Tissue & cell最新文献

{"title":"Corrigendum to 'Cell therapy for kidney diseases' [Tissue Cell, 104 (2027) 103769].","authors":"Qibin Huang, Shiqi Wen, Mingying Zhang, Chengqing Song, Guanyuan Tian, Kefei Wu, Qinghua Liu","doi":"10.1016/j.tice.2026.103849","DOIUrl":"10.1016/j.tice.2026.103849","url":null,"abstract":"","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":" ","pages":"103849"},"PeriodicalIF":3.1,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148707721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to \"The role of macrophage-myofibroblast transition in the pathogenesis of multi-organ fibrosis\" [Tissue Cell 103 (2026) 103702].","authors":"Congcong Guo, Ran Cao, Lin Liao, Junyu Zhao, Tianzuo Wang, Junhan Li, Yue Zhang, Haotian Li","doi":"10.1016/j.tice.2026.103824","DOIUrl":"10.1016/j.tice.2026.103824","url":null,"abstract":"","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":" ","pages":"103824"},"PeriodicalIF":3.1,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148798139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction notice to \"Asiatic acid reverses cisplatin resistance in A549/DDP cells by activating the P38 MAPK/slug pathway\" [Tissue Cell 98 (2026) 103145].","authors":"Min Yu, Qian Zhang, Wenli Shang, Shenghong Wei, Hongxia Wen, Shufen Huo, Xiang Li, Xuan Li, Heng Zhang, Yingxuan Tian","doi":"10.1016/j.tice.2026.103835","DOIUrl":"10.1016/j.tice.2026.103835","url":null,"abstract":"","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":" ","pages":"103835"},"PeriodicalIF":3.1,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148762205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Echinatin inhibits the growth and metastasis of human hepatocellular carcinoma cells through p38 and JNK signaling pathways\" [Tissue Cell 95 (2025) 102907].","authors":"Jiayu Wang, Ziyun Li, Xueqian Han, Zhou Xie, Yajun Hou, Miao Liu, Yuhang Cheng, Qiuping Lu, Jinyong Luo, Hongbo Wang","doi":"10.1016/j.tice.2026.103804","DOIUrl":"10.1016/j.tice.2026.103804","url":null,"abstract":"","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":" ","pages":"103804"},"PeriodicalIF":3.1,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148580177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CD38-driven NAD⁺ depletion governs crypt structure and barrier dysfunction in fluorouracil-induced colonic mucositis: From metabolic collapse to architectural remodeling.","authors":"Elsayed A Elmorsy, Rabab S Hamad, Mohammed Alorini, Attia M Gabr, Hamad Alsaykhan, Mostafa M Khodeir, Mohamed F Hindawy, Abdulaziz A Alsalloom, Eman Mohamad El Nashar, Ahmed G Hamad, Haytham Ali, Mohammed Ashraf Ali, Abdel-Moneim Hafez Abdel-Moneim, Maha M Amer, Mohamed R Abdel-Hamed, Mohamed El-Sayed, Sameh Saber","doi":"10.1016/j.tice.2026.103739","DOIUrl":"10.1016/j.tice.2026.103739","url":null,"abstract":"<p><p>5-fluorouracil (5-FU)-induced colonic mucositis is characterized by epithelial injury, crypt architectural disruption, inflammatory infiltration, oxidative stress, and loss of barrier integrity. The metabolic determinants that regulate epithelial resilience and architectural recovery remain incompletely defined, although 5-FU exposure reproducibly induces these structural lesions. Nicotinamide adenine dinucleotide (NAD⁺) supports epithelial energy balance and redox homeostasis, while accelerated NAD⁺ consumption may amplify tissue injury during toxic stress. CD38 is a principal NAD⁺ hydrolase; yet, its contribution to mucosal structural injury and barrier failure has not been fully elucidated. Herein, we tested whether pharmacological inhibition of CD38 using the small-molecule CD38 inhibitor 78c preserves colonic tissue architecture in a mouse 5-FU-induced mucositis model. We also evaluated the requirement for NAD⁺ biosynthesis. 5-FU produced prominent histopathological injury marked by epithelial damage/apoptosis, crypt disorganization, inflammatory-cell infiltration, oxidative-injury, and disrupted tight junctions with barrier dysfunction. CD38 inhibition mitigated these abnormalities to preserve crypt-architecture and epithelial continuity. As a result, inflammatory infiltration, oxidative stress, and apoptotic signaling were attenuated, with concurrent restoration of tight junction integrity and intestinal barrier function. Protection was associated with significant improvement in colonic NAD⁺ levels and the NAD⁺/NADH balance, increased SIRT1 activity, reduced PARP activation, and activation of Nrf2-linked stress response. Markedly, inhibition of NAD⁺ biosynthesis with a NAMPT inhibitor abrogated the structural and barrier-protective effects of CD38 inhibition across histological, biochemical, and molecular readouts, indicating dependence on NAD⁺ availability. These findings identify the CD38-NAD⁺ axis as a metabolic regulator of colonic-crypt architecture and epithelial barrier organization during 5-FU-induced mucositis.</p>","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":"103 ","pages":"103739"},"PeriodicalIF":3.1,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148369975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to 'Huangqin decoction improves chemotherapy-induced diarrhea by restoring the intestinal mechanical barrier and Lyn/snail/E-cadherin signaling pathway' [Tissue and Cell, Vol. 104, Part 1, (2027), 103841].","authors":"Botao Wang, Qingqing Liu, Yujie Gao, Yunjing He, Chenglu Yang, Yusu Wang, Siyu Han, Yuke Ren, Ke Nie","doi":"10.1016/j.tice.2026.103862","DOIUrl":"10.1016/j.tice.2026.103862","url":null,"abstract":"","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":" ","pages":"103862"},"PeriodicalIF":3.1,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148765681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological and ultrastructural characterization of the male accessory glands in Moechotypa diphysis (Coleoptera: Cerambycidae).","authors":"Hui-Xin Tan, Xin Tong","doi":"10.1016/j.tice.2026.103744","DOIUrl":"10.1016/j.tice.2026.103744","url":null,"abstract":"<p><p>The male accessory glands (MAGs) in insects play a crucial role in the reproductive system, secreting substances such as seminal fluid, mating plugs, and spermatophores. Across various insects, MAGs exhibit significant differences in number, embryological origin, function, and secretory products, as well as in their morphological and ultrastructural characteristics. Within Cerambycidae, interspecific variations in MAGs are also evident, yet they remain understudied. Moechotypa diphysis (Coleoptera: Cerambycidae: Lamiinae) is a wood-boring pest that damages oak trees and creates ecological risks. In this study, an investigation of the histological and ultrastructural characteristics of the MAGs in M. diphysis was performed using light microscopy and transmission electron microscopy. The results demonstrate that M. diphysis possess two pairs of elongated tubular accessory glands. These glands, whose epithelia are not covered by a cuticular intima, are mesodermal glands (mesadenia) and share a common opening into the vas deferens at their base. Ultrastructurally, although both pairs of glands are composed of a muscular layer, an epithelium, and a lumen, they exhibit distinct characteristics. In one pair of glands, the nuclei are positioned close to the cell base, and the cytoplasm is predominantly occupied by extensive rough endoplasmic reticulum (RER). In the other pair, the epithelial cells contain high abundance of large autolysosomes. Additionally, significant differences were observed in microvilli structure and secretory products between the two pairs of glands. This study provides a comparative morphological and ultrastructural description of accessory glands in a species of Cerambycidae, aiming to reveal the cellular-level adaptations driven by natural selection in the context of reproductive competition.</p>","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":"103 ","pages":"103744"},"PeriodicalIF":3.1,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148369991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A bioactive NGF-functionalized dermal scaffold promotes functional and morphological recovery with favorable hematological profiles after sciatic nerve injury in rats.","authors":"Ahmed Hjazi","doi":"10.1016/j.tice.2026.104058","DOIUrl":"https://doi.org/10.1016/j.tice.2026.104058","url":null,"abstract":"<p><p>Peripheral nerve injuries involving complete nerve transection remain a major clinical challenge due to limited regenerative capacity and insufficient functional recovery after conventional repair strategies. Bioactive nerve guidance scaffolds capable of providing structural support and localized delivery of neurotrophic signals have emerged as promising approaches for enhancing peripheral nerve regeneration. In this work, I developed a tubular nerve repair scaffold from decellularized dermal extracellular matrix and incorporated nerve growth factor (NGF) into the construct to provide localized neurotrophic support following sciatic nerve transection in rats. The regenerative potential of NGF-functionalized dermal collagen-derived scaffolds (DerCS-NGF) was evaluated in a rat sciatic nerve transection model and compared with untreated defects and unloaded scaffold groups. Functional recovery was assessed using behavioral tests, while histological, stereological, molecular, hematological, and biochemical analyses were performed after 12 weeks. Implantation of DerCS-NGF significantly enhanced nerve regeneration, as demonstrated by increased nerve fiber density, improved myelin sheath thickness, preservation of sensory and motor neuronal populations, reduced gastrocnemius muscle atrophy, and superior functional recovery compared with untreated and unloaded scaffold groups. Furthermore, NGF delivery through the dermal scaffold significantly reduced local inflammatory cytokine levels, including TNF-α, IL-1β, and IFN-γ, and upregulated the expression of regeneration-associated genes, including NF200, S100, and βIII-tubulin. Hematological and biochemical parameters, including RBC, HGB, WBC, lymphocytes, neutrophils, MPV, ALT, AST, creatinine, and urea, were additionally assessed at the 12-week endpoint to evaluate systemic responses following scaffold implantation. Overall, this study demonstrates that the NGF-functionalized dermal extracellular matrix-derived scaffold promotes structural and functional recovery after sciatic nerve injury and provides a bioactive platform with a favorable systemic safety profile for the repair of severe peripheral nerve injuries.</p>","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":"104 Pt 3","pages":"104058"},"PeriodicalIF":3.1,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to ''Inhibition of proliferation, migration and invasion of RM-1 cells by roemerine: Insights from in vitro and in vivo studies'' [Tissue Cell, vol. 93, April (2025), 102693].","authors":"Juntai Xu, Hongbin Ma","doi":"10.1016/j.tice.2026.103322","DOIUrl":"10.1016/j.tice.2026.103322","url":null,"abstract":"","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":" ","pages":"103322"},"PeriodicalIF":3.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148034817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \" Knockdown of TRPM2 promotes osteogenic differentiation of Human Periodontal Ligament Stem Cells by modulating NF-κB /NLRP3 pathway\", Tissue Cell, 2023, 84: 102184.","authors":"Xiaosong Xiang, YongXin Hu, Zhiqiang Song, Chunlin Wang","doi":"10.1016/j.tice.2026.103661","DOIUrl":"10.1016/j.tice.2026.103661","url":null,"abstract":"","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":" ","pages":"103661"},"PeriodicalIF":3.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148158369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}