发布求助
文献互助 智能选刊 最新文献

Trends in molecular medicine最新文献

筛选
英文 中文
Advancements in intensive eating disorder treatments: the benefit of CBT-E and integrated care models. 进食障碍强化治疗的进展：CBT-E 和综合护理模式的益处。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-12-01 Epub Date: 2024-07-29 DOI: 10.1016/j.molmed.2024.07.007
Agnes Ayton
{"title":"Advancements in intensive eating disorder treatments: the benefit of CBT-E and integrated care models.","authors":"Agnes Ayton","doi":"10.1016/j.molmed.2024.07.007","DOIUrl":"10.1016/j.molmed.2024.07.007","url":null,"abstract":"","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"1094-1095"},"PeriodicalIF":12.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141856571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment and research needs for severe eating disorders: a response to Dr Ayton. 严重进食障碍的治疗和研究需求：对艾顿博士的回应。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-12-01 Epub Date: 2024-09-21 DOI: 10.1016/j.molmed.2024.09.003
Daire Douglas, Callum Bryson, Ulrike Schmidt
{"title":"Treatment and research needs for severe eating disorders: a response to Dr Ayton.","authors":"Daire Douglas, Callum Bryson, Ulrike Schmidt","doi":"10.1016/j.molmed.2024.09.003","DOIUrl":"10.1016/j.molmed.2024.09.003","url":null,"abstract":"","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"1096"},"PeriodicalIF":12.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Science around the world. 世界各地的科学
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-12-01 Epub Date: 2024-11-22 DOI: 10.1016/j.molmed.2024.10.013
Alessandro Cherubini, David J Granville, Mana M Parast, Qi Su
{"title":"Science around the world.","authors":"Alessandro Cherubini, David J Granville, Mana M Parast, Qi Su","doi":"10.1016/j.molmed.2024.10.013","DOIUrl":"10.1016/j.molmed.2024.10.013","url":null,"abstract":"","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"1091-1093"},"PeriodicalIF":12.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancements and challenges in mouse models of Alzheimer's disease. 阿尔茨海默病小鼠模型的进展与挑战。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-12-01 Epub Date: 2024-11-14 DOI: 10.1016/j.molmed.2024.10.010
Zhengjiang Qian, Yanjiao Li, Keqiang Ye
{"title":"Advancements and challenges in mouse models of Alzheimer's disease.","authors":"Zhengjiang Qian, Yanjiao Li, Keqiang Ye","doi":"10.1016/j.molmed.2024.10.010","DOIUrl":"10.1016/j.molmed.2024.10.010","url":null,"abstract":"<p><p>Alzheimer's disease (AD) poses a significant health challenge worldwide, and the development of effective treatments necessitates a comprehensive understanding of its pathophysiology. Mouse models have been instrumental in offering insights into the crucial pathogenesis of AD. However, current models rarely recapitulate all aspects of AD pathology in patients; thus, translating the findings from mouse to human clinical trials has proved to be complex. In this review, we outline the development of some prevalently used AD mice, with a particular emphasis on the latest advances in newly generated models. In addition, we discuss the advantages and limitations in mouse models of AD and their applications in blood-based biomarkers. Finally, we speculate on potential future research directions.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"1152-1164"},"PeriodicalIF":12.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EVolution in ALS diagnosis: molecular markers in extracellular vesicles. ALS 诊断中的 EVolution：细胞外囊泡中的分子标记。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-12-01 Epub Date: 2024-07-27 DOI: 10.1016/j.molmed.2024.07.006
Philippe Codron, Stéphanie Millecamps, Philippe Corcia
{"title":"EVolution in ALS diagnosis: molecular markers in extracellular vesicles.","authors":"Philippe Codron, Stéphanie Millecamps, Philippe Corcia","doi":"10.1016/j.molmed.2024.07.006","DOIUrl":"10.1016/j.molmed.2024.07.006","url":null,"abstract":"<p><p>The identification of biomarkers for amyotrophic lateral sclerosis (ALS) is a central issue in disease research. In a recent article, Chatterjee et al. show that blood extracellular vesicles (EVs) with high levels of transactive response DNA-binding protein 43 (TDP-43) accurately discriminate patients with ALS from controls and correlate with disease severity, providing a promising biomarker for early diagnosis and monitoring.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"1097-1099"},"PeriodicalIF":12.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Granzyme B in aging and age-related pathologies. 衰老和老年相关病症中的 Granzyme B。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-12-01 Epub Date: 2024-08-23 DOI: 10.1016/j.molmed.2024.07.010
Katlyn C Richardson, Karen Jung, Joanne A Matsubara, Jonathan C Choy, David J Granville
{"title":"Granzyme B in aging and age-related pathologies.","authors":"Katlyn C Richardson, Karen Jung, Joanne A Matsubara, Jonathan C Choy, David J Granville","doi":"10.1016/j.molmed.2024.07.010","DOIUrl":"10.1016/j.molmed.2024.07.010","url":null,"abstract":"<p><p>Aging is a major risk factor for pathologies that manifest later in life. Much attention is devoted towards elucidating how prolonged environmental exposures and inflammation promote biological (accelerated) tissue aging. Granzymes, a family of serine proteases, are increasingly recognized for their emerging roles in biological aging and disease. Widely recognized as intracellular mediators of cell death, granzymes, particularly granzyme B (GzmB), also accumulate in the extracellular milieu of tissues with age, contributing to chronic tissue injury, inflammation, and impaired healing. Consequently, this has prompted the field to reconsider how GzmB regulation, accumulation, and proteolysis impact health and disease with age. While GzmB is observed in numerous age-related conditions, the current review focuses on mechanistic studies where proof-of-concept has been forwarded.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"1165-1179"},"PeriodicalIF":12.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142056601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sexual dimorphism of metabolic dysfunction-associated steatotic liver disease. 代谢功能障碍相关脂肪性肝病的性别双态性。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-12-01 Epub Date: 2024-06-17 DOI: 10.1016/j.molmed.2024.05.013
Alessandro Cherubini, Sara Della Torre, Serena Pelusi, Luca Valenti
{"title":"Sexual dimorphism of metabolic dysfunction-associated steatotic liver disease.","authors":"Alessandro Cherubini, Sara Della Torre, Serena Pelusi, Luca Valenti","doi":"10.1016/j.molmed.2024.05.013","DOIUrl":"10.1016/j.molmed.2024.05.013","url":null,"abstract":"<p><p>Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver condition. MASLD is a sexually dimorphic condition, with its development and progression influenced by sex chromosomes and hormones. Estrogens typically protect against, whereas androgens promote, MASLD. Therapeutic approaches for a sex-specific personalized medicine include estrogen replacement, androgen blockers, and novel drugs targeting hormonal pathways. However, the interactions between hormonal factors and inherited genetic variation impacts MASLD risk, necessitating more tailored therapies. Understanding sex disparities and the role of estrogens could improve MASLD interventions and management, whereas clinical trials addressing sex differences are crucial for advancing personalized treatment. This review explores the underappreciated impact of sexual dimorphism in MASLD and discusses the potential therapeutic application of sex-related hormones.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"1126-1136"},"PeriodicalIF":12.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141421054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
m6A and beyond: RNA modifications shaping angiogenesis.
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-11-27 DOI: 10.1016/j.molmed.2024.11.001
Yu Luan, Renbing Jia, Peiwei Chai, Xianqun Fan
{"title":"m<sup>6</sup>A and beyond: RNA modifications shaping angiogenesis.","authors":"Yu Luan, Renbing Jia, Peiwei Chai, Xianqun Fan","doi":"10.1016/j.molmed.2024.11.001","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.11.001","url":null,"abstract":"<p><p>RNA modifications are crucial post-transcriptional processes that significantly influence gene expression, RNA stability, nuclear transport, and translational capacity. Angiogenesis, the formation of new blood vessels, is a physiological process that is dysregulated in many pathological conditions, including ocular diseases, immune disorders, and cancer. In this review, we compile the current understanding of the intricate relationship between various RNA modifications and angiogenic mechanisms, spotlighting emerging evidence that underscore their pivotal regulatory roles in both physiological and pathological angiogenesis. Furthermore, we delve into recent advances in innovative therapeutic approaches that target RNA modifications to modulate angiogenesis, offering insights into their potential as novel treatment modalities.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Harnessing IL-22 for metabolic health: promise and pitfalls. 利用 IL-22 促进代谢健康：希望与陷阱。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-11-21 DOI: 10.1016/j.molmed.2024.10.016
Haressh Sajiir, Grant A Ramm, Graeme A Macdonald, Michael A McGuckin, Johannes B Prins, Sumaira Z Hasnain
{"title":"Harnessing IL-22 for metabolic health: promise and pitfalls.","authors":"Haressh Sajiir, Grant A Ramm, Graeme A Macdonald, Michael A McGuckin, Johannes B Prins, Sumaira Z Hasnain","doi":"10.1016/j.molmed.2024.10.016","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.10.016","url":null,"abstract":"<p><p>Primarily perceived as an anti-inflammatory and antimicrobial mediator in mucosa and skin, interleukin-22 (IL-22) has emerged as a pivotal metabolic regulator. Central to IL-22 signaling is its receptor, IL-22RA1. Through IL-22RA1, IL-22 orchestrates glucose homeostasis by modulating insulin secretion, reducing cellular stress in pancreatic islets, promoting beta-cell regeneration, and influencing hepatic glucose and lipid metabolism. These actions suggest its potential as a therapeutic for metabolic dysfunctions like diabetes, obesity, and steatohepatitis. However, clinical applications of IL-22 face challenges related to off-target effects and safety concerns. This review explores IL-22's physiological roles, regulatory mechanisms, and profound influence on metabolic tissues. It also underscores IL-22's dual role in metabolic health and disease, advocating further research to harness its therapeutic potential.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tertiary lymphoid structures in the central nervous system. 中枢神经系统的三级淋巴结构。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-11-21 DOI: 10.1016/j.molmed.2024.10.014
Chao Yang, Yu-Xiang Cai, Ze-Fen Wang, Su-Fang Tian, Zhi-Qiang Li
{"title":"Tertiary lymphoid structures in the central nervous system.","authors":"Chao Yang, Yu-Xiang Cai, Ze-Fen Wang, Su-Fang Tian, Zhi-Qiang Li","doi":"10.1016/j.molmed.2024.10.014","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.10.014","url":null,"abstract":"<p><p>Tertiary lymphoid structures (TLSs) frequently occur at sites of chronic inflammation. A more advanced stage of multiple sclerosis (MS) has been associated with certain TLSs. However, tumor-associated TLSs have been shown to correlate with a greater treatment response rate and a better prognosis in glioma mouse models. In this review, we evaluate the clinical significances of TLSs in prognosis and treatment response, as well as the status of TLS-directed therapies targeting alternative biochemical pathways in various central nervous system (CNS) disorders. Potential molecular mechanisms underlying the development of TLSs are also discussed. Exploring these areas may provide an essential understanding of the processes behind disease advancement, uncover new therapeutic objectives, and detect biomarkers that forecast disease progression and treatment efficacy.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信