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Trends in molecular medicine最新文献

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Understanding preeclampsia: from phenotypes to treatment. 了解先兆子痫：从表型到治疗。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-06-18 DOI: 10.1016/j.molmed.2025.05.008
Priscila R Nunes, Ana C T Palei, Valeria C Sandrim
{"title":"Understanding preeclampsia: from phenotypes to treatment.","authors":"Priscila R Nunes, Ana C T Palei, Valeria C Sandrim","doi":"10.1016/j.molmed.2025.05.008","DOIUrl":"https://doi.org/10.1016/j.molmed.2025.05.008","url":null,"abstract":"","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IL-15 in CAR engineering: striking an efficacy-safety balance. IL-15在CAR工程中的应用：达到疗效与安全性的平衡。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-06-18 DOI: 10.1016/j.molmed.2025.05.014
Yan-Ruide Li, Yichen Zhu, Lili Yang
{"title":"IL-15 in CAR engineering: striking an efficacy-safety balance.","authors":"Yan-Ruide Li, Yichen Zhu, Lili Yang","doi":"10.1016/j.molmed.2025.05.014","DOIUrl":"https://doi.org/10.1016/j.molmed.2025.05.014","url":null,"abstract":"<p><p>Interleukin (IL)-15 engineering in chimeric antigen receptor (CAR)-cell therapy has demonstrated promising antitumor efficacy against both hematological malignancies and solid tumors in recent clinical trials. However, increased cytokine release syndrome (CRS) toxicity is primarily observed in conventional CAR-T cells, underscoring the need to balance safety and efficacy in IL-15-enhanced CAR therapy for clinical application.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fighting aging-associated clonal hematopoiesis with microbial metabolite. 利用微生物代谢物对抗衰老相关克隆造血。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-06-17 DOI: 10.1016/j.molmed.2025.06.001
Shuqin Zeng, Dezhi Mu, Shaopu Wang
{"title":"Fighting aging-associated clonal hematopoiesis with microbial metabolite.","authors":"Shuqin Zeng, Dezhi Mu, Shaopu Wang","doi":"10.1016/j.molmed.2025.06.001","DOIUrl":"https://doi.org/10.1016/j.molmed.2025.06.001","url":null,"abstract":"<p><p>Age-related clonal hematopoiesis in the elderly is mediated by expansion of mutant pre-leukemic hematopoietic cells, but the mechanism remains unclear. Recently, Agarwal et al. found elderly individuals exhibit the gut microbial dysbiosis with enriched Gram-negative bacteria that release ADP-heptose into systemic circulation, which promotes pre-leukemic cell expansion through ALPK1-dependent signaling.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidermolysis bullosa: understanding the disease, diagnosis, and advances in treatment strategies. 大疱性表皮松解症：了解疾病、诊断和治疗策略的进展。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-06-17 DOI: 10.1016/j.molmed.2025.05.009
Madalina Alexandru, Jemima E Mellerio, Joanna Jacków-Malinowska
{"title":"Epidermolysis bullosa: understanding the disease, diagnosis, and advances in treatment strategies.","authors":"Madalina Alexandru, Jemima E Mellerio, Joanna Jacków-Malinowska","doi":"10.1016/j.molmed.2025.05.009","DOIUrl":"https://doi.org/10.1016/j.molmed.2025.05.009","url":null,"abstract":"","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Priorities for modelling arbovirus transmission under climate change. 气候变化下虫媒病毒传播建模的优先事项。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-06-16 DOI: 10.1016/j.molmed.2025.05.010
Ilaria Dorigatti, Katy A M Gaythorpe, Victoria M Cox, Francis A Windram, Lauren Cator
{"title":"Priorities for modelling arbovirus transmission under climate change.","authors":"Ilaria Dorigatti, Katy A M Gaythorpe, Victoria M Cox, Francis A Windram, Lauren Cator","doi":"10.1016/j.molmed.2025.05.010","DOIUrl":"https://doi.org/10.1016/j.molmed.2025.05.010","url":null,"abstract":"<p><p>The transmission potential of arboviruses is extremely sensitive to environmental conditions. This sensitivity is due to both their intimate relationship with ectothermic vectors and, in many cases, also to the involvement of multiple host species in zoonotic transmission cycles. Here, we review how climate change will alter the transmission ecology and risk of these important infections. The challenge of predicting how climate change will impact these systems is daunting, but the need for tools to manage arbovirus risk under climate change is urgent and imperative. We argue that the development of climate-driven mechanistic models of disease transmission informed by empirical surveillance data is urgently needed to inform future responses and for generating the evidence that policy needs to tackle this global public health risk.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Toll-like receptors in B cells and obesity. B细胞中的toll样受体与肥胖。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-06-16 DOI: 10.1016/j.molmed.2025.05.005
Pai Wang, Can Hou, F Susan Wong, Li Wen
{"title":"Toll-like receptors in B cells and obesity.","authors":"Pai Wang, Can Hou, F Susan Wong, Li Wen","doi":"10.1016/j.molmed.2025.05.005","DOIUrl":"https://doi.org/10.1016/j.molmed.2025.05.005","url":null,"abstract":"<p><p>Toll-like receptors (TLRs) play a pivotal role in both innate and adaptive immunity, primarily by detecting pathogen-associated molecular patterns (PAMPs) and orchestrating immune responses. Although TLR-driven activation of dendritic cells (DCs) and subsequent T cell differentiation are well characterized, the function of TLRs in B cells remains underexplored. In the context of obesity, excessive adipose tissue accumulation triggers chronic inflammation driven in part by activation of TLR signaling. This review explores the expression, function, and signaling mechanisms of TLRs in B cells, and emphasizes their role in modulating immune responses associated with obesity. Furthermore, we discuss how TLR-mediated inflammatory activity in B cells may contribute to metabolic dysregulation, and offer insights into the crosstalk between immune function and metabolic disease in obesity.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decidual macrophages as therapeutic targets in preterm labour. 巨噬细胞作为早产的治疗靶点。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-06-16 DOI: 10.1016/j.molmed.2025.05.013
Emilie O Paterson, Daniel J Short, Victoria Male
{"title":"Decidual macrophages as therapeutic targets in preterm labour.","authors":"Emilie O Paterson, Daniel J Short, Victoria Male","doi":"10.1016/j.molmed.2025.05.013","DOIUrl":"https://doi.org/10.1016/j.molmed.2025.05.013","url":null,"abstract":"<p><p>The initiation of labour in humans remains poorly understood, although there is mounting evidence for a role for decidual macrophages. These may trigger labour by promoting a proinflammatory state, thereby modulating progesterone signalling and weakening fetal membranes. Preclinical work targeting macrophages therapeutically shows promise in preventing preterm labour, underscoring their significance in this process.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
OTU deubiquitinases in disease: roles and targeting. OTU去泛素酶在疾病中的作用和靶向。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-06-16 DOI: 10.1016/j.molmed.2025.05.006
Yu Deng, Pengda Liu
{"title":"OTU deubiquitinases in disease: roles and targeting.","authors":"Yu Deng, Pengda Liu","doi":"10.1016/j.molmed.2025.05.006","DOIUrl":"https://doi.org/10.1016/j.molmed.2025.05.006","url":null,"abstract":"<p><p>Dysregulation of protein homeostasis contributes to many human diseases and is an emerging therapeutic target. Proteasome-mediated degradation requires ubiquitin tagging, a process regulated by E3 ligases and reversed by deubiquitinases (DUBs). Among DUBs, the ovarian tumor protease (OTU) family exhibits poly-ubiquitin linkage-specific activity and regulates diverse cellular processes. OTU dysregulation has been linked to diseases such as cancer, highlighting their potential as drug targets. This review summarizes current knowledge of OTU functions, regulatory mechanisms, and disease associations, as well as therapeutic strategies targeting OTUs. By examining these aspects, we aim to provide insights into the pathophysiological roles of OTUs and support ongoing efforts to develop OTU-targeted therapies for human diseases.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psoriatic arthritis: diagnosis, pathogenesis, and emerging therapies. 银屑病关节炎：诊断、发病机制和新兴疗法。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-06-10 DOI: 10.1016/j.molmed.2025.05.003
Iannis E Adamopoulos, Xenofon Baraliakos, Christopher Ritchlin
{"title":"Psoriatic arthritis: diagnosis, pathogenesis, and emerging therapies.","authors":"Iannis E Adamopoulos, Xenofon Baraliakos, Christopher Ritchlin","doi":"10.1016/j.molmed.2025.05.003","DOIUrl":"https://doi.org/10.1016/j.molmed.2025.05.003","url":null,"abstract":"","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fibroblasts in AKI: small army, big help. AKI的成纤维细胞：小军队，大帮助。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-06-10 DOI: 10.1016/j.molmed.2025.05.012
Saiya Zhu, Yuan Gui, Jia-Jun Liu, Silvia Liu, Dong Zhou
{"title":"Fibroblasts in AKI: small army, big help.","authors":"Saiya Zhu, Yuan Gui, Jia-Jun Liu, Silvia Liu, Dong Zhou","doi":"10.1016/j.molmed.2025.05.012","DOIUrl":"https://doi.org/10.1016/j.molmed.2025.05.012","url":null,"abstract":"<p><p>Acute kidney injury (AKI), with high morbidity and mortality, stems from tubular injury, vascular damage, and inflammation. Although often overlooked, early fibroblast activation is critical for kidney repair, challenging traditional associations of fibroblasts with fibrosis. Here, we summarize fibroblast origins, heterogeneity, functions, and therapeutics in preventing or mitigating AKI.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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