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The circadian clock in inflammatory bowel diseases. 炎症性肠病的生物钟。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-07-01 Epub Date: 2024-12-05 DOI: 10.1016/j.molmed.2024.11.008
Oren Froy, Yael Weintraub
{"title":"The circadian clock in inflammatory bowel diseases.","authors":"Oren Froy, Yael Weintraub","doi":"10.1016/j.molmed.2024.11.008","DOIUrl":"10.1016/j.molmed.2024.11.008","url":null,"abstract":"<p><p>Inflammatory bowel diseases (IBDs) involve relapsing-remitting immune activation and inflammation. Both immune system activity and digestive tract function exhibit diurnal variations, regulated by the circadian clock. Disruption of this clock is linked to inflammation, suggesting that circadian regulators may play a pivotal role in the inflammatory process of IBD.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"588-590"},"PeriodicalIF":12.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physical activity, cathepsin B, and cognitive health. 体育活动、组织蛋白酶B和认知健康。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-07-01 Epub Date: 2025-01-23 DOI: 10.1016/j.molmed.2024.12.010
Qian Yu, Zhihao Zhang, Fabian Herold, Sebastian Ludyga, Jin Kuang, Yanxia Chen, Zijun Liu, Kirk I Erickson, Bret H Goodpaster, Boris Cheval, Dominika M Pindus, Arthur F Kramer, Charles H Hillman, Teresa Liu-Ambrose, Keith W Kelley, Hyo Youl Moon, Aiguo Chen, Liye Zou
{"title":"Physical activity, cathepsin B, and cognitive health.","authors":"Qian Yu, Zhihao Zhang, Fabian Herold, Sebastian Ludyga, Jin Kuang, Yanxia Chen, Zijun Liu, Kirk I Erickson, Bret H Goodpaster, Boris Cheval, Dominika M Pindus, Arthur F Kramer, Charles H Hillman, Teresa Liu-Ambrose, Keith W Kelley, Hyo Youl Moon, Aiguo Chen, Liye Zou","doi":"10.1016/j.molmed.2024.12.010","DOIUrl":"10.1016/j.molmed.2024.12.010","url":null,"abstract":"<p><p>Regular physical activity (PA) is beneficial for cognitive health, and cathepsin B (CTSB) - a protease released by skeletal muscle during PA - acts as a potential molecular mediator of this association. PA-induced metabolic and mechanical stress appears to increase plasma/serum CTSB levels. CTSB facilitates neurogenesis and synaptic plasticity in brain regions (e.g., hippocampus and prefrontal cortex) that support performance in specific cognitive domains including memory, learning, and executive function. However, the evidence regarding the role of PA-induced changes in CTSB as a mediator of PA-induced cognitive health in humans is mixed. To guide future research, this article identifies key factors that may explain the observed heterogeneity in the findings from human studies and proposes a PA-CTSB-cognition model.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"595-609"},"PeriodicalIF":12.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gastric cancer: from biomarkers to functional precision medicine. 胃癌：从生物标志物到功能精准医学。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-06-23 DOI: 10.1016/j.molmed.2025.05.007
Philipp Albrecht, Ekin Karabati, Matthias P Ebert, Johannes Betge
{"title":"Gastric cancer: from biomarkers to functional precision medicine.","authors":"Philipp Albrecht, Ekin Karabati, Matthias P Ebert, Johannes Betge","doi":"10.1016/j.molmed.2025.05.007","DOIUrl":"https://doi.org/10.1016/j.molmed.2025.05.007","url":null,"abstract":"<p><p>Gastric cancer (GC) remains a deadly disease because of late detection and limited treatment options at advanced stages. Treatment of patients with metastatic disease is based on chemotherapy, complemented by antibodies targeting HER2, VEGFR2, and more recently PD-1 or claudin 18.2. Further targets, such as FGFR2b, as well as novel drug classes including antibody-drug conjugates (ADCs) and bispecific antibodies, are promising developments in GC treatment. Despite the failure of several targeted agents, the landscape of GC therapy is evolving rapidly, facilitated by umbrella or platform precision medicine trials. The integration of next-generation sequencing and other omics techniques into molecular tumor boards, as well as functional drug testing on patient-derived models, might bring us closer to personalized oncology and ultimately improve patient survival.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144485995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Technologies for chimeric antigen receptor transgene delivery. 嵌合抗原受体转基因传递技术。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-06-19 DOI: 10.1016/j.molmed.2025.05.011
Yudian Xiao, Bowen Wu, Qiuping Zhou, Fan Wu, Nei Li, Chenqi Xu, Xuexiang Han
{"title":"Technologies for chimeric antigen receptor transgene delivery.","authors":"Yudian Xiao, Bowen Wu, Qiuping Zhou, Fan Wu, Nei Li, Chenqi Xu, Xuexiang Han","doi":"10.1016/j.molmed.2025.05.011","DOIUrl":"10.1016/j.molmed.2025.05.011","url":null,"abstract":"<p><p>Ex vivo chimeric antigen receptor (CAR) T cell therapy has achieved clinical success in hematological malignancies; yet, viral transduction risks insertional mutagenesis. Developing safe and efficient nonviral approaches for the genetic engineering of T cells and other immune cells is the key to next-generation immunotherapy for cancer and noncancerous diseases. mRNA is an emerging modality for CAR engineering because of its transient expression and minimal risks. As a clinically validated nonviral vector, lipid nanoparticles (LNPs) are gaining popularity for ex vivo/in vivo mRNA-based CAR engineering of immune cells, making cell therapy safer and affordable. This review discusses the progress, delivery approaches, and challenges of CAR therapy and highlights mRNA-LNP advancements in shaping future CAR immune cell therapy for oncology and non-oncology.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144337037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Understanding preeclampsia: from phenotypes to treatment. 了解先兆子痫：从表型到治疗。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-06-18 DOI: 10.1016/j.molmed.2025.05.008
Priscila R Nunes, Ana C T Palei, Valeria C Sandrim
{"title":"Understanding preeclampsia: from phenotypes to treatment.","authors":"Priscila R Nunes, Ana C T Palei, Valeria C Sandrim","doi":"10.1016/j.molmed.2025.05.008","DOIUrl":"10.1016/j.molmed.2025.05.008","url":null,"abstract":"","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IL-15 in CAR engineering: striking an efficacy-safety balance. IL-15在CAR工程中的应用：达到疗效与安全性的平衡。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-06-18 DOI: 10.1016/j.molmed.2025.05.014
Yan-Ruide Li, Yichen Zhu, Lili Yang
{"title":"IL-15 in CAR engineering: striking an efficacy-safety balance.","authors":"Yan-Ruide Li, Yichen Zhu, Lili Yang","doi":"10.1016/j.molmed.2025.05.014","DOIUrl":"10.1016/j.molmed.2025.05.014","url":null,"abstract":"<p><p>Interleukin (IL)-15 engineering in chimeric antigen receptor (CAR)-cell therapy has demonstrated promising antitumor efficacy against both hematological malignancies and solid tumors in recent clinical trials. However, increased cytokine release syndrome (CRS) toxicity is primarily observed in conventional CAR-T cells, underscoring the need to balance safety and efficacy in IL-15-enhanced CAR therapy for clinical application.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fighting aging-associated clonal hematopoiesis with microbial metabolite. 利用微生物代谢物对抗衰老相关克隆造血。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-06-17 DOI: 10.1016/j.molmed.2025.06.001
Shuqin Zeng, Dezhi Mu, Shaopu Wang
{"title":"Fighting aging-associated clonal hematopoiesis with microbial metabolite.","authors":"Shuqin Zeng, Dezhi Mu, Shaopu Wang","doi":"10.1016/j.molmed.2025.06.001","DOIUrl":"https://doi.org/10.1016/j.molmed.2025.06.001","url":null,"abstract":"<p><p>Age-related clonal hematopoiesis in the elderly is mediated by expansion of mutant pre-leukemic hematopoietic cells, but the mechanism remains unclear. Recently, Agarwal et al. found elderly individuals exhibit the gut microbial dysbiosis with enriched Gram-negative bacteria that release ADP-heptose into systemic circulation, which promotes pre-leukemic cell expansion through ALPK1-dependent signaling.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidermolysis bullosa: understanding the disease, diagnosis, and advances in treatment strategies. 大疱性表皮松解症：了解疾病、诊断和治疗策略的进展。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-06-17 DOI: 10.1016/j.molmed.2025.05.009
Madalina Alexandru, Jemima E Mellerio, Joanna Jacków-Malinowska
{"title":"Epidermolysis bullosa: understanding the disease, diagnosis, and advances in treatment strategies.","authors":"Madalina Alexandru, Jemima E Mellerio, Joanna Jacków-Malinowska","doi":"10.1016/j.molmed.2025.05.009","DOIUrl":"https://doi.org/10.1016/j.molmed.2025.05.009","url":null,"abstract":"","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Priorities for modelling arbovirus transmission under climate change. 气候变化下虫媒病毒传播建模的优先事项。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-06-16 DOI: 10.1016/j.molmed.2025.05.010
Ilaria Dorigatti, Katy A M Gaythorpe, Victoria M Cox, Francis A Windram, Lauren Cator
{"title":"Priorities for modelling arbovirus transmission under climate change.","authors":"Ilaria Dorigatti, Katy A M Gaythorpe, Victoria M Cox, Francis A Windram, Lauren Cator","doi":"10.1016/j.molmed.2025.05.010","DOIUrl":"https://doi.org/10.1016/j.molmed.2025.05.010","url":null,"abstract":"<p><p>The transmission potential of arboviruses is extremely sensitive to environmental conditions. This sensitivity is due to both their intimate relationship with ectothermic vectors and, in many cases, also to the involvement of multiple host species in zoonotic transmission cycles. Here, we review how climate change will alter the transmission ecology and risk of these important infections. The challenge of predicting how climate change will impact these systems is daunting, but the need for tools to manage arbovirus risk under climate change is urgent and imperative. We argue that the development of climate-driven mechanistic models of disease transmission informed by empirical surveillance data is urgently needed to inform future responses and for generating the evidence that policy needs to tackle this global public health risk.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Toll-like receptors in B cells and obesity. B细胞中的toll样受体与肥胖。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-06-16 DOI: 10.1016/j.molmed.2025.05.005
Pai Wang, Can Hou, F Susan Wong, Li Wen
{"title":"Toll-like receptors in B cells and obesity.","authors":"Pai Wang, Can Hou, F Susan Wong, Li Wen","doi":"10.1016/j.molmed.2025.05.005","DOIUrl":"https://doi.org/10.1016/j.molmed.2025.05.005","url":null,"abstract":"<p><p>Toll-like receptors (TLRs) play a pivotal role in both innate and adaptive immunity, primarily by detecting pathogen-associated molecular patterns (PAMPs) and orchestrating immune responses. Although TLR-driven activation of dendritic cells (DCs) and subsequent T cell differentiation are well characterized, the function of TLRs in B cells remains underexplored. In the context of obesity, excessive adipose tissue accumulation triggers chronic inflammation driven in part by activation of TLR signaling. This review explores the expression, function, and signaling mechanisms of TLRs in B cells, and emphasizes their role in modulating immune responses associated with obesity. Furthermore, we discuss how TLR-mediated inflammatory activity in B cells may contribute to metabolic dysregulation, and offer insights into the crosstalk between immune function and metabolic disease in obesity.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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