Tissue & cell最新文献

{"title":"Berberine attenuates liver damage, hematological, biochemical, and molecular changes induced by cadmium chloride via inflammation, apoptosis, and oxidative stress suppression.","authors":"Ali B Jebur, Raghda A El-Sayed, Mohamed M Abdel-Daim, Fatma M El-Demerdash","doi":"10.1016/j.tice.2026.103529","DOIUrl":"10.1016/j.tice.2026.103529","url":null,"abstract":"<p><p>Cadmium (Cd) is a toxic heavy metal widely recognized for its detrimental effects on human and animal health. The liver, a primary organ for detoxification, is particularly susceptible to cadmium-induced damage. Berberine (BBR) is a natural alkaloid extracted from a plant known for its antioxidant and chemoprotective effects on the liver. Twenty-eight Male Wistar rats were divided into four groups: control, berberine (BBR; 150 mg/kg BW/day), cadmium chloride (CdCl₂, 1.8 mg/kg BW/day), and BBR+ Cd (Cd after 2 h of BBR administration). Dosages of BBR and CdCl₂ were given orally for 21 consecutive days. Rats treated with Cd displayed remarkable changes in hematological parameters, lipid profile, and oxidative stress markers (TBARS, H₂O₂), and a marked decrease in enzymatic and non-enzymatic antioxidants, transaminases, and alkaline phosphatase activities, and serum protein level. Additionally, Cd administration induced apoptosis and inflammation, in addition to histological abnormalities, in the liver tissue. Otherwise, BBR intake alone significantly reduced lipid peroxidation and improved the antioxidant status. Moreover, supplementation with BBR followed by CdCl₂ intoxication restored most of the studied indices compared to the CdCl₂ group. In summary, BBR demonstrated its exceptional ability to eliminate CdCl₂ toxicity. Because of its antioxidant potential, it may offer a novel approach to treating metal poisoning.</p>","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":"101 ","pages":"103529"},"PeriodicalIF":3.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fisetin promotes liver regeneration by inducing β-catenin-mediated inhibition of p53 and suppression of TGF-β.","authors":"Ghada Ibrahem Draz, Huda El-Tahry, Rania Naem Sherif, Amira Elsayed Farage, Randa El-Gamal, Ahmed Mohammed Elsabbagh, Hassan Reda Hassan Elsayed","doi":"10.1016/j.tice.2026.103525","DOIUrl":"10.1016/j.tice.2026.103525","url":null,"abstract":"<p><p>Partial hepatectomy (PHx) is frequently done for the repair of traumatic liver injury, tumor resection, and donation. The regenerative ability of the residual liver impacts mortality and morbidity. Fisetin is an antioxidant flavonoid that was found to target β-catenin, inducing regeneration in cardiac, nervous, bony tissues, and skin. This study assesses the impact of fisetin on liver regeneration following major PHx. Twenty-four rats were assigned to four groups: sham, fisetin control, 70% PHx, and PHx + Fisetin (10 mg/kg/day) for four days prior to surgery, and two days after surgery. Animals were sacrificed two days following PHx. Serum liver enzymes, AST, ALT, liver oxidative markers, GSH, and MDA, were measured. Immunohistochemical expression of hepatic PCNA, Cyclin D1 (cell proliferation marker), and β-catenin (liver regeneration mediator), as well as mRNA expression for hepatic P53 (senescence marker), TGF-β (regeneration stop inducer), and VEGF (angiogenesis marker), was performed. Fisetin boosted hepatectomy-induced hepatic regeneration, significantly increased relative liver weight, hepatocyte mitotic index, liver PCNA, cyclin D1, and β-catenin, reduced hepatic histopathological injury, serum AST and ALT levels, and liver MDA levels, and increased liver GSH, demonstrating antioxidant status. Fisetin reduced PHx-induced increases in p53, indicating suppression of cell senescence, and in TGF-β, demonstrating the elimination of TGF-β-mediated termination of liver regeneration; however, fisetin didn't show a significant change in PHx-enhanced angiogenesis, as marked by VEGF expression. Fisetin enhances PHx-induced liver regeneration via upregulating β-catenin and suppressing the P53 senescence pathway and TGF-β signaling.</p>","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":"101 ","pages":"103525"},"PeriodicalIF":3.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to : The nano-biointerface as a structural regulator of cell behavior: Interactions of extracellular vesicles, synthetic nanocarriers, and nanofibers with cells [Tissue Cell, Vol. 101, August 2026, 103431].","authors":"Rabab S Hamad, Sameh Saber, Alshaimaa A Farrag, Hanan Eissa, Elsayed A Elmorsy, Attalla F El-Kott, Mohammed A AlShehri, Eman A Al-Shahari, Waleed Eltantawy, Mohamed A M Ali, Anis Ahmad Chaudhary, Ahmed Gaafar, Ahmed Abdel-Monem Elmetwally, Ahmed Shata, Ahmed Y Kira","doi":"10.1016/j.tice.2026.103460","DOIUrl":"10.1016/j.tice.2026.103460","url":null,"abstract":"","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":" ","pages":"103460"},"PeriodicalIF":2.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147435702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Targeting Siglec-15 mediates mitochondrial retrograde regulation of cervical cancer development\" [Tissue Cell 93 (2025) 102713].","authors":"Jing Wang, Zenghui Li, Yifan He, Yongli Chu","doi":"10.1016/j.tice.2026.103478","DOIUrl":"10.1016/j.tice.2026.103478","url":null,"abstract":"","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":" ","pages":"103478"},"PeriodicalIF":2.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147494459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphology of the male reproductive system and spermatozoa of Horiola picta (Coquebert, 1801) (Hemiptera: Membracidae).","authors":"Dayvson Ayala Costa, Mauricio da Silva Paulo, Francisco Witallo Souza Nascimento, Ana Clara Pereira Teixeira, Paulo Henrique Rezende, Glenda Dias, José Lino-Neto","doi":"10.1016/j.tice.2026.103528","DOIUrl":"10.1016/j.tice.2026.103528","url":null,"abstract":"<p><p>Membracidae is a family of insects known for its diverse pronotal shapes and coloration, which are used for mimicry. It is common to find species of this family that maintain mutualistic relationships with ants and bees, to which the membracids provide a sweet substance in exchange for protection. One such species with a mutualistic relationship is Horiola picta (Coquebert, 1801) (Smiliinae: Tragopini), considered a cocoa pest in several regions of Brazil. To complement morphological studies, we describe the morphology of the male reproductive system and sperm of H. picta. The male reproductive system is similar to that of other Membracoidea species. However, the number of testicular follicles varies from 12 to 14, which is higher than that observed in other Membracoidea families, which vary from 4 to 13. Based on histology, we observed that follicles contain cysts at different stages of spermatogenesis, suggesting that sperm production is continuous in adulthood and that males copulate multiple times throughout their lives. Furthermore, spermatozoa are long compared to other Membracoidea species, measuring 189.74 ± 1.76 µm in length, and nuclei are 27.30 ± 3.58 µm in length. Two to five terminal flagellar filaments are present, a characteristic unique to Membracoidea and not observed in other groups such as Cercopoidea and Cicadoidea. In the seminal vesicles, the spermatozoa remain organized in spermatodesmata-type bundles, as previously reported in Cicadellidae. This work aims to contribute to knowledge of the species' reproductive biology and to provide relevant morphological data on the reproductive organs, with a view to future taxonomic and phylogenetic analyses of the family and Membracoidea.</p>","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":"101 ","pages":"103528"},"PeriodicalIF":3.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antagonism of GPR75 inhibits gestational diabetes mellitus-induced placental tissue injury by preventing activation of the NLRP3 inflammasome.","authors":"Qiaoling Tong, Man Hu, Yuan Guan, Fang Song","doi":"10.1016/j.tice.2026.103515","DOIUrl":"10.1016/j.tice.2026.103515","url":null,"abstract":"<p><p>Gestational diabetes mellitus (GDM) is a common pregnancy complication associated with significant maternal and fetal risks. The 20-hydroxyeicosatetraenoic acid (20-HETE) and its receptor GPR75 have been implicated in metabolic dysregulation, but their role in GDM remains unclear. This study investigated the pathophysiological role of the 20-HETE/GPR75 axis in GDM and evaluated the therapeutic potential of a GPR75 antagonist. In a mouse model of GDM, we found significantly elevated levels of 20-HETE in plasma (2.4-fold) and placental tissue (1.6-fold), alongside increased GPR75 expression at both mRNA (2.3-fold, P < 0.01) and protein levels (2.1-fold). Administration of the GPR75 antagonist AAA (10 mg/kg/day) markedly attenuated hyperglycemia (143.3 ± 14.2 vs. 195.2 ± 21.3 mg/dL, P < 0.01), improved insulin levels (5.7 ± 0.59 vs. 3.9 ± 0.39 mg/dL, P < 0.01), corrected dyslipidemia (TC: 113.5 ± 15.1 vs. 168.7 ± 20.2 mg/dL, P < 0.01; TG: 124.9 ± 13.8 vs. 215.3 ± 23.6 mg/dL, P < 0.01), and improved fetal survival rate (97.2% vs. 81.2%, P < 0.05). Mechanistically, the antagonist reduced oxidative stress (TBARS decreased by 58%, ROS levels reduced by approximately 42%, both P < 0.01), suppressed NLRP3 inflammasome activation (NLRP3 expression reduced by 48%, P < 0.01; IL-1β: 1.7 ± 0.16 vs. 3.5 ± 0.37 ng/g protein, P < 0.01), and inhibited the MAPK p38/NF-κB signaling pathway (p-p38/p38 ratio reduced from 2.8 ± 0.25-1.3 ± 0.13, p-NF-κB p65 from 2.3 ± 0.24-1.2 ± 0.11, both P < 0.01) in the placenta. Our findings demonstrate that the 20-HETE/GPR75 pathway is upregulated in GDM and contributes to its pathophysiology. Targeting GPR75 represents a promising therapeutic strategy for mitigating GDM symptoms and improving placental function.</p>","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":"101 ","pages":"103515"},"PeriodicalIF":3.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147654951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time-dependent renal protection by remote ischemic preconditioning through a hydrogen sulfide-mediated antioxidative and anti-inflammatory pathway.","authors":"Khojasteh Malekmohammad, Firouzeh Gholampour, Zeinab Karimi, Gholamreza Daryabor","doi":"10.1016/j.tice.2026.103521","DOIUrl":"10.1016/j.tice.2026.103521","url":null,"abstract":"<p><p>This study compared the protective effects of early (<1 h) and late (>24 h) remote ischemic pre-conditioning (RIPreC) against renal I/R injury and elucidated the key role of H₂S signaling in mediating RIPreC-induced renoprotection. Randomly fifty-six male rats were allocated into eight groups: sham, I/R, early RIPreC+I/R, late RIPreC+I/R, NaHS + early RIPreC+I/R, NaHS+late RIPreC+I/R, PAG+early RIPreC+I/R, and PAG+late RIPreC+I/R. Renal I/R was created by 60 min of renal pedicle occlusion, followed by 24 h of reperfusion. RIPreC was induced by three cycles of femoral artery occlusion and reperfusion, each lasting 5 min. Blood, urine, and kidney tissues were gathered after the reperfusion period. Renal I/R led to serious dysfunction, elevated FE_Na, reduced C_Cr and urine osmolality, increased oxidative stress, and histological damage. These changes were accompanied by downregulation of CBS and CSE and upregulation of NF-κB and TNF-α. Both early and late RIPreC preserved renal function, decreased total oxidant status, enhanced total antioxidant capacity, reduced inflammation, and ameliorated histological injury. Notably, late RIPreC provided greater protection than early RIPreC. Administration of NaHS enhanced the RIPreC effects, whereas PAG abolished them. RIPreC confers remarkable protection against renal I/R damage, with the late window proving more effective than the early window. The renoprotective effects of RIPreC are exerted by increasing the activation of the hydrogen sulfide (H₂S) signaling pathway through upregulation of CBS and CSE. Pharmacological enhancement of H₂S signaling may improve RIPreC's clinical utility in preventing acute kidney injury (AKI).</p>","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":"101 ","pages":"103521"},"PeriodicalIF":3.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147654891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histological effects of intranasal clove essential oil on the olfactory bulb in a rat model of depression.","authors":"Walaa Elfakharany, Majorelle Magdy Shafik, Mariam Asaad Amin, Marian Mokhtar","doi":"10.1016/j.tice.2026.103508","DOIUrl":"10.1016/j.tice.2026.103508","url":null,"abstract":"<p><strong>Background: </strong>depression is the most widespread psychiatric disorder, making it the fourth leading cause of death among adults. The olfactory system is a component of the limbic system. Repeated exposure to stressful events has been reported to affect emotions and olfactory perception. Clove oil is an essential oil that exhibits immunomodulatory properties and is used in the recovery of olfactory dysfunctions during the COVID-19 outbreak.</p><p><strong>Aim: </strong>Detect the potential hazards of stress-induced depression on the olfactory bulbs and investigate the possible role of clove oil in ameliorating these effects.</p><p><strong>Material and methods: </strong>Twenty-four adult male albino rats were divided equally into three groups: a control group (I), Group (II): depression group, rats were subjected to CUMS Model for 21 days, then were subdivided equally into group (IIa): rats were sacrificed after 21 days, and group (IIb): rats were left for spontaneous recovery for 14 days, then sacrificed. Group (III): rats were subjected to CUMS Model for 21 days, then clove was applied intranasally (0.02 mL/kg) daily for 14 days, then sacrificed. Olfactory bulb specimens were examined by light microscopy. The depression altered the normal tissue morphology of the bulb; Glomeruli appeared shrunken in the glomerular layer. Mitral cells appeared fewer in number, with deeply stained nuclei. The granule cells were aggregated with areas of vacuolated neuropil. Clove oil group restored the normal architecture of the olfactory bulb.</p><p><strong>Conclusion: </strong>Clove oil has an ameliorating effect on the injury of the olfactory bulb in the depression induced animal model of Albino rats.</p>","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":"101 ","pages":"103508"},"PeriodicalIF":3.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PRMT1-rich exosomes derived from M2 macrophages as novel therapeutics for enhancing fracture healing","authors":"Haifeng Hong ,&nbsp;Cuiyun Zhou ,&nbsp;Haibing Wang ,&nbsp;Changhui Lin ,&nbsp;Min Fang ,&nbsp;Juntian Liu ,&nbsp;Minhui Yang","doi":"10.1016/j.tice.2026.103348","DOIUrl":"10.1016/j.tice.2026.103348","url":null,"abstract":"<div><h3>Purpose</h3><div>sM2 macrophage-derived exosomes (M2-Exo) have emerged as promising mediators of bone repair due to their anti-inflammatory and pro-regenerative properties. However, the molecular mechanisms underlying the interaction between M2-Exo and bone marrow mesenchymal stem cells (BMSCs) are awaiting clarification. Our previous study found that protein arginine methyltransferase 1 (PRMT1) in fracture-derived exosomes promotes bone healing. This study aimed to determine whether PRMT1-containing M2-Exo exerts an osteoprotective effect during fracture healing and elucidate its underlying mechanisms.</div></div><div><h3>Methods</h3><div>Following knockdown of PRMT1 in M2-Exo and then treating BMSCs, osteogenic differentiation ability of BMSCs was evaluated by qRT-PCR, western blot, Alizarin Red S, and Alkaline phosphatase (ALP). Immunoprecipitation was employed to clarify regulatory effect of PRMT1 on Src-associated in mitosis 68 kDa (Sam68) and its asymmetric dimethylarginine (ADMA) modification.</div></div><div><h3>Results</h3><div>PRMT1 was overexpressed in M2-Exo extracted from serum samples of fracture rats. M2-Exo delivered PRMT1 to BMSCs. PRMT1 knockdown in M2-Exo impaired osteogenic differentiation, as evidenced by suppressing mineral deposition and ALP activity (42.3 % and 60.8 % reduction vs. sh-NC; p &lt; 0.01), with a decrease in expression of Bone Morphogenetic Protein 2 (BMP2) and RUNX Family Transcription Factor 2 (RUNX2) (74.9 % and 61.8 % decline vs. sh-NC; p &lt; 0.01). PRMT1 interacted with Sam68, and its knockdown reduced ADMA modification and Sam68 protein expression. Sam68 overexpression partially rescued the osteogenic defects caused by PRMT1 knockdown, with increased mineralization level and ALP (44.3 % and 87.6 % increase vs. M2-Exo-sh-PRMT1 + oe-NC; p &lt; 0.05), along with elevated BMP2 and RUNX2 expression (79.5 % and 98.8 % increase vs. M2-Exo-sh-PRMT1 + oe-NC; p &lt; 0.01).</div></div><div><h3>Conclusion</h3><div>PRMT1 released by M2-Exo is delivered to BMSCs, which enhances the osteogenic differentiation by catalyzing Sam68 ADMA. These findings provide a mechanistic and preclinical rationale for the potential use of M2-Exo to improve bone healing.</div></div>","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":"100 ","pages":"Article 103348"},"PeriodicalIF":2.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146079855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrastructural features of the excurrent ducts of the testis of a wild bird, the cattle egret (Bubulcus ibis)","authors":"Narindra H. Roopnarine ,&nbsp;Tom A. Aire ,&nbsp;Antoinette V. Lensink ,&nbsp;Sunil K. Gupta ,&nbsp;Curtis.E. Hopkins ,&nbsp;Matthew B. Charles","doi":"10.1016/j.tice.2026.103329","DOIUrl":"10.1016/j.tice.2026.103329","url":null,"abstract":"<div><div>The structure and functions of components of the excurrent ducts of the testis of birds are still poorly understood. Most of the few reports on these ducts are on domesticated avian species. This report on the cattle egret is one of the very few studies on wild birds. Tissues from the ducts of five sexually mature and active male birds were routinely prepared and stained for light and transmission electron microscopy. The epididymis and ductus deferens of the cattle egret are generally similar structurally to those reported for domestic birds, with a number of cellular differences. The epithelium of certain segments of the egret’s rete testis displayed numerous, large intercellular spaces, not usually observed in most domestic avian species. As in the domestic species of birds, the proximal efferent ducts in the cattle egret displayed a robust endocytic apparatus as well as abundant lysosomes, but there were very few heterolysosomes and telolysosomes, which were common in domestic species. The border between the proximal and distal efferent ducts also demonstrated active spermiophagy. In addition to evidence of moderate secretary activities, the presence of extremely large heterolysosomes and telolysosomes also demonstrated the endocytic and digestive ability of cells lining the ductus deferens.</div></div>","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":"100 ","pages":"Article 103329"},"PeriodicalIF":2.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146039544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}