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Trends in molecular medicine最新文献

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MicroRNAs: a symphony orchestrating evolution and disease dynamics. 微小核糖核酸：进化与疾病动态的交响乐。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-08-06 DOI: 10.1016/j.molmed.2024.07.004
Shan Quah, Gowtham Subramanian, Jonathan S L Tan, Kagistia Hana Utami, Prabha Sampath
{"title":"MicroRNAs: a symphony orchestrating evolution and disease dynamics.","authors":"Shan Quah, Gowtham Subramanian, Jonathan S L Tan, Kagistia Hana Utami, Prabha Sampath","doi":"10.1016/j.molmed.2024.07.004","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.07.004","url":null,"abstract":"<p><p>The genesis of human disease lies in our evolutionary past. Evolution has featured a general trend towards increased morphological complexity, partly conferred by expansion in gene regulatory capacity via microRNA (miRNA) innovation. Many human diseases are directly related to the evolved roles of these miRNAs, and miRNA-based therapies are emerging as an appealing strategy for precision medicine. We focus on three categories of human disease - cancer, inflammation-linked pathologies, and neurological disorders - which are highly prevalent and are associated with substantial disease burden worldwide. In each category we discuss the pathogenic roles of miRNAs in the context of their evolved functions, as well as current and potential advances in targeting these miRNAs for disease therapy.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141902989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interdisciplinary approaches for the discovery of novel antifungals. 发现新型抗真菌药物的跨学科方法。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-08-01 Epub Date: 2024-05-21 DOI: 10.1016/j.molmed.2024.04.018
Bonnie Yiu, Nicole Robbins, Leah E Cowen
{"title":"Interdisciplinary approaches for the discovery of novel antifungals.","authors":"Bonnie Yiu, Nicole Robbins, Leah E Cowen","doi":"10.1016/j.molmed.2024.04.018","DOIUrl":"10.1016/j.molmed.2024.04.018","url":null,"abstract":"<p><p>Pathogenic fungi are an increasing public health concern. The emergence of antifungal resistance coupled with the scarce antifungal arsenal highlights the need for novel therapeutics. Fortunately, the past few years have witnessed breakthroughs in antifungal development. Here, we discuss pivotal interdisciplinary approaches for the discovery of novel compounds with efficacy against diverse fungal pathogens. We highlight breakthroughs in improving current antifungal scaffolds, as well as the utility of compound combinations to extend the lifespan of antifungals. Finally, we describe efforts to refine candidate chemical scaffolds by leveraging structure-guided approaches, and the use of functional genomics to expand our knowledge of druggable antifungal targets. Overall, we emphasize the importance of interdisciplinary collaborations in the endeavor to develop innovative antifungal strategies.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"723-735"},"PeriodicalIF":12.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141081421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic disorder: the dark side of ovarian aging. 代谢紊乱：卵巢衰老的阴暗面。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-08-01 Epub Date: 2024-06-05 DOI: 10.1016/j.molmed.2024.05.007
Zhiyun Xue, Xiuying Chen, Jin Li
{"title":"Metabolic disorder: the dark side of ovarian aging.","authors":"Zhiyun Xue, Xiuying Chen, Jin Li","doi":"10.1016/j.molmed.2024.05.007","DOIUrl":"10.1016/j.molmed.2024.05.007","url":null,"abstract":"<p><p>Ovarian aging plays an important role in the aging process of the whole body. It has been reported that metabolic disorder may significantly contribute to ovarian aging. This article highlights recent advances in metabolic regulation of ovarian aging and highlights key issues in the field.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"705-707"},"PeriodicalIF":12.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141284853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunomodulatory drugs: a promising clinical ally for cancer immunotherapy. 免疫调节药物：癌症免疫疗法前景广阔的临床盟友。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-08-01 Epub Date: 2024-05-30 DOI: 10.1016/j.molmed.2024.05.001
Abigail Colley, Timothy Brauns, Ann E Sluder, Mark C Poznansky, Yohannes Gemechu
{"title":"Immunomodulatory drugs: a promising clinical ally for cancer immunotherapy.","authors":"Abigail Colley, Timothy Brauns, Ann E Sluder, Mark C Poznansky, Yohannes Gemechu","doi":"10.1016/j.molmed.2024.05.001","DOIUrl":"10.1016/j.molmed.2024.05.001","url":null,"abstract":"<p><p>While immunomodulatory imide drugs (IMiDs) have been authorised for treatment of haematological cancers for over two decades, the appreciation of their ability to stimulate antitumour T cell and natural killer (NK) cell responses is relatively recent. Clinical trial data increasingly show that targeted immunotherapies, such as antibodies, T cells, and vaccines, improve outcomes when delivered in combination with the IMiD derivatives lenalidomide or pomalidomide. Here, we review these clinical data to highlight the relevance of IMiDs in combinatorial immunotherapy for both haematological and solid tumours. Further research into the molecular mechanisms of IMiDs and an increased understanding of their immunomodulatory effects may refine the specific applications of IMiDs and improve the design of future clinical trials, moving IMiDs to the forefront of combinatorial cancer immunotherapy.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"765-780"},"PeriodicalIF":12.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141184717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Science around the world. 世界各地的科学
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-08-01 Epub Date: 2024-07-23 DOI: 10.1016/j.molmed.2024.06.013
Boris Cheval, Yohannes Gemechu, Parastoo Shahrouzi, Liye Zou
{"title":"Science around the world.","authors":"Boris Cheval, Yohannes Gemechu, Parastoo Shahrouzi, Liye Zou","doi":"10.1016/j.molmed.2024.06.013","DOIUrl":"10.1016/j.molmed.2024.06.013","url":null,"abstract":"","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"699-701"},"PeriodicalIF":12.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human dopaminergic system in the exercise-cognition link. 人类多巴胺能系统在运动与认知之间的联系。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-08-01 Epub Date: 2024-05-07 DOI: 10.1016/j.molmed.2024.04.011
Meijun Hou, Fabian Herold, Zhihao Zhang, Soichi Ando, Boris Cheval, Sebastian Ludyga, Kirk I Erickson, Charles H Hillman, Qian Yu, Teresa Liu-Ambrose, Jin Kuang, Arthur F Kramer, Yanxia Chen, Joseph T Costello, Chong Chen, Olivier Dupuy, Dominika M Pindus, Terry McMorris, Lars Stiernman, Liye Zou
{"title":"Human dopaminergic system in the exercise-cognition link.","authors":"Meijun Hou, Fabian Herold, Zhihao Zhang, Soichi Ando, Boris Cheval, Sebastian Ludyga, Kirk I Erickson, Charles H Hillman, Qian Yu, Teresa Liu-Ambrose, Jin Kuang, Arthur F Kramer, Yanxia Chen, Joseph T Costello, Chong Chen, Olivier Dupuy, Dominika M Pindus, Terry McMorris, Lars Stiernman, Liye Zou","doi":"10.1016/j.molmed.2024.04.011","DOIUrl":"10.1016/j.molmed.2024.04.011","url":null,"abstract":"<p><p>While the dopaminergic system is important for cognitive processes, it is also sensitive to the influence of physical activity (PA). We summarize current evidence on whether PA-related changes in the human dopaminergic system are associated with alterations in cognitive performance, discuss recent advances, and highlight challenges and opportunities for future research.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"708-712"},"PeriodicalIF":12.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140892558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond the danger signal: RNA aggregates orchestrate immunotherapy. 超越危险信号：RNA 聚集体可协调免疫疗法。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-08-01 Epub Date: 2024-06-11 DOI: 10.1016/j.molmed.2024.05.018
Quazi T H Shubhra, Tivadar Feczkó, Qiang Cai
{"title":"Beyond the danger signal: RNA aggregates orchestrate immunotherapy.","authors":"Quazi T H Shubhra, Tivadar Feczkó, Qiang Cai","doi":"10.1016/j.molmed.2024.05.018","DOIUrl":"10.1016/j.molmed.2024.05.018","url":null,"abstract":"<p><p>Mendez-Gomez et al. recently demonstrated the transformative potential of RNA-lipid particle aggregates (RNA-LPAs) in immunotherapy. By reprogramming the tumor microenvironment (TME) and potentiating antitumor immunity, RNA-LPAs target primary tumors and elicit robust systemic immunity. This innovative platform holds promise for translating preclinical success into tangible clinical benefits.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"702-704"},"PeriodicalIF":12.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141311823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Copy number alterations: a catastrophic orchestration of the breast cancer genome. 拷贝数改变：乳腺癌基因组的灾难性编排。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-08-01 Epub Date: 2024-05-20 DOI: 10.1016/j.molmed.2024.04.017
Parastoo Shahrouzi, Farzaneh Forouz, Anthony Mathelier, Vessela N Kristensen, Pascal H G Duijf
{"title":"Copy number alterations: a catastrophic orchestration of the breast cancer genome.","authors":"Parastoo Shahrouzi, Farzaneh Forouz, Anthony Mathelier, Vessela N Kristensen, Pascal H G Duijf","doi":"10.1016/j.molmed.2024.04.017","DOIUrl":"10.1016/j.molmed.2024.04.017","url":null,"abstract":"<p><p>Breast cancer (BCa) is a prevalent malignancy that predominantly affects women around the world. Somatic copy number alterations (CNAs) are tumor-specific amplifications or deletions of DNA segments that often drive BCa development and therapy resistance. Hence, the complex patterns of CNAs complement BCa classification systems. In addition, understanding the precise contributions of CNAs is essential for tailoring personalized treatment approaches. This review highlights how tumor evolution drives the acquisition of CNAs, which in turn shape the genomic landscapes of BCas. It also discusses advanced methodologies for identifying recurrent CNAs, studying CNAs in BCa and their clinical impact.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"750-764"},"PeriodicalIF":12.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141076698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond memory impairment: the complex phenotypic landscape of Alzheimer's disease. 超越记忆障碍：阿尔茨海默病的复杂表型。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-08-01 Epub Date: 2024-05-30 DOI: 10.1016/j.molmed.2024.04.016
Stathis Argyriou, John F Fullard, Josh M Krivinko, Donghoon Lee, Thomas S Wingo, Aliza P Wingo, Robert A Sweet, Panos Roussos
{"title":"Beyond memory impairment: the complex phenotypic landscape of Alzheimer's disease.","authors":"Stathis Argyriou, John F Fullard, Josh M Krivinko, Donghoon Lee, Thomas S Wingo, Aliza P Wingo, Robert A Sweet, Panos Roussos","doi":"10.1016/j.molmed.2024.04.016","DOIUrl":"10.1016/j.molmed.2024.04.016","url":null,"abstract":"<p><p>Neuropsychiatric symptoms (NPSs) in Alzheimer's disease (AD) constitute multifaceted behavioral manifestations that reflect processes of emotional regulation, thinking, and social behavior. They are as prevalent in AD as cognitive impairment and develop independently during the progression of neurodegeneration. As studying NPSs in AD is clinically challenging, most AD research to date has focused on cognitive decline. In this opinion article we summarize emerging literature on the prevalence, time course, and the underlying genetic, molecular, and pathological mechanisms related to NPSs in AD. Overall, we propose that NPSs constitute a cluster of core symptoms in AD, and understanding their neurobiology can lead to a more holistic approach to AD research, paving the way for more accurate diagnostic tests and personalized treatments embracing the goals of precision medicine.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"713-722"},"PeriodicalIF":12.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11329360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141184728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Safety of non-replicative and oncolytic replication-selective HSV vectors. 非复制型和溶瘤型选择性复制 HSV 载体的安全性。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-08-01 Epub Date: 2024-06-17 DOI: 10.1016/j.molmed.2024.05.014
Alberto L Epstein, Samuel D Rabkin
{"title":"Safety of non-replicative and oncolytic replication-selective HSV vectors.","authors":"Alberto L Epstein, Samuel D Rabkin","doi":"10.1016/j.molmed.2024.05.014","DOIUrl":"10.1016/j.molmed.2024.05.014","url":null,"abstract":"<p><p>Herpes simplex virus type 1 (HSV-1) is a DNA virus and human pathogen used to construct promising therapeutic vectors. HSV-1 vectors fall into two classes: replication-selective oncolytic vectors for cancer therapy and defective non-replicative vectors for gene therapy. Vectors from each class can accommodate ≥30 kb of inserts, have been approved clinically, and demonstrate a relatively benign safety profile. Despite oncolytic HSV (oHSV) replication in tumors and elicited immune responses, the virus is well tolerated in cancer patients. Current non-replicative vectors elicit only limited immune responses. Seropositivity and immune responses against HSV-1 do not eliminate either the vector or infected cells, and the vectors can therefore be re-administered. In this review we highlight vectors that have been translated to the clinic and host-virus immune interactions that impact on the safety and efficacy of HSVs.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"781-794"},"PeriodicalIF":12.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11329358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141421052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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