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Short-chain fatty acids in viral infection: the underlying mechanisms, opportunities, and challenges. 病毒感染中的短链脂肪酸：潜在机制、机遇和挑战。
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-11-05 DOI: 10.1016/j.tim.2024.10.001
Yee Tsui, Xueqi Wu, Xi Zhang, Ye Peng, Chris Ka Pun Mok, Francis K L Chan, Siew C Ng, Hein Min Tun
{"title":"Short-chain fatty acids in viral infection: the underlying mechanisms, opportunities, and challenges.","authors":"Yee Tsui, Xueqi Wu, Xi Zhang, Ye Peng, Chris Ka Pun Mok, Francis K L Chan, Siew C Ng, Hein Min Tun","doi":"10.1016/j.tim.2024.10.001","DOIUrl":"https://doi.org/10.1016/j.tim.2024.10.001","url":null,"abstract":"<p><p>Viral infections can cause cellular pathway derangements, cell death, and immunopathological responses, leading to host inflammation. Short-chain fatty acids (SCFAs), produced by the microbiota, have emerged as a potential therapeutic for viral infections due to their ability to modulate these processes. However, SCFAs have been reported to have both beneficial and detrimental effects, necessitating a comprehensive understanding of the underlying mechanisms. This review highlights the complex mechanisms underlying SCFAs' effects on viral infection outcomes. We also emphasize the importance of considering how SCFAs' activities may differ under diverse contexts, including but not limited to target cells with different metabolic wiring, different viral causes of infection, the target organism/cell's nutrient availability and/or energy balance, and hosts with varying microbiome compositions.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":null,"pages":null},"PeriodicalIF":14.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Linking microbiome temporal dynamics to host ecology in the wild. 将微生物组的时间动态与野外宿主生态学联系起来。
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-11-01 Epub Date: 2024-05-25 DOI: 10.1016/j.tim.2024.05.001
Kirsty J Marsh, Stuart Bearhop, Xavier A Harrison
{"title":"Linking microbiome temporal dynamics to host ecology in the wild.","authors":"Kirsty J Marsh, Stuart Bearhop, Xavier A Harrison","doi":"10.1016/j.tim.2024.05.001","DOIUrl":"10.1016/j.tim.2024.05.001","url":null,"abstract":"<p><p>Ignoring the dynamic nature of microbial communities risks underestimating the power of microbes to impact the health of their hosts. Microbiomes are thought to be important for host fitness, yet the coarse temporal scale and population-level focus of many studies precludes the ability to investigate the importance of among-individual variation in stability and identify the ecological contexts in which this variation matters. Here we briefly summarise current knowledge of temporal dynamics in wild host-associated microbial communities. We then discuss the implications of among-individual variation in microbiota stability and suggest analytical approaches for understanding these patterns. One major requirement is for future studies to conduct individual-level longitudinal analyses, with some systems already well set up for answering these questions.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":null,"pages":null},"PeriodicalIF":14.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141155593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Methane-dependent denitrification by Methylomirabilis: an indirect nitrous oxide sink? Methylomirabilis的甲烷依赖性反硝化作用：间接的氧化亚氮汇？
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-11-01 Epub Date: 2024-08-09 DOI: 10.1016/j.tim.2024.07.008
Xiangwu Yao, Baolan Hu
{"title":"Methane-dependent denitrification by Methylomirabilis: an indirect nitrous oxide sink?","authors":"Xiangwu Yao, Baolan Hu","doi":"10.1016/j.tim.2024.07.008","DOIUrl":"10.1016/j.tim.2024.07.008","url":null,"abstract":"<p><p>Methane-dependent complete denitrification primarily involves nitrate reduction to nitrite by ANME-2d archaea and nitrite reduction to dinitrogen by Methylomirabilis bacteria. 'Candidatus Methylomirabilis sinica' integrates the divisional labor. Physiological traits of this bacterium potentially enable the simultaneous reduction of N<sub>2</sub>O and CH<sub>4</sub> emissions. This forum article explores these traits and possible microbial mechanisms for co-reduction, providing guidance for greenhouse gas management strategies.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":null,"pages":null},"PeriodicalIF":14.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141914085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The double play of a phage HTH regulator. 噬菌体 HTH 调节器的双重作用。
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-11-01 Epub Date: 2024-09-25 DOI: 10.1016/j.tim.2024.09.005
Zacharie Morneau, Sylvain Moineau
{"title":"The double play of a phage HTH regulator.","authors":"Zacharie Morneau, Sylvain Moineau","doi":"10.1016/j.tim.2024.09.005","DOIUrl":"10.1016/j.tim.2024.09.005","url":null,"abstract":"<p><p>Bacteriophages use anti-CRISPR (Acr) proteins to inhibit CRISPR-Cas systems. The expression of Acr is regulated by anti-CRISPR-associated (Aca) proteins, which are helix-turn-helix (HTH) repressors that bind DNA. Recently, Birkholz et al. discovered that an Aca can also repress Acr expression by binding RNA, revealing a new function for HTH repressors.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":null,"pages":null},"PeriodicalIF":14.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Flagellar evolution and flagella-independent motility in Actinobacteria. 放线菌的鞭毛进化和不依赖鞭毛的运动。
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-11-01 Epub Date: 2024-08-16 DOI: 10.1016/j.tim.2024.07.010
Yuanyuan Chen, Siqi Zhu, Fan Liu, Beile Gao
{"title":"Flagellar evolution and flagella-independent motility in Actinobacteria.","authors":"Yuanyuan Chen, Siqi Zhu, Fan Liu, Beile Gao","doi":"10.1016/j.tim.2024.07.010","DOIUrl":"10.1016/j.tim.2024.07.010","url":null,"abstract":"<p><p>Actinobacterial species are mostly thought to be nonmotile. Recent studies have revealed the degenerate evolution of flagella in this phylum and different flagellar rod compositions from the classical model. Moreover, flagella-independent motility by various means has been reported in Streptomyces spp. and Mycobacterium spp., but the underlying mechanisms remain elusive.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":null,"pages":null},"PeriodicalIF":14.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141996573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human-pathogens and plants, a Neolithic evolutionary tale. 人类-病原体-植物，一个新石器时代的进化故事。
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-11-01 Epub Date: 2024-08-29 DOI: 10.1016/j.tim.2024.07.011
Andrea Quagliariello, Massimiliano Marvasi
{"title":"Human-pathogens and plants, a Neolithic evolutionary tale.","authors":"Andrea Quagliariello, Massimiliano Marvasi","doi":"10.1016/j.tim.2024.07.011","DOIUrl":"10.1016/j.tim.2024.07.011","url":null,"abstract":"<p><p>This forum explores the hypothesis that plants serve as a hub for the evolution of generalist Salmonella strains, and can be traced back to the Neolithic era when agriculture emerged. It suggests a unique interconnection among humans, plants, animals, and Salmonella, potentially driving the evolution of the pathogen on farms.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":null,"pages":null},"PeriodicalIF":14.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142112340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Heteroresistance: a hidden cause behind antifungal prophylaxis failure. 异抗性：抗真菌预防失败背后的隐患。
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-11-01 Epub Date: 2024-10-01 DOI: 10.1016/j.tim.2024.09.008
Anaïs Hérivaux, Nicolas Papon, Florent Morio
{"title":"Heteroresistance: a hidden cause behind antifungal prophylaxis failure.","authors":"Anaïs Hérivaux, Nicolas Papon, Florent Morio","doi":"10.1016/j.tim.2024.09.008","DOIUrl":"10.1016/j.tim.2024.09.008","url":null,"abstract":"<p><p>Invasive fungal infections in allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients on antimicrobial prophylaxis is a major cause of infectious mortality, although its underlying pathophysiological mechanisms remain unclear. In a new report, Zhai and colleagues provide evidence that heteroresistance drives breakthrough Candida parapsilosis bloodstream infections in allo-HSCT recipients receiving micafungin prophylaxis.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":null,"pages":null},"PeriodicalIF":14.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142366593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Element cycling and microbial life in the hadal realm. 哈达尔界的元素循环和微生物生命。
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-11-01 Epub Date: 2024-07-31 DOI: 10.1016/j.tim.2024.07.004
Ronnie N Glud, Clemens Schauberger
{"title":"Element cycling and microbial life in the hadal realm.","authors":"Ronnie N Glud, Clemens Schauberger","doi":"10.1016/j.tim.2024.07.004","DOIUrl":"10.1016/j.tim.2024.07.004","url":null,"abstract":"<p><p>Hadal trenches represent the deepest oceanic realm and were once considered to be deprived of life. However, trenches act as important depocenters for organic matter with highly elevated microbial activity. In this forum, we discuss the biogeochemistry of the hadal realm and its microbial communities thriving at extreme hydrostatic pressure.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":null,"pages":null},"PeriodicalIF":14.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141860989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bacteria-derived short-chain fatty acids as potential regulators of fungal commensalism and pathogenesis. 细菌衍生的短链脂肪酸是真菌共生和致病的潜在调节剂。
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-11-01 Epub Date: 2024-05-09 DOI: 10.1016/j.tim.2024.04.004
Christopher McCrory, Megan Lenardon, Ana Traven
{"title":"Bacteria-derived short-chain fatty acids as potential regulators of fungal commensalism and pathogenesis.","authors":"Christopher McCrory, Megan Lenardon, Ana Traven","doi":"10.1016/j.tim.2024.04.004","DOIUrl":"10.1016/j.tim.2024.04.004","url":null,"abstract":"<p><p>The human gastrointestinal microbiome encompasses bacteria, fungi, and viruses forming complex bionetworks which, for organismal health, must be in a state of homeostasis. An important homeostatic mechanism derives from microbial competition, which maintains the relative abundance of microbial species in a healthy balance. Microbes compete for nutrients and secrete metabolites that inhibit other microbes. Short-chain fatty acids (SCFAs) are one such class of metabolites made by gut bacteria to very high levels. SCFAs are metabolised by microbes and host cells and have multiple roles in regulating cell physiology. Here, we review the mechanisms by which SCFAs regulate the fungal gut commensal Candida albicans. We discuss SCFA's ability to inhibit fungal growth, limit invasive behaviours and modulate cell surface antigens recognised by immune cells. We review the mechanisms underlying these roles: regulation of gene expression, metabolism, signalling and SCFA-driven post-translational protein modifications by acylation, which contribute to changes in acylome dynamics of C. albicans with potentially large consequences for cell physiology. Given that the gut mycobiome is a reservoir for systemic disease and has also been implicated in inflammatory bowel disease, understanding the mechanisms by which bacterial metabolites, such as SCFAs, control the mycobiome might provide therapeutic avenues.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":null,"pages":null},"PeriodicalIF":14.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140903789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
C4 cereal and biofuel crop microbiomes. C4 谷物和生物燃料作物微生物群。
IF 14 1区 生物学
Trends in Microbiology Pub Date : 2024-11-01 Epub Date: 2024-05-21 DOI: 10.1016/j.tim.2024.04.008
Xiaoyu Zai, Viviane Cordovez, Feng Zhu, Meicheng Zhao, Xianmin Diao, Fusuo Zhang, Jos M Raaijmakers, Chunxu Song
{"title":"C4 cereal and biofuel crop microbiomes.","authors":"Xiaoyu Zai, Viviane Cordovez, Feng Zhu, Meicheng Zhao, Xianmin Diao, Fusuo Zhang, Jos M Raaijmakers, Chunxu Song","doi":"10.1016/j.tim.2024.04.008","DOIUrl":"10.1016/j.tim.2024.04.008","url":null,"abstract":"<p><p>Microbiomes provide multiple life-support functions for plants, including nutrient acquisition and tolerance to abiotic and biotic stresses. Considering the importance of C4 cereal and biofuel crops for food security under climate change conditions, more attention has been given recently to C4 plant microbiome assembly and functions. Here, we review the current status of C4 cereal and biofuel crop microbiome research with a focus on beneficial microbial traits for crop growth and health. We highlight the importance of environmental factors and plant genetics in C4 crop microbiome assembly and pinpoint current knowledge gaps. Finally, we discuss the potential of foxtail millet as a C4 model species and outline future perspectives of C4 plant microbiome research.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":null,"pages":null},"PeriodicalIF":14.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141076814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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