scotland after removal of age criteria for red cell transfusion.","authors":"Nicole Priddee, Katie Hands, Jennifer Laird, Louisa McIlwaine, Fernando Pinto, Susan Baird","doi":"10.1111/tme.13147","DOIUrl":"10.1111/tme.13147","url":null,"abstract":"","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"403-404"},"PeriodicalIF":1.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of elevated leukocyte levels on ABO blood group typing and cross-matching.","authors":"Hongmei Qiu, Xuechun Wang, Hongyun Wang","doi":"10.1111/tme.13157","DOIUrl":"10.1111/tme.13157","url":null,"abstract":"","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"405-408"},"PeriodicalIF":1.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}