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The molecular underpinnings of female predominance in lupus. 狼疮女性优势的分子基础。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-12-02 DOI: 10.1016/j.molmed.2024.11.002
Despoina Kosmara, Elpida Neofotistou-Themeli, Maria Semitekolou, George Bertsias
{"title":"The molecular underpinnings of female predominance in lupus.","authors":"Despoina Kosmara, Elpida Neofotistou-Themeli, Maria Semitekolou, George Bertsias","doi":"10.1016/j.molmed.2024.11.002","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.11.002","url":null,"abstract":"<p><p>Most people affected by systemic lupus erythematosus (SLE) are women. Although the role of sex hormones has been appreciated, we discuss emerging evidence that links X-linked genes escaping from dosage compensation to female predisposition to lupus. This is exemplified by TLR7 and CXorf21 whose female-biased expression may converge to enhance interferon responses and promote autoantibody-producing B cells, which are hallmarks of SLE. Notably, autosomal transcription factors with female overexpression may regulate molecular programs in the skin that are sufficient to induce lupus. These findings indicate a multifactorial basis for female vulnerability; however, several areas remain elusive, including the epigenetic landscape of X-chromosome inactivation (XCI) in SLE, the interplay with environmental factors, and the role of male-specific factors such as Y-linked genes.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Senescence and tissue fibrosis: opportunities for therapeutic targeting. 衰老和组织纤维化：靶向治疗的机会。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-12-01 Epub Date: 2024-06-17 DOI: 10.1016/j.molmed.2024.05.012
Steven O'Reilly, Pei-Suen Tsou, John Varga
{"title":"Senescence and tissue fibrosis: opportunities for therapeutic targeting.","authors":"Steven O'Reilly, Pei-Suen Tsou, John Varga","doi":"10.1016/j.molmed.2024.05.012","DOIUrl":"10.1016/j.molmed.2024.05.012","url":null,"abstract":"<p><p>Cellular senescence is a key hallmark of aging. It has now emerged as a key mediator in normal tissue turnover and is associated with a variety of age-related diseases, including organ-specific fibrosis and systemic sclerosis (SSc). This review discusses the recent evidence of the role of senescence in tissue fibrosis, with an emphasis on SSc, a systemic autoimmune rheumatic disease. We discuss the physiological role of these cells, their role in fibrosis, and that targeting these cells specifically could be a new therapeutic avenue in fibrotic disease. We argue that targeting senescent cells, with senolytics or senomorphs, is a viable therapeutic target in fibrotic diseases which remain largely intractable.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"1113-1125"},"PeriodicalIF":12.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141421053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring new frontiers in type 1 diabetes through advanced mass-spectrometry-based molecular measurements. 通过先进的质谱分子测量技术探索 1 型糖尿病的新领域。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-12-01 Epub Date: 2024-08-15 DOI: 10.1016/j.molmed.2024.07.009
Soumyadeep Sarkar, Xueyun Zheng, Geremy C Clair, Yu Mi Kwon, Youngki You, Adam C Swensen, Bobbie-Jo M Webb-Robertson, Ernesto S Nakayasu, Wei-Jun Qian, Thomas O Metz
{"title":"Exploring new frontiers in type 1 diabetes through advanced mass-spectrometry-based molecular measurements.","authors":"Soumyadeep Sarkar, Xueyun Zheng, Geremy C Clair, Yu Mi Kwon, Youngki You, Adam C Swensen, Bobbie-Jo M Webb-Robertson, Ernesto S Nakayasu, Wei-Jun Qian, Thomas O Metz","doi":"10.1016/j.molmed.2024.07.009","DOIUrl":"10.1016/j.molmed.2024.07.009","url":null,"abstract":"<p><p>Type 1 diabetes (T1D) is a devastating autoimmune disease for which advanced mass spectrometry (MS) methods are increasingly used to identify new biomarkers and better understand underlying mechanisms. For example, integration of MS analysis and machine learning has identified multimolecular biomarker panels. In mechanistic studies, MS has contributed to the discovery of neoepitopes, and pathways involved in disease development and identifying therapeutic targets. However, challenges remain in understanding the role of tissue microenvironments, spatial heterogeneity, and environmental factors in disease pathogenesis. Recent advancements in MS, such as ultra-fast ion-mobility separations, and single-cell and spatial omics, can play a central role in addressing these challenges. Here, we review recent advancements in MS-based molecular measurements and their role in understanding T1D.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"1137-1151"},"PeriodicalIF":12.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11631641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141996569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancements in intensive eating disorder treatments: the benefit of CBT-E and integrated care models. 进食障碍强化治疗的进展：CBT-E 和综合护理模式的益处。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-12-01 Epub Date: 2024-07-29 DOI: 10.1016/j.molmed.2024.07.007
Agnes Ayton
{"title":"Advancements in intensive eating disorder treatments: the benefit of CBT-E and integrated care models.","authors":"Agnes Ayton","doi":"10.1016/j.molmed.2024.07.007","DOIUrl":"10.1016/j.molmed.2024.07.007","url":null,"abstract":"","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"1094-1095"},"PeriodicalIF":12.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141856571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment and research needs for severe eating disorders: a response to Dr Ayton. 严重进食障碍的治疗和研究需求：对艾顿博士的回应。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-12-01 Epub Date: 2024-09-21 DOI: 10.1016/j.molmed.2024.09.003
Daire Douglas, Callum Bryson, Ulrike Schmidt
{"title":"Treatment and research needs for severe eating disorders: a response to Dr Ayton.","authors":"Daire Douglas, Callum Bryson, Ulrike Schmidt","doi":"10.1016/j.molmed.2024.09.003","DOIUrl":"10.1016/j.molmed.2024.09.003","url":null,"abstract":"","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"1096"},"PeriodicalIF":12.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Science around the world. 世界各地的科学
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-12-01 Epub Date: 2024-11-22 DOI: 10.1016/j.molmed.2024.10.013
Alessandro Cherubini, David J Granville, Mana M Parast, Qi Su
{"title":"Science around the world.","authors":"Alessandro Cherubini, David J Granville, Mana M Parast, Qi Su","doi":"10.1016/j.molmed.2024.10.013","DOIUrl":"10.1016/j.molmed.2024.10.013","url":null,"abstract":"","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"1091-1093"},"PeriodicalIF":12.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancements and challenges in mouse models of Alzheimer's disease. 阿尔茨海默病小鼠模型的进展与挑战。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-12-01 Epub Date: 2024-11-14 DOI: 10.1016/j.molmed.2024.10.010
Zhengjiang Qian, Yanjiao Li, Keqiang Ye
{"title":"Advancements and challenges in mouse models of Alzheimer's disease.","authors":"Zhengjiang Qian, Yanjiao Li, Keqiang Ye","doi":"10.1016/j.molmed.2024.10.010","DOIUrl":"10.1016/j.molmed.2024.10.010","url":null,"abstract":"<p><p>Alzheimer's disease (AD) poses a significant health challenge worldwide, and the development of effective treatments necessitates a comprehensive understanding of its pathophysiology. Mouse models have been instrumental in offering insights into the crucial pathogenesis of AD. However, current models rarely recapitulate all aspects of AD pathology in patients; thus, translating the findings from mouse to human clinical trials has proved to be complex. In this review, we outline the development of some prevalently used AD mice, with a particular emphasis on the latest advances in newly generated models. In addition, we discuss the advantages and limitations in mouse models of AD and their applications in blood-based biomarkers. Finally, we speculate on potential future research directions.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"1152-1164"},"PeriodicalIF":12.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EVolution in ALS diagnosis: molecular markers in extracellular vesicles. ALS 诊断中的 EVolution：细胞外囊泡中的分子标记。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-12-01 Epub Date: 2024-07-27 DOI: 10.1016/j.molmed.2024.07.006
Philippe Codron, Stéphanie Millecamps, Philippe Corcia
{"title":"EVolution in ALS diagnosis: molecular markers in extracellular vesicles.","authors":"Philippe Codron, Stéphanie Millecamps, Philippe Corcia","doi":"10.1016/j.molmed.2024.07.006","DOIUrl":"10.1016/j.molmed.2024.07.006","url":null,"abstract":"<p><p>The identification of biomarkers for amyotrophic lateral sclerosis (ALS) is a central issue in disease research. In a recent article, Chatterjee et al. show that blood extracellular vesicles (EVs) with high levels of transactive response DNA-binding protein 43 (TDP-43) accurately discriminate patients with ALS from controls and correlate with disease severity, providing a promising biomarker for early diagnosis and monitoring.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"1097-1099"},"PeriodicalIF":12.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Granzyme B in aging and age-related pathologies. 衰老和老年相关病症中的 Granzyme B。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-12-01 Epub Date: 2024-08-23 DOI: 10.1016/j.molmed.2024.07.010
Katlyn C Richardson, Karen Jung, Joanne A Matsubara, Jonathan C Choy, David J Granville
{"title":"Granzyme B in aging and age-related pathologies.","authors":"Katlyn C Richardson, Karen Jung, Joanne A Matsubara, Jonathan C Choy, David J Granville","doi":"10.1016/j.molmed.2024.07.010","DOIUrl":"10.1016/j.molmed.2024.07.010","url":null,"abstract":"<p><p>Aging is a major risk factor for pathologies that manifest later in life. Much attention is devoted towards elucidating how prolonged environmental exposures and inflammation promote biological (accelerated) tissue aging. Granzymes, a family of serine proteases, are increasingly recognized for their emerging roles in biological aging and disease. Widely recognized as intracellular mediators of cell death, granzymes, particularly granzyme B (GzmB), also accumulate in the extracellular milieu of tissues with age, contributing to chronic tissue injury, inflammation, and impaired healing. Consequently, this has prompted the field to reconsider how GzmB regulation, accumulation, and proteolysis impact health and disease with age. While GzmB is observed in numerous age-related conditions, the current review focuses on mechanistic studies where proof-of-concept has been forwarded.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"1165-1179"},"PeriodicalIF":12.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142056601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sexual dimorphism of metabolic dysfunction-associated steatotic liver disease. 代谢功能障碍相关脂肪性肝病的性别双态性。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-12-01 Epub Date: 2024-06-17 DOI: 10.1016/j.molmed.2024.05.013
Alessandro Cherubini, Sara Della Torre, Serena Pelusi, Luca Valenti
{"title":"Sexual dimorphism of metabolic dysfunction-associated steatotic liver disease.","authors":"Alessandro Cherubini, Sara Della Torre, Serena Pelusi, Luca Valenti","doi":"10.1016/j.molmed.2024.05.013","DOIUrl":"10.1016/j.molmed.2024.05.013","url":null,"abstract":"<p><p>Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver condition. MASLD is a sexually dimorphic condition, with its development and progression influenced by sex chromosomes and hormones. Estrogens typically protect against, whereas androgens promote, MASLD. Therapeutic approaches for a sex-specific personalized medicine include estrogen replacement, androgen blockers, and novel drugs targeting hormonal pathways. However, the interactions between hormonal factors and inherited genetic variation impacts MASLD risk, necessitating more tailored therapies. Understanding sex disparities and the role of estrogens could improve MASLD interventions and management, whereas clinical trials addressing sex differences are crucial for advancing personalized treatment. This review explores the underappreciated impact of sexual dimorphism in MASLD and discusses the potential therapeutic application of sex-related hormones.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"1126-1136"},"PeriodicalIF":12.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141421054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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