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IF 13.6 1区 医学
Trends in molecular medicine Pub Date : 2024-09-11 DOI: 10.1016/s1471-4914(24)00229-6
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/s1471-4914(24)00229-6","DOIUrl":"https://doi.org/10.1016/s1471-4914(24)00229-6","url":null,"abstract":"No Abstract","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":"18 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142220326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sterols in ferroptosis: from molecular mechanisms to therapeutic strategies 铁中毒中的甾醇：从分子机制到治疗策略
IF 13.6 1区 医学
Trends in molecular medicine Pub Date : 2024-09-10 DOI: 10.1016/j.molmed.2024.08.007
Yaxu Li, Zan Li, Qiao Ran, Ping Wang
{"title":"Sterols in ferroptosis: from molecular mechanisms to therapeutic strategies","authors":"Yaxu Li, Zan Li, Qiao Ran, Ping Wang","doi":"10.1016/j.molmed.2024.08.007","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.08.007","url":null,"abstract":"<p>Ferroptosis, a novel cell death mode driven by iron-dependent phospholipid (PL) peroxidation, has emerged as a promising therapeutic strategy for the treatments of cancer, cardiovascular diseases, and ischemic-reperfusion injury (IRI). PL peroxidation, the key process of ferroptosis, requires polyunsaturated fatty acid (PUFA)-containing PLs (PL-PUFAs) as substrates, undergoing a chain reaction with iron and oxygen. Cells prevent ferroptosis by maintaining a homeostatic equilibrium among substrates, processes, and detoxification of PL peroxidation. Sterols, lipids abundant in cell membranes, directly participate in PL peroxidation and influence ferroptosis sensitivity. Sterol metabolism also plays a key role in ferroptosis, and targeting sterols presents significant potential for treating numerous ferroptosis-associated disorders. This review elucidates the fundamental mechanisms of ferroptosis, emphasizing how sterols modulate this process and their therapeutic potential.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":"10 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142220327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploiting the gut microbiome for brain tumour treatment 利用肠道微生物组治疗脑肿瘤
IF 13.6 1区 医学
Trends in molecular medicine Pub Date : 2024-09-10 DOI: 10.1016/j.molmed.2024.08.008
Lily Keane, John F. Cryan, Jack P. Gleeson
{"title":"Exploiting the gut microbiome for brain tumour treatment","authors":"Lily Keane, John F. Cryan, Jack P. Gleeson","doi":"10.1016/j.molmed.2024.08.008","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.08.008","url":null,"abstract":"<p>Increasing evidence suggests that the gut microbiome plays a key role in a host of pathological conditions, including cancer. Indeed, the bidirectional communication that occurs between the gut and the brain, known as the ‘gut–brain axis,’ has recently been implicated in brain tumour pathology. Here, we focus on current research that supports a gut microbiome–brain tumour link with emphasis on high-grade gliomas, the most aggressive of all brain tumours, and the impact on the glioma tumour microenvironment. We discuss the potential use of gut–brain axis signals to improve responses to current and future therapeutic approaches. We highlight that the success of novel treatment strategies may rely on patient-specific microbiome profiles, and these should be considered for personalised treatment approaches.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":"12 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142220328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The inaccessible road to science for people with disabilities. 残疾人通往科学的无障碍之路。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-09-10 DOI: 10.1016/j.molmed.2024.08.006
Lisa M Meeks, Mytien Nguyen, Karina Pereira-Lima, Zoie C Sheets, Rylee Betchkal, Bonnielin K Swenor
{"title":"The inaccessible road to science for people with disabilities.","authors":"Lisa M Meeks, Mytien Nguyen, Karina Pereira-Lima, Zoie C Sheets, Rylee Betchkal, Bonnielin K Swenor","doi":"10.1016/j.molmed.2024.08.006","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.08.006","url":null,"abstract":"<p><p>This article examines the contributions of disabled scientists and the barriers they face, including systemic ableism and lack of inclusivity. It offers recommendations to foster an inclusive STEM environment, underscoring the importance of supporting disabled scientists to boost innovation and equity.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142366582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Harnessing the immune system: vaccines to fight neurodegenerative diseases 利用免疫系统：抗击神经退行性疾病的疫苗
IF 13.6 1区 医学
Trends in molecular medicine Pub Date : 2024-09-09 DOI: 10.1016/j.molmed.2024.08.005
Alba Gonzalez-Artero, Jordi Pujols, Salvador Ventura
{"title":"Harnessing the immune system: vaccines to fight neurodegenerative diseases","authors":"Alba Gonzalez-Artero, Jordi Pujols, Salvador Ventura","doi":"10.1016/j.molmed.2024.08.005","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.08.005","url":null,"abstract":"<p>Neurodegenerative diseases strongly impact our aging society, with treatments providing only symptomatic relief. Recent advancements in active immunotherapy offer solutions by stimulating the immune system to produce antibodies against misfolded and toxic amyloid proteins. We discuss vaccines under clinical evaluation for Alzheimer’s and Parkinson’s diseases, highlighting successes and ongoing trials.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":"6 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142220329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vaccine-based immunotherapy and related preclinical models for glioma: (Trends in Molecular Medicine, published online July 15, 2024). 基于疫苗的胶质瘤免疫疗法及相关临床前模型：（《分子医学趋势》，2024 年 7 月 15 日在线发表）。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-09-02 DOI: 10.1016/j.molmed.2024.08.003
Binghao Zhao, Longping Yao, Maryam Hatami, Wenbin Ma, Thomas Skutella
{"title":"Vaccine-based immunotherapy and related preclinical models for glioma: (Trends in Molecular Medicine, published online July 15, 2024).","authors":"Binghao Zhao, Longping Yao, Maryam Hatami, Wenbin Ma, Thomas Skutella","doi":"10.1016/j.molmed.2024.08.003","DOIUrl":"10.1016/j.molmed.2024.08.003","url":null,"abstract":"","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142126758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Science around the world.
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-09-01 Epub Date: 2024-08-14 DOI: 10.1016/j.molmed.2024.07.012
Meaghan J Griffiths, Rui J Nobre
{"title":"Science around the world.","authors":"Meaghan J Griffiths, Rui J Nobre","doi":"10.1016/j.molmed.2024.07.012","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.07.012","url":null,"abstract":"","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":"30 9","pages":"795-796"},"PeriodicalIF":12.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142795118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erythropoietic protoporphyrias: updates and advances. 红细胞生成性原卟啉症：最新进展。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-09-01 Epub Date: 2024-06-17 DOI: 10.1016/j.molmed.2024.05.006
Antoine Poli, Caroline Schmitt, Hervé Puy, Neila Talbi, Thibaud Lefebvre, Laurent Gouya
{"title":"Erythropoietic protoporphyrias: updates and advances.","authors":"Antoine Poli, Caroline Schmitt, Hervé Puy, Neila Talbi, Thibaud Lefebvre, Laurent Gouya","doi":"10.1016/j.molmed.2024.05.006","DOIUrl":"10.1016/j.molmed.2024.05.006","url":null,"abstract":"<p><p>Protoporphyrias are caused by pathogenic variants in genes encoding enzymes involved in heme biosynthesis. They induce the accumulation of a hydrophobic phototoxic compound, protoporphyrin (PPIX), in red blood cells (RBCs). PPIX is responsible for painful cutaneous photosensitivity, which severely impairs quality of life. Hepatic elimination of PPIX increases the risk of cholestatic liver disease, requiring lifelong monitoring. Treatment options are scarce and mainly limited to supportive care such as protection from visible light. Here, we review the pathophysiology of protoporphyrias, their diagnosis, and current recommendations for medical care. We discuss new therapeutic strategies, some of which are currently undergoing clinical trials and are likely to radically alter the severity of the disease in the years to come.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"863-874"},"PeriodicalIF":12.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141421050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Science around the world. 世界各地的科学
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-09-01 Epub Date: 2024-08-14 DOI: 10.1016/j.molmed.2024.07.012
Meaghan J Griffiths, Rui J Nobre
{"title":"Science around the world.","authors":"Meaghan J Griffiths, Rui J Nobre","doi":"10.1016/j.molmed.2024.07.012","DOIUrl":"10.1016/j.molmed.2024.07.012","url":null,"abstract":"","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"795-796"},"PeriodicalIF":12.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141988989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endometriosis: recent advances that could accelerate diagnosis and improve care. 子宫内膜异位症：可加快诊断和改善护理的最新进展。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-09-01 Epub Date: 2024-07-10 DOI: 10.1016/j.molmed.2024.06.008
Meaghan J Griffiths, Andrew W Horne, Douglas A Gibson, Neil Roberts, Philippa T K Saunders
{"title":"Endometriosis: recent advances that could accelerate diagnosis and improve care.","authors":"Meaghan J Griffiths, Andrew W Horne, Douglas A Gibson, Neil Roberts, Philippa T K Saunders","doi":"10.1016/j.molmed.2024.06.008","DOIUrl":"10.1016/j.molmed.2024.06.008","url":null,"abstract":"<p><p>Endometriosis is a common disorder associated with pain, gastrointestinal and urinary symptoms, infertility, and fatigue. It is defined by the presence of endometrial-like lesions found predominantly in the pelvis. Mechanisms that contribute to disease aetiology include changes in hormonal, inflammatory, and pain pathways. In this article, we focus on recent developments in imaging technologies, on our improved understanding of mechanisms contributing to infertility, on drug therapies that are in clinical trials, and on insights from studies on the gut that offer potential to support self-management strategies. We postulate that improvements in the quality of life of patients will be accelerated by reframing endometriosis as a multi-system disorder and learning from treatments targeting symptoms shared between endometriosis, neuroinflammatory, and gastrointestinal disorders.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"875-889"},"PeriodicalIF":12.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141591472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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