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Trends in molecular medicine最新文献

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MicroRNAs: a symphony orchestrating evolution and disease dynamics. 微小核糖核酸：进化与疾病动态的交响乐。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-01-01 Epub Date: 2024-08-06 DOI: 10.1016/j.molmed.2024.07.004
Shan Quah, Gowtham Subramanian, Jonathan S L Tan, Kagistia Hana Utami, Prabha Sampath
{"title":"MicroRNAs: a symphony orchestrating evolution and disease dynamics.","authors":"Shan Quah, Gowtham Subramanian, Jonathan S L Tan, Kagistia Hana Utami, Prabha Sampath","doi":"10.1016/j.molmed.2024.07.004","DOIUrl":"10.1016/j.molmed.2024.07.004","url":null,"abstract":"<p><p>The genesis of human disease lies in our evolutionary past. Evolution has featured a general trend towards increased morphological complexity, partly conferred by expansion in gene regulatory capacity via microRNA (miRNA) innovation. Many human diseases are directly related to the evolved roles of these miRNAs, and miRNA-based therapies are emerging as an appealing strategy for precision medicine. We focus on three categories of human disease - cancer, inflammation-linked pathologies, and neurological disorders - which are highly prevalent and are associated with substantial disease burden worldwide. In each category we discuss the pathogenic roles of miRNAs in the context of their evolved functions, as well as current and potential advances in targeting these miRNAs for disease therapy.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"21-35"},"PeriodicalIF":12.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141902989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multiple sclerosis: a smoldering disease. 多发性硬化症：一种燃烧的疾病。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-01-01 Epub Date: 2024-12-16 DOI: 10.1016/j.molmed.2024.11.005
Martina Absinta
{"title":"Multiple sclerosis: a smoldering disease.","authors":"Martina Absinta","doi":"10.1016/j.molmed.2024.11.005","DOIUrl":"10.1016/j.molmed.2024.11.005","url":null,"abstract":"","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"94-95"},"PeriodicalIF":12.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142839865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Circadian phase instability in bipolar disorder: a neglected essence. 躁郁症的昼夜相位不稳定性：一个被忽视的本质。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-01-01 Epub Date: 2024-07-14 DOI: 10.1016/j.molmed.2024.06.012
Francisco Romo-Nava
{"title":"Circadian phase instability in bipolar disorder: a neglected essence.","authors":"Francisco Romo-Nava","doi":"10.1016/j.molmed.2024.06.012","DOIUrl":"10.1016/j.molmed.2024.06.012","url":null,"abstract":"<p><p>Circadian system disruption is an essential but poorly understood feature of bipolar disorder (BD) and associated comorbidities. This forum article summarizes current evidence regarding the emerging concept of circadian phase instability (CPI) as a neglected phenomenon with possibly unique features in BD that could be harnessed to develop individually tailored chronobiological interventions.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"7-10"},"PeriodicalIF":12.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11717640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141617166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cell-free and extrachromosomal DNA profiling of small cell lung cancer. 小细胞肺癌的无细胞和染色体外 DNA 图谱。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-01-01 Epub Date: 2024-09-04 DOI: 10.1016/j.molmed.2024.08.004
Roya Behrouzi, Alexandra Clipson, Kathryn L Simpson, Fiona Blackhall, Dominic G Rothwell, Caroline Dive, Florent Mouliere
{"title":"Cell-free and extrachromosomal DNA profiling of small cell lung cancer.","authors":"Roya Behrouzi, Alexandra Clipson, Kathryn L Simpson, Fiona Blackhall, Dominic G Rothwell, Caroline Dive, Florent Mouliere","doi":"10.1016/j.molmed.2024.08.004","DOIUrl":"10.1016/j.molmed.2024.08.004","url":null,"abstract":"<p><p>Small cell lung cancer (SCLC) is highly aggressive with poor prognosis. Despite a relative prevalence of circulating tumour DNA (ctDNA) in SCLC, liquid biopsies are not currently implemented, unlike non-SCLC where cell-free DNA (cfDNA) mutation profiling in the blood has utility for guiding targeted therapies and assessing minimal residual disease. cfDNA methylation profiling is highly sensitive for SCLC detection and holds promise for disease monitoring and molecular subtyping; cfDNA fragmentation profiling has also demonstrated clinical potential. Extrachromosomal DNA (ecDNA), that is often observed in SCLC, promotes tumour heterogeneity and chemotherapy resistance and can be detected in blood. We discuss how these cfDNA profiling modalities can be harnessed to expand the clinical applications of liquid biopsy in SCLC.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"64-78"},"PeriodicalIF":12.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vascular dysfunction in Hutchinson-Gilford progeria syndrome.
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-12-30 DOI: 10.1016/j.molmed.2024.12.008
Yaping Zhao, Li Wang, Suowen Xu
{"title":"Vascular dysfunction in Hutchinson-Gilford progeria syndrome.","authors":"Yaping Zhao, Li Wang, Suowen Xu","doi":"10.1016/j.molmed.2024.12.008","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.12.008","url":null,"abstract":"<p><p>Most patients with Hutchinson-Gilford progeria syndrome (HGPS) succumb to cardiovascular disease. Recent studies by Barettino et al., Cardoso et al., and Vakili et al. utilized progeria mouse models to elucidate novel mechanisms by which vascular smooth muscle cell (VSMC) and endothelial cell (EC) dysfunction accelerate the progress of the disease, thus providing directions for the development of new targeted pharmaco-therapies.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142910894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting CDK2 to circumvent treatment resistance in HR+ breast cancer.
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-12-27 DOI: 10.1016/j.molmed.2024.12.009
Leire Arrizabalaga, Esmeralda García-Torralba, Lorenzo Galluzzi, Aitziber Buqué
{"title":"Targeting CDK2 to circumvent treatment resistance in HR<sup>+</sup> breast cancer.","authors":"Leire Arrizabalaga, Esmeralda García-Torralba, Lorenzo Galluzzi, Aitziber Buqué","doi":"10.1016/j.molmed.2024.12.009","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.12.009","url":null,"abstract":"<p><p>Genetic and epigenetic defects of the p53 system have previously been associated with resistance to CDK4/6 inhibitors in women with HR<sup>+</sup> breast cancer. Recent data from Kudo et al. demonstrate that CDK2-targeting agents may offer an effective strategy to circumvent such resistance by enforcing cellular senescence downstream of RBL2 dephosphorylation.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142898449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Short-chain fatty acids in fetal development and metabolism.
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-12-17 DOI: 10.1016/j.molmed.2024.11.014
Xueyun Qin, Mo Zhang, Shiting Chen, Yunhui Tang, Jiajun Cui, Guolian Ding
{"title":"Short-chain fatty acids in fetal development and metabolism.","authors":"Xueyun Qin, Mo Zhang, Shiting Chen, Yunhui Tang, Jiajun Cui, Guolian Ding","doi":"10.1016/j.molmed.2024.11.014","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.11.014","url":null,"abstract":"<p><p>Short-chain fatty acids (SCFAs), primarily derived from gut microbiota, play a role in regulating fetal development; however, the mechanism remains unclear. Fetal SCFAs levels depends on maternal SCFAs transported via the placenta. Metabolic stress, particularly from diabetes and obesity, can disrupt maternal SCFAs levels, impairing fetal metabolic reprogramming. Dysregulated SCFAs may negatively impact the development of the fetal cardiovascular, nervous, and immune systems, potentially contributing to adverse outcomes in adulthood. This review focuses on recent advances regarding the role of maternal SCFAs in shaping the metabolic profile of offspring, especially in the context of various maternal metabolic disorders. Given that SCFAs may influence fetal development through the placenta-embryo axis, targeted SCFAs supplementation could be a promising strategy against developmental diseases associated with intrauterine risk factors.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New therapeutic approaches for fibrosis: harnessing translational regulation.
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-12-16 DOI: 10.1016/j.molmed.2024.11.012
Sumeen Kaur Gill, Richard H Gomer
{"title":"New therapeutic approaches for fibrosis: harnessing translational regulation.","authors":"Sumeen Kaur Gill, Richard H Gomer","doi":"10.1016/j.molmed.2024.11.012","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.11.012","url":null,"abstract":"<p><p>Idiopathic pulmonary fibrosis (IPF) is a progressive and debilitating lung disease characterized by excessive extracellular matrix deposition and tissue scarring. The median survival of patients with IPF is only 4.5 years following diagnosis, and effective treatment options are scarce. Recent studies found aberrant translation of specific mRNAs in various fibrosing diseases, highlighting the role of key translational regulators, including RNA binding proteins (RBPs), microRNAs, long noncoding RNAs, and transcript modifications. Notably, when inhibited, 10 profibrotic RBPs cause a significant attenuation of fibrosis, illuminating potential therapeutic targets. In this review, we describe translational regulation in fibrosis and highlight a model where a conserved evolutionary mechanism may explain this regulation.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Galectin-3 in metabolic disorders: mechanisms and therapeutic potential.
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-12-16 DOI: 10.1016/j.molmed.2024.11.006
Qian Jiang, Qijin Zhao, Pingping Li
{"title":"Galectin-3 in metabolic disorders: mechanisms and therapeutic potential.","authors":"Qian Jiang, Qijin Zhao, Pingping Li","doi":"10.1016/j.molmed.2024.11.006","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.11.006","url":null,"abstract":"<p><p>Galectin-3 (Gal3), a β-galactoside-binding lectin, is expressed predominantly in immunological and inflammatory cells. Gal3 expression is elevated in metabolic diseases, including obesity, diabetes, and metabolic dysfunction-associated steatotic liver disease (MASLD), and plays an important role in the progression of these diseases. In this review, we summarize the structure and post-translational modifications of Gal3 and the cellular functions of Gal3 according to its subcellular localization. We focused on the pathological functions and molecular mechanisms of Gal3 in various cell types. In particular, extracellular Gal3 and intracellular Gal3 may have different physiological and pathological functions. We also discuss promising Gal3 inhibitors or antibodies that are currently in clinical trials and outstanding questions and challenges for future pursuit.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treating Niemann-Pick C lysosomal storage: approved and emerging approaches.
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-12-12 DOI: 10.1016/j.molmed.2024.11.011
Andrés D Klein, Emily R Eden, Silvana Zanlungo
{"title":"Treating Niemann-Pick C lysosomal storage: approved and emerging approaches.","authors":"Andrés D Klein, Emily R Eden, Silvana Zanlungo","doi":"10.1016/j.molmed.2024.11.011","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.11.011","url":null,"abstract":"","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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