Katerina Hönigova, Katerina Hadrava Vanova, Martina Raudenska, Ondrej Uher, Zdenek Kejik, Milan Jakubek, Michal Masarik, Karel Pacak
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引用次数: 0
Abstract
Preventing metastasis remains a major challenge in cancer therapy. Effective strategies should combine immune activation with the inhibition of cancer cell migration and invasion. In this Opinion article, we propose a multimodal approach that integrates migrastatic agents with photodynamic therapy (PDT) and intratumoral immunotherapy (ITI). Migrastatics inhibit cell motility and may reduce the risk of tumor cell dissemination. PDT promotes immunogenic cell death and enhances immune recognition while minimizing damage to healthy tissues. ITI delivers immune stimulants directly into tumors to stimulate local immune responses. This therapeutic strategy could suppress cancer cell plasticity, limit metastasis, and activate antitumor immunity, potentially improving outcomes in cancers prone to early invasion. This comprehensive approach is discussed in the context of current clinical practice.
期刊介绍：
Trends in Molecular Medicine (TMM) aims to offer concise and contextualized perspectives on the latest research advancing biomedical science toward better diagnosis, treatment, and prevention of human diseases. It focuses on research at the intersection of basic biology and clinical research, covering new concepts in human biology and pathology with clear implications for diagnostics and therapy. TMM reviews bridge the gap between bench and bedside, discussing research from preclinical studies to patient-enrolled trials. The major themes include disease mechanisms, tools and technologies, diagnostics, and therapeutics, with a preference for articles relevant to multiple themes. TMM serves as a platform for discussion, pushing traditional boundaries and fostering collaboration between scientists and clinicians. The journal seeks to publish provocative and authoritative articles that are also accessible to a broad audience, inspiring new directions in molecular medicine to enhance human health.
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