MicroRNAs in the biology and hallmarks of neurodegenerative diseases.

IF 12.8 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in molecular medicine Pub Date : 2025-04-07 DOI:10.1016/j.molmed.2025.03.006

Shivnarayan Dhuppar, Wolfram C Poller, Gopal Murugaiyan

引用次数: 0

Abstract

A combination of intracellular and extracellular abnormalities of the nervous system, coupled with inflammation and intestinal dysbiosis, form the hallmarks of neurodegenerative diseases (NDDs). While it is difficult to identify the precise order in which these hallmarks manifest in NDDs because of their mutualistic nature, they cumulatively result in nervous or neuronal damage that characterizes neurodegeneration. In this review we discuss the roles of microRNAs (miRNAs) in the maintenance of nervous system homeostasis and their implication for NDDs. We further highlight recent advances in, and limitations of, miRNA therapeutics in NDDs and their future potential.

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神经退行性疾病的生物学和标志中的microrna。

神经系统的细胞内和细胞外异常，加上炎症和肠道生态失调，形成了神经退行性疾病（ndd）的标志。由于这些特征的相互作用性质，很难确定这些特征在ndd中表现的确切顺序，但它们累积导致神经或神经元损伤，这是神经变性的特征。在这篇综述中，我们讨论了microRNAs （miRNAs）在维持神经系统稳态中的作用及其在ndd中的意义。我们进一步强调了miRNA治疗ndd的最新进展和局限性及其未来潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in molecular medicine 医学-生化与分子生物学

CiteScore

24.60

自引率

0.00%

发文量

142

审稿时长

6-12 weeks

期刊介绍： Trends in Molecular Medicine (TMM) aims to offer concise and contextualized perspectives on the latest research advancing biomedical science toward better diagnosis, treatment, and prevention of human diseases. It focuses on research at the intersection of basic biology and clinical research, covering new concepts in human biology and pathology with clear implications for diagnostics and therapy. TMM reviews bridge the gap between bench and bedside, discussing research from preclinical studies to patient-enrolled trials. The major themes include disease mechanisms, tools and technologies, diagnostics, and therapeutics, with a preference for articles relevant to multiple themes. TMM serves as a platform for discussion, pushing traditional boundaries and fostering collaboration between scientists and clinicians. The journal seeks to publish provocative and authoritative articles that are also accessible to a broad audience, inspiring new directions in molecular medicine to enhance human health.