Tissue & cell最新文献

{"title":"Immunolocalization of cell proliferation and tumor markers in the regenerating tail of the lizard Podarcis muralis likely involved in cell proliferation control.","authors":"Lorenzo Alibardi","doi":"10.1016/j.tice.2025.102782","DOIUrl":"10.1016/j.tice.2025.102782","url":null,"abstract":"<p><strong>Purpose: </strong>The lizard blastema expresses typical genes present in cancer cells, and CD44 and S100A4 markers are known to be associated with metastasis, a process that is absent during tail regeneration in lizard.</p><p><strong>Method: </strong>The present immunohistochemical study analyzes the distribution of hyaluronate, its main receptor CD44, and S100A4 (metastasin-1) in relation to proliferating cells in the early regenerating tail of the lizard Podarcis muralis.</p><p><strong>Results: </strong>The regenerating blastema contains sparse proliferating cells immersed in a hyaluronate-rich extracellular matrix and these cells show a diffuse labeling for CD44 and S100A4. These proteins are more intensely localized in the apical regenerating (wound) epidermis and ependymal ampulla (regenerating spinal cord), two tissues essential for the stimulation of tail regeneration in lizards. Both markers generally show a cytoplasmic localization, but also a nuclear labeling is present in basal cells of the regenerating epidermis in the blastema, especially for S100A4. The latter protein is highly expressed in differentiating epidermis of regenerating scales, especially in the forming beta-layer.</p><p><strong>Conclusions: </strong>The expression of these two marker oncoproteins, however, like others previously studied, is not associated with metastasis in the lizard blastema that instead develops into a new tail. The activation of cancer marker genes and proteins in the regenerating blastema does not determine degeneration into a tumor outgrowth. This process remains so far unexplained but is worth of a detailed molecular and cellular analysis aiming to find key processes on this physiological mechanism of tumor self-remission.</p>","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":"93 ","pages":"102782"},"PeriodicalIF":2.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143410880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macro- and microscopic morphology of the rectal gland of the Brazilian guitarfish (Pseudobatos horkelii) from Southeastern Brazil.","authors":"Beatriz França Lopes, Géssica Vieira Gomes, Hassan Jerdy, Rachel Ann Hauser-Davis, Eulógio Carlos Queiroz de Carvalho","doi":"10.1016/j.tice.2025.102769","DOIUrl":"10.1016/j.tice.2025.102769","url":null,"abstract":"<p><p>Sharks and rays present an osmoregulatory mechanism essentially exercised by a rectal salt gland. Histological assessments of this gland, however, are notoriously lacking. In this sense, histological assessments of the rectal gland of the Brazilian guitarfish, Pseudobatos horkelii obtained from off the coast of Rio de Janeiro, Brazil, were carried out herein. Rectal gland samples were histologically processed with hematoxylin/eosin and special Masson's Trichrome stain. Three main regions were identified: the capsule, secretory parenchyma and central duct. Highly vascularized connective tissue was observed in the capsular region, surrounded by a superficial epithelium composed of a layer of cubic cells. Lymphoid tissue was present outside the capsule. The capsule presented connective tissue invaginations, forming interlobular septa. Each septum, surrounded by fibroelastic tissue, delimited the secretory lobes filled with secretory tubules, whose lumens exhibited a larger diameter and a greater number of secretory cells as they approached the central duct. The duct to which the organ's secretory tubules open, at the center of the rectal gland, presents a lumen lined with stratified epithelium, containing acidophilic intraepithelial and mucous cells. Most analyzed morphological characteristics are in accordance with morphological aspects reported in previous ray studies concerning other species presenting similar phylogeny, habitat and feeding characteristics as P. horkelii. These assessments are paramount in understanding species-specific osmoregulation and informing conservation strategies, particularly for threatened species like the Brazilian guitarfish.</p>","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":"93 ","pages":"102769"},"PeriodicalIF":2.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143410965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Possible therapeutic effects of PROK2 in testicular ischemia/reperfusion injury: A preclinical study in Wistar albino rats.","authors":"Ilayda Uysal, Nesibe Yilmaz, Semir Gul, Kevser Tanbek, Umit Yilmaz","doi":"10.1016/j.tice.2025.102778","DOIUrl":"10.1016/j.tice.2025.102778","url":null,"abstract":"<p><p>This study aimed to investigate the therapeutic effects of PROK2 on oxidative stress, inflammatory response, and tissue damage caused by ischaemia/reperfusion (I/R) in testicular tissue. A total of 48 prepubertal male Wistar albino rats were divided into four groups: sham, testicular torsion/detorsion (TTD), testicular torsion + PROK2 + detorsion (TT + PROK2 + TD), and testicular torsion/detorsion + PROK2 (TTD + PROK2) (n = 12). Testicular torsion/detorsion surgeries (2 hours of torsion followed by 24 hours of detorsion) were performed on all groups except the sham group. The TT + PROK2 + TD group received a single dose of PROK2 (60 nmol/kg) intraperitoneally 30 minutes before the end of torsion, while the TTD + PROK2 group received a single dose of PROK2 (60 nmol/kg) at the beginning of detorsion. Subsequently, biochemical parameters (serum testosterone level, total antioxidant capacity (TAS), total oxidant capacity (TOS), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) levels in testicular tissue), as well as histopathological and immunohistochemical changes, were evaluated. In TTD, a significant decrease was observed in testosterone and TAS levels, while there was an increase in TOS, TNF-α, and IL-6 levels. PROK2 treatment reduced inflammatory parameters and enhanced antioxidant parameters and testosterone levels. Additionally, a low Johnsen's score and spermatogonia count in the TTD group improved with PROK2 treatment. We concluded that PROK2, by exhibiting antioxidative and anti-inflammatory properties, may have a therapeutic effect on I/R-induced tissue damage in testicular tissue.</p>","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":"93 ","pages":"102778"},"PeriodicalIF":2.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and immunohistochemical effects of OncoTherad (MRB-CFI-1) nanoimmunotherapy on SERBP1, HABP4, CD44 and Ki-67 in BCG-unresponsive non-muscle invasive bladder cancer.","authors":"Maria Izabel de Barros Frazão Salmazo, João Carlos Cardoso Alonso, Gabriela Cardoso de Arruda Camargo, Gabriela de Oliveira, André da Silva Santos, Monaliza Ávila, Isadora Manzato Roberto, Leandro Luiz Lopes de Freitas, Martim Corrêa Bottene, Jean Felipe Prodocimo Lestingi, Paulo Henrique Ferreira Caria, Nelson Durán, Jörg Kobarg, Wagner José Fávaro","doi":"10.1016/j.tice.2025.102783","DOIUrl":"10.1016/j.tice.2025.102783","url":null,"abstract":"<p><p>Non-muscle-invasive bladder cancer (NMIBC) is a malignancy with a high recurrence and progression rate, particularly in patients who fail to respond to standard Bacillus Calmette-Guérin (BCG) therapy. OncoTherad (MRB-CFI-1) nanoimmunotherapy has emerged as a promising therapeutic option, with potential to modulate immune responses and inhibit tumor progression. This study evaluated the clinical efficacy of OncoTherad (MRB-CFI-1) nanoimmunotherapy in patients with BCG-unresponsive NMIBC and investigated correlations between therapeutic outcomes and histopathological and molecular findings. In this retrospective cross-sectional study, 20 patients with BCG-unresponsive NMIBC were treated with OncoTherad (MRB-CFI-1) across two clinical centers. Bladder tissue samples were collected before and after treatment, and immunohistochemical analyses were performed to assess the expression of SERBP1, HABP4, CD44, and Ki-67. Primary endpoints included pathological complete response (pCR), recurrence-free survival (RFS), and duration of response (DoR), which were analyzed in relation to immunohistochemical biomarker findings. Our results demonstrated that high Ki-67 proliferative index and elevated immunoreactivity for CD44 and SERBP1 were associated with shorter RFS. Treatment with OncoTherad (MRB-CFI-1) significantly reduced (p < 0.05) the immunoreactivity of SERBP1 and CD44, which was accompanied by a marked decrease in Ki-67 proliferative index, indicating effective suppression of tumor activity. Conversely, a significant increase (p < 0.05) in HABP4 immunoreactivity was observed, suggesting a protective role against NMIBC recurrence and progression. A pCR was achieved in 65 % of patients, with a median RFS of 21.1 months and a median DoR of 15.7 months, underscoring the clinical efficacy of OncoTherad (MRB-CFI-1). These findings suggest that OncoTherad (MRB-CFI-1) nanoimmunotherapy offers a novel and effective treatment strategy for patients with BCG-unresponsive NMIBC, providing a promising alternative to radical cystectomy and significantly improving patient outcomes.</p>","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":"93 ","pages":"102783"},"PeriodicalIF":2.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143410953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The bioactive compound of traditional herbal ointment accelerates wound closure, epithelialization, and angiogenesis in patients with second-degree burn wound: A randomized clinical trial.","authors":"Mahdi Heydari, Hajir Mehrbani, Seyyed Mohsen Seyyedkazemi, Auob Rustamzadeh, Mohammad Taghi Joghataei, Nader Sadigh, Enam Alhagh Charkhat Gorgich, Hamidreza Alizadeh-Otaghvar","doi":"10.1016/j.tice.2025.102787","DOIUrl":"10.1016/j.tice.2025.102787","url":null,"abstract":"<p><strong>Introduction: </strong>This study endeavors to draw a comparative analysis between a traditional herbal ointment, specifically Swalin, and silver sulfadiazine ointment in the context of repairing deep second-degree burns.</p><p><strong>Methods: </strong>A randomized clinical trial was conducted at the Iran University of Medical Sciences. In this investigation, a cohort comprising eighty-two patients was stratified into two groups, namely Swalin (n = 41) and Silver sulfadiazine (SSD) (n = 41). Over 28 days, ointment applications were administered twice daily. The quantification of ointment compounds was conducted employing Gas Chromatography-Mass Spectrometry (GC-MS). The study encompassed a comprehensive assessment involving clinical examination, quantitative and qualitative histopathological evaluations, pain level determination, and scrutiny of wound closure. Statistical analyses, encompassing chi-square and Mann-Whitney U tests, were performed using SPSS software.</p><p><strong>Results: </strong>Our investigation revealed that the predominant compounds in the ointment were linoleic acid (41.37 %) and elaidic acid (37.45 %). On the 28th day, the Swalin group demonstrated a significantly higher rate of wound closure (81.52 ± 7.76) compared to the SSD group (69.91 ± 2.48) (p < 0.001). Furthermore, a statistically significant distinction was observed between the two groups concerning the degree of epithelialization (P = 0.048). Fibroblast density exhibited a notable discrepancy between the groups (P = 0.02). In terms of angiogenesis and collagen deposition, the Swalin group displayed a significant contrast with the SSD group (P = 0.008 and P = 0.007, respectively), while no statistical distinction was discerned in the number of immune cells (P > 0.05). Histological examination of SSD illustrated a pronounced infiltration of inflammatory cells in the dermis, predominantly lymphocytes. Conversely, the Swalin group exhibited well-formed dermal layers, minimal infiltration, and a profusion of vessels.</p><p><strong>Conclusion: </strong>In conclusion, the findings of this study highlight the potential therapeutic benefits of Swalin ointment, attributed to its rich composition of fatty acids, particularly linoleic acid, and the presence of vitamins C and E.</p>","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":"93 ","pages":"102787"},"PeriodicalIF":2.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fish and bovine collagen promote higher migration and adhesion of dermal cells pre-treated with wound-healing herbal extracts.","authors":"Marwa Rejeb, Aida Lahmar, Mohamed Bayrem Ghedira, Arem Selmi, Tahsine Kosksi, Nawres Debbabi, Leila Chekir Ghedira","doi":"10.1016/j.tice.2025.102762","DOIUrl":"10.1016/j.tice.2025.102762","url":null,"abstract":"<p><strong>Purpose: </strong>Dermal cells fabricate and interact with the extracellular matrix to preserve structural integrity and further healthy function during wound healing. Collagen is a critical component of the matrix, challenging collagen's stability during wound injury. Natural sources especially plant extracts can promote wound healing and interact with collagen to increase its action. In this context, we studied the effect of extracted fish and bovine collagen in controlling cell proliferation, migration, and adhesion in dermal cells pretreated with plant extract.</p><p><strong>Methods: </strong>An acid-solubilization procedure was used to extract collagen fish (CF) and bovine (CB). Three different hydro-ethanolic extracts were prepared Pistacia lentiscus leaves (PL), Calendula officinalis leaves (FL), and flowers (FS). Migration potency was determined using scratch assay. The covered surface area was estimated after 16 hours and 24 hours after cell seeding. The chemotaxis was determined by the Boyden chamber, and the film was coated with CF or CB (10 µg/mL). or poly-L-lysine (50 µg/mL).</p><p><strong>Findings: </strong>We show that CF and CB increase adherence and migration of 3T3-L1 cells, which are pretreated with PL, FL, and FS. In addition, we highlighted a significantly higher cell adhesion on the CF matrix compared to CB. However, in the case of cells pre-treated with PL, the attachment to CF and CB increased significantly compared to untreated cells. The exposition of Hacat cells to plant extracts regulates the secretion of MMP2 and MMP and the production of reactive oxygen species.</p><p><strong>Conclusion: </strong>CF and CB promote higher migration and adhesion of dermal cells pre-treated with wound-healing herbal extracts. In future studies, composite dressings based on collagen, P. lentiscus, and C. officinalis extracts can potentially be developed for tissue regeneration.</p>","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":"93 ","pages":"102762"},"PeriodicalIF":2.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143371221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of mRNA technology in neuronal protection of human mature brain-derived neurotrophic factor.","authors":"Liang Wang, Fengjuan Su, Heng Huang, Qiuhong Jiang, Haifang Kong, Zhong Pei","doi":"10.1016/j.tice.2025.102788","DOIUrl":"10.1016/j.tice.2025.102788","url":null,"abstract":"<p><strong>Background: </strong>Although human mature brain-derived neurotrophic factor (hmBDNF) offers potential neuronal protection, its clinical translation remains challenging. Messenger RNA (mRNA) technology is promising in selectively upregulating protein cleavage products. This proof-of-concept study aims to evaluate the neuronal protective effects of hmBDNF mRNA in vitro.</p><p><strong>Methods: </strong>We optimized and synthesized hmBDNF mRNA and conducted dose-response and time-response analyses in SH-SY5Y cells. mRNA expression was assessed via qPCR, while protein expression was evaluated through immunostaining and ELISA. Cell survival rate was measured using cell counting kit-8. We examined cell survival rates in both differentiated and non-differentiated SH-SY5Y cells exposed to H2O2 or serum deprivation following hmBDNF mRNA incubation. Additionally, we assessed the expression of synapse-relevant genes (MAP2, synaptophysin) and the mBDNF receptor (TrkB) in both cell types.</p><p><strong>Results: </strong>The optimized hmBDNF mRNA effectively upregulated hmBDNF expression in SH-SY5Y cells with minimal impact on endogenous proBDNF expression. Dose-response and time-response analyses identified the optimal dose and time point for maximum hmBDNF expression. hmBDNF mRNA significantly increased cell survival in differentiated SH-SY5Y cells expressing MAP2, synaptophysin and TrkB after exposure to oxidative stress or serum deprivation. However, hmBDNF mRNA did not enhance cell survival in non-differentiated SH-SY5Y cells.</p><p><strong>Conclusion: </strong>The optimized hmBDNF mRNA demonstrated a capacity for neuronal protection in vitro. Further in-vivo studies are required to assess its potential for clinical translation.</p>","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":"93 ","pages":"102788"},"PeriodicalIF":2.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exosome-derived Uc.339 as a potential biomarker for bone metastasis from pulmonary adenocarcinoma.","authors":"Weiqiang Lai, Jinchang Huang, Xuwang Lai, Yuli Wang","doi":"10.1016/j.tice.2025.102747","DOIUrl":"10.1016/j.tice.2025.102747","url":null,"abstract":"<p><p>This study explored the role of Uc.339, which is a highly expressed genomic sequence in tumor cell-derived exosomes, in mediating bone metastasis from lung adenocarcinoma. By integrating clinical samples, in vitro experiments, and in vivo murine models, we elucidated the molecular mechanisms underlying this process. Clinical blood samples from patients with lung adenocarcinoma revealed elevated Uc.339 expression in exosomes, particularly in those with bone metastasis. In vitro experiments using A549 cell-derived exosomes demonstrated an increase in osteoclast formation, implicating Uc.339 in bone microenvironment modulation. Mechanistically, Uc.339 functions as a decoy for miR-339-3p, disrupting the gene expression balance. In vivo experiments in a murine model confirmed disrupted bone microstructure in the presence of elevated Uc.339, alongside altered expression of key regulators, including SQSTM1, RANKL, nuclear factor kappa B, and miR-339-3p. Our findings underscore the systemic impact of Uc.339 in exosomes, suggesting its potential as both a biomarker and a mediator of bone metastasis. Moreover, the identified molecular alterations provide potential therapeutic targets for managing bone metastasis in patients with lung adenocarcinoma. This study contributes to a deeper understanding of the complex interplay between cancer cells and the bone microenvironment, paving the way for targeted interventions and improved clinical outcomes.</p>","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":"93 ","pages":"102747"},"PeriodicalIF":2.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ghrelin alleviates inflammation and pyroptosis by inhibiting TNF-α /caspase-8/caspase-3/ GSDME signalling pathways in an in vitro model of high glucose induced liver injury.","authors":"Jingwen Gao, Xinrui Wang, Shengying Ye, Yixin Zhang, Yan Qin","doi":"10.1016/j.tice.2024.102672","DOIUrl":"10.1016/j.tice.2024.102672","url":null,"abstract":"<p><p>Diabetic liver injury (DLI) refers to liver injury resulting from prolonged chronic hyperglycemia and represents a significant complication associated with diabetes, The specific pathogenic mechanism of DLI remains incompletely understood. Tumor necrosis factor α (TNF-α) has been demonstrated to play a crucial role in diabetic complications through intricate signalling pathways, including pyroptosis. However, it remains uncertain whether TNF-α mediates pyroptosis in DLI, we initially established an in vitro model of DLI and confirmed the presence of an inflammatory state characterized by TNF-α in DLI. Furthermore, evidence of gasdermin E (GSDME)-mediated pyroptosis and the activation of cysteinyl aspartate specific proteinase (caspase)-8 was observed in AML-12 cell exposed to high glucose concentrations. We subsequently demonstrated that TNF-α can trigger caspase-8 activation, leading to GSDME-mediated cellular pyroptosis. Furthermore, treatment with ghrelin effectively suppressed hepatic cell pyroptosis induced by high glucose concentrations and provided protection against liver injury. Therefore, we propose that the TNF-α/caspase-8/caspase-3/GSDME pathway represents a novel mechanism underlying pyrodeath in DLI cells and to explore the protective role and molecular mechanisms underlying the effects of ghrelin on DLI by this special pathway, These findings may present potential therapeutic implications for the management of DLI.</p>","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":"93 ","pages":"102672"},"PeriodicalIF":2.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142898180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"PDE4B abrogation extenuates angiotensin II-induced endothelial dysfunction related to hypertension through up-regulation of AMPK/Sirt1/Nrf2/ARE signaling\" [Tissue Cell 91 (2024) 102637].","authors":"Yong Chen, Suipeng Li, Xuqing Hou, Yinfeng Jia","doi":"10.1016/j.tice.2025.102738","DOIUrl":"10.1016/j.tice.2025.102738","url":null,"abstract":"","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":" ","pages":"102738"},"PeriodicalIF":2.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}