Pure red cell aplasia after ABO incompatible allogeneic stem cell transplantation treated with therapeutic plasma exchange: A case report.

IF 1.5 4区医学 Q3 HEMATOLOGY

Transfusion Medicine Pub Date : 2025-05-28 DOI:10.1111/tme.13153

Abhijit Baheti, Brinda Kakkar, Sameer Melinkeri, Anusree Prabhakaran, Urmi Sheth, Vijaya Gadage, Sanjiv Ketkar

引用次数: 0

Abstract

Pure red cell aplasia (PRCA) is a known complication of major/bi-directional ABO incompatible allogeneic stem cell transplantation (ABOi allo-SCT). Persistence of recipient's antibodies against the donor's red blood cells (RBCs) leads to delay in recovery of RBCs which can last up to several months. This complication can result in patients becoming transfusion dependent. There is no standard treatment but a combination of different treatment strategies which includes tapering immunosuppression/discontinuation, steroid, erythropoietin, anti-CD-20 monoclonal antibody, daratumumab and therapeutic plasma exchange (TPE). Here we report a case of PRCA after ABOi allogeneic peripheral blood SCT treated successfully with TPE.

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治疗性血浆交换治疗ABO不相容异基因干细胞移植后的纯红细胞发育不全1例报告。

纯红细胞发育不全（PRCA）是主要/双向ABO不相容同种异体干细胞移植（ABOi allo-SCT）的已知并发症。受体抗体对供体红细胞（红细胞）的持续存在导致红细胞恢复延迟，这可能持续数月。这种并发症可导致患者依赖输血。没有标准的治疗方法，但不同的治疗策略的组合，包括逐渐减少免疫抑制/停药，类固醇，促红细胞生成素，抗cd -20单克隆抗体，达拉单抗和治疗性血浆交换（TPE）。我们在此报告一例abi异体外周血SCT经TPE成功治疗后发生PRCA的病例。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Transfusion Medicine 医学-血液学

CiteScore

2.70

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Transfusion Medicine publishes articles on transfusion medicine in its widest context, including blood transfusion practice (blood procurement, pharmaceutical, clinical, scientific, computing and documentary aspects), immunohaematology, immunogenetics, histocompatibility, medico-legal applications, and related molecular biology and biotechnology. In addition to original articles, which may include brief communications and case reports, the journal contains a regular educational section (based on invited reviews and state-of-the-art reports), technical section (including quality assurance and current practice guidelines), leading articles, letters to the editor, occasional historical articles and signed book reviews. Some lectures from Society meetings that are likely to be of general interest to readers of the Journal may be published at the discretion of the Editor and subject to the availability of space in the Journal.