肺动脉高压与癌症：探讨其作为通道病变的相似性。

IF 12.8 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in molecular medicine Pub Date : 2025-04-01 DOI:10.1016/j.molmed.2025.03.002

Fabrice Antigny, David Crottès, Christophe Vandier, Véronique Capuano, Maxime Guéguinou

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引用次数: 0

摘要

肺动脉高压（PAH）和癌症起初似乎没有关系，但越来越多的证据表明它们有许多共同的特征和复杂性。PAH中的肺血管细胞与癌细胞相似，表现出异常的生长模式、抵抗细胞死亡、代谢变化和通道病变。这些相似之处为研究人员和临床医生将癌症治疗策略应用于多环芳烃并可能逆转病情开辟了新的可能性。这篇综述探讨了多环芳烃和癌症之间复杂的相似之处，并强调了它们在分子、细胞和临床水平上类似的通道病样特征。我们还讨论了这些相似性对开发新疗法的潜在影响。

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Pulmonary arterial hypertension and cancer: exploring their resemblance as channelopathies.

Pulmonary arterial hypertension (PAH) and cancer may appear to be unrelated at first, but there is increasing evidence that they share many characteristics and complexities. Pulmonary vascular cells in PAH resemble cancer cells in that they display abnormal growth patterns, resistance to cell death, metabolic changes, and channelopathies. These similarities open new possibilities for researchers and clinicians to apply cancer treatment strategies to PAH and possibly reverse the condition. This review explores the complex parallels between PAH and cancer, and emphasizes their similar channelopathy-like features at the molecular, cellular, and clinical levels. We also discuss the potential implications of these similarities for developing new treatments.

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来源期刊

Trends in molecular medicine 医学-生化与分子生物学

CiteScore

24.60

自引率

0.00%

发文量

142

审稿时长

6-12 weeks

期刊介绍： Trends in Molecular Medicine (TMM) aims to offer concise and contextualized perspectives on the latest research advancing biomedical science toward better diagnosis, treatment, and prevention of human diseases. It focuses on research at the intersection of basic biology and clinical research, covering new concepts in human biology and pathology with clear implications for diagnostics and therapy. TMM reviews bridge the gap between bench and bedside, discussing research from preclinical studies to patient-enrolled trials. The major themes include disease mechanisms, tools and technologies, diagnostics, and therapeutics, with a preference for articles relevant to multiple themes. TMM serves as a platform for discussion, pushing traditional boundaries and fostering collaboration between scientists and clinicians. The journal seeks to publish provocative and authoritative articles that are also accessible to a broad audience, inspiring new directions in molecular medicine to enhance human health.