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Microbes and mood: innovative biomarker approaches in depression. 微生物与情绪：抑郁症的创新生物标记方法。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-09-30 DOI: 10.1016/j.molmed.2024.09.002
Miranda Green, Madhukar H Trivedi, Jane A Foster
{"title":"Microbes and mood: innovative biomarker approaches in depression.","authors":"Miranda Green, Madhukar H Trivedi, Jane A Foster","doi":"10.1016/j.molmed.2024.09.002","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.09.002","url":null,"abstract":"<p><p>Although the field of psychiatry has made gains in biomarker discovery, our ability to change long-term outcomes remains inadequate. Matching individuals to the best treatment for them is a persistent clinical challenge. Moreover, the development of novel treatments has been hampered in part due to a limited understanding of the biological mechanisms underlying individual differences that contribute to clinical heterogeneity. The gut microbiome has become an area of intensive research in conditions ranging from metabolic disorders to cancer. Innovation in these spaces has led to translational breakthroughs, offering novel microbiome-informed approaches that may improve patient outcomes. In this review we examine how translational microbiome research is poised to advance biomarker discovery in mental health, with a focus on depression.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":null,"pages":null},"PeriodicalIF":12.8,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142366581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment and research needs for severe eating disorders: a response to Dr Ayton. 严重进食障碍的治疗和研究需求：对艾顿博士的回应。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-09-21 DOI: 10.1016/j.molmed.2024.09.003
Daire Douglas, Callum Bryson, Ulrike Schmidt
{"title":"Treatment and research needs for severe eating disorders: a response to Dr Ayton.","authors":"Daire Douglas, Callum Bryson, Ulrike Schmidt","doi":"10.1016/j.molmed.2024.09.003","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.09.003","url":null,"abstract":"","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":null,"pages":null},"PeriodicalIF":12.8,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The trio of circadian clock, intestinal flora, and cancer 昼夜节律、肠道菌群和癌症三重奏
IF 13.6 1区 医学
Trends in molecular medicine Pub Date : 2024-09-19 DOI: 10.1016/j.molmed.2024.09.001
Weici Liu, Zheshun Pi, Wenjun Mao
{"title":"The trio of circadian clock, intestinal flora, and cancer","authors":"Weici Liu, Zheshun Pi, Wenjun Mao","doi":"10.1016/j.molmed.2024.09.001","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.09.001","url":null,"abstract":"<p>Dysbiotic intestinal flora and a disrupted circadian clock are intimately related to cancer biological behaviors, yet their interwoven regulatory mechanisms remain an explorative field. Studies by <span><span>Ren <em>et al</em>.</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span> and <span><span>Liu <em>et al</em>.</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span> provide deeper insights into the potential roles of intestinal flora and the circadian clock in colorectal tumorigenesis and lung metastasis.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":null,"pages":null},"PeriodicalIF":13.6,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142259812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fibrodysplasia ossificans progressiva emerges from obscurity 渐进性骨纤维增生症从默默无闻中崭露头角
IF 13.6 1区 医学
Trends in molecular medicine Pub Date : 2024-09-18 DOI: 10.1016/j.molmed.2024.08.010
Frederick S. Kaplan, Eileen M. Shore, Robert J. Pignolo
{"title":"Fibrodysplasia ossificans progressiva emerges from obscurity","authors":"Frederick S. Kaplan, Eileen M. Shore, Robert J. Pignolo","doi":"10.1016/j.molmed.2024.08.010","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.08.010","url":null,"abstract":"<p>Fibrodysplasia ossificans progressiva (FOP), a disorder of congenital skeletal malformations and progressive extraskeletal ossification, is the most severe form of heterotopic ossification (HO) in humans. Gain-of-function pathogenic variants in activin A receptor type I (ACVR1), a bone morphogenetic protein (BMP) type 1 receptor, cause FOP by dramatically altering the normal physiologic functions of ACVR1, impacting BMP signaling and other interacting pathways. These alterations affect various systems, including inflammation, innate immunity, hypoxia sensing, wound healing, aging, temperature and mechanical thresholds, pain sensitivity, skeletal growth, diarthrodial joint patterning, joint function and fate, and HO. This article examines the emergent properties of FOP’s diverse phenotypes, proposes a schema for targeting these phenotypes, and highlights outstanding questions and knowledge gaps.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":null,"pages":null},"PeriodicalIF":13.6,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142269312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incorporating placental pathology into clinical care and research 将胎盘病理学纳入临床护理和研究中
IF 13.6 1区 医学
Trends in molecular medicine Pub Date : 2024-09-18 DOI: 10.1016/j.molmed.2024.08.002
Drucilla Roberts, Omonigho Aisagbonhi, Mana M. Parast
{"title":"Incorporating placental pathology into clinical care and research","authors":"Drucilla Roberts, Omonigho Aisagbonhi, Mana M. Parast","doi":"10.1016/j.molmed.2024.08.002","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.08.002","url":null,"abstract":"<p>Despite recent standardization of placental evaluation and establishment of criteria for diagnosis of major patterns of placental injury, placental pathological examination remains undervalued and under-utilized. The placenta can harbor a significant amount of information relevant to both the pregnant person and offspring. Placental pathology can also provide a significant context for pathophysiological study of adverse pregnancy outcomes, helping to optimally subcategorize the ‘great obstetric syndromes’ of pre-eclampsia (PE), spontaneous preterm birth (sPTB), and fetal growth restriction (FGR), and to identify causes of stillbirth. We hereby propose that placental evaluation should be incorporated into routine delivery of obstetric and neonatal care, and further suggest that its integration into clinical, translational, and basic research could significantly advance our understanding of pregnancy complications and adverse neonatal outcomes.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":null,"pages":null},"PeriodicalIF":13.6,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142259813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Science around the world 世界各地的科学
IF 13.6 1区 医学
Trends in molecular medicine Pub Date : 2024-09-18 DOI: 10.1016/j.molmed.2024.08.009
Olivier R. Baris, Alon Herschhorn, Yulan Xiong
{"title":"Science around the world","authors":"Olivier R. Baris, Alon Herschhorn, Yulan Xiong","doi":"10.1016/j.molmed.2024.08.009","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.08.009","url":null,"abstract":"No Abstract","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":null,"pages":null},"PeriodicalIF":13.6,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142259811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会和内容
IF 13.6 1区 医学
Trends in molecular medicine Pub Date : 2024-09-11 DOI: 10.1016/s1471-4914(24)00226-0
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/s1471-4914(24)00226-0","DOIUrl":"https://doi.org/10.1016/s1471-4914(24)00226-0","url":null,"abstract":"No Abstract","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":null,"pages":null},"PeriodicalIF":13.6,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142220325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅和版权信息
IF 13.6 1区 医学
Trends in molecular medicine Pub Date : 2024-09-11 DOI: 10.1016/s1471-4914(24)00229-6
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/s1471-4914(24)00229-6","DOIUrl":"https://doi.org/10.1016/s1471-4914(24)00229-6","url":null,"abstract":"No Abstract","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":null,"pages":null},"PeriodicalIF":13.6,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142220326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sterols in ferroptosis: from molecular mechanisms to therapeutic strategies 铁中毒中的甾醇：从分子机制到治疗策略
IF 13.6 1区 医学
Trends in molecular medicine Pub Date : 2024-09-10 DOI: 10.1016/j.molmed.2024.08.007
Yaxu Li, Zan Li, Qiao Ran, Ping Wang
{"title":"Sterols in ferroptosis: from molecular mechanisms to therapeutic strategies","authors":"Yaxu Li, Zan Li, Qiao Ran, Ping Wang","doi":"10.1016/j.molmed.2024.08.007","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.08.007","url":null,"abstract":"<p>Ferroptosis, a novel cell death mode driven by iron-dependent phospholipid (PL) peroxidation, has emerged as a promising therapeutic strategy for the treatments of cancer, cardiovascular diseases, and ischemic-reperfusion injury (IRI). PL peroxidation, the key process of ferroptosis, requires polyunsaturated fatty acid (PUFA)-containing PLs (PL-PUFAs) as substrates, undergoing a chain reaction with iron and oxygen. Cells prevent ferroptosis by maintaining a homeostatic equilibrium among substrates, processes, and detoxification of PL peroxidation. Sterols, lipids abundant in cell membranes, directly participate in PL peroxidation and influence ferroptosis sensitivity. Sterol metabolism also plays a key role in ferroptosis, and targeting sterols presents significant potential for treating numerous ferroptosis-associated disorders. This review elucidates the fundamental mechanisms of ferroptosis, emphasizing how sterols modulate this process and their therapeutic potential.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":null,"pages":null},"PeriodicalIF":13.6,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142220327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploiting the gut microbiome for brain tumour treatment 利用肠道微生物组治疗脑肿瘤
IF 13.6 1区 医学
Trends in molecular medicine Pub Date : 2024-09-10 DOI: 10.1016/j.molmed.2024.08.008
Lily Keane, John F. Cryan, Jack P. Gleeson
{"title":"Exploiting the gut microbiome for brain tumour treatment","authors":"Lily Keane, John F. Cryan, Jack P. Gleeson","doi":"10.1016/j.molmed.2024.08.008","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.08.008","url":null,"abstract":"<p>Increasing evidence suggests that the gut microbiome plays a key role in a host of pathological conditions, including cancer. Indeed, the bidirectional communication that occurs between the gut and the brain, known as the ‘gut–brain axis,’ has recently been implicated in brain tumour pathology. Here, we focus on current research that supports a gut microbiome–brain tumour link with emphasis on high-grade gliomas, the most aggressive of all brain tumours, and the impact on the glioma tumour microenvironment. We discuss the potential use of gut–brain axis signals to improve responses to current and future therapeutic approaches. We highlight that the success of novel treatment strategies may rely on patient-specific microbiome profiles, and these should be considered for personalised treatment approaches.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":null,"pages":null},"PeriodicalIF":13.6,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142220328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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