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3-O-acylated bile acids: disrupters or harmonizers of metabolism? 3-O-acylated 胆汁酸：新陈代谢的破坏者还是协调者？
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-06-25 DOI: 10.1016/j.molmed.2024.06.003
Runzhi Chen, Xinhua Chen, Jiangtao Gao
{"title":"3-O-acylated bile acids: disrupters or harmonizers of metabolism?","authors":"Runzhi Chen, Xinhua Chen, Jiangtao Gao","doi":"10.1016/j.molmed.2024.06.003","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.06.003","url":null,"abstract":"<p><p>Unveiling a metabolic mystery, this article explores how 3-O-acylated bile acids, specifically 3-O-succinylated cholic acid (3-sucCA) and 3-acetylated cholic acid (3-acetyCA), modified by gut microbes Bacteroides uniformis and Christensenella minuta, respectively, may either disrupt or harmonize our metabolic processes, offering novel therapeutic avenues for conditions such as metabolic dysfunction-associated steatohepatitis (MASH) and type 2 diabetes mellitus (T2D).</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141459475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Senescence and tissue fibrosis: opportunities for therapeutic targeting. 衰老和组织纤维化：靶向治疗的机会。
IF 13.6 1区 医学
Trends in molecular medicine Pub Date : 2024-06-17 DOI: 10.1016/j.molmed.2024.05.012
Steven O'Reilly, Pei-Suen Tsou, John Varga
{"title":"Senescence and tissue fibrosis: opportunities for therapeutic targeting.","authors":"Steven O'Reilly, Pei-Suen Tsou, John Varga","doi":"10.1016/j.molmed.2024.05.012","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.05.012","url":null,"abstract":"<p><p>Cellular senescence is a key hallmark of aging. It has now emerged as a key mediator in normal tissue turnover and is associated with a variety of age-related diseases, including organ-specific fibrosis and systemic sclerosis (SSc). This review discusses the recent evidence of the role of senescence in tissue fibrosis, with an emphasis on SSc, a systemic autoimmune rheumatic disease. We discuss the physiological role of these cells, their role in fibrosis, and that targeting these cells specifically could be a new therapeutic avenue in fibrotic disease. We argue that targeting senescent cells, with senolytics or senomorphs, is a viable therapeutic target in fibrotic diseases which remain largely intractable.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141421053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sexual dimorphism of metabolic dysfunction-associated steatotic liver disease. 代谢功能障碍相关脂肪性肝病的性别双态性。
IF 13.6 1区 医学
Trends in molecular medicine Pub Date : 2024-06-17 DOI: 10.1016/j.molmed.2024.05.013
Alessandro Cherubini, Sara Della Torre, Serena Pelusi, Luca Valenti
{"title":"Sexual dimorphism of metabolic dysfunction-associated steatotic liver disease.","authors":"Alessandro Cherubini, Sara Della Torre, Serena Pelusi, Luca Valenti","doi":"10.1016/j.molmed.2024.05.013","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.05.013","url":null,"abstract":"<p><p>Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver condition. MASLD is a sexually dimorphic condition, with its development and progression influenced by sex chromosomes and hormones. Estrogens typically protect against, whereas androgens promote, MASLD. Therapeutic approaches for a sex-specific personalized medicine include estrogen replacement, androgen blockers, and novel drugs targeting hormonal pathways. However, the interactions between hormonal factors and inherited genetic variation impacts MASLD risk, necessitating more tailored therapies. Understanding sex disparities and the role of estrogens could improve MASLD interventions and management, whereas clinical trials addressing sex differences are crucial for advancing personalized treatment. This review explores the underappreciated impact of sexual dimorphism in MASLD and discusses the potential therapeutic application of sex-related hormones.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141421054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅和版权信息
IF 13.6 1区 医学
Trends in molecular medicine Pub Date : 2024-06-12 DOI: 10.1016/s1471-4914(24)00145-x
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/s1471-4914(24)00145-x","DOIUrl":"https://doi.org/10.1016/s1471-4914(24)00145-x","url":null,"abstract":"No Abstract","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":"53 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141521536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会和内容
IF 13.6 1区 医学
Trends in molecular medicine Pub Date : 2024-06-12 DOI: 10.1016/s1471-4914(24)00142-4
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/s1471-4914(24)00142-4","DOIUrl":"https://doi.org/10.1016/s1471-4914(24)00142-4","url":null,"abstract":"No Abstract","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":"30 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141529003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Responding to the ripple effects of sexual harassment: an emergency management framework. 应对性骚扰的连锁反应：应急管理框架。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-06-01 Epub Date: 2024-05-10 DOI: 10.1016/j.molmed.2024.04.007
Elizabeth M Viglianti, Andrea L Oliverio, Lisa M Meeks, Amy Bohnert, Sue Anne Bell
{"title":"Responding to the ripple effects of sexual harassment: an emergency management framework.","authors":"Elizabeth M Viglianti, Andrea L Oliverio, Lisa M Meeks, Amy Bohnert, Sue Anne Bell","doi":"10.1016/j.molmed.2024.04.007","DOIUrl":"10.1016/j.molmed.2024.04.007","url":null,"abstract":"<p><p>Sexual harassment in academia is endemic driven by gender-based inequalities and sustained through organizational tolerance, and its impact extends beyond the primary victim(s). Applying principles of emergency management provides a framework for institutions to balance their obligations to the primary victim(s) while also acknowledging the need to restore the well-being and culture of secondary victims.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"521-523"},"PeriodicalIF":12.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11500615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140909129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hyperemesis gravidarum theories dispelled by recent research: a paradigm change for better care and outcomes. 最新研究揭开了孕吐理论的神秘面纱：改变模式，改善护理和治疗效果。
IF 13.6 1区 医学
Trends in molecular medicine Pub Date : 2024-06-01 Epub Date: 2024-05-22 DOI: 10.1016/j.molmed.2024.04.006
Marlena Schoenberg Fejzo
{"title":"Hyperemesis gravidarum theories dispelled by recent research: a paradigm change for better care and outcomes.","authors":"Marlena Schoenberg Fejzo","doi":"10.1016/j.molmed.2024.04.006","DOIUrl":"10.1016/j.molmed.2024.04.006","url":null,"abstract":"<p><p>Nausea and vomiting (NVP) affect most pregnant women. At the severe end of the clinical spectrum, hyperemesis gravidarum (HG) can be life-threatening. The condition is fraught with misconceptions that have slowed progress and left women undertreated. Herein, recent scientific advances are presented that dispel common myths associated with HG related to maternal/offspring outcomes, etiology, and evolution. There is now strong evidence that (i) HG is associated with poor outcomes, (ii) a common cause of NVP and HG has been identified, and (iii) NVP is likely a protective evolutionary mechanism that occurs throughout the animal kingdom but is no longer necessary for human survival. Therefore, it is encouraging that we are finally on the cusp of testing treatments that may put an end to unnecessary suffering.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"530-540"},"PeriodicalIF":13.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141088706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Redefining the biological and pathophysiological role of dimethylarginine dimethylaminohydrolase 2. 重新定义二甲基精氨酸二甲氨基水解酶 2 的生物学和病理生理学作用。
IF 13.6 1区 医学
Trends in molecular medicine Pub Date : 2024-06-01 Epub Date: 2024-03-29 DOI: 10.1016/j.molmed.2024.03.001
Pramod C Nair, Arduino A Mangoni, Roman N Rodionov
{"title":"Redefining the biological and pathophysiological role of dimethylarginine dimethylaminohydrolase 2.","authors":"Pramod C Nair, Arduino A Mangoni, Roman N Rodionov","doi":"10.1016/j.molmed.2024.03.001","DOIUrl":"10.1016/j.molmed.2024.03.001","url":null,"abstract":"<p><p>The enzyme dimethylarginine dimethylaminohydrolase (DDAH) 1 metabolizes asymmetric dimethylarginine (ADMA), a critical endogenous cardiovascular risk factor. In the past two decades, there has been significant controversy about whether DDAH2, the other DDAH isoform, is also able to directly metabolize ADMA. There has been evidence that DDAH2 regulates several critical processes involved in cardiovascular and immune homeostasis. However, the molecular mechanisms underpinning these effects are unclear. In this opinion, we discuss the previous and current knowledge of ADMA metabolism by DDAH in light of a recent consortium study, which convincingly demonstrated that DDAH2 is not capable of metabolizing ADMA, unlike DDAH1. Thus, further research in this field is needed to uncover the molecular mechanisms of DDAH2 and its role in various disorders.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"552-561"},"PeriodicalIF":13.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140327194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Science around the world. 世界各地的科学
IF 13.6 1区 医学
Trends in molecular medicine Pub Date : 2024-06-01 Epub Date: 2024-05-23 DOI: 10.1016/j.molmed.2024.04.019
Alzbeta Chabronova, Qiurong Ding, Miriam Martini, Pramod C Nair
{"title":"Science around the world.","authors":"Alzbeta Chabronova, Qiurong Ding, Miriam Martini, Pramod C Nair","doi":"10.1016/j.molmed.2024.04.019","DOIUrl":"10.1016/j.molmed.2024.04.019","url":null,"abstract":"","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"517-520"},"PeriodicalIF":13.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141094300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Leveraging zebrafish to investigate pancreatic development, regeneration, and diabetes 利用斑马鱼研究胰腺发育、再生和糖尿病
IF 13.6 1区 医学
Trends in molecular medicine Pub Date : 2024-06-01 DOI: 10.1016/j.molmed.2024.05.002
Jiarui Mi, Lipeng Ren, Olov Andersson
{"title":"Leveraging zebrafish to investigate pancreatic development, regeneration, and diabetes","authors":"Jiarui Mi, Lipeng Ren, Olov Andersson","doi":"10.1016/j.molmed.2024.05.002","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.05.002","url":null,"abstract":"<p>The zebrafish has become an outstanding model for studying organ development and tissue regeneration, which is prominently leveraged for studies of pancreatic development, insulin-producing β-cells, and diabetes. Although studied for more than two decades, many aspects remain elusive and it has only recently been possible to investigate these due to technical advances in transcriptomics, chemical-genetics, genome editing, drug screening, and <em>in vivo</em> imaging. Here, we review recent findings on zebrafish pancreas development, β-cell regeneration, and how zebrafish can be used to provide novel insights into gene functions, disease mechanisms, and therapeutic targets in diabetes, inspiring further use of zebrafish for the development of novel therapies for diabetes.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":"41 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141195662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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