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Epidermolysis bullosa: understanding the disease, diagnosis, and advances in treatment strategies. 大疱性表皮松解症：了解疾病、诊断和治疗策略的进展。
IF 13.8 1区 医学
Trends in molecular medicine Pub Date : 2025-09-01 Epub Date: 2025-06-18 DOI: 10.1016/j.molmed.2025.05.009
Madalina Alexandru, Jemima E Mellerio, Joanna Jacków-Malinowska
{"title":"Epidermolysis bullosa: understanding the disease, diagnosis, and advances in treatment strategies.","authors":"Madalina Alexandru, Jemima E Mellerio, Joanna Jacków-Malinowska","doi":"10.1016/j.molmed.2025.05.009","DOIUrl":"10.1016/j.molmed.2025.05.009","url":null,"abstract":"","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"876-877"},"PeriodicalIF":13.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel universal vaccines to mitigate emerging avian influenza viruses. 减轻新出现禽流感病毒的新型通用疫苗。
IF 13.8 1区 医学
Trends in molecular medicine Pub Date : 2025-09-01 Epub Date: 2025-03-25 DOI: 10.1016/j.molmed.2025.03.001
Yu Liu, Lifang Wang, Alexander Lai, Mei Kang, Yangrui Qi, Andres Merits, Xinyi Jiao, Xinyu Wang, Xiangrong Yu, Shuo Su, Zhiwen Jiang
{"title":"Novel universal vaccines to mitigate emerging avian influenza viruses.","authors":"Yu Liu, Lifang Wang, Alexander Lai, Mei Kang, Yangrui Qi, Andres Merits, Xinyi Jiao, Xinyu Wang, Xiangrong Yu, Shuo Su, Zhiwen Jiang","doi":"10.1016/j.molmed.2025.03.001","DOIUrl":"10.1016/j.molmed.2025.03.001","url":null,"abstract":"<p><p>Frequent spillovers and recent geospatial expansion of avian influenza virus (AIV) pose significant economic and public health threats. Recent advances in vaccine technologies, bioinformatics, and artificial intelligence will provide newer approaches to target genetically diverse and rapidly evolving AIVs. Here, we review recent advances in, and perspectives on, developing universal vaccines needed for the effective control of AIVs.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"773-777"},"PeriodicalIF":13.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New insights into gut microbiota-prostate cancer crosstalk. 肠道微生物与前列腺癌相互作用的新见解。
IF 13.8 1区 医学
Trends in molecular medicine Pub Date : 2025-09-01 Epub Date: 2025-05-14 DOI: 10.1016/j.molmed.2025.03.015
Jalal Laaraj, Gabriel Lachance, Alain Bergeron, Yves Fradet, Karine Robitaille, Vincent Fradet
{"title":"New insights into gut microbiota-prostate cancer crosstalk.","authors":"Jalal Laaraj, Gabriel Lachance, Alain Bergeron, Yves Fradet, Karine Robitaille, Vincent Fradet","doi":"10.1016/j.molmed.2025.03.015","DOIUrl":"10.1016/j.molmed.2025.03.015","url":null,"abstract":"<p><p>Recent evidence underscores a reciprocal relationship between the gut microbiota and prostate cancer (PCa). Dysbiosis, often driven by Western dietary habits and antibiotic use, can heighten systemic inflammation and hinder antitumor immunity, thereby fostering PCa onset and progression. Conversely, certain gut microbes and their metabolites may protect against tumor growth by modulating immune and hormonal pathways that impact therapeutic responses, including androgen deprivation therapy (ADT). Emerging evidence links gut microbial shifts to PCa aggressiveness, potentially sustaining local androgen production and promoting resistance. In this review, we explore current understanding of the gut-PCa interplay, highlighting key knowledge gaps and the need for further research to clarify how targeting the microbiome might influence PCa outcomes.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"778-800"},"PeriodicalIF":13.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
NF2-associated schwannomatosis (NF2): genetics, manifestations, and emerging therapeutic approaches. NF2相关神经鞘瘤病（NF2）：遗传学、表现和新兴治疗方法
IF 13.8 1区 医学
Trends in molecular medicine Pub Date : 2025-08-29 DOI: 10.1016/j.molmed.2025.08.002
Osama Elzaafarany, Daniel Lester, Sepideh Mokhtari, Joseph L Kissil
{"title":"NF2-associated schwannomatosis (NF2): genetics, manifestations, and emerging therapeutic approaches.","authors":"Osama Elzaafarany, Daniel Lester, Sepideh Mokhtari, Joseph L Kissil","doi":"10.1016/j.molmed.2025.08.002","DOIUrl":"10.1016/j.molmed.2025.08.002","url":null,"abstract":"","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":13.8,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12404673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cholesterol efflux in HIV-associated atherosclerosis: mechanisms and targets. hiv相关动脉粥样硬化中的胆固醇外排：机制和目标
IF 13.8 1区 医学
Trends in molecular medicine Pub Date : 2025-08-29 DOI: 10.1016/j.molmed.2025.08.003
Emily Lu, Vignesh Chidambaram, Amudha Kumar, Hannah G Cotto Aparicio, Yasmeen Golzar, Nataliya Pyslar, Jawahar L Mehta, Petros C Karakousis
{"title":"Cholesterol efflux in HIV-associated atherosclerosis: mechanisms and targets.","authors":"Emily Lu, Vignesh Chidambaram, Amudha Kumar, Hannah G Cotto Aparicio, Yasmeen Golzar, Nataliya Pyslar, Jawahar L Mehta, Petros C Karakousis","doi":"10.1016/j.molmed.2025.08.003","DOIUrl":"https://doi.org/10.1016/j.molmed.2025.08.003","url":null,"abstract":"<p><p>Antiretroviral therapy (ART) has transformed HIV infection into a chronic, manageable condition; however, people living with HIV (PLWH) have an increased risk of atherosclerotic cardiovascular disease (ASCVD). Impaired cholesterol efflux due to dysfunction of macrophage lipid transporters and high-density lipoprotein (HDL) is an important mechanism in HIV-associated atherosclerosis. HIV Nef protein inhibits ATP-binding cassette transporter (ABC)A1-mediated cholesterol efflux via post-transcriptional downregulation, mislocalization, and enhanced degradation. Although ART partially improves macrophage and HDL functionality through viral suppression, cholesterol efflux impairment persists. Emerging therapies, including nuclear receptor agonists, apolipoprotein mimetics, and HDL-based nanoparticles, offer dual benefits by enhancing reverse cholesterol transport and reducing HIV replication. In this review, we explore the molecular mechanisms of HIV-induced cholesterol efflux impairment and potential therapies targeting ASCVD risk in HIV.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":13.8,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic symphony coordinates the muscle regeneration niche. 代谢交响曲协调肌肉再生生态位。
IF 13.8 1区 医学
Trends in molecular medicine Pub Date : 2025-08-21 DOI: 10.1016/j.molmed.2025.07.006
Yang Lu, Zhexu Chi, Di Wang
{"title":"Metabolic symphony coordinates the muscle regeneration niche.","authors":"Yang Lu, Zhexu Chi, Di Wang","doi":"10.1016/j.molmed.2025.07.006","DOIUrl":"https://doi.org/10.1016/j.molmed.2025.07.006","url":null,"abstract":"<p><p>The muscle regeneration niche comprises various cell types, including muscle stem cells (MuSCs; also termed satellite cells), immune cells, and stromal cells, all of which have crucial roles in the regeneration process. Intracellular metabolic reprogramming during injury responses is closely linked to the functional activities of these cells, thus necessitating a comprehensive understanding for developing targeted metabolic interventions that promote regeneration. Recent studies have suggested the existence of a more intricate network, involving cell-cell metabolic crosstalk and even cross-organ regulation, which underpins muscle regeneration. In addition, aging and diseases that disrupt overall metabolic homeostasis contribute to muscle dysfunction, due, in part, to metabolic disorders in the regeneration niche. In this review, we provide a comprehensive overview of the metabolic profile within the muscle regeneration niche and highlight potential interventions to reprogram metabolism to improve regenerative capacity.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":13.8,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Women in science: bridging gaps in basic sciences. 科学中的女性：弥合基础科学中的差距。
IF 13.8 1区 医学
Trends in molecular medicine Pub Date : 2025-08-11 DOI: 10.1016/j.molmed.2025.07.005
Bhavita Kumari, Narjis Fatima Hussain, Stephen H Kennedy, Aris T Papageorghiou, Jai K Das, Zulfiqar A Bhutta
{"title":"Women in science: bridging gaps in basic sciences.","authors":"Bhavita Kumari, Narjis Fatima Hussain, Stephen H Kennedy, Aris T Papageorghiou, Jai K Das, Zulfiqar A Bhutta","doi":"10.1016/j.molmed.2025.07.005","DOIUrl":"https://doi.org/10.1016/j.molmed.2025.07.005","url":null,"abstract":"<p><p>The Supporting Women in Science (SWIS) program aims to strengthen female representation in research in developing countries. This article highlights the program participation, mentorship challenges, and systemic barriers. Findings inform inclusive, discipline-specific strategies designed to support women's research capacity, academic leadership, and advancement in the global scientific community.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":13.8,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Block, expose, and immunize: triple attack on cancer. 阻断、暴露和免疫：对癌症的三重攻击。
IF 13.8 1区 医学
Trends in molecular medicine Pub Date : 2025-08-05 DOI: 10.1016/j.molmed.2025.06.009
Katerina Hönigova, Katerina Hadrava Vanova, Martina Raudenska, Ondrej Uher, Zdenek Kejik, Milan Jakubek, Michal Masarik, Karel Pacak
{"title":"Block, expose, and immunize: triple attack on cancer.","authors":"Katerina Hönigova, Katerina Hadrava Vanova, Martina Raudenska, Ondrej Uher, Zdenek Kejik, Milan Jakubek, Michal Masarik, Karel Pacak","doi":"10.1016/j.molmed.2025.06.009","DOIUrl":"https://doi.org/10.1016/j.molmed.2025.06.009","url":null,"abstract":"<p><p>Preventing metastasis remains a major challenge in cancer therapy. Effective strategies should combine immune activation with the inhibition of cancer cell migration and invasion. In this Opinion article, we propose a multimodal approach that integrates migrastatic agents with photodynamic therapy (PDT) and intratumoral immunotherapy (ITI). Migrastatics inhibit cell motility and may reduce the risk of tumor cell dissemination. PDT promotes immunogenic cell death and enhances immune recognition while minimizing damage to healthy tissues. ITI delivers immune stimulants directly into tumors to stimulate local immune responses. This therapeutic strategy could suppress cancer cell plasticity, limit metastasis, and activate antitumor immunity, potentially improving outcomes in cancers prone to early invasion. This comprehensive approach is discussed in the context of current clinical practice.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":13.8,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synergizing metabolomics and artificial intelligence for advancing precision oncology. 协同代谢组学和人工智能推进精准肿瘤学。
IF 13.8 1区 医学
Trends in molecular medicine Pub Date : 2025-08-01 Epub Date: 2025-02-15 DOI: 10.1016/j.molmed.2025.01.016
Yipeng Xu, Xiaojuan Jiang, Zeping Hu
{"title":"Synergizing metabolomics and artificial intelligence for advancing precision oncology.","authors":"Yipeng Xu, Xiaojuan Jiang, Zeping Hu","doi":"10.1016/j.molmed.2025.01.016","DOIUrl":"10.1016/j.molmed.2025.01.016","url":null,"abstract":"<p><p>Metabolomics has emerged as a transformative tool in precision oncology, with substantial potential for advancing biomarker discovery, monitoring treatment responses, and aiding drug development. Integrating artificial intelligence (AI) into metabolomics optimizes data acquisition and analysis, facilitating the interpretation of complex metabolic networks and enabling more effective multiomics integration. In this opinion, we explore recent advances in the application of metabolomics within precision oncology, emphasizing the unique advantages that AI-driven metabolomics offers. We propose that AI not only complements but also amplifies the potential of current platforms, accelerating research progress and ultimately improving patient outcomes. Finally, we discuss the opportunities and challenges involved in translating AI-driven metabolomics into clinical practice for precision oncology.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"692-701"},"PeriodicalIF":13.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular subtypes of intrahepatic cholangiocarcinoma. 肝内胆管癌的分子亚型。
IF 13.8 1区 医学
Trends in molecular medicine Pub Date : 2025-08-01 Epub Date: 2025-02-15 DOI: 10.1016/j.molmed.2025.01.008
Alessandro De Santis, Lei Zhu, Jianxin Tao, Christoph Reißfelder, Sebastian Schölch
{"title":"Molecular subtypes of intrahepatic cholangiocarcinoma.","authors":"Alessandro De Santis, Lei Zhu, Jianxin Tao, Christoph Reißfelder, Sebastian Schölch","doi":"10.1016/j.molmed.2025.01.008","DOIUrl":"10.1016/j.molmed.2025.01.008","url":null,"abstract":"<p><p>Intrahepatic cholangiocarcinoma (iCCA) presents in two clinically distinct subtypes: large duct (LD-iCCA) and small duct (SD-iCCA). These subtypes exhibit significant molecular, genetic, and histopathological differences that impact patient prognosis and treatment responsiveness. This review advocates for a subtype-specific approach to iCCA research and clinical management, including tailored therapeutic strategies that consider distinct genetic profiles and tumor microenvironments. Current therapeutic approaches hold promise, yet efficacy varies by subtype. Additionally, subtype-specific molecular diagnostics, including DNA methylation-based classifiers and transcriptomic sequencing, have shown potential in refining iCCA subclassification, thereby guiding precision medicine efforts. This article outlines existing clinical trials, key research trajectories, and future directions for developing more effective subtype-adapted therapies for iCCA.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"755-769"},"PeriodicalIF":13.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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