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Functional precision medicine: the future of cancer care. 功能性精准医疗：癌症治疗的未来。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-11-19 DOI: 10.1016/j.molmed.2024.10.015
Arlet M Acanda de la Rocha, Noah E Berlow, Diana J Azzam
{"title":"Functional precision medicine: the future of cancer care.","authors":"Arlet M Acanda de la Rocha, Noah E Berlow, Diana J Azzam","doi":"10.1016/j.molmed.2024.10.015","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.10.015","url":null,"abstract":"<p><p>Functional precision medicine (FPM), combining ex vivo drug sensitivity testing with genomic profiling to identify treatment options for recurrent/refractory cancer, is feasible and poised to accelerate. This forum explores the history of FPM, recent clinical advancements, and barriers to expanding the clinical utility and accessibility for pediatric/adolescent and adult cancers.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronobiological and neuroendocrine insights into dry eye. 从时间生物学和神经内分泌学角度看干眼症。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-11-16 DOI: 10.1016/j.molmed.2024.10.012
Licheng Li, Haoyu Li, Baihua Chen
{"title":"Chronobiological and neuroendocrine insights into dry eye.","authors":"Licheng Li, Haoyu Li, Baihua Chen","doi":"10.1016/j.molmed.2024.10.012","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.10.012","url":null,"abstract":"<p><p>Dry eye, a prevalent ocular surface disease, is significantly influenced by modern lifestyle factors such as night-shift work and extended screen time. Emerging evidence suggests a strong correlation between disturbances in circadian rhythm, sleep disorders, and dry eye. However, the precise underlying mechanisms remain unclear. Recent studies have underscored the crucial role of circadian rhythms and neuroendocrine regulation in maintaining ocular surface health. Advances in treatment strategies targeting neuroendocrine pathways have shown promising developments. This review explores the interplay between circadian rhythms, neuroendocrine regulation, and the ocular surface, examines the impact of circadian disruption on the pathophysiology of dry eye, and proposes intervention strategies to alleviate dry eye associated with disturbances in circadian rhythms.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Significant challenges to translating breakthrough science in Mexico. 墨西哥在转化突破性科学方面面临重大挑战。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-11-08 DOI: 10.1016/j.molmed.2024.10.011
Carlos Federico Cota-Romero, Guillermo Aquino-Jarquin
{"title":"Significant challenges to translating breakthrough science in Mexico.","authors":"Carlos Federico Cota-Romero, Guillermo Aquino-Jarquin","doi":"10.1016/j.molmed.2024.10.011","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.10.011","url":null,"abstract":"<p><p>Translational medicine is crucial for addressing health issues and translating research findings to improve population health. This Science and Society article highlights the potential of translational medicine in Mexico. It discusses the obstacles and challenges encountered in the translation process, instilling a sense of optimism for the future of healthcare in Mexico.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Follow the CSF flow: probing multiciliated ependymal cells in brain pathology. 追踪 CSF 流：探测脑病理学中的多纤毛上皮细胞。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-11-07 DOI: 10.1016/j.molmed.2024.10.007
Adam M R Groh, Liam Hodgson, Danilo Bzdok, Jo Anne Stratton
{"title":"Follow the CSF flow: probing multiciliated ependymal cells in brain pathology.","authors":"Adam M R Groh, Liam Hodgson, Danilo Bzdok, Jo Anne Stratton","doi":"10.1016/j.molmed.2024.10.007","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.10.007","url":null,"abstract":"<p><p>Multiciliated ependymal cells regulate cerebrospinal fluid (CSF) microcirculation and form a dynamic CSF-brain interface. Emerging evidence suggests that ependymal cells enter reactive states in response to pathology that are associated with ciliary and junctional protein alterations. The drivers of these alterations, likely from both acquired and inherited mechanisms, remain elusive.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Striking senescence with sodium transporter inhibition. 通过抑制钠转运体来阻止衰老
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-11-01 Epub Date: 2024-07-14 DOI: 10.1016/j.molmed.2024.07.002
Bettina Schock, Steven O'Reilly
{"title":"Striking senescence with sodium transporter inhibition.","authors":"Bettina Schock, Steven O'Reilly","doi":"10.1016/j.molmed.2024.07.002","DOIUrl":"10.1016/j.molmed.2024.07.002","url":null,"abstract":"<p><p>Senescence is associated with multiple morbidities and therapeutic targeting of these cells is a key aim. In a recent study, Katsuumi et al. found that targeting sodium-glucose co-transporter 2 (SGLT2) promoted immune clearance of senescent cells via programmed cell death-1 ligand (PD-L1) suppression, thus promoting immunosurveillance. This could have profound implications for many age-related diseases, including cancer and frailty.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"1004-1006"},"PeriodicalIF":12.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141617167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lost in translation: challenges of current pharmacotherapy for sarcopenia. 翻译中的迷失：当前肌肉疏松症药物疗法面临的挑战。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-11-01 Epub Date: 2024-06-15 DOI: 10.1016/j.molmed.2024.05.016
Shih-Yin Tsai
{"title":"Lost in translation: challenges of current pharmacotherapy for sarcopenia.","authors":"Shih-Yin Tsai","doi":"10.1016/j.molmed.2024.05.016","DOIUrl":"10.1016/j.molmed.2024.05.016","url":null,"abstract":"<p><p>A healthy lifespan relies on independent living, in which active skeletal muscle is a critical element. The cost of not recognizing and acting earlier on unhealthy or aging muscle could be detrimental, since muscular weakness is inversely associated with all-cause mortality. Sarcopenia is characterized by a decline in skeletal muscle mass and strength and is associated with aging. Exercise is the only effective therapy to delay sarcopenia development and improve muscle health in older adults. Although numerous interventions have been proposed to reduce sarcopenia, none has yet succeeded in clinical trials. This review evaluates the biological gap between recent clinical trials targeting sarcopenia and the preclinical studies on which they are based, and suggests an alternative approach to bridge the discrepancy.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"1047-1060"},"PeriodicalIF":12.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141331846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ubiquitin-like modification dependent proteasomal degradation and disease therapy. 依赖蛋白酶体降解的泛素样修饰与疾病治疗。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-11-01 Epub Date: 2024-06-08 DOI: 10.1016/j.molmed.2024.05.005
Tiantian Wang, Jie Jiang, Xue Zhang, Xisong Ke, Yi Qu
{"title":"Ubiquitin-like modification dependent proteasomal degradation and disease therapy.","authors":"Tiantian Wang, Jie Jiang, Xue Zhang, Xisong Ke, Yi Qu","doi":"10.1016/j.molmed.2024.05.005","DOIUrl":"10.1016/j.molmed.2024.05.005","url":null,"abstract":"<p><p>Although it is believed that ubiquitin (Ub) modification is required for protein degradation in the proteasome system (UPS), several proteins are subject to Ub-independent proteasome degradation, and in many cases ubiquitin-like (UBL) modifications, including neddylation, FAT10ylation, SUMOylation, ISGylation, and urmylation, are essential instead. In this Review, we focus on UBL-dependent proteasome degradation (UBLPD), on proteasome regulators especially shuttle factors and receptors, as well as potential competition and coordination with UPS. We propose that there is a distinct UBL-proteasome system (UBLPS) that might be underestimated in protein degradation. Finally, we investigate the association of UBLPD with muscle wasting and neurodegenerative diseases in which the proteasome is abnormally activated and impaired, respectively, and suggest strategies to modulate UBLPD for disease therapy.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"1061-1075"},"PeriodicalIF":12.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141293763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting epigenetic dysregulation in autism spectrum disorders. 针对自闭症谱系障碍的表观遗传失调。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-11-01 Epub Date: 2024-07-05 DOI: 10.1016/j.molmed.2024.06.004
Macarena L Herrera, Juan Paraíso-Luna, Isabel Bustos-Martínez, Ángel Barco
{"title":"Targeting epigenetic dysregulation in autism spectrum disorders.","authors":"Macarena L Herrera, Juan Paraíso-Luna, Isabel Bustos-Martínez, Ángel Barco","doi":"10.1016/j.molmed.2024.06.004","DOIUrl":"10.1016/j.molmed.2024.06.004","url":null,"abstract":"<p><p>Autism spectrum disorders (ASD) comprise a range of neurodevelopmental pathologies characterized by deficits in social interaction and repetitive behaviors, collectively affecting almost 1% of the worldwide population. Deciphering the etiology of ASD has proven challenging due to the intricate interplay of genetic and environmental factors and the variety of molecular pathways affected. Epigenomic alterations have emerged as key players in ASD etiology. Their research has led to the identification of biomarkers for diagnosis and pinpointed specific gene targets for therapeutic interventions. This review examines the role of epigenetic alterations, resulting from both genetic and environmental influences, as a central causative factor in ASD, delving into its contribution to pathogenesis and treatment strategies.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"1028-1046"},"PeriodicalIF":12.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141545310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The dual role of the TSC complex in cancer. TSC 复合物在癌症中的双重作用。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-11-01 DOI: 10.1016/j.molmed.2024.10.009
Josephine Hartung, Christine Müller, Cornelis F Calkhoven
{"title":"The dual role of the TSC complex in cancer.","authors":"Josephine Hartung, Christine Müller, Cornelis F Calkhoven","doi":"10.1016/j.molmed.2024.10.009","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.10.009","url":null,"abstract":"<p><p>The tuberous sclerosis complex (TSC1/TSC2/TBC1D7) primarily functions to inhibit the mechanistic target of rapamycin complex 1 (mTORC1), a crucial regulator of cell growth. Mutations in TSC1 or TSC2 cause tuberous sclerosis complex (TSC), a rare autosomal dominant genetic disorder marked by benign tumors in multiple organs that rarely progress to malignancy. Traditionally, TSC proteins are considered tumor suppressive due to their inhibition of mTORC1 and other mechanisms. However, more recent studies have shown that TSC proteins can also promote tumorigenesis in certain cancer types. In this review, we explore the composition and function of the TSC protein complex, the roles of its individual components in cancer biology, and potential future therapeutic targeting strategies.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142563777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The aging lipidome: exercise is medicine. 衰老的脂质体：运动就是药物。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-11-01 Epub Date: 2024-06-24 DOI: 10.1016/j.molmed.2024.06.006
Abel Plaza-Florido, Inmaculada Pérez-Prieto, Alejandro Lucia
{"title":"The aging lipidome: exercise is medicine.","authors":"Abel Plaza-Florido, Inmaculada Pérez-Prieto, Alejandro Lucia","doi":"10.1016/j.molmed.2024.06.006","DOIUrl":"10.1016/j.molmed.2024.06.006","url":null,"abstract":"<p><p>The molecular mechanisms behind the potential 'anti-aging' effects of exercise remain to be elucidated. Janssens et al. studied the lipidome of different mouse tissues and human skeletal muscle. They identified an evolutionary conserved 'lipid aging' signature, characterized by bis(monoacylglycero)phosphate accumulation, which, at the muscle level, can be attenuated by exercise.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"1001-1003"},"PeriodicalIF":12.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141451599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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