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Tackling 'lost in translation' issues: a response to Perez-Campos et al. 解决“翻译迷失”问题：对Perez-Campos等人的回应。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-03-01 Epub Date: 2025-01-28 DOI: 10.1016/j.molmed.2025.01.007
Guillermo Aquino-Jarquin
{"title":"Tackling 'lost in translation' issues: a response to Perez-Campos et al.","authors":"Guillermo Aquino-Jarquin","doi":"10.1016/j.molmed.2025.01.007","DOIUrl":"10.1016/j.molmed.2025.01.007","url":null,"abstract":"","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"204-205"},"PeriodicalIF":12.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143068081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pi-ecing together brain calcification mechanisms for therapeutic advancement. 结合脑钙化机制促进治疗进展。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-03-01 Epub Date: 2025-01-04 DOI: 10.1016/j.molmed.2024.12.003
Åse K Bekkelund, Anette Siggervåg, Henriette Aksnes
{"title":"P<sub>i</sub>-ecing together brain calcification mechanisms for therapeutic advancement.","authors":"Åse K Bekkelund, Anette Siggervåg, Henriette Aksnes","doi":"10.1016/j.molmed.2024.12.003","DOIUrl":"10.1016/j.molmed.2024.12.003","url":null,"abstract":"<p><p>Seven primary familial brain calcification genes have been identified but their role in disease mechanisms has been less explored. Cheng et al. recently demonstrated that astrocyte-mediated regulation of brain phosphate (P<sub>i</sub>) involves direct and functional interactions among three of these proteins, paving the way for new strategies to combat brain calcification.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"206-208"},"PeriodicalIF":12.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Considerations for capsid-targeting antiretrovirals in pre-exposure prophylaxis. 衣壳靶向抗逆转录病毒药物用于暴露前预防的考虑。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-02-27 DOI: 10.1016/j.molmed.2025.01.013
William M McFadden, Mia Faerch, Karen A Kirby, Robert A Dick, Bruce E Torbett, Stefan G Sarafianos
{"title":"Considerations for capsid-targeting antiretrovirals in pre-exposure prophylaxis.","authors":"William M McFadden, Mia Faerch, Karen A Kirby, Robert A Dick, Bruce E Torbett, Stefan G Sarafianos","doi":"10.1016/j.molmed.2025.01.013","DOIUrl":"https://doi.org/10.1016/j.molmed.2025.01.013","url":null,"abstract":"<p><p>Antiretroviral therapy (ART) impairs viral replication in people living with HIV (PLWH) by suppressing infection or spread. However, not all treatment strategies apply to preventive applications like pre-exposure prophylaxis (PrEP) for uninfected individuals. To prevent the establishment of HIV infection, PrEP must block viral replication either before, or at the stage of integration into the host genome. A promising PrEP approach under investigation utilizes lenacapavir (LEN), which targets the HIV-1 capsid protein (CA) potently before integration. LEN, a first-in-class antiretroviral, has shown high protective efficacy in the ongoing PURPOSE trials thus far. Here, we discuss clinical investigations of LEN, theoretical suitability of preclinical CA-binding antivirals in PrEP, and other key considerations for preventing HIV-1 infection by targeting the capsid.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is there a place for engineered immune cell therapies in autoimmune diseases? 工程免疫细胞疗法在自身免疫性疾病中有一席之地吗？
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-02-20 DOI: 10.1016/j.molmed.2025.01.011
Luca Perico, Federica Casiraghi, Ariela Benigni, Giuseppe Remuzzi
{"title":"Is there a place for engineered immune cell therapies in autoimmune diseases?","authors":"Luca Perico, Federica Casiraghi, Ariela Benigni, Giuseppe Remuzzi","doi":"10.1016/j.molmed.2025.01.011","DOIUrl":"https://doi.org/10.1016/j.molmed.2025.01.011","url":null,"abstract":"<p><p>The ability to engineer immune cells yielded a transformative era in oncology. Early clinical trials demonstrated the efficacy of chimeric antigen receptor (CAR) T cells in resetting the immune system, motivating the expansion of this treatment beyond cancer, including autoimmune conditions. In this review, we discuss the current state of CAR T cell research in autoimmune diseases, examining the main challenges that limit widespread adoption of this therapy, such as complex isolation protocols, stringent immunosuppression, risk of secondary malignancies, and variable efficacy. We also review the studies addressing these limitations by development of off-the-shelf allogeneic CAR T cells, tunable safety systems, and antigen-specific therapies, which hold the potential to improve safety and accessibility of this treatment in clinical practice.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143473004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gene therapies for neurogenetic disorders. 神经遗传疾病的基因治疗。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-02-17 DOI: 10.1016/j.molmed.2025.01.015
Orrin Devinsky, Jeff Coller, Rebecca Ahrens-Nicklas, X Shawn Liu, Nadav Ahituv, Beverly L Davidson, Kathie M Bishop, Yael Weiss, Ana Mingorance
{"title":"Gene therapies for neurogenetic disorders.","authors":"Orrin Devinsky, Jeff Coller, Rebecca Ahrens-Nicklas, X Shawn Liu, Nadav Ahituv, Beverly L Davidson, Kathie M Bishop, Yael Weiss, Ana Mingorance","doi":"10.1016/j.molmed.2025.01.015","DOIUrl":"https://doi.org/10.1016/j.molmed.2025.01.015","url":null,"abstract":"<p><p>Pathogenic variants in over 1700 genes can cause neurogenetic disorders. Monogenetic diseases are ideal targets for genetic therapies; however, the blood-brain barrier (BBB), post-mitotic neurons, and inefficient delivery platforms make gene therapies for neurogenetic diseases challenging. Following nusinersen's 2016 approval, the development of gene therapies for neurogenetic disorders has advanced rapidly, with new delivery vehicles [e.g., BBB-crossing capsids, engineered viral-like proteins, lipid nanoparticles (LNPs)] and novel therapeutic strategies (e.g., regulatory elements, novel RNA therapeutics, tRNA therapies, epigenetic and gene editing). Patient-led disease foundations have accelerated treatment development by addressing trial readiness and supporting translational research. We review the current landscape and future directions in developing gene therapies for neurogenetic disorders.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143450316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synergizing metabolomics and artificial intelligence for advancing precision oncology. 协同代谢组学和人工智能推进精准肿瘤学。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-02-15 DOI: 10.1016/j.molmed.2025.01.016
Yipeng Xu, Xiaojuan Jiang, Zeping Hu
{"title":"Synergizing metabolomics and artificial intelligence for advancing precision oncology.","authors":"Yipeng Xu, Xiaojuan Jiang, Zeping Hu","doi":"10.1016/j.molmed.2025.01.016","DOIUrl":"https://doi.org/10.1016/j.molmed.2025.01.016","url":null,"abstract":"<p><p>Metabolomics has emerged as a transformative tool in precision oncology, with substantial potential for advancing biomarker discovery, monitoring treatment responses, and aiding drug development. Integrating artificial intelligence (AI) into metabolomics optimizes data acquisition and analysis, facilitating the interpretation of complex metabolic networks and enabling more effective multiomics integration. In this opinion, we explore recent advances in the application of metabolomics within precision oncology, emphasizing the unique advantages that AI-driven metabolomics offers. We propose that AI not only complements but also amplifies the potential of current platforms, accelerating research progress and ultimately improving patient outcomes. Finally, we discuss the opportunities and challenges involved in translating AI-driven metabolomics into clinical practice for precision oncology.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular subtypes of intrahepatic cholangiocarcinoma. 肝内胆管癌的分子亚型。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-02-14 DOI: 10.1016/j.molmed.2025.01.008
Alessandro De Santis, Lei Zhu, Jianxin Tao, Christoph Reißfelder, Sebastian Schölch
{"title":"Molecular subtypes of intrahepatic cholangiocarcinoma.","authors":"Alessandro De Santis, Lei Zhu, Jianxin Tao, Christoph Reißfelder, Sebastian Schölch","doi":"10.1016/j.molmed.2025.01.008","DOIUrl":"https://doi.org/10.1016/j.molmed.2025.01.008","url":null,"abstract":"<p><p>Intrahepatic cholangiocarcinoma (iCCA) presents in two clinically distinct subtypes: large duct (LD-iCCA) and small duct (SD-iCCA). These subtypes exhibit significant molecular, genetic, and histopathological differences that impact patient prognosis and treatment responsiveness. This review advocates for a subtype-specific approach to iCCA research and clinical management, including tailored therapeutic strategies that consider distinct genetic profiles and tumor microenvironments. Current therapeutic approaches hold promise, yet efficacy varies by subtype. Additionally, subtype-specific molecular diagnostics, including DNA methylation-based classifiers and transcriptomic sequencing, have shown potential in refining iCCA subclassification, thereby guiding precision medicine efforts. This article outlines existing clinical trials, key research trajectories, and future directions for developing more effective subtype-adapted therapies for iCCA.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spatial biology - unravelling complexity within the glioblastoma microenvironment. 空间生物学——揭示胶质母细胞瘤微环境的复杂性。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-02-10 DOI: 10.1016/j.molmed.2025.01.014
Stephen D Robinson, Chrysa Filippopoulou, Simoni Besta, Mark Samuels, Andrea L Betrán, Maha Abu Ajamieh, Viviana Vella, William Jones, Georgios Giamas
{"title":"Spatial biology - unravelling complexity within the glioblastoma microenvironment.","authors":"Stephen D Robinson, Chrysa Filippopoulou, Simoni Besta, Mark Samuels, Andrea L Betrán, Maha Abu Ajamieh, Viviana Vella, William Jones, Georgios Giamas","doi":"10.1016/j.molmed.2025.01.014","DOIUrl":"https://doi.org/10.1016/j.molmed.2025.01.014","url":null,"abstract":"<p><p>The advent and refinement of state-of-the-art spatial biology technologies have facilitated analysis that combines the advantages of high-throughput single cell analysis with techniques that preserve tissue architecture. This combination of cellular phenotyping with retained spatial context provides a much greater understanding of cellular interactions within the tumour microenvironment (TME). For glioblastoma, with its significant intra-tumoural heterogeneity, cellular plasticity, and complex TME, appreciating and understanding these spatial patterns may prove key to improving patient outcomes. This review examines the advances in spatial biology techniques, discusses how these methodologies are being applied to study glioblastoma, and explores how spatial information improves understanding of the TME. Ultimately, it is this spatial context that will accelerate the identification of more effective treatments for glioblastoma.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The emerging regulatory interface between DNA repair and steroid hormone receptors in cancer. 癌症中DNA修复和类固醇激素受体之间新出现的调控界面。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-02-10 DOI: 10.1016/j.molmed.2025.01.006
Bim de Klein, Nils Eickhoff, Wilbert Zwart
{"title":"The emerging regulatory interface between DNA repair and steroid hormone receptors in cancer.","authors":"Bim de Klein, Nils Eickhoff, Wilbert Zwart","doi":"10.1016/j.molmed.2025.01.006","DOIUrl":"https://doi.org/10.1016/j.molmed.2025.01.006","url":null,"abstract":"<p><p>Human cells potentiate highly diverse functions through tight transcriptional regulation and maintenance of genome integrity. While the DNA damage response (DDR) safeguards the genome, ligand-activated transcription factors, such as steroid hormone receptors (SHRs), provide complex transcriptional outputs. Interestingly, an increasing body of evidence reveals a direct biological and functional interplay between DDR factors and SHR cascades in cancer. SHRs can directly affect DDR gene expression, but DDR factors in turn act as transcriptional coregulators, enabling oncogenic SHR-mediated signaling, which has the potential for novel therapeutic interventions. With a focus on breast and prostate cancer, we describe in this review recent developments in, and insights into, the complex interplay between SHR signaling and the DDR, highlighting opportunities for future clinical interventions.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond pluripotency: Yamanaka factors drive brain growth and regeneration. 超越多能性：山中因子驱动大脑生长和再生。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-02-01 Epub Date: 2024-12-12 DOI: 10.1016/j.molmed.2024.11.013
Sunwoo Choi, Mingzi Zhang, Ruslan Rust
{"title":"Beyond pluripotency: Yamanaka factors drive brain growth and regeneration.","authors":"Sunwoo Choi, Mingzi Zhang, Ruslan Rust","doi":"10.1016/j.molmed.2024.11.013","DOIUrl":"10.1016/j.molmed.2024.11.013","url":null,"abstract":"<p><p>The Yamanaka factors (YFs), a set of four transcription factors, are widely studied for their ability to dedifferentiate somatic cells into a pluripotent state. In a recent study, Shen and colleagues show that transient expression of YFs in the mouse brain expands the developing cortex and prevents cognitive decline in an Alzheimer's disease (AD) model.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"100-102"},"PeriodicalIF":12.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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