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From pixels to patients: the evolution and future of deep learning in cancer diagnostics. 从像素到病人：癌症诊断中深度学习的发展和未来。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-06-01 Epub Date: 2024-12-11 DOI: 10.1016/j.molmed.2024.11.009
Yichen Yang, Hongru Shen, Kexin Chen, Xiangchun Li
{"title":"From pixels to patients: the evolution and future of deep learning in cancer diagnostics.","authors":"Yichen Yang, Hongru Shen, Kexin Chen, Xiangchun Li","doi":"10.1016/j.molmed.2024.11.009","DOIUrl":"10.1016/j.molmed.2024.11.009","url":null,"abstract":"<p><p>Deep learning has revolutionized cancer diagnostics, shifting from pixel-based image analysis to more comprehensive, patient-centric care. This opinion article explores recent advancements in neural network architectures, highlighting their evolution in biomedical research and their impact on medical imaging interpretation and multimodal data integration. We emphasize the need for domain-specific artificial intelligence (AI) systems capable of handling complex clinical tasks, advocating for the development of multimodal large language models that can integrate diverse data sources. These models have the potential to significantly enhance the precision and efficiency of cancer diagnostics, transforming AI from a supplementary tool into a core component of clinical decision-making, ultimately improving patient outcomes and advancing cancer care.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"548-558"},"PeriodicalIF":12.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronobiological and neuroendocrine insights into dry eye. 从时间生物学和神经内分泌学角度看干眼症。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-06-01 Epub Date: 2024-11-16 DOI: 10.1016/j.molmed.2024.10.012
Licheng Li, Haoyu Li, Baihua Chen
{"title":"Chronobiological and neuroendocrine insights into dry eye.","authors":"Licheng Li, Haoyu Li, Baihua Chen","doi":"10.1016/j.molmed.2024.10.012","DOIUrl":"10.1016/j.molmed.2024.10.012","url":null,"abstract":"<p><p>Dry eye, a prevalent ocular surface disease, is significantly influenced by modern lifestyle factors such as night-shift work and extended screen time. Emerging evidence suggests a strong correlation between disturbances in circadian rhythm, sleep disorders, and dry eye. However, the precise underlying mechanisms remain unclear. Recent studies have underscored the crucial role of circadian rhythms and neuroendocrine regulation in maintaining ocular surface health. Advances in treatment strategies targeting neuroendocrine pathways have shown promising developments. This review explores the interplay between circadian rhythms, neuroendocrine regulation, and the ocular surface, examines the impact of circadian disruption on the pathophysiology of dry eye, and proposes intervention strategies to alleviate dry eye associated with disturbances in circadian rhythms.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"522-534"},"PeriodicalIF":12.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fc-optimized checkpoint antibodies for cancer immunotherapy. 用于癌症免疫疗法的 Fc 优化检查点抗体。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-06-01 Epub Date: 2024-11-01 DOI: 10.1016/j.molmed.2024.10.008
Rony Dahan, Alan J Korman
{"title":"Fc-optimized checkpoint antibodies for cancer immunotherapy.","authors":"Rony Dahan, Alan J Korman","doi":"10.1016/j.molmed.2024.10.008","DOIUrl":"10.1016/j.molmed.2024.10.008","url":null,"abstract":"<p><p>The development of checkpoint antibodies for cancer therapy has been guided by the principle of blocking T cell inhibitory signals. Recognition of the role of the Fc domain in therapeutic activities, through the depletion of immunosuppressive populations and myeloid cell activation, prompts a shift toward the development of optimized Fc-engineered checkpoint antibodies.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"501-505"},"PeriodicalIF":12.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142563513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting the Yin and Yang of KRASG12C. 靶向KRASG12C的阴阳。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-06-01 Epub Date: 2025-04-03 DOI: 10.1016/j.molmed.2025.03.007
Christos Adamopoulos, Kostas A Papavassiliou, Athanasios G Papavassiliou
{"title":"Targeting the Yin and Yang of KRAS<sup>G12C</sup>.","authors":"Christos Adamopoulos, Kostas A Papavassiliou, Athanasios G Papavassiliou","doi":"10.1016/j.molmed.2025.03.007","DOIUrl":"10.1016/j.molmed.2025.03.007","url":null,"abstract":"<p><p>In a recent study in Cancer Discovery, Maciag et al. introduce BBO-8520, a novel inhibitor targeting both the active and inactive states of KRAS<sup>G12C</sup>. This dual inhibition shows superior target engagement and prolonged tumor suppression, offering a compelling strategy to overcome resistance development and improve outcomes in KRAS<sup>G12C</sup>-mutant cancers.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"498-500"},"PeriodicalIF":12.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute lymphoblastic leukemia relapse: biomarkers, hopes, and challenges. 急性淋巴细胞白血病复发：生物标志物，希望和挑战。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-05-23 DOI: 10.1016/j.molmed.2025.04.005
Joseph Adomako, Karina E Jiménez-Camacho, M Victor M Correa-Lara, Juan C Núñez-Enriquez, Michael Schnoor
{"title":"Acute lymphoblastic leukemia relapse: biomarkers, hopes, and challenges.","authors":"Joseph Adomako, Karina E Jiménez-Camacho, M Victor M Correa-Lara, Juan C Núñez-Enriquez, Michael Schnoor","doi":"10.1016/j.molmed.2025.04.005","DOIUrl":"https://doi.org/10.1016/j.molmed.2025.04.005","url":null,"abstract":"<p><p>Acute lymphoblastic leukemia (ALL) is a rare disease in adults, but is the most common pediatric malignancy and the leading cause of death among children with cancer worldwide. While initial treatment regimens induce remission in most patients, relapses still occur in many cases during or after treatment. Relapses are difficult to treat and continue to be one of the leading causes of ALL-related deaths. Thus, it is essential to understand the biological mechanisms underlying ALL relapses, and to identify reliable biomarkers for better relapse risk prediction and novel druggable targets for precision treatments tailored to risk profiles. Here we review the latest developments in ALL research with a focus on relapse mechanisms, and we discuss related hopes and challenges.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Powering immunity: mitochondrial dynamics in natural killer cells. 增强免疫力：自然杀伤细胞中的线粒体动力学。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-05-19 DOI: 10.1016/j.molmed.2025.04.004
Tias Verhezen, An Wouters, Evelien Smits, Jorrit De Waele
{"title":"Powering immunity: mitochondrial dynamics in natural killer cells.","authors":"Tias Verhezen, An Wouters, Evelien Smits, Jorrit De Waele","doi":"10.1016/j.molmed.2025.04.004","DOIUrl":"https://doi.org/10.1016/j.molmed.2025.04.004","url":null,"abstract":"<p><p>Natural killer (NK) cells are innate lymphocytes that are crucial for eliminating malignant and infected cells, and have significant therapeutic potential against cancer and viral infections. However, their functionality is often impaired under pathological conditions. Emerging evidence identifies mitochondria as key regulators of NK cell metabolism, fitness, and fate. This review examines how mitochondrial dysfunction impacts on NK cell activity in cancer, viral infections, and inflammatory disorders. We discuss strategies to target mitochondrial architecture, dynamics, and function as potential therapies to restore NK cell fitness. Finally, we highlight unanswered questions and future directions to better understand mitochondrial regulation in NK cells and its implications for therapeutic development.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting mitochondrial transfer as a promising therapeutic strategy. 靶向线粒体转移作为一种有前途的治疗策略。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-05-06 DOI: 10.1016/j.molmed.2025.04.002
Bo Li, Bingzhi Li, Xianghe Qiao, Wanrong Meng, Yuhang Xie, Jiajing Gong, Yi Fan, Zhihe Zhao, Longjiang Li
{"title":"Targeting mitochondrial transfer as a promising therapeutic strategy.","authors":"Bo Li, Bingzhi Li, Xianghe Qiao, Wanrong Meng, Yuhang Xie, Jiajing Gong, Yi Fan, Zhihe Zhao, Longjiang Li","doi":"10.1016/j.molmed.2025.04.002","DOIUrl":"https://doi.org/10.1016/j.molmed.2025.04.002","url":null,"abstract":"<p><p>Despite the primary impression of mitochondria as energy factories, these organelles are increasingly recognized for their multifaceted roles beyond energy production. Intriguingly, mitochondria can transfer between cells, influencing physiological and pathological processes through intercellular trafficking termed 'mitochondrial transfer.' This phenomenon is important in maintaining metabolic homeostasis, enhancing tissue regeneration, exacerbating cancer progression, and facilitating immune modulation, depending on the cell type and microenvironment. Recently, mitochondrial transfer has emerged as a promising therapeutic target for tissue repair and antitumor therapy. Here, we summarize and critically review recent advances in this field. We aim to provide an updated overview of the mechanisms and potential therapeutic avenues associated with mitochondrial transfer in various diseases from the perspective of different donor cells.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New insights into gut microbiota-prostate cancer crosstalk. 肠道微生物与前列腺癌相互作用的新见解。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-05-06 DOI: 10.1016/j.molmed.2025.03.015
Jalal Laaraj, Gabriel Lachance, Alain Bergeron, Yves Fradet, Karine Robitaille, Vincent Fradet
{"title":"New insights into gut microbiota-prostate cancer crosstalk.","authors":"Jalal Laaraj, Gabriel Lachance, Alain Bergeron, Yves Fradet, Karine Robitaille, Vincent Fradet","doi":"10.1016/j.molmed.2025.03.015","DOIUrl":"https://doi.org/10.1016/j.molmed.2025.03.015","url":null,"abstract":"<p><p>Recent evidence underscores a reciprocal relationship between the gut microbiota and prostate cancer (PCa). Dysbiosis, often driven by Western dietary habits and antibiotic use, can heighten systemic inflammation and hinder antitumor immunity, thereby fostering PCa onset and progression. Conversely, certain gut microbes and their metabolites may protect against tumor growth by modulating immune and hormonal pathways that impact therapeutic responses, including androgen deprivation therapy (ADT). Emerging evidence links gut microbial shifts to PCa aggressiveness, potentially sustaining local androgen production and promoting resistance. In this review, we explore current understanding of the gut-PCa interplay, highlighting key knowledge gaps and the need for further research to clarify how targeting the microbiome might influence PCa outcomes.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting monoamine oxidases in cancer: advances and opportunities. 以癌症中的单胺氧化酶为靶点：进展与机遇。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-05-01 Epub Date: 2024-10-21 DOI: 10.1016/j.molmed.2024.09.010
Jing Wei, Boyang Jason Wu
{"title":"Targeting monoamine oxidases in cancer: advances and opportunities.","authors":"Jing Wei, Boyang Jason Wu","doi":"10.1016/j.molmed.2024.09.010","DOIUrl":"10.1016/j.molmed.2024.09.010","url":null,"abstract":"<p><p>Monoamine oxidases (MAOs) are a crucial pair of isoenzymes responsible for degrading monoamine neurotransmitters and dietary amines. In addition to extensive studies of their roles in the context of brain functions and disorders over decades, emerging evidence indicates that MAOs are also often dysregulated and associated with clinical outcomes in diverse cancers, with the ability to differentially regulate cancer growth, invasion, metastasis, progression, and therapy response depending on the cancer type. In this review, we summarize recent advances in understanding the clinical relevance, functional importance, and mechanisms of MAOs in a broad range of cancers, and discuss the application and therapeutic benefit of MAO inhibitors (MAOIs) for cancer treatment, highlighting the roles of MAOs as novel regulators, prognostic biomarkers, and therapeutic targets in cancer.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"479-491"},"PeriodicalIF":12.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vascular dysfunction in Hutchinson-Gilford progeria syndrome. 哈钦森-吉尔福德早衰综合征的血管功能障碍。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2025-05-01 Epub Date: 2024-12-30 DOI: 10.1016/j.molmed.2024.12.008
Yaping Zhao, Li Wang, Suowen Xu
{"title":"Vascular dysfunction in Hutchinson-Gilford progeria syndrome.","authors":"Yaping Zhao, Li Wang, Suowen Xu","doi":"10.1016/j.molmed.2024.12.008","DOIUrl":"10.1016/j.molmed.2024.12.008","url":null,"abstract":"<p><p>Most patients with Hutchinson-Gilford progeria syndrome (HGPS) succumb to cardiovascular disease. Recent studies by Barettino et al., Cardoso et al., and Vakili et al. utilized progeria mouse models to elucidate novel mechanisms by which vascular smooth muscle cell (VSMC) and endothelial cell (EC) dysfunction accelerate the progress of the disease, thus providing directions for the development of new targeted pharmaco-therapies.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"401-403"},"PeriodicalIF":12.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142910894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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