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Rett syndrome: a complex disorder with promising therapeutic prospects. Rett综合征：一种具有良好治疗前景的复杂疾病。
IF 13.8 1区 医学
Trends in molecular medicine Pub Date : 2025-10-01 Epub Date: 2025-07-16 DOI: 10.1016/j.molmed.2025.06.006
Jawdat Sandakly, Angelisa Frasca, Nicoletta Landsberger
{"title":"Rett syndrome: a complex disorder with promising therapeutic prospects.","authors":"Jawdat Sandakly, Angelisa Frasca, Nicoletta Landsberger","doi":"10.1016/j.molmed.2025.06.006","DOIUrl":"10.1016/j.molmed.2025.06.006","url":null,"abstract":"","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"970-971"},"PeriodicalIF":13.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mesothelial and immune cells interplay in the tumor microenvironment. 间皮细胞和免疫细胞在肿瘤微环境中相互作用。
IF 13.8 1区 医学
Trends in molecular medicine Pub Date : 2025-10-01 Epub Date: 2025-04-29 DOI: 10.1016/j.molmed.2025.03.014
Rong Sheng, Yujia Yin, Xipeng Wang
{"title":"Mesothelial and immune cells interplay in the tumor microenvironment.","authors":"Rong Sheng, Yujia Yin, Xipeng Wang","doi":"10.1016/j.molmed.2025.03.014","DOIUrl":"10.1016/j.molmed.2025.03.014","url":null,"abstract":"<p><p>Mesothelial cells (MCs) constitute a dynamic mesothelium in which their numerous crucial functions synergistically interact with other cells to maintain serosal integrity and homeostasis. Previous studies have confirmed the crucial role of interactions between MCs and tumor cells in tumorigenesis and progression in the tumor microenvironment (TME). However, recent research has found that MCs can induce an immunosuppressive microenvironment by secreting various cytokines, chemokines, and exosomes which recruit immunosuppressive cells or interact with immune cells, thus contributing to tumor progression. This review primarily examines the immunoregulatory role of MCs in the TME of mesothelioma and metastatic pleural and peritoneal carcinomas. It also explores the potential mechanisms by which these interactions induce immunosuppression and their impact on tumor growth and therapy.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"895-908"},"PeriodicalIF":13.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MicroRNAs in the biology and hallmarks of neurodegenerative diseases. 神经退行性疾病的生物学和标志中的microrna。
IF 13.8 1区 医学
Trends in molecular medicine Pub Date : 2025-10-01 Epub Date: 2025-04-07 DOI: 10.1016/j.molmed.2025.03.006
Shivnarayan Dhuppar, Wolfram C Poller, Gopal Murugaiyan
{"title":"MicroRNAs in the biology and hallmarks of neurodegenerative diseases.","authors":"Shivnarayan Dhuppar, Wolfram C Poller, Gopal Murugaiyan","doi":"10.1016/j.molmed.2025.03.006","DOIUrl":"10.1016/j.molmed.2025.03.006","url":null,"abstract":"<p><p>A combination of intracellular and extracellular abnormalities of the nervous system, coupled with inflammation and intestinal dysbiosis, form the hallmarks of neurodegenerative diseases (NDDs). While it is difficult to identify the precise order in which these hallmarks manifest in NDDs because of their mutualistic nature, they cumulatively result in nervous or neuronal damage that characterizes neurodegeneration. In this review we discuss the roles of microRNAs (miRNAs) in the maintenance of nervous system homeostasis and their implication for NDDs. We further highlight recent advances in, and limitations of, miRNA therapeutics in NDDs and their future potential.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"955-969"},"PeriodicalIF":13.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12353848/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting mitochondrial transfer as a promising therapeutic strategy. 靶向线粒体转移作为一种有前途的治疗策略。
IF 13.8 1区 医学
Trends in molecular medicine Pub Date : 2025-10-01 Epub Date: 2025-05-06 DOI: 10.1016/j.molmed.2025.04.002
Bo Li, Bingzhi Li, Xianghe Qiao, Wanrong Meng, Yuhang Xie, Jiajing Gong, Yi Fan, Zhihe Zhao, Longjiang Li
{"title":"Targeting mitochondrial transfer as a promising therapeutic strategy.","authors":"Bo Li, Bingzhi Li, Xianghe Qiao, Wanrong Meng, Yuhang Xie, Jiajing Gong, Yi Fan, Zhihe Zhao, Longjiang Li","doi":"10.1016/j.molmed.2025.04.002","DOIUrl":"10.1016/j.molmed.2025.04.002","url":null,"abstract":"<p><p>Despite the primary impression of mitochondria as energy factories, these organelles are increasingly recognized for their multifaceted roles beyond energy production. Intriguingly, mitochondria can transfer between cells, influencing physiological and pathological processes through intercellular trafficking termed 'mitochondrial transfer.' This phenomenon is important in maintaining metabolic homeostasis, enhancing tissue regeneration, exacerbating cancer progression, and facilitating immune modulation, depending on the cell type and microenvironment. Recently, mitochondrial transfer has emerged as a promising therapeutic target for tissue repair and antitumor therapy. Here, we summarize and critically review recent advances in this field. We aim to provide an updated overview of the mechanisms and potential therapeutic avenues associated with mitochondrial transfer in various diseases from the perspective of different donor cells.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"909-924"},"PeriodicalIF":13.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two-pronged immune evasion of pseudouridine-modified RNA. 假尿嘧啶修饰RNA的双重免疫逃避。
IF 13.8 1区 医学
Trends in molecular medicine Pub Date : 2025-10-01 Epub Date: 2025-09-10 DOI: 10.1016/j.molmed.2025.08.007
Jonas Cerneckis, Yanhong Shi
{"title":"Two-pronged immune evasion of pseudouridine-modified RNA.","authors":"Jonas Cerneckis, Yanhong Shi","doi":"10.1016/j.molmed.2025.08.007","DOIUrl":"10.1016/j.molmed.2025.08.007","url":null,"abstract":"<p><p>It is well established that pseudouridine (Ψ) and its derivative N<sup>1</sup>-methylpseudouridine (m<sup>1</sup>Ψ) suppress unwanted immunogenicity of RNA-based therapeutics. However, molecular mechanisms governing such immune evasion remain elusive. In a recent article, Bérouti, Wagner, and colleagues show that Ψ impairs the processing of Toll-like receptor (TLR)-agonistic ligands and hinders TLR activation.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"879-881"},"PeriodicalIF":13.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12436447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pulmonary arterial hypertension and cancer: exploring their resemblance as channelopathies. 肺动脉高压与癌症：探讨其作为通道病变的相似性。
IF 13.8 1区 医学
Trends in molecular medicine Pub Date : 2025-10-01 Epub Date: 2025-04-01 DOI: 10.1016/j.molmed.2025.03.002
Fabrice Antigny, David Crottès, Christophe Vandier, Véronique Capuano, Maxime Guéguinou
{"title":"Pulmonary arterial hypertension and cancer: exploring their resemblance as channelopathies.","authors":"Fabrice Antigny, David Crottès, Christophe Vandier, Véronique Capuano, Maxime Guéguinou","doi":"10.1016/j.molmed.2025.03.002","DOIUrl":"10.1016/j.molmed.2025.03.002","url":null,"abstract":"<p><p>Pulmonary arterial hypertension (PAH) and cancer may appear to be unrelated at first, but there is increasing evidence that they share many characteristics and complexities. Pulmonary vascular cells in PAH resemble cancer cells in that they display abnormal growth patterns, resistance to cell death, metabolic changes, and channelopathies. These similarities open new possibilities for researchers and clinicians to apply cancer treatment strategies to PAH and possibly reverse the condition. This review explores the complex parallels between PAH and cancer, and emphasizes their similar channelopathy-like features at the molecular, cellular, and clinical levels. We also discuss the potential implications of these similarities for developing new treatments.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"936-954"},"PeriodicalIF":13.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endometriosis and comorbidities: molecular mechanisms and clinical implications. 子宫内膜异位症和合并症：分子机制和临床意义。
IF 13.8 1区 医学
Trends in molecular medicine Pub Date : 2025-10-01 DOI: 10.1016/j.molmed.2025.09.002
Felice Petraglia, Silvia Vannuccini, Chiara Donati, Maxime Jeljeli, Mathilde Bourdon, Charles Chapron
{"title":"Endometriosis and comorbidities: molecular mechanisms and clinical implications.","authors":"Felice Petraglia, Silvia Vannuccini, Chiara Donati, Maxime Jeljeli, Mathilde Bourdon, Charles Chapron","doi":"10.1016/j.molmed.2025.09.002","DOIUrl":"https://doi.org/10.1016/j.molmed.2025.09.002","url":null,"abstract":"<p><p>Endometriosis, traditionally viewed as a gynecological condition, is increasingly recognized as a systemic disease due to its frequent association with inflammatory and autoimmune comorbidities. Recent molecular and genetic insights reveal dysregulated hormone receptor signaling, heightened inflammatory responses, and immune dysfunction as central drivers of disease progression. These discoveries offer compelling explanations for extra-pelvic symptoms and open up avenues for targeted diagnostics and therapies. This review integrates emerging evidence to highlight endometriosis as a multisystem disorder, underscoring the need for multidisciplinary care. By redefining endometriosis beyond reproductive health, this perspective encourages a broader, systemic view of women's health and fosters innovation in precision medicine.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":13.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Empty follicle syndrome: underlying etiology and precise treatment. 空卵泡综合征：病因及精准治疗。
IF 13.8 1区 医学
Trends in molecular medicine Pub Date : 2025-09-30 DOI: 10.1016/j.molmed.2025.09.001
Xiaolei Chen, Ping Yang, Yikun Wang, Zi-Jiang Chen, Han Zhao
{"title":"Empty follicle syndrome: underlying etiology and precise treatment.","authors":"Xiaolei Chen, Ping Yang, Yikun Wang, Zi-Jiang Chen, Han Zhao","doi":"10.1016/j.molmed.2025.09.001","DOIUrl":"https://doi.org/10.1016/j.molmed.2025.09.001","url":null,"abstract":"<p><p>With the use of assisted reproductive technology to treat infertility, there has been an increase in the condition known as empty follicle syndrome (EFS). EFS is characterized by the failure to retrieve oocytes from multiple mature follicles despite normal follicle development following ovarian stimulation. Despite its clinical significance, there is a lack of comprehensive and up-to-date reviews on this syndrome. In addition, the borderline form of EFS, that is characterized by low oocyte retrieval rates and is more common in clinical practice, has not been extensively discussed. This review aims to update perspectives on EFS, and covers its classification, etiology, treatment, prediction, prevention, and prognosis with the goal of leading to better clinical management and future research that improves outcomes for infertility patients.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":13.8,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deciphering the MYCN-driven metabolic microenvironment of neuroblastoma. 解读神经母细胞瘤mycn驱动的代谢微环境。
IF 13.8 1区 医学
Trends in molecular medicine Pub Date : 2025-09-23 DOI: 10.1016/j.molmed.2025.08.005
Amber Wolf, Davide Leardini, Lingzhi Li, Riccardo Masetti, Costas A Lyssiotis, Eveline Barbieri
{"title":"Deciphering the MYCN-driven metabolic microenvironment of neuroblastoma.","authors":"Amber Wolf, Davide Leardini, Lingzhi Li, Riccardo Masetti, Costas A Lyssiotis, Eveline Barbieri","doi":"10.1016/j.molmed.2025.08.005","DOIUrl":"https://doi.org/10.1016/j.molmed.2025.08.005","url":null,"abstract":"<p><p>Oncogenic MYCN drives aggressive disease in many cancers including neuroblastoma (NB). Metabolic reprogramming is essential to support cancer cell homeostasis and survival under nutrient- and oxygen-deprived conditions. MYCN directly reprograms many nodes of tumor-intrinsic metabolism, which have significant repercussions on the cells of the tumor microenvironment (TME), resulting in complex intercellular metabolic circuits that contribute to the immunosuppressive microenvironment of NB. These metabolic circuits are also regulated by the organismal and cellular circadian clock and host diet to further impact the TME and NB oncogenesis. This review discusses the mechanisms by which MYCN regulates the metabolic crosstalk between tumor, TME, and host, and provides evidence that therapeutic targeting of MYCN-reprogrammed metabolism can improve patient outcomes.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":13.8,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Migraine: advances in treatment. 偏头痛：治疗进展。
IF 13.8 1区 医学
Trends in molecular medicine Pub Date : 2025-09-18 DOI: 10.1016/j.molmed.2025.08.009
Usman Ashraf, Peter J Goadsby
{"title":"Migraine: advances in treatment.","authors":"Usman Ashraf, Peter J Goadsby","doi":"10.1016/j.molmed.2025.08.009","DOIUrl":"https://doi.org/10.1016/j.molmed.2025.08.009","url":null,"abstract":"<p><p>Increased understanding of the pathophysiology of migraine has resulted in the development of therapies targeting calcitonin gene-related peptide and its receptor. Ditans, which are serotonin 5HT<sub>1F</sub> receptor agonists, have demonstrated efficacy in acute management and bypass vascular risks associated with triptans, which are 5HT<sub>1B/1D</sub> receptor agonists. However, despite favourable safety and efficacy data, many patients do not respond to these therapies. Treatments targeting pituitary adenylate cyclase activating polypeptide and other potential targets, including amylin and adrenomedullin and their receptors, K<sub>ATP</sub> and transient receptor potential ion channels, as well as neuronal nitric oxide synthase, are emerging. Improving our understanding of patient heterogeneity in migraine biology may pave the way for precision medicine in migraine management.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":13.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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