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Trends in molecular medicine最新文献

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Unraveling host genetics and microbiome genome crosstalk: a novel therapeutic approach. 揭示宿主遗传学和微生物组基因组串扰：一种新的治疗方法。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-11-01 Epub Date: 2024-06-27 DOI: 10.1016/j.molmed.2024.06.007
Qian Zhang, Dennis Schwarz, Yumei Cheng, Yahya Sohrabi
{"title":"Unraveling host genetics and microbiome genome crosstalk: a novel therapeutic approach.","authors":"Qian Zhang, Dennis Schwarz, Yumei Cheng, Yahya Sohrabi","doi":"10.1016/j.molmed.2024.06.007","DOIUrl":"10.1016/j.molmed.2024.06.007","url":null,"abstract":"<p><p>The ability of the gut microbiome to adapt to a new environment and utilize a new metabolite or dietary compound by inducing structural variations (SVs) in the genome has an important role in human health. Here, we discuss recent data on host genetic regulation of SV induction and its use as a new therapeutic approach.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"1007-1009"},"PeriodicalIF":12.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141474672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cognitive impairment in people living with HIV: mechanisms, controversies, and future perspectives. 艾滋病病毒感染者的认知障碍：机制、争议和未来展望。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-11-01 Epub Date: 2024-07-01 DOI: 10.1016/j.molmed.2024.06.005
Charalampos D Moschopoulos, Kate Alford, Anastasia Antoniadou, Jaime H Vera
{"title":"Cognitive impairment in people living with HIV: mechanisms, controversies, and future perspectives.","authors":"Charalampos D Moschopoulos, Kate Alford, Anastasia Antoniadou, Jaime H Vera","doi":"10.1016/j.molmed.2024.06.005","DOIUrl":"10.1016/j.molmed.2024.06.005","url":null,"abstract":"<p><p>Despite the dramatic decrease in HIV-associated neurocognitive impairment (NCI) in the combined antiretroviral treatment (cART) era, subtler neuropsychological complications remain prevalent. In this review, we discuss the changing pathophysiology of HIV-associated NCI, considering recent evidence of HIV neuropathogenesis, and the pivotal role of cART. Furthermore, we address the multifactorial nature of NCI in people living with HIV, including legacy and ongoing insults to the brain, as well as host-specific factors. We also summarize the ongoing debate about the refinement of diagnostic criteria, exploring the strengths and limitations of these recent approaches. Finally, we present current research in NCI management in people living with HIV and highlight the need for using both pharmacological and nonpharmacological pathways toward a holistic approach.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"1076-1089"},"PeriodicalIF":12.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141493537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fc-optimized checkpoint antibodies for cancer immunotherapy. 用于癌症免疫疗法的 Fc 优化检查点抗体。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-11-01 DOI: 10.1016/j.molmed.2024.10.008
Rony Dahan, Alan J Korman
{"title":"Fc-optimized checkpoint antibodies for cancer immunotherapy.","authors":"Rony Dahan, Alan J Korman","doi":"10.1016/j.molmed.2024.10.008","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.10.008","url":null,"abstract":"<p><p>The development of checkpoint antibodies for cancer therapy has been guided by the principle of blocking T cell inhibitory signals. Recognition of the role of the Fc domain in therapeutic activities, through the depletion of immunosuppressive populations and myeloid cell activation, prompts a shift toward the development of optimized Fc-engineered checkpoint antibodies.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142563513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Virus as the cause of type 1 diabetes. 病毒是 1 型糖尿病的病因。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-11-01 Epub Date: 2024-07-13 DOI: 10.1016/j.molmed.2024.06.011
Knut Dahl-Jørgensen
{"title":"Virus as the cause of type 1 diabetes.","authors":"Knut Dahl-Jørgensen","doi":"10.1016/j.molmed.2024.06.011","DOIUrl":"10.1016/j.molmed.2024.06.011","url":null,"abstract":"<p><p>Type 1 diabetes (T1D), a severe disease requiring intensive insulin treatment, carries an increased risk for complications and reduced lifespan. Certain viruses have been implicated in T1D's etiology, with 'live', replicating enteroviruses (EVs) recently found in the pancreas at diagnosis. This discovery prompted a trial to slow down disease progression using antiviral drugs. A 6-month treatment combining pleconaril and ribavirin in new-onset T1D patients preserved residual insulin production after 1 year, unlike placebo. The results support the theory that viruses may cause T1D in genetically susceptible individuals. A low-grade, persistent viral infection may initiate a cascade of pathogenic mechanisms initially involving the innate immune system, inducing β-cell stress and neoantigen release, leading to autoimmunity, and eventually the destruction of insulin-producing β-cells.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"1020-1027"},"PeriodicalIF":12.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141604195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Science around the world. 世界各地的科学
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-10-29 DOI: 10.1016/j.molmed.2024.09.007
Abel Plaza-Florido, Olga Gursky, Macarena Lorena Herrera, Charalampos D Moschopoulos, Yahya Sohrabi
{"title":"Science around the world.","authors":"Abel Plaza-Florido, Olga Gursky, Macarena Lorena Herrera, Charalampos D Moschopoulos, Yahya Sohrabi","doi":"10.1016/j.molmed.2024.09.007","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.09.007","url":null,"abstract":"","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in Hodgkin lymphoma research. 霍奇金淋巴瘤研究进展。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-10-22 DOI: 10.1016/j.molmed.2024.10.004
Ralf Küppers
{"title":"Advances in Hodgkin lymphoma research.","authors":"Ralf Küppers","doi":"10.1016/j.molmed.2024.10.004","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.10.004","url":null,"abstract":"<p><p>Hodgkin lymphoma (HL) has been and still is the most enigmatic lymphoid malignancy in humans. Since the first molecular analysis of isolated Hodgkin and Reed-Sternberg (HRS) tumor cells of classic HL 30 years ago, substantial advances in our understanding of HL have been made. This review describes the cellular origin of HL, summarizes the current knowledge about the genetic lesions in HRS cells, and highlights the role of Epstein-Barr virus (EBV) in HL pathogenesis. Moreover, the pathobiological roles of altered gene expression and deregulated signaling pathways are discussed and key aspects of the HL microenvironment are presented.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting monoamine oxidases in cancer: advances and opportunities. 以癌症中的单胺氧化酶为靶点：进展与机遇。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-10-21 DOI: 10.1016/j.molmed.2024.09.010
Jing Wei, Boyang Jason Wu
{"title":"Targeting monoamine oxidases in cancer: advances and opportunities.","authors":"Jing Wei, Boyang Jason Wu","doi":"10.1016/j.molmed.2024.09.010","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.09.010","url":null,"abstract":"<p><p>Monoamine oxidases (MAOs) are a crucial pair of isoenzymes responsible for degrading monoamine neurotransmitters and dietary amines. In addition to extensive studies of their roles in the context of brain functions and disorders over decades, emerging evidence indicates that MAOs are also often dysregulated and associated with clinical outcomes in diverse cancers, with the ability to differentially regulate cancer growth, invasion, metastasis, progression, and therapy response depending on the cancer type. In this review, we summarize recent advances in understanding the clinical relevance, functional importance, and mechanisms of MAOs in a broad range of cancers, and discuss the application and therapeutic benefit of MAO inhibitors (MAOIs) for cancer treatment, highlighting the roles of MAOs as novel regulators, prognostic biomarkers, and therapeutic targets in cancer.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of the therapeutic potential of salubrinal for ME/CFS and long-COVID. 评估柳氮磺吡啶对 ME/CFS 和长期 COVID 的治疗潜力。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-10-21 DOI: 10.1016/j.molmed.2024.10.001
Aseel Warrayat, Ayah Ali, Joulin Waked, Darcy Tocci, Robert C Speth
{"title":"Assessment of the therapeutic potential of salubrinal for ME/CFS and long-COVID.","authors":"Aseel Warrayat, Ayah Ali, Joulin Waked, Darcy Tocci, Robert C Speth","doi":"10.1016/j.molmed.2024.10.001","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.10.001","url":null,"abstract":"<p><p>Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic debilitating condition with no cure that shares commonality with long-COVID. This review examines current understanding of long-COVID symptoms, characteristics of the affected population, the connection with ME/CFS, and the potential for salubrinal, an agent known for its influence on cellular stress pathways, to mitigate these disorders It also describes the historical development and mechanism of action of salubrinal, to mitigate endoplasmic reticulum (ER)/cellular stress responses, that could potentially contribute to symptom improvement in both ME/CFS and long-COVID patients. Further research and clinical trials are warranted to advance our understanding of the potential role of salubrinal in improving the quality of life for individuals with long-COVID-related ME/CFS symptoms as well as ME/CFS patients.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pig models for translational Duchenne muscular dystrophy research. 用于杜兴氏肌肉萎缩症转化研究的猪模型。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-10-01 Epub Date: 2024-05-14 DOI: 10.1016/j.molmed.2024.04.013
Michael Stirm, Nikolai Klymiuk, Hiroshi Nagashima, Christian Kupatt, Eckhard Wolf
{"title":"Pig models for translational Duchenne muscular dystrophy research.","authors":"Michael Stirm, Nikolai Klymiuk, Hiroshi Nagashima, Christian Kupatt, Eckhard Wolf","doi":"10.1016/j.molmed.2024.04.013","DOIUrl":"10.1016/j.molmed.2024.04.013","url":null,"abstract":"<p><p>Duchenne muscular dystrophy (DMD) is caused by mutations in the X-linked DMD gene, resulting in the absence of dystrophin, progressive muscle degeneration, and heart failure. Genetically tailored pig models resembling human DMD mutations recapitulate the biochemical, clinical, and pathological hallmarks of DMD with an accelerated disease progression compared to human patients. DMD pigs have been used to evaluate therapeutic concepts such as gene editing to reframe a disrupted DMD reading frame or the delivery of artificial chromosome vectors carrying the complete DMD gene. Moreover, DMD pigs have been instrumental in validating new diagnostic modalities such as multispectral optoacoustic tomography (MSOT) for non-invasive monitoring of disease progression. DMD pigs may thus help to bridge the gap between proof-of-concept studies in cellular or rodent models and clinical studies in patients.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"950-964"},"PeriodicalIF":12.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140945954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Does glial lipid dysregulation alter sleep in Alzheimer's and Parkinson's disease? 神经胶质脂质失调会改变阿尔茨海默氏症和帕金森氏症患者的睡眠吗？
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-10-01 Epub Date: 2024-05-15 DOI: 10.1016/j.molmed.2024.04.010
Lindsey D Goodman, Matthew J Moulton, Guang Lin, Hugo J Bellen
{"title":"Does glial lipid dysregulation alter sleep in Alzheimer's and Parkinson's disease?","authors":"Lindsey D Goodman, Matthew J Moulton, Guang Lin, Hugo J Bellen","doi":"10.1016/j.molmed.2024.04.010","DOIUrl":"10.1016/j.molmed.2024.04.010","url":null,"abstract":"<p><p>In this opinion article, we discuss potential connections between sleep disturbances observed in Alzheimer's disease (AD) and Parkinson's disease (PD) and the dysregulation of lipids in the brain. Research using Drosophila has highlighted the role of glial-mediated lipid metabolism in sleep and diurnal rhythms. Relevant to AD, the formation of lipid droplets in glia, which occurs in response to elevated neuronal reactive oxygen species (ROS), is required for sleep. In disease models, this process is disrupted, arguing a connection to sleep dysregulation. Relevant to PD, the degradation of neuronally synthesized glucosylceramides by glia requires glucocerebrosidase (GBA, a PD-associated risk factor) and this regulates sleep. Loss of GBA in glia causes an accumulation of glucosylceramides and neurodegeneration. Overall, research primarily using Drosophila has highlighted how dysregulation of glial lipid metabolism may underlie sleep disturbances in neurodegenerative diseases.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"913-923"},"PeriodicalIF":12.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11466711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140959229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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