Transfusion Medicine最新文献

{"title":"Rare combination of anti-In^b and anti-D in pregnancy: Challenges in diagnosis and transfusion management.","authors":"Naveen Reddy Ambati, Abhishekh Basavarajegowda, Aparna Krishna, K M Hari Priya, Dibyajyoti Sahoo","doi":"10.1111/tme.70051","DOIUrl":"10.1111/tme.70051","url":null,"abstract":"","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":"205-208"},"PeriodicalIF":1.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145726394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Motives and barriers to blood donation among adults aged over 50 years: A qualitative analysis.","authors":"Melissa K Hyde, Barbara M Masser, Rachel Thorpe, Aaron Akpu Philip, Amanda Salmon, Theresa L Scott, Tanya E Davison","doi":"10.1111/tme.70077","DOIUrl":"https://doi.org/10.1111/tme.70077","url":null,"abstract":"<p><strong>Background: </strong>Ageing populations will increase demand for blood-products and donors who supply them. While blood collection agencies (BCAs) typically target younger people to expand supply, recruiting donors aged 50+ is also a potential solution. However, few studies focus exclusively on this group. We aimed to explore motives, barriers, costs, benefits, and BCA support and engagement of donors and non-donors aged 50+.</p><p><strong>Methods/materials: </strong>Semi-structured interviews were conducted with 31 donors who began or returned to donating (after >25 years) aged 50+, and 28 non-donors aged 50+ who had never donated or not donated in >30 years. We used reflexive and codebook thematic analysis of data.</p><p><strong>Results: </strong>Seven themes were generated: awareness of donation, accessibility and ease of donation, health and donation, age or life-stage and donation, helping self and others, social connections, and inspiration and incentives. Donors discussed their growing capacity for donation while others planned donation around busy lifestyles. Awareness of the need for blood motivated donors, alongside their desire to give back (i.e. reciprocity). Donors uniquely discussed their health privilege enabling donation and feeling obligated to help others less healthy. Non-donors lacked information and awareness about donating. Donation sites were viewed as inaccessible and family/work priorities limited capacity. Non-donors uniquely discussed being 'too old' to donate. They felt unwanted by and invisible to BCAs who do not target them in messaging/campaigns.</p><p><strong>Conclusion: </strong>To ensure sustainability of blood supplies and avoid marginalising those aged 50+, BCAs should be more inclusive with greater awareness raising, targeted marketing, and maximising accessible donation opportunities.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147475293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early cryoprecipitate transfusion through goal-directed bleeding management in a real world setting-How important it is to focus on the fibrinogen in major obstetric Haemorrhage.","authors":"Ganesh Mohan, Shamee Shastry, Prethika P A, Deepika Chenna, Bemma Paonam","doi":"10.1111/tme.70072","DOIUrl":"https://doi.org/10.1111/tme.70072","url":null,"abstract":"<p><strong>Background: </strong>Postpartum haemorrhage (PPH) causes ~70 000 maternal deaths annually, making it one of the leading causes of preventable maternal mortality. This study evaluated the effectiveness of individualised goal-directed bleeding management (GDBM) in severe PPH in our centre with unique geographical challenges.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of severe PPH requiring massive transfusion over 1 years. Patients were classified into a fixed ratio (1:1:1) massive transfusion protocol (Group 1) and GDBM (Group 2). Study outcomes included blood utilisation, persistence of coagulopathy after resuscitation and mortality. The target was to keep a fibrinogen level of >200 mg/dL during the resuscitation. Thromboelastography was used to guide GDBM, and data were analysed using mean, median, percentage changes, chi-square test, student t test, and Mann-Whitney U-test.</p><p><strong>Results: </strong>Out of 96 patients (42 were in Group 1 and 54 in Group 2), GDBM led to increased cryoprecipitate utilisation (410 vs. 297 units) and a higher post-resuscitation fibrinogen value (252 [185.32-426.42] mg/dL vs. 204.6 [154.5-274.05] mg/dL, p = 0.02). The cryoprecipitate turnaround time was improved (41 vs. 73 min, p < 0.001) with GDBM ensuring timely administration. Increased fibrinolysis activity was observed in 24% of the patients in TEG. The persistence of coagulopathy after deactivation of MTP was lower in GDBM (7.4% vs. 26.19%). Out of the three patients who did not survive, two were in Group 1.</p><p><strong>Conclusion: </strong>Individualised GDBM optimises blood utilisation, reduces turnaround time and improves coagulopathy in PPH and needs to be prioritised.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147475315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge and attitudes toward perioperative patient blood management: A cross-sectional study among Anaesthesiology and Orthopaedic Surgery Departments at a university hospital.","authors":"Chayapa Luckanachanthachote, Wittawat Mingmongkolchaikul, Piyanut Jungkhananan, Mingkwan Wongyingsinn","doi":"10.1111/tme.70070","DOIUrl":"https://doi.org/10.1111/tme.70070","url":null,"abstract":"<p><strong>Background: </strong>Perioperative patient blood management (PBM) is a crucial, multidisciplinary, evidence-based approach aimed at optimising patient outcomes by reducing unnecessary erythrocyte transfusions. This study assessed the knowledge and attitudes of healthcare professionals in two key surgical specialties toward PBM.</p><p><strong>Methods: </strong>This cross-sectional questionnaire-based survey involved personnel from the Department of Anaesthesiology and the Department of Orthopaedic Surgery at a university hospital. The questionnaire assessed knowledge (scored out of 100) and attitudes (specifically self-reported adherence, scored out of 100). The correct responses were based on the PBM guidelines and institutional protocols. Multivariable logistic regression was used to identify predictors of adherence.</p><p><strong>Results: </strong>The overall response rate was 86.2% (n = 250) from 163 Anaesthesiology and 87 Orthopaedic Surgery. The Orthopaedic Surgery group scored significantly lower on knowledge assessments than the Anaesthesiology group (median score 48 vs. 58, p < 0.001). However, the attitude scores were statistically similar (median score 77 vs. 76, p = 0.237), revealing a knowledge-attitude paradox. Multivariable logistic regression identified hierarchical position as the only significant independent predictor: staff physicians were 7.1 times more likely to report adherence compared to residents (adjusted odds ratios 7.1, 95% confidence interval 3.1-16.2, p < 0.001). Individual knowledge level was not a significant predictor.</p><p><strong>Conclusions: </strong>Our study demonstrates that hierarchical mandate, not individual knowledge or department affiliation, is the primary driver of PBM adherence. Implementation efforts must therefore leverage staff physician leadership to mandate PBM as the institutional standard of care, ensuring that positive attitudes translate into consistent practice.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147435495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circadian patterns in transfusion-associated circulatory overload.","authors":"Krishna G Badami, Anna Y Zhou","doi":"10.1111/tme.70074","DOIUrl":"https://doi.org/10.1111/tme.70074","url":null,"abstract":"<p><strong>Objectives: </strong>To examine if transfusion-associated circulatory overload (TACO) shows a circadian pattern.</p><p><strong>Background: </strong>Non-urgent transfusions often take place during the night-time. This interferes with patient rest and patient monitoring. Also, transfusion reactions like TACO may be more likely during the night for pathophysiologic reasons.</p><p><strong>Materials and methods: </strong>Using New Zealand haemovigilance and transfusion data for the three-year period between January 2022 and December 2024, we compared the daytime and night-time rates of TACO and two other transfusion reactions (allergic reactions and transfusion-associated hypotension, TAH).</p><p><strong>Results: </strong>A quarter of transfusion episodes happened during the night-time. The night-time TACO rate was twice the daytime rate (p = <0.0001). This was also seen in males alone (p = <0.0001), but not in females. With allergic reactions, the daytime and night-time rates were similar. With TAH, it appeared to be higher, but our TAH numbers are small.</p><p><strong>Conclusion: </strong>The night-time TACO rate was higher than the daytime rate. As with cardiogenic acute pulmonary edema and other cardio- and cerebro-vascular conditions which are more frequent at night, this may involve biological clocks, external stressors (e.g. recumbency and transfusion), and individual risk factors. This is yet another reason to avoid overnight transfusions unless urgently needed.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147390955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune-mediated platelet refractoriness: Mechanisms, diagnostics, and therapeutic breakthroughs.","authors":"Lei Ma, Lina Wu, Jinhui Xie","doi":"10.1111/tme.70071","DOIUrl":"https://doi.org/10.1111/tme.70071","url":null,"abstract":"<p><p>Platelets are increasingly recognised as key mediators of immunity, contributing to clinical challenges such as platelet transfusion refractoriness (PTR). While predominantly driven by non-immune factors, immune-mediated PTR-primarily due to alloimmunisation against human leukocyte antigens (HLA) and/or human platelet antigens (HPA)-presents distinct management difficulties. Current therapies are often suboptimal, and emerging strategies require validation. This review synthesises current knowledge on antibody pathogenesis, advanced detection methods, and novel therapies for immune-mediated PTR, aiming to inform clinical decision-making and future research. A comprehensive literature review was conducted, focusing on peer-reviewed articles addressing immune-mediated PTR, mechanisms of alloimmunisation, diagnostic techniques for HLA/HPA antibodies, and therapeutic innovations. Key studies and emerging data were analysed to evaluate current evidence and identify knowledge gaps. Immune-mediated PTR arises primarily from alloantibodies against HLA class I and/or HPA, leading to accelerated platelet clearance. Advanced detection methods, including multiplex bead arrays and genotyping platforms, have improved identification of incompatible donors. Current management relies on provision of antigen-negative or crossmatch-compatible platelets, with immunosuppressive therapy reserved for refractory cases. Novel strategies such as platelet genome editing, antibody inhibition, and nanoparticle-based immune modulation are under investigation, but robust clinical validation is lacking. This review highlights the central role of alloimmunisation in immune-mediated PTR and the importance of accurate antibody detection and antigen matching. While existing therapies remain suboptimal for some patients, emerging technologies hold potential but require further clinical evaluation. Improved understanding of pathogenesis and validation of novel approaches are essential to advance management and reduce the burden of PTR.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147370413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of the BioBox LAB10 for maintaining temperature and quality of packed red blood cells during in-hospital storage and transport.","authors":"Yohei Sakai, Takato Ozeki, Hideaki Matsuura, Rie Nakagawa, Yuya Ishihara, Hiroki Doi, Yasuo Miura","doi":"10.1111/tme.70073","DOIUrl":"https://doi.org/10.1111/tme.70073","url":null,"abstract":"<p><strong>Background: </strong>Packed red blood cells (PRBC) are stored at 2°C-6°C to ensure quality. Improper temperature control during PRBC transport reduces the quality of downstream blood products and wastes PRBC units. This study evaluated the suitability of the BioBox LAB10 for in-hospital PRBC transport.</p><p><strong>Methods: </strong>Temperatures of the box interior and simulated formulation were measured to assess cooling capabilities. Quality was evaluated by measuring red blood cell count, haemoglobin concentration, haematocrit, pH, potassium concentration, and ATP concentration of PRBC samples. The storage capacity, size, weight, and cost of the BioBox was compared with that of the ATR700.</p><p><strong>Results: </strong>The BioBox cooled to ≤6°C within 14 min. PRBC temperature remained ≤6°C for approximately 19 h. None of the quality parameters, including ATP concentration, differed significantly between samples stored in the BioBox or in a refrigerator. The BioBox is smaller, lighter, and 84% less expensive than the ATR700, with an equivalent storage capacity.</p><p><strong>Conclusions: </strong>The BioBox effectively maintains temperature and PRBC quality during transport and provides a practical solution for in-hospital transport of blood for transfusion owing to its compact, lightweight design, and affordability.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147370470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of safety, efficacy, and guideline compliance in home-based red blood cell transfusions: An 8.5-year retrospective study in suburban Tokyo.","authors":"Takeshi Hagino, Tomohiko Sato, Takenori Hayashi, Naoya Kaneko, Satoshi Noto, Daigo Hashimoto, Naoki Takezako, Takanori Teshima","doi":"10.1111/tme.70069","DOIUrl":"10.1111/tme.70069","url":null,"abstract":"<p><strong>Objectives: </strong>This study evaluated the safety, efficacy, and guideline adherence of home transfusions at a single institution over nearly a decade.</p><p><strong>Background: </strong>In Japan, demand for home-based red blood cell (RBC) transfusions is increasing due to population aging and promotion of community-based care. Although national guidelines were issued by the Japanese Society of Transfusion Medicine and Cell Therapy (JSTMCT) in 2017, evidence regarding their real-world application and safety remains limited.</p><p><strong>Methods/materials: </strong>We retrospectively reviewed 1007 planned RBC transfusion procedures in 181 patients (median age 81 years, range 37-97) between March 2016 and September 2024 in suburban Tokyo. Data included patient characteristics, transfusion details, haemoglobin (Hb) levels, adverse events, and JSTMCT guideline compliance. Paired Hb values were analysed using the Wilcoxon signed-rank test.</p><p><strong>Results: </strong>Malignancy was the most common underlying condition (173/181 patients, 95.6%), with haematological disorders predominant (102/181, 56.4%). Of 1007 planned procedures, 48 (4.8%) were cancelled. The median number of procedures per patient was 7 (range 1-232). Among 410 procedures with paired Hb values within 15 days, Hb increased significantly (median 6.8 g/dL pre- vs. 7.4 g/dL post-transfusion, p < 0.05). Mild adverse reactions occurred in 0.31% (3/959), lower than the JSTMCT-reported hospital rate of 0.64%. Compliance with JSTMCT guidelines was highest for caregiver presence (100%) but lowest for initial hospital-based transfusion (74.6%).</p><p><strong>Conclusion: </strong>Home-based RBC transfusions demonstrated excellent safety and efficacy profiles with lower adverse reaction rates than hospital-based transfusions. This study suggests that the JSTMCT guideline revisions should consider real-world practices, particularly initial transfusion requirements and hospital-clinic collaboration.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147285410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First-time red blood cell transfusions in the emergency department: A deficiency in micronutrient testing.","authors":"Andrea Coetzee, Karryn Brown, Jessica Opie, Jody Rusch, Annemarie Kropman, Vernon Louw","doi":"10.1111/tme.70068","DOIUrl":"https://doi.org/10.1111/tme.70068","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate laboratory investigations for micronutrient deficiencies as the cause of anaemia prior to first-time red blood cell transfusions in the medical emergency department (ED) of a large academic hospital.</p><p><strong>Background: </strong>The ED is often the first point of contact for acutely ill anaemic patients, yet patient blood management principles are underutilised. Because micronutrient deficiencies are common, treatable causes of anaemia, they should be screened for to guide targeted treatment and reduce unnecessary transfusions.</p><p><strong>Methods: </strong>We conducted a retrospective cross-sectional study of 198 adult patients receiving first-time transfusions in the medical emergency unit at Groote Schuur Hospital, South Africa, between April and October 2023. Laboratory investigations for iron, vitamin B12, and folate deficiencies were analysed and stratified by pre-transfusion mean corpuscular volume (MCV). Iron deficiency was evaluated using three locally used criteria. Data about haematinic supplementation were also collected.</p><p><strong>Results: </strong>Only 29% of patients received a full micronutrient deficiency workup, while 39% had no testing. Iron deficiency was the most frequent abnormality, and up to 30% of these patients had normocytic indices. Iron supplementation rates were high, but many patients without iron deficiency also received iron.</p><p><strong>Conclusion: </strong>The ED encounter should be used as an opportunity to initiate basic micronutrient deficiency screening for anaemia, regardless of MCV.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146158517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What is the best approach to blood transfusion in sickle cell disease? A scientometric analysis and literature review.","authors":"Christiane Ruffato Carminati, Lucas Fernandes Ananias, Saulo Fernando Moreira da Silva, Anna Cecília Dias Maciel Carneiro, Helio Moraes de Souza, Sarah Cristina Sato Vaz Tanaka, Fernanda Bernadelli De Vito","doi":"10.1111/tme.70064","DOIUrl":"https://doi.org/10.1111/tme.70064","url":null,"abstract":"<p><strong>Background: </strong>Blood transfusion remains a cornerstone in the management of sickle cell disease (SCD); however, it is frequently complicated by red cell alloimmunisation. A significant debate persists within the scientific community regarding the optimal strategy to mitigate this risk: the traditional, pragmatic approach of serologic phenotyping versus molecular genotyping, which is technically superior yet more resource-intensive.</p><p><strong>Objectives: </strong>This mini-review aims to map the framework of this scientific debate and synthesize current evidence through a dual methodology.</p><p><strong>Methods and materials: </strong>A scientometric analysis was conducted on 224 articles indexed in Scopus and Web of Science using the Bibliometrix package for R, followed by a structured narrative review of 26 selected studies.</p><p><strong>Results: </strong>The scientometric findings confirm growing interest in this topic, identifying two distinct yet interconnected research clusters that reflect the ongoing dialectic between phenotyping and genotyping, with the latter emerging as a 'hot topic' over the past decade. The narrative synthesis highlights a predominance of evidence supporting genotyping as the most accurate approach to preventing alloimmunisation, particularly given the high prevalence of RH system variants in individuals with SCD. In contrast, cost-effectiveness analyses and implementation studies underscore substantial financial and logistical barriers that favour a more pragmatic, stepwise approach.</p><p><strong>Conclusion: </strong>We conclude that the future of transfusion safety in SCD does not lie in a binary choice but rather in a synergistic and stratified integration of both strategies. Implementing protocols that target genotyping for high-risk patients, while simultaneously optimising the use of extended phenotyping, represents the most promising pathway to balance safety, cost and accessibility-ultimately ensuring the best possible transfusion therapy for this vulnerable population.</p>","PeriodicalId":23306,"journal":{"name":"Transfusion Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146114384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}