发布求助
文献互助 智能选刊 最新文献

Trends in molecular medicine最新文献

筛选
英文 中文
The inaccessible road to science for people with disabilities. 残疾人通往科学的无障碍之路。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-09-10 DOI: 10.1016/j.molmed.2024.08.006
Lisa M Meeks, Mytien Nguyen, Karina Pereira-Lima, Zoie C Sheets, Rylee Betchkal, Bonnielin K Swenor
{"title":"The inaccessible road to science for people with disabilities.","authors":"Lisa M Meeks, Mytien Nguyen, Karina Pereira-Lima, Zoie C Sheets, Rylee Betchkal, Bonnielin K Swenor","doi":"10.1016/j.molmed.2024.08.006","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.08.006","url":null,"abstract":"<p><p>This article examines the contributions of disabled scientists and the barriers they face, including systemic ableism and lack of inclusivity. It offers recommendations to foster an inclusive STEM environment, underscoring the importance of supporting disabled scientists to boost innovation and equity.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142366582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Harnessing the immune system: vaccines to fight neurodegenerative diseases 利用免疫系统：抗击神经退行性疾病的疫苗
IF 13.6 1区 医学
Trends in molecular medicine Pub Date : 2024-09-09 DOI: 10.1016/j.molmed.2024.08.005
Alba Gonzalez-Artero, Jordi Pujols, Salvador Ventura
{"title":"Harnessing the immune system: vaccines to fight neurodegenerative diseases","authors":"Alba Gonzalez-Artero, Jordi Pujols, Salvador Ventura","doi":"10.1016/j.molmed.2024.08.005","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.08.005","url":null,"abstract":"<p>Neurodegenerative diseases strongly impact our aging society, with treatments providing only symptomatic relief. Recent advancements in active immunotherapy offer solutions by stimulating the immune system to produce antibodies against misfolded and toxic amyloid proteins. We discuss vaccines under clinical evaluation for Alzheimer’s and Parkinson’s diseases, highlighting successes and ongoing trials.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":"6 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142220329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cell-free and extrachromosomal DNA profiling of small cell lung cancer. 小细胞肺癌的无细胞和染色体外 DNA 图谱。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-09-03 DOI: 10.1016/j.molmed.2024.08.004
Roya Behrouzi, Alexandra Clipson, Kathryn L Simpson, Fiona Blackhall, Dominic G Rothwell, Caroline Dive, Florent Mouliere
{"title":"Cell-free and extrachromosomal DNA profiling of small cell lung cancer.","authors":"Roya Behrouzi, Alexandra Clipson, Kathryn L Simpson, Fiona Blackhall, Dominic G Rothwell, Caroline Dive, Florent Mouliere","doi":"10.1016/j.molmed.2024.08.004","DOIUrl":"https://doi.org/10.1016/j.molmed.2024.08.004","url":null,"abstract":"<p><p>Small cell lung cancer (SCLC) is highly aggressive with poor prognosis. Despite a relative prevalence of circulating tumour DNA (ctDNA) in SCLC, liquid biopsies are not currently implemented, unlike non-SCLC where cell-free DNA (cfDNA) mutation profiling in the blood has utility for guiding targeted therapies and assessing minimal residual disease. cfDNA methylation profiling is highly sensitive for SCLC detection and holds promise for disease monitoring and molecular subtyping; cfDNA fragmentation profiling has also demonstrated clinical potential. Extrachromosomal DNA (ecDNA), that is often observed in SCLC, promotes tumour heterogeneity and chemotherapy resistance and can be detected in blood. We discuss how these cfDNA profiling modalities can be harnessed to expand the clinical applications of liquid biopsy in SCLC.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vaccine-based immunotherapy and related preclinical models for glioma: (Trends in Molecular Medicine, published online July 15, 2024). 基于疫苗的胶质瘤免疫疗法及相关临床前模型：（《分子医学趋势》，2024 年 7 月 15 日在线发表）。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-09-02 DOI: 10.1016/j.molmed.2024.08.003
Binghao Zhao, Longping Yao, Maryam Hatami, Wenbin Ma, Thomas Skutella
{"title":"Vaccine-based immunotherapy and related preclinical models for glioma: (Trends in Molecular Medicine, published online July 15, 2024).","authors":"Binghao Zhao, Longping Yao, Maryam Hatami, Wenbin Ma, Thomas Skutella","doi":"10.1016/j.molmed.2024.08.003","DOIUrl":"10.1016/j.molmed.2024.08.003","url":null,"abstract":"","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142126758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erythropoietic protoporphyrias: updates and advances. 红细胞生成性原卟啉症：最新进展。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-09-01 Epub Date: 2024-06-17 DOI: 10.1016/j.molmed.2024.05.006
Antoine Poli, Caroline Schmitt, Hervé Puy, Neila Talbi, Thibaud Lefebvre, Laurent Gouya
{"title":"Erythropoietic protoporphyrias: updates and advances.","authors":"Antoine Poli, Caroline Schmitt, Hervé Puy, Neila Talbi, Thibaud Lefebvre, Laurent Gouya","doi":"10.1016/j.molmed.2024.05.006","DOIUrl":"10.1016/j.molmed.2024.05.006","url":null,"abstract":"<p><p>Protoporphyrias are caused by pathogenic variants in genes encoding enzymes involved in heme biosynthesis. They induce the accumulation of a hydrophobic phototoxic compound, protoporphyrin (PPIX), in red blood cells (RBCs). PPIX is responsible for painful cutaneous photosensitivity, which severely impairs quality of life. Hepatic elimination of PPIX increases the risk of cholestatic liver disease, requiring lifelong monitoring. Treatment options are scarce and mainly limited to supportive care such as protection from visible light. Here, we review the pathophysiology of protoporphyrias, their diagnosis, and current recommendations for medical care. We discuss new therapeutic strategies, some of which are currently undergoing clinical trials and are likely to radically alter the severity of the disease in the years to come.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"863-874"},"PeriodicalIF":12.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141421050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Science around the world. 世界各地的科学
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-09-01 Epub Date: 2024-08-14 DOI: 10.1016/j.molmed.2024.07.012
Meaghan J Griffiths, Rui J Nobre
{"title":"Science around the world.","authors":"Meaghan J Griffiths, Rui J Nobre","doi":"10.1016/j.molmed.2024.07.012","DOIUrl":"10.1016/j.molmed.2024.07.012","url":null,"abstract":"","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"795-796"},"PeriodicalIF":12.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141988989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endometriosis: recent advances that could accelerate diagnosis and improve care. 子宫内膜异位症：可加快诊断和改善护理的最新进展。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-09-01 Epub Date: 2024-07-10 DOI: 10.1016/j.molmed.2024.06.008
Meaghan J Griffiths, Andrew W Horne, Douglas A Gibson, Neil Roberts, Philippa T K Saunders
{"title":"Endometriosis: recent advances that could accelerate diagnosis and improve care.","authors":"Meaghan J Griffiths, Andrew W Horne, Douglas A Gibson, Neil Roberts, Philippa T K Saunders","doi":"10.1016/j.molmed.2024.06.008","DOIUrl":"10.1016/j.molmed.2024.06.008","url":null,"abstract":"<p><p>Endometriosis is a common disorder associated with pain, gastrointestinal and urinary symptoms, infertility, and fatigue. It is defined by the presence of endometrial-like lesions found predominantly in the pelvis. Mechanisms that contribute to disease aetiology include changes in hormonal, inflammatory, and pain pathways. In this article, we focus on recent developments in imaging technologies, on our improved understanding of mechanisms contributing to infertility, on drug therapies that are in clinical trials, and on insights from studies on the gut that offer potential to support self-management strategies. We postulate that improvements in the quality of life of patients will be accelerated by reframing endometriosis as a multi-system disorder and learning from treatments targeting symptoms shared between endometriosis, neuroinflammatory, and gastrointestinal disorders.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"875-889"},"PeriodicalIF":12.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141591472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular therapy for polyQ disorders: from bench to clinical trials. 多 Q 疾病的分子疗法：从实验室到临床试验。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-09-01 Epub Date: 2024-06-04 DOI: 10.1016/j.molmed.2024.05.004
João de Sousa-Lourenço, Ana C Silva, Luís Pereira de Almeida, Rui J Nobre
{"title":"Molecular therapy for polyQ disorders: from bench to clinical trials.","authors":"João de Sousa-Lourenço, Ana C Silva, Luís Pereira de Almeida, Rui J Nobre","doi":"10.1016/j.molmed.2024.05.004","DOIUrl":"10.1016/j.molmed.2024.05.004","url":null,"abstract":"<p><p>Polyglutamine (polyQ) disorders are monogenic neurodegenerative disorders. Currently, no therapies are available for this complex group of disorders. Here, we aim to provide an overview of recent promising preclinical studies and the ongoing clinical trials focusing on molecular therapies for polyQ disorders.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"804-808"},"PeriodicalIF":12.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141262081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Boosting endogenous dopamine production: a novel therapeutic approach for Parkinson's disease. 促进内源性多巴胺分泌：治疗帕金森病的新方法。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-09-01 Epub Date: 2024-06-25 DOI: 10.1016/j.molmed.2024.06.002
Erik H Douma, Marten P Smidt, Lars P van der Heide
{"title":"Boosting endogenous dopamine production: a novel therapeutic approach for Parkinson's disease.","authors":"Erik H Douma, Marten P Smidt, Lars P van der Heide","doi":"10.1016/j.molmed.2024.06.002","DOIUrl":"10.1016/j.molmed.2024.06.002","url":null,"abstract":"<p><p>Innovative therapeutic strategies are urgently needed for Parkinson's disease due to limited efficacy of current treatments and a weak therapeutic pipeline. In this forum article, we propose targeting tyrosine hydroxylase phosphorylation as a novel mechanism of action to address this critical need.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"800-803"},"PeriodicalIF":12.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141459476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pathogenic mechanisms in genetically defined Ehlers-Danlos syndromes. 基因定义的埃勒斯-丹洛斯综合征的致病机制。
IF 12.8 1区 医学
Trends in molecular medicine Pub Date : 2024-09-01 Epub Date: 2024-08-14 DOI: 10.1016/j.molmed.2024.06.001
Delfien Syx, Fransiska Malfait
{"title":"Pathogenic mechanisms in genetically defined Ehlers-Danlos syndromes.","authors":"Delfien Syx, Fransiska Malfait","doi":"10.1016/j.molmed.2024.06.001","DOIUrl":"10.1016/j.molmed.2024.06.001","url":null,"abstract":"<p><p>The Ehlers-Danlos syndromes (EDS) are a group of rare heritable connective tissue disorders, common hallmarks of which are skin hyperextensibility, joint hypermobility, and generalized connective tissue fragility. Currently, 13 EDS types are recognized, caused by defects in 20 genes which consequently alter biosynthesis, organization, and/or supramolecular assembly of collagen fibrils in the extracellular matrix (ECM). Molecular analyses on patient samples (mostly dermal fibroblast cultures), combined with studies on animal models, have highlighted that part of EDS pathogenesis can be attributed to impaired cellular dynamics. Although our understanding of the full extent of (extra)cellular consequences is still limited, this narrative review aims to provide a comprehensive overview of our current knowledge on the extracellular, pericellular, and intracellular alterations implicated in EDS pathogenesis.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":" ","pages":"824-843"},"PeriodicalIF":12.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141988988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信