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EVolution in ALS diagnosis: molecular markers in extracellular vesicles. ALS 诊断中的 EVolution：细胞外囊泡中的分子标记。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-07-27 DOI: 10.1016/j.molmed.2024.07.006
Philippe Codron, Stéphanie Millecamps, Philippe Corcia
{"title":"EVolution in ALS diagnosis: molecular markers in extracellular vesicles.","authors":"Philippe Codron, Stéphanie Millecamps, Philippe Corcia","doi":"10.1016/j.molmed.2024.07.006","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.07.006","url":null,"abstract":"<p><p>The identification of biomarkers for amyotrophic lateral sclerosis (ALS) is a central issue in disease research. In a recent article, Chatterjee et al. show that blood extracellular vesicles (EVs) with high levels of transactive response DNA-binding protein 43 (TDP-43) accurately discriminate patients with ALS from controls and correlate with disease severity, providing a promising biomarker for early diagnosis and monitoring.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lactate/lactylation in ocular development and diseases. 眼部发育和疾病中的乳酸/乳酰化。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-07-24 DOI: 10.1016/j.molmed.2024.07.001
Peiwei Chai, Fei Zhao, Renbing Jia, Xiangtian Zhou, Xianqun Fan
{"title":"Lactate/lactylation in ocular development and diseases.","authors":"Peiwei Chai, Fei Zhao, Renbing Jia, Xiangtian Zhou, Xianqun Fan","doi":"10.1016/j.molmed.2024.07.001","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.07.001","url":null,"abstract":"<p><p>Lactylation, a post-translational modification (PTM) induced by lactate, has crucial roles in the regulation of transcription, DNA repair, and mitochondrial metabolism. Here, we discuss the role of lactate/lactylation signaling in regulating eye morphogenesis and retinal homeostasis, as well as various ophthalmic disorders, such as myopia, intraocular malignancies, and retinal angiogenesis.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Circadian phase instability in bipolar disorder: a neglected essence. 躁郁症的昼夜相位不稳定性：一个被忽视的本质。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-07-13 DOI: 10.1016/j.molmed.2024.06.012
Francisco Romo-Nava
{"title":"Circadian phase instability in bipolar disorder: a neglected essence.","authors":"Francisco Romo-Nava","doi":"10.1016/j.molmed.2024.06.012","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.06.012","url":null,"abstract":"<p><p>Circadian system disruption is an essential but poorly understood feature of bipolar disorder (BD) and associated comorbidities. This forum article summarizes current evidence regarding the emerging concept of circadian phase instability (CPI) as a neglected phenomenon with possibly unique features in BD that could be harnessed to develop individually tailored chronobiological interventions.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141617166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会和内容
IF 13.6 1区 医学
Trends in molecular medicine Pub Date : 2024-07-10 DOI: 10.1016/s1471-4914(24)00171-0
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/s1471-4914(24)00171-0","DOIUrl":"https://doi.org/10.1016/s1471-4914(24)00171-0","url":null,"abstract":"No Abstract","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":"81 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141587259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅和版权信息
IF 13.6 1区 医学
Trends in molecular medicine Pub Date : 2024-07-10 DOI: 10.1016/s1471-4914(24)00174-6
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/s1471-4914(24)00174-6","DOIUrl":"https://doi.org/10.1016/s1471-4914(24)00174-6","url":null,"abstract":"No Abstract","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":"22 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141588578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New insights on gut microbiome and autism 关于肠道微生物组与自闭症的新见解
IF 13.6 1区 医学
Trends in molecular medicine Pub Date : 2024-07-09 DOI: 10.1016/j.molmed.2024.06.010
Yating Wan, Qi Su, Siew C. Ng
{"title":"New insights on gut microbiome and autism","authors":"Yating Wan, Qi Su, Siew C. Ng","doi":"10.1016/j.molmed.2024.06.010","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.06.010","url":null,"abstract":"<p>Autism spectrum disorder (ASD) is a complex neurodevelopmental condition that often coincides with gut dysbiosis. Studies show that alterations in gut microbiota influence brain function and could serve as diagnostic biomarkers and therapeutic targets. This forum article discusses the role of gut microbiota in ASD pathogenesis and its diagnostic and therapeutic potential.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":"13 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141573702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endoscopic duodenal mucosa ablation: the future of diabetes treatment? 内镜十二指肠粘膜消融术：糖尿病治疗的未来？
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-07-01 Epub Date: 2024-03-29 DOI: 10.1016/j.molmed.2024.03.003
Giovanni Musso, Maurizio Cassader, Roberto Gambino
{"title":"Endoscopic duodenal mucosa ablation: the future of diabetes treatment?","authors":"Giovanni Musso, Maurizio Cassader, Roberto Gambino","doi":"10.1016/j.molmed.2024.03.003","DOIUrl":"10.1016/j.molmed.2024.03.003","url":null,"abstract":"<p><p>Duodenal mucosa ablation (DMA) is a novel approach to treat diabetes, consisting of endoscopic ablation of dysfunctional diabetic duodenal mucosa, which, following the healing response, is replaced by normally functioning mucosa. Two techniques, duodenal mucosal resurfacing (DMR) and recellularization via electroporation therapy (ReCET), recently showed promise in type 2 diabetes mellitus (T2DM) patients.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"612-616"},"PeriodicalIF":12.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140327193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PD-L1 at the crossroad between RNA metabolism and immunosuppression. PD-L1处于 RNA 代谢与免疫抑制的十字路口。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-07-01 Epub Date: 2024-05-31 DOI: 10.1016/j.molmed.2024.04.008
Axel Arthur, Sanae Nejmi, Don-Marc Franchini, Estelle Espinos, Stefania Millevoi
{"title":"PD-L1 at the crossroad between RNA metabolism and immunosuppression.","authors":"Axel Arthur, Sanae Nejmi, Don-Marc Franchini, Estelle Espinos, Stefania Millevoi","doi":"10.1016/j.molmed.2024.04.008","DOIUrl":"10.1016/j.molmed.2024.04.008","url":null,"abstract":"<p><p>Programmed death ligand-1 (PD-L1) is a key component of tumor immunosuppression. The uneven therapeutic results of PD-L1 therapy have stimulated intensive studies to better understand the mechanisms underlying altered PD-L1 expression in cancer cells, and to determine whether, beyond its immune function, PD-L1 might have intracellular functions promoting tumor progression and resistance to treatments. In this Opinion, we focus on paradigmatic examples highlighting the central role of PD-L1 in post-transcriptional regulation, with PD-L1 being both a target and an effector of molecular mechanisms featured prominently in RNA research, such as RNA methylation, phase separation and RNA G-quadruplex structures, in order to highlight vulnerabilities on which future anti-PD-L1 therapies could be built.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"620-632"},"PeriodicalIF":12.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141187027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Science around the world. 世界各地的科学
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-07-01 Epub Date: 2024-06-05 DOI: 10.1016/j.molmed.2024.05.011
Michael Bauer, Aneta Škarková, Chenju Yi
{"title":"Science around the world.","authors":"Michael Bauer, Aneta Škarková, Chenju Yi","doi":"10.1016/j.molmed.2024.05.011","DOIUrl":"10.1016/j.molmed.2024.05.011","url":null,"abstract":"","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"607-608"},"PeriodicalIF":12.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141284854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hormesis as an adaptive response to infection. 作为对感染的一种适应性反应的激素作用。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-07-01 Epub Date: 2024-05-13 DOI: 10.1016/j.molmed.2024.04.012
Michael Bauer, Maria Ermolaeva, Mervyn Singer, Reinhard Wetzker, Miguel P Soares
{"title":"Hormesis as an adaptive response to infection.","authors":"Michael Bauer, Maria Ermolaeva, Mervyn Singer, Reinhard Wetzker, Miguel P Soares","doi":"10.1016/j.molmed.2024.04.012","DOIUrl":"10.1016/j.molmed.2024.04.012","url":null,"abstract":"<p><p>Hormesis is a phenomenon whereby low-level stress can improve cellular, organ, or organismal fitness in response to a subsequent similar or other stress insult. Whereas hormesis is thought to contribute to the fitness benefits arising from symbiotic host-microbe interactions, the putative benefits of hormesis in host-pathogen interactions have yet to be explored. Hormetic responses have nonetheless been reported in experimental models of infection, a common feature of which is regulation of host mitochondrial function. We propose that these mitohormetic responses could be harnessed therapeutically to limit the severity of infectious diseases.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"633-641"},"PeriodicalIF":12.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140923445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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