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Advances in Hodgkin lymphoma research. 霍奇金淋巴瘤研究进展。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-04-01 Epub Date: 2024-10-22 DOI: 10.1016/j.molmed.2024.10.004
Ralf Küppers
{"title":"Advances in Hodgkin lymphoma research.","authors":"Ralf Küppers","doi":"10.1016/j.molmed.2024.10.004","DOIUrl":"10.1016/j.molmed.2024.10.004","url":null,"abstract":"<p><p>Hodgkin lymphoma (HL) has been and still is the most enigmatic lymphoid malignancy in humans. Since the first molecular analysis of isolated Hodgkin and Reed-Sternberg (HRS) tumor cells of classic HL 30 years ago, substantial advances in our understanding of HL have been made. This review describes the cellular origin of HL, summarizes the current knowledge about the genetic lesions in HRS cells, and highlights the role of Epstein-Barr virus (EBV) in HL pathogenesis. Moreover, the pathobiological roles of altered gene expression and deregulated signaling pathways are discussed and key aspects of the HL microenvironment are presented.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"326-343"},"PeriodicalIF":12.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gene therapy for β-thalassemia: current and future options. β-地中海贫血的基因治疗：当前和未来的选择。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-04-01 Epub Date: 2025-01-10 DOI: 10.1016/j.molmed.2024.12.001
Giulia Hardouin, Annarita Miccio, Megane Brusson
{"title":"Gene therapy for β-thalassemia: current and future options.","authors":"Giulia Hardouin, Annarita Miccio, Megane Brusson","doi":"10.1016/j.molmed.2024.12.001","DOIUrl":"10.1016/j.molmed.2024.12.001","url":null,"abstract":"<p><p>Beta-thalassemia is a severe, hereditary blood disorder characterized by anemia, transfusion dependence, reduced life expectancy, and poor quality of life. Allogeneic transplantation of hematopoietic stem cells (HSCs) is the only curative treatment for transfusion-dependent β-thalassemia, but a lack of compatible donors prevents the use of this approach for most patients. Over the past 20 years, the rise of gene therapy and the development of lentiviral vectors and genome-editing tools has extended curative options to a broader range of patients. Here, we review breakthroughs in gene addition- and genome-editing-based therapies for β-thalassemia, the clinical outcomes enabling approval by regulatory agencies, and perspectives for further development.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"344-358"},"PeriodicalIF":12.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thirty years of molecular medicine: reflections from an academic physician-scientist, 1995-2025. 分子医学三十年：一位学术医师兼科学家的反思，1995-2025。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-04-01 Epub Date: 2025-02-05 DOI: 10.1016/j.molmed.2025.01.012
William A Petri
{"title":"Thirty years of molecular medicine: reflections from an academic physician-scientist, 1995-2025.","authors":"William A Petri","doi":"10.1016/j.molmed.2025.01.012","DOIUrl":"10.1016/j.molmed.2025.01.012","url":null,"abstract":"","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"298-300"},"PeriodicalIF":12.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pulmonary arterial hypertension and cancer: exploring their resemblance as channelopathies. 肺动脉高压与癌症：探讨其作为通道病变的相似性。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-04-01 DOI: 10.1016/j.molmed.2025.03.002
Fabrice Antigny, David Crottès, Christophe Vandier, Véronique Capuano, Maxime Guéguinou
{"title":"Pulmonary arterial hypertension and cancer: exploring their resemblance as channelopathies.","authors":"Fabrice Antigny, David Crottès, Christophe Vandier, Véronique Capuano, Maxime Guéguinou","doi":"10.1016/j.molmed.2025.03.002","DOIUrl":"https://doi.org/10.1016/j.molmed.2025.03.002","url":null,"abstract":"<p><p>Pulmonary arterial hypertension (PAH) and cancer may appear to be unrelated at first, but there is increasing evidence that they share many characteristics and complexities. Pulmonary vascular cells in PAH resemble cancer cells in that they display abnormal growth patterns, resistance to cell death, metabolic changes, and channelopathies. These similarities open new possibilities for researchers and clinicians to apply cancer treatment strategies to PAH and possibly reverse the condition. This review explores the complex parallels between PAH and cancer, and emphasizes their similar channelopathy-like features at the molecular, cellular, and clinical levels. We also discuss the potential implications of these similarities for developing new treatments.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of asparagine endopeptidase inhibitors for treating neurodegenerative diseases. 天冬酰胺内肽酶抑制剂治疗神经退行性疾病的研究进展。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-04-01 Epub Date: 2025-02-25 DOI: 10.1016/j.molmed.2025.01.009
Xin Meng, Bowei Li, Mengmeng Wang, Wenhua Zheng, Keqiang Ye
{"title":"Development of asparagine endopeptidase inhibitors for treating neurodegenerative diseases.","authors":"Xin Meng, Bowei Li, Mengmeng Wang, Wenhua Zheng, Keqiang Ye","doi":"10.1016/j.molmed.2025.01.009","DOIUrl":"10.1016/j.molmed.2025.01.009","url":null,"abstract":"<p><p>Asparagine endopeptidase (AEP), or legumain, is a cysteine protease implicated in various disorders, including atherosclerosis, cancers, neurodegenerative diseases, and inflammation. The development of AEP inhibitors has emerged as a promising therapeutic strategy to modulate AEP activity and slow disease progression. Various AEP inhibitors have been explored, encompassing small molecules, peptide-based, antibody-based, and natural inhibitors. Substrate-mimetic and covalent inhibitors show significant potential for selectively targeting AEP's active site, whereas noncovalent inhibitors offer reversible modulation. Additionally, FDA-approved drugs have also garnered attention for their diverse structures and multitarget capabilities. In this review, we summarize advancements in AEP inhibitors, their mechanisms of action, therapeutic applications in neurodegenerative diseases, and the challenges in translating these findings into clinical practice.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"359-372"},"PeriodicalIF":12.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143504332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel universal vaccines to mitigate emerging avian influenza viruses. 减轻新出现禽流感病毒的新型通用疫苗。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-03-25 DOI: 10.1016/j.molmed.2025.03.001
Yu Liu, Lifang Wang, Alexander Lai, Mei Kang, Yangrui Qi, Andres Merits, Xinyi Jiao, Xinyu Wang, Xiangrong Yu, Shuo Su, Zhiwen Jiang
{"title":"Novel universal vaccines to mitigate emerging avian influenza viruses.","authors":"Yu Liu, Lifang Wang, Alexander Lai, Mei Kang, Yangrui Qi, Andres Merits, Xinyi Jiao, Xinyu Wang, Xiangrong Yu, Shuo Su, Zhiwen Jiang","doi":"10.1016/j.molmed.2025.03.001","DOIUrl":"https://doi.org/10.1016/j.molmed.2025.03.001","url":null,"abstract":"<p><p>Frequent spillovers and recent geospatial expansion of avian influenza virus (AIV) pose significant economic and public health threats. Recent advances in vaccine technologies, bioinformatics, and artificial intelligence will provide newer approaches to target genetically diverse and rapidly evolving AIVs. Here, we review recent advances in, and perspectives on, developing universal vaccines needed for the effective control of AIVs.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Significant challenges to translating breakthrough science in Mexico. 墨西哥在转化突破性科学方面面临重大挑战。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-03-01 Epub Date: 2024-11-08 DOI: 10.1016/j.molmed.2024.10.011
Carlos Federico Cota-Romero, Guillermo Aquino-Jarquin
{"title":"Significant challenges to translating breakthrough science in Mexico.","authors":"Carlos Federico Cota-Romero, Guillermo Aquino-Jarquin","doi":"10.1016/j.molmed.2024.10.011","DOIUrl":"10.1016/j.molmed.2024.10.011","url":null,"abstract":"<p><p>Translational medicine is crucial for addressing health issues and translating research findings to improve population health. This Science and Society article highlights the potential of translational medicine in Mexico. It discusses the obstacles and challenges encountered in the translation process, instilling a sense of optimism for the future of healthcare in Mexico.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"197-201"},"PeriodicalIF":12.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular evolution of central nervous system metastasis and therapeutic implications. 中枢神经系统转移的分子演化及治疗意义。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-03-01 Epub Date: 2024-10-17 DOI: 10.1016/j.molmed.2024.09.008
David Gritsch, Priscilla K Brastianos
{"title":"Molecular evolution of central nervous system metastasis and therapeutic implications.","authors":"David Gritsch, Priscilla K Brastianos","doi":"10.1016/j.molmed.2024.09.008","DOIUrl":"10.1016/j.molmed.2024.09.008","url":null,"abstract":"<p><p>The increasing prevalence and poor prognosis of central nervous system (CNS) metastases pose a significant challenge in oncology, necessitating improved therapeutic strategies. Recent research has shed light on the complex genomic landscape of brain metastases, identifying unique and potentially actionable genetic alterations. These insights offer new avenues for targeted therapy, highlighting the potential of precision medicine approaches in treating CNS metastases. However, translating these discoveries into clinical practice requires overcoming challenges such as availability of tissue for characterization, access to molecular testing, drug delivery across the blood-brain barrier (BBB) and addressing intra- and intertumoral genetic heterogeneity. This review explores novel insights into the evolution of CNS metastases, the molecular mechanisms underlying their development, and implications for therapeutic interventions.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"240-251"},"PeriodicalIF":12.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11908961/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Promoting proteostasis by cAMP/PKA and cGMP/PKG. 通过 cAMP/PKA 和 cGMP/PKG 促进蛋白稳态。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-03-01 Epub Date: 2024-10-29 DOI: 10.1016/j.molmed.2024.10.006
Md Salim Ahammed, Xuejun Wang
{"title":"Promoting proteostasis by cAMP/PKA and cGMP/PKG.","authors":"Md Salim Ahammed, Xuejun Wang","doi":"10.1016/j.molmed.2024.10.006","DOIUrl":"10.1016/j.molmed.2024.10.006","url":null,"abstract":"<p><p>Proteasome functional insufficiency (PFI) is implicated in neurodegeneration and heart failure, where aberrant protein aggregation is common and impairs the ubiquitin (Ub)-proteasome system (UPS), exacerbating increased proteotoxic stress (IPTS) and creating a vicious circle. Breaking this circle represents a key to treating these diseases. Protein kinase (PK)-A and PKG can activate the proteasome and promote proteasomal degradation of misfolded proteins. PKA does so by phosphorylating Ser14-RPN6/PSMD11, but how PKG activates the proteasome remains unknown. Emerging evidence supports a strategy to treat diseases with IPTS by augmenting cAMP/PKA and cGMP/PKG. Conceivably, targeted activation of PKA and PKG at proteasome nanodomains would minimize the undesired effects from their actions on other targets. In this review, we discuss PKA and PKG regulation of proteostasis via the UPS.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"224-239"},"PeriodicalIF":12.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11908951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bridging translational gaps in Mexico's new science era. 弥合墨西哥新科学时代的转化差距。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-03-01 Epub Date: 2025-01-21 DOI: 10.1016/j.molmed.2025.01.003
Eduardo Perez-Campos, Victor Del Rio, Hector A Cabrera-Fuentes
{"title":"Bridging translational gaps in Mexico's new science era.","authors":"Eduardo Perez-Campos, Victor Del Rio, Hector A Cabrera-Fuentes","doi":"10.1016/j.molmed.2025.01.003","DOIUrl":"10.1016/j.molmed.2025.01.003","url":null,"abstract":"","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"202-203"},"PeriodicalIF":12.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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