Beyond pluripotency: Yamanaka factors drive brain growth and regeneration.

IF 12.8 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in molecular medicine Pub Date : 2025-02-01 Epub Date: 2024-12-12 DOI:10.1016/j.molmed.2024.11.013

Sunwoo Choi, Mingzi Zhang, Ruslan Rust

引用次数: 0

Abstract

The Yamanaka factors (YFs), a set of four transcription factors, are widely studied for their ability to dedifferentiate somatic cells into a pluripotent state. In a recent study, Shen and colleagues show that transient expression of YFs in the mouse brain expands the developing cortex and prevents cognitive decline in an Alzheimer's disease (AD) model.

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超越多能性：山中因子驱动大脑生长和再生。

Yamanaka因子（YFs）是一组四种转录因子，因其能够将体细胞去分化为多能状态而被广泛研究。在最近的一项研究中，Shen和他的同事们发现，YFs在小鼠大脑中的短暂表达扩大了发育中的皮层，并防止了阿尔茨海默病（AD）模型的认知能力下降。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in molecular medicine 医学-生化与分子生物学

CiteScore

24.60

自引率

0.00%

发文量

142

审稿时长

6-12 weeks

期刊介绍： Trends in Molecular Medicine (TMM) aims to offer concise and contextualized perspectives on the latest research advancing biomedical science toward better diagnosis, treatment, and prevention of human diseases. It focuses on research at the intersection of basic biology and clinical research, covering new concepts in human biology and pathology with clear implications for diagnostics and therapy. TMM reviews bridge the gap between bench and bedside, discussing research from preclinical studies to patient-enrolled trials. The major themes include disease mechanisms, tools and technologies, diagnostics, and therapeutics, with a preference for articles relevant to multiple themes. TMM serves as a platform for discussion, pushing traditional boundaries and fostering collaboration between scientists and clinicians. The journal seeks to publish provocative and authoritative articles that are also accessible to a broad audience, inspiring new directions in molecular medicine to enhance human health.