霍奇金淋巴瘤研究进展。

IF 12.8 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in molecular medicine Pub Date : 2024-10-22 DOI:10.1016/j.molmed.2024.10.004

Ralf Küppers

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引用次数: 0

摘要

霍奇金淋巴瘤（HL）过去是，现在仍然是人类最神秘的淋巴恶性肿瘤。自 30 年前首次对典型 HL 的分离霍奇金和里德-斯特恩伯格（HRS）肿瘤细胞进行分子分析以来，我们对 HL 的认识取得了重大进展。这篇综述描述了 HL 的细胞起源，总结了目前有关 HRS 细胞遗传病变的知识，并强调了 Epstein-Barr 病毒（EBV）在 HL 发病机制中的作用。此外，还讨论了基因表达改变和信号通路失调的病理生物学作用，并介绍了 HL 微环境的主要方面。

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Advances in Hodgkin lymphoma research.

Hodgkin lymphoma (HL) has been and still is the most enigmatic lymphoid malignancy in humans. Since the first molecular analysis of isolated Hodgkin and Reed-Sternberg (HRS) tumor cells of classic HL 30 years ago, substantial advances in our understanding of HL have been made. This review describes the cellular origin of HL, summarizes the current knowledge about the genetic lesions in HRS cells, and highlights the role of Epstein-Barr virus (EBV) in HL pathogenesis. Moreover, the pathobiological roles of altered gene expression and deregulated signaling pathways are discussed and key aspects of the HL microenvironment are presented.

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来源期刊

Trends in molecular medicine 医学-生化与分子生物学

CiteScore

24.60

自引率

0.00%

发文量

142

审稿时长

6-12 weeks

期刊介绍： Trends in Molecular Medicine (TMM) aims to offer concise and contextualized perspectives on the latest research advancing biomedical science toward better diagnosis, treatment, and prevention of human diseases. It focuses on research at the intersection of basic biology and clinical research, covering new concepts in human biology and pathology with clear implications for diagnostics and therapy. TMM reviews bridge the gap between bench and bedside, discussing research from preclinical studies to patient-enrolled trials. The major themes include disease mechanisms, tools and technologies, diagnostics, and therapeutics, with a preference for articles relevant to multiple themes. TMM serves as a platform for discussion, pushing traditional boundaries and fostering collaboration between scientists and clinicians. The journal seeks to publish provocative and authoritative articles that are also accessible to a broad audience, inspiring new directions in molecular medicine to enhance human health.