Fighting aging-associated clonal hematopoiesis with microbial metabolite.

IF 12.8 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in molecular medicine Pub Date : 2025-06-17 DOI:10.1016/j.molmed.2025.06.001

Shuqin Zeng, Dezhi Mu, Shaopu Wang

引用次数: 0

Abstract

Age-related clonal hematopoiesis in the elderly is mediated by expansion of mutant pre-leukemic hematopoietic cells, but the mechanism remains unclear. Recently, Agarwal et al. found elderly individuals exhibit the gut microbial dysbiosis with enriched Gram-negative bacteria that release ADP-heptose into systemic circulation, which promotes pre-leukemic cell expansion through ALPK1-dependent signaling.

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利用微生物代谢物对抗衰老相关克隆造血。

老年人年龄相关性克隆造血是由突变的白血病前造血细胞扩增介导的，但其机制尚不清楚。最近，Agarwal等人发现老年人表现出肠道微生物失调，富含革兰氏阴性菌，释放adp -庚糖进入体循环，通过alpk1依赖性信号传导促进白血病前期细胞扩张。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in molecular medicine 医学-生化与分子生物学

CiteScore

24.60

自引率

0.00%

发文量

142

审稿时长

6-12 weeks

期刊介绍： Trends in Molecular Medicine (TMM) aims to offer concise and contextualized perspectives on the latest research advancing biomedical science toward better diagnosis, treatment, and prevention of human diseases. It focuses on research at the intersection of basic biology and clinical research, covering new concepts in human biology and pathology with clear implications for diagnostics and therapy. TMM reviews bridge the gap between bench and bedside, discussing research from preclinical studies to patient-enrolled trials. The major themes include disease mechanisms, tools and technologies, diagnostics, and therapeutics, with a preference for articles relevant to multiple themes. TMM serves as a platform for discussion, pushing traditional boundaries and fostering collaboration between scientists and clinicians. The journal seeks to publish provocative and authoritative articles that are also accessible to a broad audience, inspiring new directions in molecular medicine to enhance human health.