AKI的成纤维细胞：小军队，大帮助。

IF 12.8 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in molecular medicine Pub Date : 2025-06-10 DOI:10.1016/j.molmed.2025.05.012

Saiya Zhu, Yuan Gui, Jia-Jun Liu, Silvia Liu, Dong Zhou

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引用次数: 0

摘要

急性肾损伤（AKI）是由肾小管损伤、血管损伤和炎症引起的，具有很高的发病率和死亡率。尽管经常被忽视，但早期成纤维细胞激活对肾脏修复至关重要，挑战了成纤维细胞与纤维化的传统关联。在这里，我们总结成纤维细胞的起源、异质性、功能和预防或减轻AKI的治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Fibroblasts in AKI: small army, big help.

Acute kidney injury (AKI), with high morbidity and mortality, stems from tubular injury, vascular damage, and inflammation. Although often overlooked, early fibroblast activation is critical for kidney repair, challenging traditional associations of fibroblasts with fibrosis. Here, we summarize fibroblast origins, heterogeneity, functions, and therapeutics in preventing or mitigating AKI.

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来源期刊

Trends in molecular medicine 医学-生化与分子生物学

CiteScore

24.60

自引率

0.00%

发文量

142

审稿时长

6-12 weeks

期刊介绍： Trends in Molecular Medicine (TMM) aims to offer concise and contextualized perspectives on the latest research advancing biomedical science toward better diagnosis, treatment, and prevention of human diseases. It focuses on research at the intersection of basic biology and clinical research, covering new concepts in human biology and pathology with clear implications for diagnostics and therapy. TMM reviews bridge the gap between bench and bedside, discussing research from preclinical studies to patient-enrolled trials. The major themes include disease mechanisms, tools and technologies, diagnostics, and therapeutics, with a preference for articles relevant to multiple themes. TMM serves as a platform for discussion, pushing traditional boundaries and fostering collaboration between scientists and clinicians. The journal seeks to publish provocative and authoritative articles that are also accessible to a broad audience, inspiring new directions in molecular medicine to enhance human health.