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MicroRNAs in the biology and hallmarks of neurodegenerative diseases. 神经退行性疾病的生物学和标志中的microrna。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-04-07 DOI: 10.1016/j.molmed.2025.03.006
Shivnarayan Dhuppar, Wolfram C Poller, Gopal Murugaiyan
{"title":"MicroRNAs in the biology and hallmarks of neurodegenerative diseases.","authors":"Shivnarayan Dhuppar, Wolfram C Poller, Gopal Murugaiyan","doi":"10.1016/j.molmed.2025.03.006","DOIUrl":"https://doi.org/10.1016/j.molmed.2025.03.006","url":null,"abstract":"<p><p>A combination of intracellular and extracellular abnormalities of the nervous system, coupled with inflammation and intestinal dysbiosis, form the hallmarks of neurodegenerative diseases (NDDs). While it is difficult to identify the precise order in which these hallmarks manifest in NDDs because of their mutualistic nature, they cumulatively result in nervous or neuronal damage that characterizes neurodegeneration. In this review we discuss the roles of microRNAs (miRNAs) in the maintenance of nervous system homeostasis and their implication for NDDs. We further highlight recent advances in, and limitations of, miRNA therapeutics in NDDs and their future potential.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting the Yin and Yang of KRASG12C. 靶向KRASG12C的阴阳。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-04-03 DOI: 10.1016/j.molmed.2025.03.007
Christos Adamopoulos, Kostas A Papavassiliou, Athanasios G Papavassiliou
{"title":"Targeting the Yin and Yang of KRAS<sup>G12C</sup>.","authors":"Christos Adamopoulos, Kostas A Papavassiliou, Athanasios G Papavassiliou","doi":"10.1016/j.molmed.2025.03.007","DOIUrl":"https://doi.org/10.1016/j.molmed.2025.03.007","url":null,"abstract":"<p><p>In a recent study in Cancer Discovery, Maciag et al. introduce BBO-8520, a novel inhibitor targeting both the active and inactive states of KRAS<sup>G12C</sup>. This dual inhibition shows superior target engagement and prolonged tumor suppression, offering a compelling strategy to overcome resistance development and improve outcomes in KRAS<sup>G12C</sup>-mutant cancers.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pulmonary arterial hypertension and cancer: exploring their resemblance as channelopathies. 肺动脉高压与癌症：探讨其作为通道病变的相似性。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-04-01 DOI: 10.1016/j.molmed.2025.03.002
Fabrice Antigny, David Crottès, Christophe Vandier, Véronique Capuano, Maxime Guéguinou
{"title":"Pulmonary arterial hypertension and cancer: exploring their resemblance as channelopathies.","authors":"Fabrice Antigny, David Crottès, Christophe Vandier, Véronique Capuano, Maxime Guéguinou","doi":"10.1016/j.molmed.2025.03.002","DOIUrl":"https://doi.org/10.1016/j.molmed.2025.03.002","url":null,"abstract":"<p><p>Pulmonary arterial hypertension (PAH) and cancer may appear to be unrelated at first, but there is increasing evidence that they share many characteristics and complexities. Pulmonary vascular cells in PAH resemble cancer cells in that they display abnormal growth patterns, resistance to cell death, metabolic changes, and channelopathies. These similarities open new possibilities for researchers and clinicians to apply cancer treatment strategies to PAH and possibly reverse the condition. This review explores the complex parallels between PAH and cancer, and emphasizes their similar channelopathy-like features at the molecular, cellular, and clinical levels. We also discuss the potential implications of these similarities for developing new treatments.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel universal vaccines to mitigate emerging avian influenza viruses. 减轻新出现禽流感病毒的新型通用疫苗。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-03-25 DOI: 10.1016/j.molmed.2025.03.001
Yu Liu, Lifang Wang, Alexander Lai, Mei Kang, Yangrui Qi, Andres Merits, Xinyi Jiao, Xinyu Wang, Xiangrong Yu, Shuo Su, Zhiwen Jiang
{"title":"Novel universal vaccines to mitigate emerging avian influenza viruses.","authors":"Yu Liu, Lifang Wang, Alexander Lai, Mei Kang, Yangrui Qi, Andres Merits, Xinyi Jiao, Xinyu Wang, Xiangrong Yu, Shuo Su, Zhiwen Jiang","doi":"10.1016/j.molmed.2025.03.001","DOIUrl":"https://doi.org/10.1016/j.molmed.2025.03.001","url":null,"abstract":"<p><p>Frequent spillovers and recent geospatial expansion of avian influenza virus (AIV) pose significant economic and public health threats. Recent advances in vaccine technologies, bioinformatics, and artificial intelligence will provide newer approaches to target genetically diverse and rapidly evolving AIVs. Here, we review recent advances in, and perspectives on, developing universal vaccines needed for the effective control of AIVs.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A sex-biased target against demyelination in Alzheimer's disease. 针对阿尔茨海默病脱髓鞘的性别偏见靶点。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-03-24 DOI: 10.1016/j.molmed.2025.03.004
Kelsey R Babcock, Doudou Yu, Ashley E Webb
{"title":"A sex-biased target against demyelination in Alzheimer's disease.","authors":"Kelsey R Babcock, Doudou Yu, Ashley E Webb","doi":"10.1016/j.molmed.2025.03.004","DOIUrl":"https://doi.org/10.1016/j.molmed.2025.03.004","url":null,"abstract":"<p><p>Aging and Alzheimer's disease (AD) exhibit sex differences in several biological processes, including demyelination. In a recent study, Lopez-Lee et al. uncover the contributions of sex chromosomes and gonadal hormones to sex differences in demyelination and identify Toll-like receptor 7 (TLR7) as a potential target to ameliorate tauopathy-induced demyelination in men.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cystic fibrosis at a glance: from disease mechanism to therapy. 囊性纤维化概览：从发病机制到治疗。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-03-21 DOI: 10.1016/j.molmed.2025.02.001
Kasper Gryspeert, Laudonia L Dipalo, Ana L Da Silva Cunha, Mattijs Bulcaen, Marjolein M Ensinck, Marianne S Carlon
{"title":"Cystic fibrosis at a glance: from disease mechanism to therapy.","authors":"Kasper Gryspeert, Laudonia L Dipalo, Ana L Da Silva Cunha, Mattijs Bulcaen, Marjolein M Ensinck, Marianne S Carlon","doi":"10.1016/j.molmed.2025.02.001","DOIUrl":"https://doi.org/10.1016/j.molmed.2025.02.001","url":null,"abstract":"","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The bleeding edge: broadening horizons for hematopoietic stem cell therapies. 前沿：拓宽造血干细胞治疗的视野。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-03-21 DOI: 10.1016/j.molmed.2025.03.003
Spencer D Shelton, Vijay G Sankaran
{"title":"The bleeding edge: broadening horizons for hematopoietic stem cell therapies.","authors":"Spencer D Shelton, Vijay G Sankaran","doi":"10.1016/j.molmed.2025.03.003","DOIUrl":"10.1016/j.molmed.2025.03.003","url":null,"abstract":"<p><p>Recent reports of gene therapy using autologous hematopoietic stem cell transplantation (HSCT) have addressed protein deficiencies of extra-hematopoietic origin. In a recent study, Srivastava et al. report that patients with hemophilia A receiving F8 lentiviral HSCT gene therapy achieved lasting factor VIII restoration and clinical improvement, marking an advance that could enable broader applications of HSCT.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic causes of obesity: mapping a path forward. 肥胖的遗传原因：绘制前进的路径。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-03-14 DOI: 10.1016/j.molmed.2025.02.002
Ruth J F Loos
{"title":"Genetic causes of obesity: mapping a path forward.","authors":"Ruth J F Loos","doi":"10.1016/j.molmed.2025.02.002","DOIUrl":"https://doi.org/10.1016/j.molmed.2025.02.002","url":null,"abstract":"<p><p>Over the past 30 years, significant progress has been made in understanding the genetic causes of obesity. In the coming years, catalogs that map each genetic variant to its genomic function are expected to accelerate variant-to-function (V2F) translation. Given that obesity is a heterogeneous disease, research will have to move beyond body mass index (BMI). Gene discovery efforts for more refined adiposity traits are poised to reveal additional genetic loci, pointing to new biological mechanisms. Obesity genetics research is reaching unprecedented heights and, along with a renewed interest in the development of weight-loss medication, it holds the potential to identify new drug targets. Polygenic scores (PGSs) that predict obesity risk are expected to further improve and will be particularly valuable early in life for timely prevention.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular evolution of central nervous system metastasis and therapeutic implications. 中枢神经系统转移的分子演化及治疗意义。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-03-01 Epub Date: 2024-10-17 DOI: 10.1016/j.molmed.2024.09.008
David Gritsch, Priscilla K Brastianos
{"title":"Molecular evolution of central nervous system metastasis and therapeutic implications.","authors":"David Gritsch, Priscilla K Brastianos","doi":"10.1016/j.molmed.2024.09.008","DOIUrl":"10.1016/j.molmed.2024.09.008","url":null,"abstract":"<p><p>The increasing prevalence and poor prognosis of central nervous system (CNS) metastases pose a significant challenge in oncology, necessitating improved therapeutic strategies. Recent research has shed light on the complex genomic landscape of brain metastases, identifying unique and potentially actionable genetic alterations. These insights offer new avenues for targeted therapy, highlighting the potential of precision medicine approaches in treating CNS metastases. However, translating these discoveries into clinical practice requires overcoming challenges such as availability of tissue for characterization, access to molecular testing, drug delivery across the blood-brain barrier (BBB) and addressing intra- and intertumoral genetic heterogeneity. This review explores novel insights into the evolution of CNS metastases, the molecular mechanisms underlying their development, and implications for therapeutic interventions.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"240-251"},"PeriodicalIF":12.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11908961/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Significant challenges to translating breakthrough science in Mexico. 墨西哥在转化突破性科学方面面临重大挑战。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-03-01 Epub Date: 2024-11-08 DOI: 10.1016/j.molmed.2024.10.011
Carlos Federico Cota-Romero, Guillermo Aquino-Jarquin
{"title":"Significant challenges to translating breakthrough science in Mexico.","authors":"Carlos Federico Cota-Romero, Guillermo Aquino-Jarquin","doi":"10.1016/j.molmed.2024.10.011","DOIUrl":"10.1016/j.molmed.2024.10.011","url":null,"abstract":"<p><p>Translational medicine is crucial for addressing health issues and translating research findings to improve population health. This Science and Society article highlights the potential of translational medicine in Mexico. It discusses the obstacles and challenges encountered in the translation process, instilling a sense of optimism for the future of healthcare in Mexico.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"197-201"},"PeriodicalIF":12.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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