CRISPR-Cas: a game-changer in vaccine development and the fight against viral infections.

IF 14 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Fayu Yang, Saba Aliyari, Zixiang Zhu, Haixue Zheng, Genhong Cheng, Shilei Zhang
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引用次数: 0

Abstract

Understanding the mechanisms of virus-host interactions is crucial for advancing our knowledge of viral pathogenesis and developing effective antiviral strategies. As novel, highly virulent pathogens continue to emerge, overcoming the challenges in virus-host biology and infection control is more important than ever. The CRISPR-Cas system has revolutionized genetic engineering, offering a precise and efficient application in synthetic biology. It is also invaluable in virology research, diagnostics, and antiviral therapeutics. In this review, we explore the latest advances in CRISPR-Cas-based approaches to elucidate virus-host interactions, focusing on the identification of key receptors and host factors essential for virus infection. Furthermore, we discuss the potential of the CRISPR-Cas system as an antiviral strategy for tackling newly emerging and re-emerging viruses. Finally, we discuss the potential of CRISPR-Cas-based gene editing for the development of innovative viral vaccines.

CRISPR-Cas:疫苗开发和对抗病毒感染的游戏规则改变者
了解病毒-宿主相互作用的机制对于提高我们对病毒发病机制的认识和制定有效的抗病毒策略至关重要。随着新型高毒力病原体的不断出现,克服病毒-宿主生物学和感染控制方面的挑战比以往任何时候都更加重要。CRISPR-Cas系统彻底改变了基因工程,在合成生物学中提供了精确和有效的应用。它在病毒学研究、诊断和抗病毒治疗方面也是无价的。在这篇综述中,我们探讨了基于crispr - cas的方法来阐明病毒与宿主相互作用的最新进展,重点是鉴定病毒感染所必需的关键受体和宿主因子。此外,我们讨论了CRISPR-Cas系统作为应对新出现和再出现病毒的抗病毒策略的潜力。最后,我们讨论了基于crispr - cas的基因编辑在开发创新病毒疫苗方面的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Trends in Microbiology
Trends in Microbiology 生物-生化与分子生物学
CiteScore
25.30
自引率
0.60%
发文量
193
审稿时长
6-12 weeks
期刊介绍: Trends in Microbiology serves as a comprehensive, multidisciplinary forum for discussing various aspects of microbiology, spanning cell biology, immunology, genetics, evolution, virology, bacteriology, protozoology, and mycology. In the rapidly evolving field of microbiology, technological advancements, especially in genome sequencing, impact prokaryote biology from pathogens to extremophiles, influencing developments in drugs, vaccines, and industrial enzyme research.
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