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The 22nd International Workshop on Campylobacter, Helicobacter, and Related Organisms (CHRO) 2024.
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-12-22 DOI: 10.1016/j.tim.2024.11.008
Guy D Eslick, Alfred C Y Tay, Li Zhang, Barry J Marshall
{"title":"The 22nd International Workshop on Campylobacter, Helicobacter, and Related Organisms (CHRO) 2024.","authors":"Guy D Eslick, Alfred C Y Tay, Li Zhang, Barry J Marshall","doi":"10.1016/j.tim.2024.11.008","DOIUrl":"https://doi.org/10.1016/j.tim.2024.11.008","url":null,"abstract":"","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":" ","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-viral predators of marine picocyanobacteria.
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-12-20 DOI: 10.1016/j.tim.2024.11.010
Anvita U Kerkar, Kelly R Sutherland, Anne W Thompson
{"title":"Non-viral predators of marine picocyanobacteria.","authors":"Anvita U Kerkar, Kelly R Sutherland, Anne W Thompson","doi":"10.1016/j.tim.2024.11.010","DOIUrl":"https://doi.org/10.1016/j.tim.2024.11.010","url":null,"abstract":"<p><p>The Earth's most abundant photosynthetic cells, the picocyanobacteria - Prochlorococcus and Synechococcus - play a fundamental global role in aquatic ecosystems. The success of these picocyanobacteria is interpreted through a cross-scale systems framework that integrates bottom-up controls on growth (e.g., nutrients and light), diversity, and the selective pressures and response to predation. While viral predators are well studied and experimentally tractable, the diverse non-viral predators of picocyanobacteria are disconnected from this framework and experimentally challenging, leaving a major gap in understanding the picocyanobacteria. This review presents existing research on non-viral picocyanobacterial predators and promising research frontiers that will expand knowledge of the ecology and evolution of these crucial microorganisms.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":" ","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbiome selection and evolution within wild and domesticated plants.
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-12-18 DOI: 10.1016/j.tim.2024.11.011
Christopher James Barnes, Mo Bahram, Mogens Nicolaisen, M Thomas P Gilbert, Mette Vestergård
{"title":"Microbiome selection and evolution within wild and domesticated plants.","authors":"Christopher James Barnes, Mo Bahram, Mogens Nicolaisen, M Thomas P Gilbert, Mette Vestergård","doi":"10.1016/j.tim.2024.11.011","DOIUrl":"https://doi.org/10.1016/j.tim.2024.11.011","url":null,"abstract":"<p><p>Microbes are ubiquitously found across plant surfaces and even within their cells, forming the plant microbiome. Many of these microbes contribute to the functioning of the host and consequently affect its fitness. Therefore, in many contexts, including microbiome effects enables a better understanding of the phenotype of the plant rather than considering the genome alone. Changes in the microbiome composition are also associated with changes in the functioning of the host, and there has been considerable focus on how environmental variables regulate plant microbiomes. More recently, studies suggest that the host genome also preconditions the microbiome to the environment of the plant, and the microbiome is therefore subject to evolutionary forces. Here, we outline how plant microbiomes are governed by both environmental variables and evolutionary processes and how they can regulate plant health together.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":" ","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The exometabolome as a hidden driver of bacterial virulence and pathogenesis.
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-12-18 DOI: 10.1016/j.tim.2024.11.009
Saurabh Chugh, Fabien Létisse, Olivier Neyrolles
{"title":"The exometabolome as a hidden driver of bacterial virulence and pathogenesis.","authors":"Saurabh Chugh, Fabien Létisse, Olivier Neyrolles","doi":"10.1016/j.tim.2024.11.009","DOIUrl":"https://doi.org/10.1016/j.tim.2024.11.009","url":null,"abstract":"<p><p>The traditional view of metabolism as merely supplying energy and biosynthetic precursors is undergoing a paradigm shift. Metabolic dynamics not only regulates gene expression but also orchestrates cellular processes with remarkable precision. Most bacterial pathogens exhibit exceptional metabolic plasticity, enabling them to adapt to diverse environments, including hostile conditions within a host. While the role of intracellular bacterial metabolism in pathogen-host interactions has been extensively studied, the contributions of the extracellularly released or secreted bacterial metabolites (referred to here as the bacterial 'exometabolome') to metabolic adaptations and disease pathogenesis remain largely unexplored. In this review, we highlight the significant and intriguing roles of bacterial exometabolomes in drug tolerance, immune suppression, and disease pathogenesis, opening a new frontier in our understanding of bacterial-host interactions.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":" ","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
NCR peptides in plant-bacterial symbiosis: applications and importance.
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-12-16 DOI: 10.1016/j.tim.2024.11.012
Francisco J Guerra-Garcia, Siva Sankari
{"title":"NCR peptides in plant-bacterial symbiosis: applications and importance.","authors":"Francisco J Guerra-Garcia, Siva Sankari","doi":"10.1016/j.tim.2024.11.012","DOIUrl":"https://doi.org/10.1016/j.tim.2024.11.012","url":null,"abstract":"<p><p>While establishing symbiotic relationships with nitrogen-fixing soil bacteria certain legumes produce nodule-specific cysteine rich peptides. These peptides turn the bacteria into terminally differentiated non-replicative bacteroids. Here, we discuss the properties, essentiality, emerging clinical and agricultural applications, and the need to study the detailed mechanism of action of these peptides.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":" ","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Funding and collaboration inequalities in infectious disease research - why does it matter?
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-12-12 DOI: 10.1016/j.tim.2024.11.006
Gathsaurie Neelika Malavige, Guruprasad R Medigeshi, R Tedjo Sasmono, Chanaki Amaratunga
{"title":"Funding and collaboration inequalities in infectious disease research - why does it matter?","authors":"Gathsaurie Neelika Malavige, Guruprasad R Medigeshi, R Tedjo Sasmono, Chanaki Amaratunga","doi":"10.1016/j.tim.2024.11.006","DOIUrl":"https://doi.org/10.1016/j.tim.2024.11.006","url":null,"abstract":"<p><p>To face the current and emerging challenges due to infectious diseases, global research communities must comprehend the challenges faced by scientists in low-income and lower-middle-income countries. Here we address pertinent issues regarding funding and collaboration inequalities that could potentially cripple economic and healthcare systems, escalating to bigger global threats.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":" ","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The sticky business of Alphavirus capsid-host interactions.
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-12-10 DOI: 10.1016/j.tim.2024.11.003
Caroline K Martin, Peiqi Yin, Margaret Kielian
{"title":"The sticky business of Alphavirus capsid-host interactions.","authors":"Caroline K Martin, Peiqi Yin, Margaret Kielian","doi":"10.1016/j.tim.2024.11.003","DOIUrl":"https://doi.org/10.1016/j.tim.2024.11.003","url":null,"abstract":"<p><p>Alphaviruses are a serious threat to global health and can cause lethal encephalitic or arthritogenic disease in humans and animals. As there are no licensed antivirals, it is critical to improve our understanding of alphavirus interactions with the host cell. Here, we focus on the essential alphavirus protein capsid. While its roles in genome packaging and virus assembly have been wellstudied, much less is known about capsid's interactions with host proteins and their functional relevance for infection. Recently, several new capsid interactor candidates were identified, collectively emphasising the complexity of capsid-host biology. In this review we summarise these novel interactor candidates, highlight capsid's emerging role in immune evasion, and discuss the challenges and opportunities arising from capsid-host interactions.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":" ","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Closely related and yet special - how SPβ family phages control lysis-lysogeny decisions.
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-12-06 DOI: 10.1016/j.tim.2024.11.007
Katharina Kohm, Annabel V Clanner, Robert Hertel, Fabian M Commichau
{"title":"Closely related and yet special - how SPβ family phages control lysis-lysogeny decisions.","authors":"Katharina Kohm, Annabel V Clanner, Robert Hertel, Fabian M Commichau","doi":"10.1016/j.tim.2024.11.007","DOIUrl":"https://doi.org/10.1016/j.tim.2024.11.007","url":null,"abstract":"<p><p>Soon after the discovery of genetic competence in the Gram-positive bacterium Bacillus subtilis, lytic and temperate phages that infect this organism were isolated. For instance, the lytic phage ϕ29 became a model for studying processes such as viral DNA packaging, replication, and transcription. By contrast, only a handful of temperate B. subtilis phages have been comprehensively characterized. However, the discovery of a peptide-based quorum sensing (QS) system in 2017 has brought temperate B. subtilis phages, particularly those of the SPβ family, back into the focus of research. The QS system is used by these phages to modulate lysis-lysogeny decisions. Meanwhile, many key components of the lysis-lysogeny management system have been identified. It turned out that a complex co-adaptation between the B. subtilis host cell and SPβ-like phages occurred during evolution and that a host-encoded toxin-antitoxin system plays a key role in controlling lysis-lysogeny decisions. There are many similarities and many important differences between the two well-studied model phages. Thus, a further comparative analysis of the lysis-lysogeny systems is essential to uncover the fundamental differences between ϕ3T and SPβ. Moreover, we believe that it would be exciting to revive research on temperate B. subtilis phages that are not related to SPβ-family phages.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":" ","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current advancements in fungal engineering technologies for Sustainable Development Goals.
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-12-06 DOI: 10.1016/j.tim.2024.11.001
Shilpa Garg, Minji Kim, David Romero-Suarez
{"title":"Current advancements in fungal engineering technologies for Sustainable Development Goals.","authors":"Shilpa Garg, Minji Kim, David Romero-Suarez","doi":"10.1016/j.tim.2024.11.001","DOIUrl":"https://doi.org/10.1016/j.tim.2024.11.001","url":null,"abstract":"<p><p>Fungi are emerging as key organisms in tackling global challenges related to agricultural and food productivity, environmental sustainability, and climate change. This review delves into the transformative potential of fungal genomics and metabolic engineering, two forefront fields in modern biotechnology. Fungal genomics entails the thorough analysis and manipulation of fungal genetic material to enhance desirable traits, such as pest resistance, nutrient absorption, and stress tolerance. Metabolic engineering focuses on altering the biochemical pathways within fungi to optimize the production of valuable compounds, including biofuels, pharmaceuticals, and industrial enzymes. By artificial intelligence (AI)-driven integration of genetic and metabolic engineering techniques, we can harness the unique capabilities of both filamentous and mycorrhizal fungi to develop sustainable agricultural practices, enhance soil health, and promote ecosystem restoration. This review explores the current state of research, technological advancements, and practical applications, offering insights into scalability challenges on how integrative fungal genomics and metabolic engineering can deliver innovative solutions for a sustainable future.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":" ","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gene transfer agents: structural and functional properties of domesticated viruses. 基因转移剂：驯化病毒的结构和功能特性。
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-12-01 Epub Date: 2024-05-27 DOI: 10.1016/j.tim.2024.05.002
Matthew W Craske, Jason S Wilson, Paul C M Fogg
{"title":"Gene transfer agents: structural and functional properties of domesticated viruses.","authors":"Matthew W Craske, Jason S Wilson, Paul C M Fogg","doi":"10.1016/j.tim.2024.05.002","DOIUrl":"10.1016/j.tim.2024.05.002","url":null,"abstract":"<p><p>Horizontal exchange of DNA between bacteria and archaea is prevalent and has major potential implications for genome evolution, plasticity, and population fitness. Several transfer mechanisms have been identified, including gene transfer agents (GTAs). GTAs are intricately regulated domesticated viruses that package host DNA into virus-like capsids and transfer this DNA throughout the bacterial community. Several important advances have recently been made in our understanding of these unusual particles. In this review, we highlight some of these findings, primarily for the model GTA produced by Rhodobacter capsulatus but also for newly identified GTA producers. We provide key insights into these important genetic elements, including the differences between GTAs from their ancestral bacteriophages, their regulation and control, and their elusive evolutionary function.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":" ","pages":"1200-1211"},"PeriodicalIF":14.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141162259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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