透明质酸和合酶在软骨中的治疗作用。

IF 13.8 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in molecular medicine Pub Date : 2025-10-10 DOI:10.1016/j.molmed.2025.09.010

Gengyun Le-Chan, Sunny S K Chan, Cindy A Thomas-Charles, Yingcui Li, Kevin W-H Lo

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引用次数: 0

摘要

透明质酸合成酶（HASs）是生产透明质酸（HA）的必需酶；关节润滑和软骨健康的关键组成部分。血凝素合成失调导致关节功能障碍。在本次论坛中，我们将讨论HAS在骨关节炎（OA）的基质组装、炎症和发病机制中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Therapeutic roles of hyaluronan and synthases in cartilage.

Hyaluronan synthases (HASs) are essential enzymes for hyaluronic acid (HA) production; a key component for joint lubrication and cartilage health. Dysregulated HA synthesis contributes to joint dysfunction. In this Forum, we discuss the role of HAS in matrix assembly, inflammation and the pathogenesis of osteoarthritis (OA).

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来源期刊

Trends in molecular medicine 医学-生化与分子生物学

CiteScore

24.60

自引率

0.00%

发文量

142

审稿时长

6-12 weeks

期刊介绍： Trends in Molecular Medicine (TMM) aims to offer concise and contextualized perspectives on the latest research advancing biomedical science toward better diagnosis, treatment, and prevention of human diseases. It focuses on research at the intersection of basic biology and clinical research, covering new concepts in human biology and pathology with clear implications for diagnostics and therapy. TMM reviews bridge the gap between bench and bedside, discussing research from preclinical studies to patient-enrolled trials. The major themes include disease mechanisms, tools and technologies, diagnostics, and therapeutics, with a preference for articles relevant to multiple themes. TMM serves as a platform for discussion, pushing traditional boundaries and fostering collaboration between scientists and clinicians. The journal seeks to publish provocative and authoritative articles that are also accessible to a broad audience, inspiring new directions in molecular medicine to enhance human health.