Georges Dimitrov, Bernhard Ryffel, Dieudonnée Togbe, Valérie Quesniaux
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引用次数: 0
摘要
炎症性肠病（IBD）是一种病因不明、无法治愈的慢性病，影响着数百万人。18 岁以前发病的小儿 IBD 患者越来越多，与成人 IBD 相比，小儿 IBD 更具侵袭性，发病范围更广。这些差异在很大程度上仍无法解释。肠粘膜损伤、细胞死亡、核、线粒体或微生物群 DNA 释放以及激活 cGAS-STING 通路的 DNA 传感可能是疾病演变的原因。在实验性和人类 IBD 中，结肠 cGAS 和 STING 增加的报道越来越多。然而，对相关机制的有限了解阻碍了新治疗方案的开发。在此，我们将讨论有关 DNA 释放、DNA 传感器激活以及 cGAS-STING 通路在炎症性结肠炎中的作用和治疗潜力的最新进展和未决问题。
cGAS-STING DNA-sensing in inflammatory bowel diseases.
Inflammatory bowel diseases (IBD) are chronic, incurable pathologies with unknown causes, affecting millions of people. Pediatric-onset IBD, starting before the age of 18 years, are increasing, with more aggressive and extensive features than adult-onset IBD. These differences remain largely unexplained. Intestinal mucosal damage, cell death, DNA release from nuclear, mitochondrial, or microbiota sources, and DNA-sensing activating the cGAS-STING pathway may contribute to disease evolution. Increased colonic cGAS and STING are increasingly reported in experimental and human IBD. However, limited knowledge of the mechanisms involved hinders the development of new therapeutic options. Here, we discuss recent advances and unresolved questions regarding DNA release, DNA sensor activation, and the role and therapeutic potential of the cGAS-STING pathway in inflammatory colitis.
期刊介绍：
Trends in Molecular Medicine (TMM) aims to offer concise and contextualized perspectives on the latest research advancing biomedical science toward better diagnosis, treatment, and prevention of human diseases. It focuses on research at the intersection of basic biology and clinical research, covering new concepts in human biology and pathology with clear implications for diagnostics and therapy. TMM reviews bridge the gap between bench and bedside, discussing research from preclinical studies to patient-enrolled trials. The major themes include disease mechanisms, tools and technologies, diagnostics, and therapeutics, with a preference for articles relevant to multiple themes. TMM serves as a platform for discussion, pushing traditional boundaries and fostering collaboration between scientists and clinicians. The journal seeks to publish provocative and authoritative articles that are also accessible to a broad audience, inspiring new directions in molecular medicine to enhance human health.
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