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Trends in molecular medicine最新文献

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Beyond pluripotency: Yamanaka factors drive brain growth and regeneration.
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-12-11 DOI: 10.1016/j.molmed.2024.11.013
Sunwoo Choi, Mingzi Zhang, Ruslan Rust
{"title":"Beyond pluripotency: Yamanaka factors drive brain growth and regeneration.","authors":"Sunwoo Choi, Mingzi Zhang, Ruslan Rust","doi":"10.1016/j.molmed.2024.11.013","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.11.013","url":null,"abstract":"<p><p>The Yamanaka factors (YFs), a set of four transcription factors, are widely studied for their ability to dedifferentiate somatic cells into a pluripotent state. In a recent study, Shen and colleagues show that transient expression of YFs in the mouse brain expands the developing cortex and prevents cognitive decline in an Alzheimer's disease (AD) model.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From pixels to patients: the evolution and future of deep learning in cancer diagnostics.
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-12-11 DOI: 10.1016/j.molmed.2024.11.009
Yichen Yang, Hongru Shen, Kexin Chen, Xiangchun Li
{"title":"From pixels to patients: the evolution and future of deep learning in cancer diagnostics.","authors":"Yichen Yang, Hongru Shen, Kexin Chen, Xiangchun Li","doi":"10.1016/j.molmed.2024.11.009","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.11.009","url":null,"abstract":"<p><p>Deep learning has revolutionized cancer diagnostics, shifting from pixel-based image analysis to more comprehensive, patient-centric care. This opinion article explores recent advancements in neural network architectures, highlighting their evolution in biomedical research and their impact on medical imaging interpretation and multimodal data integration. We emphasize the need for domain-specific artificial intelligence (AI) systems capable of handling complex clinical tasks, advocating for the development of multimodal large language models that can integrate diverse data sources. These models have the potential to significantly enhance the precision and efficiency of cancer diagnostics, transforming AI from a supplementary tool into a core component of clinical decision-making, ultimately improving patient outcomes and advancing cancer care.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bursts of brain erosion: seizures and age-dependent neurological vulnerability.
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-12-10 DOI: 10.1016/j.molmed.2024.11.003
Noemie Cresto, Laurent Givalois, Jerome Badaut, Alicia Janvier, Athenais Genin, Etienne Audinat, Amy L Brewster, Nicola Marchi
{"title":"Bursts of brain erosion: seizures and age-dependent neurological vulnerability.","authors":"Noemie Cresto, Laurent Givalois, Jerome Badaut, Alicia Janvier, Athenais Genin, Etienne Audinat, Amy L Brewster, Nicola Marchi","doi":"10.1016/j.molmed.2024.11.003","DOIUrl":"10.1016/j.molmed.2024.11.003","url":null,"abstract":"<p><p>Hypersynchronous and exaggerated neuronal firing, exemplified by epileptiform activity and seizures, are disruptors of brain function across acute and chronic neuropathological conditions. Here, we focus on how seizure activity, whether as a primary symptom or a secondary comorbid event within a complex pathological setting, adversely impacts neurological trajectories. We discuss experimental and clinical evidence illustrating the participation of neurodegenerative and senescence-like adaptations. Paroxysmal neuronal events, through bidirectional causality, are linked with immune and microvascular changes, disrupting cellular homeostasis and creating a feed-forward loop that intertwines with age-related frailty to deteriorate mental health. We emphasize the clinical significance of early detection of these brain vulnerabilities through biomarkers, monitoring neurodevelopmental risks in children, and tracking neurodegenerative disease progression in aging populations.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unveiling the biological functions and therapeutic potentials of LONP1 in the ovary.
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-12-07 DOI: 10.1016/j.molmed.2024.11.010
Yi Chen, Weian Mao, Yanting Shen, Honing Huang, Hsun-Ming Chang, Xi Dong, Jingjing Jiang, Liangshan Mu
{"title":"Unveiling the biological functions and therapeutic potentials of LONP1 in the ovary.","authors":"Yi Chen, Weian Mao, Yanting Shen, Honing Huang, Hsun-Ming Chang, Xi Dong, Jingjing Jiang, Liangshan Mu","doi":"10.1016/j.molmed.2024.11.010","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.11.010","url":null,"abstract":"<p><p>Recent research highlights that Lon protease 1 (LONP1) regulates steroidogenesis in the ovary and plays a role in oocyte development and quality control. Dysregulation of LONP1 has been observed in polycystic ovary syndrome and ovarian aging. This forum article explores the role of LONP1 in the ovary and its therapeutic potential.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142795180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Splicing dysregulation: hallmark and therapeutic opportunity in pancreatic cancer. 剪接失调：胰腺癌的标志和治疗机会。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-12-07 DOI: 10.1016/j.molmed.2024.11.007
Chiara Naro, Veronica Ruta, Claudio Sette
{"title":"Splicing dysregulation: hallmark and therapeutic opportunity in pancreatic cancer.","authors":"Chiara Naro, Veronica Ruta, Claudio Sette","doi":"10.1016/j.molmed.2024.11.007","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.11.007","url":null,"abstract":"<p><p>Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer characterized by dismal prognosis. Late diagnosis, resistance to chemotherapy, and lack of efficacious targeted therapies render PDAC almost untreatable. Dysregulation of splicing, the process that excises the introns from nascent transcripts, is emerging as a hallmark of PDAC and a possible vulnerability of this devastating cancer. Splicing factors are deregulated in PDAC and contribute to all steps of tumorigenesis, from inflammation-related early events to metastasis and acquisition of chemoresistance. At the same time, splicing dysregulation offers a therapeutic opportunity to target cancer-specific vulnerabilities. We discuss mounting evidence that splicing plays a key role in PDAC and the opportunities that this essential process offers for developing new targeted therapies.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142795168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Challenges and opportunities for conceiving genetically diverse sickle cell mice.
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-12-05 DOI: 10.1016/j.molmed.2024.11.004
Rafiou Agoro, Gary A Churchill
{"title":"Challenges and opportunities for conceiving genetically diverse sickle cell mice.","authors":"Rafiou Agoro, Gary A Churchill","doi":"10.1016/j.molmed.2024.11.004","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.11.004","url":null,"abstract":"<p><p>A milestone in sickle cell disease (SCD) therapeutics was achieved in December 2023 with the FDA-approved gene therapy for patients aged 12 years and older. However, these therapies may only suit a fraction of patients because of cost or health risks. A better understanding of SCD outcome heterogeneity is needed to propose patient-specific pharmacological interventions. To achieve this, humanized and genetically diverse mouse models are essential for associating candidate genotypes with specific hematological traits, organ function, and disease resilience. Here, we discuss the challenges and opportunities in developing genetically diverse sickle cell mice (GDS mice). These models are expected to complement current approaches in SCD research and enhance our understanding of SCD heterogeneity and anemia.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The circadian clock in inflammatory bowel diseases.
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-12-05 DOI: 10.1016/j.molmed.2024.11.008
Oren Froy, Yael Weintraub
{"title":"The circadian clock in inflammatory bowel diseases.","authors":"Oren Froy, Yael Weintraub","doi":"10.1016/j.molmed.2024.11.008","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.11.008","url":null,"abstract":"<p><p>Inflammatory bowel diseases (IBDs) involve relapsing-remitting immune activation and inflammation. Both immune system activity and digestive tract function exhibit diurnal variations, regulated by the circadian clock. Disruption of this clock is linked to inflammation, suggesting that circadian regulators may play a pivotal role in the inflammatory process of IBD.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The molecular underpinnings of female predominance in lupus.
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-12-02 DOI: 10.1016/j.molmed.2024.11.002
Despoina Kosmara, Elpida Neofotistou-Themeli, Maria Semitekolou, George Bertsias
{"title":"The molecular underpinnings of female predominance in lupus.","authors":"Despoina Kosmara, Elpida Neofotistou-Themeli, Maria Semitekolou, George Bertsias","doi":"10.1016/j.molmed.2024.11.002","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.11.002","url":null,"abstract":"<p><p>Most people affected by systemic lupus erythematosus (SLE) are women. Although the role of sex hormones has been appreciated, we discuss emerging evidence that links X-linked genes escaping from dosage compensation to female predisposition to lupus. This is exemplified by TLR7 and CXorf21 whose female-biased expression may converge to enhance interferon responses and promote autoantibody-producing B cells, which are hallmarks of SLE. Notably, autosomal transcription factors with female overexpression may regulate molecular programs in the skin that are sufficient to induce lupus. These findings indicate a multifactorial basis for female vulnerability; however, several areas remain elusive, including the epigenetic landscape of X-chromosome inactivation (XCI) in SLE, the interplay with environmental factors, and the role of male-specific factors such as Y-linked genes.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring new frontiers in type 1 diabetes through advanced mass-spectrometry-based molecular measurements. 通过先进的质谱分子测量技术探索 1 型糖尿病的新领域。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-12-01 Epub Date: 2024-08-15 DOI: 10.1016/j.molmed.2024.07.009
Soumyadeep Sarkar, Xueyun Zheng, Geremy C Clair, Yu Mi Kwon, Youngki You, Adam C Swensen, Bobbie-Jo M Webb-Robertson, Ernesto S Nakayasu, Wei-Jun Qian, Thomas O Metz
{"title":"Exploring new frontiers in type 1 diabetes through advanced mass-spectrometry-based molecular measurements.","authors":"Soumyadeep Sarkar, Xueyun Zheng, Geremy C Clair, Yu Mi Kwon, Youngki You, Adam C Swensen, Bobbie-Jo M Webb-Robertson, Ernesto S Nakayasu, Wei-Jun Qian, Thomas O Metz","doi":"10.1016/j.molmed.2024.07.009","DOIUrl":"10.1016/j.molmed.2024.07.009","url":null,"abstract":"<p><p>Type 1 diabetes (T1D) is a devastating autoimmune disease for which advanced mass spectrometry (MS) methods are increasingly used to identify new biomarkers and better understand underlying mechanisms. For example, integration of MS analysis and machine learning has identified multimolecular biomarker panels. In mechanistic studies, MS has contributed to the discovery of neoepitopes, and pathways involved in disease development and identifying therapeutic targets. However, challenges remain in understanding the role of tissue microenvironments, spatial heterogeneity, and environmental factors in disease pathogenesis. Recent advancements in MS, such as ultra-fast ion-mobility separations, and single-cell and spatial omics, can play a central role in addressing these challenges. Here, we review recent advancements in MS-based molecular measurements and their role in understanding T1D.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"1137-1151"},"PeriodicalIF":12.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11631641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141996569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Senescence and tissue fibrosis: opportunities for therapeutic targeting. 衰老和组织纤维化：靶向治疗的机会。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-12-01 Epub Date: 2024-06-17 DOI: 10.1016/j.molmed.2024.05.012
Steven O'Reilly, Pei-Suen Tsou, John Varga
{"title":"Senescence and tissue fibrosis: opportunities for therapeutic targeting.","authors":"Steven O'Reilly, Pei-Suen Tsou, John Varga","doi":"10.1016/j.molmed.2024.05.012","DOIUrl":"10.1016/j.molmed.2024.05.012","url":null,"abstract":"<p><p>Cellular senescence is a key hallmark of aging. It has now emerged as a key mediator in normal tissue turnover and is associated with a variety of age-related diseases, including organ-specific fibrosis and systemic sclerosis (SSc). This review discusses the recent evidence of the role of senescence in tissue fibrosis, with an emphasis on SSc, a systemic autoimmune rheumatic disease. We discuss the physiological role of these cells, their role in fibrosis, and that targeting these cells specifically could be a new therapeutic avenue in fibrotic disease. We argue that targeting senescent cells, with senolytics or senomorphs, is a viable therapeutic target in fibrotic diseases which remain largely intractable.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"1113-1125"},"PeriodicalIF":12.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141421053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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