Pi-ecing together brain calcification mechanisms for therapeutic advancement.
IF 12.8
1区 医学
Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
引用次数: 0
Abstract
Seven primary familial brain calcification genes have been identified but their role in disease mechanisms has been less explored. Cheng et al. recently demonstrated that astrocyte-mediated regulation of brain phosphate (Pi) involves direct and functional interactions among three of these proteins, paving the way for new strategies to combat brain calcification.
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来源期刊
Trends in molecular medicine
医学-生化与分子生物学
CiteScore
24.60
自引率
0.00%
发文量
142
审稿时长
6-12 weeks
期刊介绍：
Trends in Molecular Medicine (TMM) aims to offer concise and contextualized perspectives on the latest research advancing biomedical science toward better diagnosis, treatment, and prevention of human diseases. It focuses on research at the intersection of basic biology and clinical research, covering new concepts in human biology and pathology with clear implications for diagnostics and therapy. TMM reviews bridge the gap between bench and bedside, discussing research from preclinical studies to patient-enrolled trials. The major themes include disease mechanisms, tools and technologies, diagnostics, and therapeutics, with a preference for articles relevant to multiple themes. TMM serves as a platform for discussion, pushing traditional boundaries and fostering collaboration between scientists and clinicians. The journal seeks to publish provocative and authoritative articles that are also accessible to a broad audience, inspiring new directions in molecular medicine to enhance human health.
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