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Current advancements in fungal engineering technologies for Sustainable Development Goals. 可持续发展目标中真菌工程技术的最新进展。
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2025-03-01 Epub Date: 2024-12-06 DOI: 10.1016/j.tim.2024.11.001
Shilpa Garg, Minji Kim, David Romero-Suarez
{"title":"Current advancements in fungal engineering technologies for Sustainable Development Goals.","authors":"Shilpa Garg, Minji Kim, David Romero-Suarez","doi":"10.1016/j.tim.2024.11.001","DOIUrl":"10.1016/j.tim.2024.11.001","url":null,"abstract":"<p><p>Fungi are emerging as key organisms in tackling global challenges related to agricultural and food productivity, environmental sustainability, and climate change. This review delves into the transformative potential of fungal genomics and metabolic engineering, two forefront fields in modern biotechnology. Fungal genomics entails the thorough analysis and manipulation of fungal genetic material to enhance desirable traits, such as pest resistance, nutrient absorption, and stress tolerance. Metabolic engineering focuses on altering the biochemical pathways within fungi to optimize the production of valuable compounds, including biofuels, pharmaceuticals, and industrial enzymes. By artificial intelligence (AI)-driven integration of genetic and metabolic engineering techniques, we can harness the unique capabilities of both filamentous and mycorrhizal fungi to develop sustainable agricultural practices, enhance soil health, and promote ecosystem restoration. This review explores the current state of research, technological advancements, and practical applications, offering insights into scalability challenges on how integrative fungal genomics and metabolic engineering can deliver innovative solutions for a sustainable future.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":" ","pages":"285-301"},"PeriodicalIF":14.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nasal microbiota transplantation: a gateway to novel treatments. 鼻微生物群移植：通向新疗法的大门。
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2025-03-01 Epub Date: 2025-01-14 DOI: 10.1016/j.tim.2024.12.010
Sudhanshu Shekhar, Martin Schwarzer, Achal Dhariwal, Fernanda Cristina Petersen
{"title":"Nasal microbiota transplantation: a gateway to novel treatments.","authors":"Sudhanshu Shekhar, Martin Schwarzer, Achal Dhariwal, Fernanda Cristina Petersen","doi":"10.1016/j.tim.2024.12.010","DOIUrl":"10.1016/j.tim.2024.12.010","url":null,"abstract":"<p><p>Two recent studies have highlighted the potential of nasal microbiota transplantation (NMT) to treat chronic rhinosinusitis (CRS). Here we evaluate these findings and propose that lessons from fecal microbiota transplantation (FMT) could guide NMT development, with possible implications for combating antimicrobial resistance in respiratory infections.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":" ","pages":"264-267"},"PeriodicalIF":14.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Short-chain fatty acids in viral infection: the underlying mechanisms, opportunities, and challenges. 病毒感染中的短链脂肪酸：潜在机制、机遇和挑战。
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2025-03-01 Epub Date: 2024-11-05 DOI: 10.1016/j.tim.2024.10.001
Yee Tsui, Xueqi Wu, Xi Zhang, Ye Peng, Chris Ka Pun Mok, Francis K L Chan, Siew C Ng, Hein Min Tun
{"title":"Short-chain fatty acids in viral infection: the underlying mechanisms, opportunities, and challenges.","authors":"Yee Tsui, Xueqi Wu, Xi Zhang, Ye Peng, Chris Ka Pun Mok, Francis K L Chan, Siew C Ng, Hein Min Tun","doi":"10.1016/j.tim.2024.10.001","DOIUrl":"10.1016/j.tim.2024.10.001","url":null,"abstract":"<p><p>Viral infections can cause cellular pathway derangements, cell death, and immunopathological responses, leading to host inflammation. Short-chain fatty acids (SCFAs), produced by the microbiota, have emerged as a potential therapeutic for viral infections due to their ability to modulate these processes. However, SCFAs have been reported to have both beneficial and detrimental effects, necessitating a comprehensive understanding of the underlying mechanisms. This review highlights the complex mechanisms underlying SCFAs' effects on viral infection outcomes. We also emphasize the importance of considering how SCFAs' activities may differ under diverse contexts, including but not limited to target cells with different metabolic wiring, different viral causes of infection, the target organism/cell's nutrient availability and/or energy balance, and hosts with varying microbiome compositions.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":" ","pages":"302-320"},"PeriodicalIF":14.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anaerocellum (f. Caldicellulosiruptor) bescii.
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2025-02-27 DOI: 10.1016/j.tim.2025.02.003
Kathryne C Ford, Ryan G Bing, Mohamad J H Manesh, Michael W W Adams, Robert M Kelly
{"title":"Anaerocellum (f. Caldicellulosiruptor) bescii.","authors":"Kathryne C Ford, Ryan G Bing, Mohamad J H Manesh, Michael W W Adams, Robert M Kelly","doi":"10.1016/j.tim.2025.02.003","DOIUrl":"https://doi.org/10.1016/j.tim.2025.02.003","url":null,"abstract":"","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":" ","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Getting ahead of human-associated microbial decline in Africa: the urgency of sampling in light of epidemiological transition.
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2025-02-27 DOI: 10.1016/j.tim.2025.01.004
Gugulethu T Moyo, Burcu Tepekule, Leolin Katsidzira, Martin J Blaser, C Jessica E Metcalf
{"title":"Getting ahead of human-associated microbial decline in Africa: the urgency of sampling in light of epidemiological transition.","authors":"Gugulethu T Moyo, Burcu Tepekule, Leolin Katsidzira, Martin J Blaser, C Jessica E Metcalf","doi":"10.1016/j.tim.2025.01.004","DOIUrl":"https://doi.org/10.1016/j.tim.2025.01.004","url":null,"abstract":"<p><p>Evidence is growing that human-associated early-life microbial diversity modulates health over the long term, via effects in the infant termed 'immune and metabolic education'. Documenting high microbial diversity contexts, such as in Africa, thus, has rich potential for understanding this aspect of the landscape of health. Yet, change on the continent is occurring rapidly, and microbial communities are shifting as behaviors and diets are altered, and antibiotic use expands; we may be losing the opportunity to obtain relevant data. After introducing what is known about the effects of early life microbial diversity on late life health, we provide an overview of what is known of the current, and expected future, trajectory of human-associated microbial diversity in Africa, introducing data on the core drivers. We argue that critical insights may be lost if better understanding of infant microbial communities in Africa is not obtained soon.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":" ","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bridging data gaps: African reference genomes advancing inclusive microbiome research.
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2025-02-24 DOI: 10.1016/j.tim.2025.02.001
Soumaya Kouidhi, Jo-Ann S Passmore, Mathabatha Evodia Setati, Lamech M Mwapagha, Adijat Jimoh, Ovokeraye H Oduaran
{"title":"Bridging data gaps: African reference genomes advancing inclusive microbiome research.","authors":"Soumaya Kouidhi, Jo-Ann S Passmore, Mathabatha Evodia Setati, Lamech M Mwapagha, Adijat Jimoh, Ovokeraye H Oduaran","doi":"10.1016/j.tim.2025.02.001","DOIUrl":"https://doi.org/10.1016/j.tim.2025.02.001","url":null,"abstract":"<p><p>The need for African-specific microbiome reference genomes is critical as their absence limits research in health, agriculture, and sustainability. Current global guidelines often do not take into account the region's unique needs. This commentary advocates for Africa-focused microbiome initiatives and community-driven genome projects to better reflect the continent's ecological and demographic diversity, leading to more applicable outcomes.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":" ","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143504349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Should I stay or should I go: transmission trade-offs in phages and plasmids.
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2025-02-19 DOI: 10.1016/j.tim.2025.01.007
Jana S Huisman, Andrina Bernhard, Claudia Igler
{"title":"Should I stay or should I go: transmission trade-offs in phages and plasmids.","authors":"Jana S Huisman, Andrina Bernhard, Claudia Igler","doi":"10.1016/j.tim.2025.01.007","DOIUrl":"https://doi.org/10.1016/j.tim.2025.01.007","url":null,"abstract":"<p><p>Mobile genetic elements (MGEs), like temperate bacteriophages and conjugative plasmids, are major vectors of virulence and antibiotic resistance in bacterial populations. For reproductive success, MGEs must balance horizontal and vertical transmission. Yet, the cost of horizontal transmission (metabolic burden or host death) puts these transmission modes at odds. Using virulence-transmission trade-off (VTT) theory, we identify three groups of environmental variables affecting the balance between horizontal and vertical transmission: host density, host physiology, and competitors. We find that general theoretical predictions of the optimal response to environmental cues align with experimental evidence on the regulation of transmission by phages and plasmids. We further highlight gaps between theory and experiments, differences between phages and plasmids, and suggest areas for future research.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":" ","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ESCRTs - a multi-purpose membrane remodeling device encoded in all life forms.
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2025-02-19 DOI: 10.1016/j.tim.2025.01.009
Dikla Nachmias, Béla P Frohn, Carsten Sachse, Itzhak Mizrahi, Natalie Elia
{"title":"ESCRTs - a multi-purpose membrane remodeling device encoded in all life forms.","authors":"Dikla Nachmias, Béla P Frohn, Carsten Sachse, Itzhak Mizrahi, Natalie Elia","doi":"10.1016/j.tim.2025.01.009","DOIUrl":"https://doi.org/10.1016/j.tim.2025.01.009","url":null,"abstract":"<p><p>The ESCRT (endosomal sorting complexes required for transport) membrane remodeling complex, found across all life forms, exhibits a versatility that transcends evolutionary boundaries. From orchestrating the constriction of micron-wide tubes in cell division to facilitating the budding of 50 nm vesicles in receptor degradation, ESCRTs perform diverse functions in animal cells. However, the basis of this functional diversity remains enigmatic. While extensively studied in eukaryotes, the role of ESCRTs in prokaryotes is only beginning to emerge. This review synthesizes data on ESCRT systems across the tree of life, focusing on microorganisms and drawing parallels to their functions in human cells. This comparative approach highlights the remarkable plasticity of the ESCRT system across functional, structural, and genomic levels in both prokaryotes and eukaryotes. This integrated knowledge supports a model in which the ESCRT system evolved as a multipurpose membrane remodeling tool, adaptable to specific functions within and across organisms. Our review not only underscores the significance of ESCRTs in microorganisms but also paves the way for exciting avenues of research into the intricacies of cellular membrane dynamics, offering valuable insights into the evolution of cellular complexity across diverse organisms and ecosystems.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":" ","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Not all RNAs are created equal for the antiviral RNase ISG20.
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2025-02-18 DOI: 10.1016/j.tim.2025.01.014
Jim Zoladek, Séverine Deymier, Andrea Cimarelli, Sébastien Nisole
{"title":"Not all RNAs are created equal for the antiviral RNase ISG20.","authors":"Jim Zoladek, Séverine Deymier, Andrea Cimarelli, Sébastien Nisole","doi":"10.1016/j.tim.2025.01.014","DOIUrl":"https://doi.org/10.1016/j.tim.2025.01.014","url":null,"abstract":"<p><p>ISG20 is a broad-spectrum antiviral protein capable of specifically degrading viral RNA. Here, we examine the different strategies developed by viruses to evade ISG20-mediated restriction, shedding light on how this exonuclease distinguishes between self and non-self RNAs, and highlighting the many questions that remain unanswered.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":" ","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Composing a microbial symphony: synthetic communities for promoting plant growth.
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2025-02-17 DOI: 10.1016/j.tim.2025.01.006
Xinming Xu, Caja Dinesen, Adele Pioppi, Ákos T Kovács, Carlos N Lozano-Andrade
{"title":"Composing a microbial symphony: synthetic communities for promoting plant growth.","authors":"Xinming Xu, Caja Dinesen, Adele Pioppi, Ákos T Kovács, Carlos N Lozano-Andrade","doi":"10.1016/j.tim.2025.01.006","DOIUrl":"https://doi.org/10.1016/j.tim.2025.01.006","url":null,"abstract":"<p><p>Plant microbiomes are pivotal for host development, influencing growth, health, fitness, and evolution, and have emerged as promising resources for sustainable agriculture. However, leveraging these microbiomes to improve crop yield and resilience is challenging due to the huge diversity of plant-associated and soil microorganisms and their intricate interactions. Recently, synthetic microbial communities (SynComs) have been exploited as a reductionist approach to harness microbial benefits and to understand multispecies interactions. Additionally, the advanced functionality of SynComs promises to surpass classic single-strain-based biosolutions. Nevertheless, challenges remain in designing customized, robust, and predictable SynComs for agronomic use. Here, we synthesize and discuss the logical and implemented approaches used to design and assemble SynComs, highlighting important principles, challenges, and trends in utilizing SynComs as alternatives to agrochemicals.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":" ","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143450326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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