Tissue & cell最新文献

{"title":"Amuc_1100 suppresses T cell viability and CXCL12‑induced T cell migration through GLI2 upregulation.","authors":"Xiaoou Ren, Yao Liu, Youjia Du, Jinbo Yang, Xiao Yang, Francis Lin, Ke Yang, Shoudong Ye","doi":"10.1016/j.tice.2026.104123","DOIUrl":"https://doi.org/10.1016/j.tice.2026.104123","url":null,"abstract":"<p><p>Maintaining intestinal homeostasis requires precise regulation of intestinal T cell trafficking. Dysregulated T cell activity is a key driver of chronic inflammation, as seen in inflammatory bowel disease. The gut commensal Akkermansia muciniphila and its membrane-associated protein Amuc_1100 exhibit anti‑inflammatory effects and are negatively correlated with disease severity. However, their direct mechanistic impact on T cell activity remains undefined. This study reveals that Amuc_1100 modulates human T cell function by activating TLR2, which upregulates the transcription factor GLI2. Mechanistically, GLI2 upregulation leads to downregulation of CD25 and CXCR4, ultimately suppressing T cell viability and CXCL12-induced T cell migration. To comprehensively characterize the impact of Amuc_1100 on T cell migration, we employed a D⁴-Chip featuring four parallel units for high‑throughput, real‑time analysis. Its confined cell-isolation structure positions individual T cells under tissue‑like physical constraints, enabling observation of their migration within a stable CXCL12 gradient and providing a physiologically relevant model for quantifying single‑cell migratory behavior. D⁴-Chip analysis demonstrated that Amuc_1100 broadly impairs T cell migration, as evidenced by significant reductions in the number of migrating cells, their average displacement towards gradient, average accumulated migration distance, and average migration velocity, coupled with an increased frequency of migration pauses compared to the control. GLI2 inhibition reversed these effects, confirming that Amuc_1100 modulates GLI2 to suppress T cell migration. Collectively, this work identifies GLI2 as a novel therapeutic target for modulating T cell homing in intestinal inflammation and establishes a microfluidic platform for discovering potential drugs targeting dysregulated T cell responses.</p>","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":"105 ","pages":"104123"},"PeriodicalIF":3.1,"publicationDate":"2026-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149371448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to 'Cell therapy for kidney diseases' [Tissue Cell, 104 (2027) 103769].","authors":"Qibin Huang, Shiqi Wen, Mingying Zhang, Chengqing Song, Guanyuan Tian, Kefei Wu, Qinghua Liu","doi":"10.1016/j.tice.2026.103849","DOIUrl":"10.1016/j.tice.2026.103849","url":null,"abstract":"","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":" ","pages":"103849"},"PeriodicalIF":3.1,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148707721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to \"The role of macrophage-myofibroblast transition in the pathogenesis of multi-organ fibrosis\" [Tissue Cell 103 (2026) 103702].","authors":"Congcong Guo, Ran Cao, Lin Liao, Junyu Zhao, Tianzuo Wang, Junhan Li, Yue Zhang, Haotian Li","doi":"10.1016/j.tice.2026.103824","DOIUrl":"10.1016/j.tice.2026.103824","url":null,"abstract":"","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":" ","pages":"103824"},"PeriodicalIF":3.1,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148798139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction notice to \"Asiatic acid reverses cisplatin resistance in A549/DDP cells by activating the P38 MAPK/slug pathway\" [Tissue Cell 98 (2026) 103145].","authors":"Min Yu, Qian Zhang, Wenli Shang, Shenghong Wei, Hongxia Wen, Shufen Huo, Xiang Li, Xuan Li, Heng Zhang, Yingxuan Tian","doi":"10.1016/j.tice.2026.103835","DOIUrl":"10.1016/j.tice.2026.103835","url":null,"abstract":"","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":" ","pages":"103835"},"PeriodicalIF":3.1,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148762205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Echinatin inhibits the growth and metastasis of human hepatocellular carcinoma cells through p38 and JNK signaling pathways\" [Tissue Cell 95 (2025) 102907].","authors":"Jiayu Wang, Ziyun Li, Xueqian Han, Zhou Xie, Yajun Hou, Miao Liu, Yuhang Cheng, Qiuping Lu, Jinyong Luo, Hongbo Wang","doi":"10.1016/j.tice.2026.103804","DOIUrl":"10.1016/j.tice.2026.103804","url":null,"abstract":"","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":" ","pages":"103804"},"PeriodicalIF":3.1,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148580177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CD38-driven NAD⁺ depletion governs crypt structure and barrier dysfunction in fluorouracil-induced colonic mucositis: From metabolic collapse to architectural remodeling.","authors":"Elsayed A Elmorsy, Rabab S Hamad, Mohammed Alorini, Attia M Gabr, Hamad Alsaykhan, Mostafa M Khodeir, Mohamed F Hindawy, Abdulaziz A Alsalloom, Eman Mohamad El Nashar, Ahmed G Hamad, Haytham Ali, Mohammed Ashraf Ali, Abdel-Moneim Hafez Abdel-Moneim, Maha M Amer, Mohamed R Abdel-Hamed, Mohamed El-Sayed, Sameh Saber","doi":"10.1016/j.tice.2026.103739","DOIUrl":"10.1016/j.tice.2026.103739","url":null,"abstract":"<p><p>5-fluorouracil (5-FU)-induced colonic mucositis is characterized by epithelial injury, crypt architectural disruption, inflammatory infiltration, oxidative stress, and loss of barrier integrity. The metabolic determinants that regulate epithelial resilience and architectural recovery remain incompletely defined, although 5-FU exposure reproducibly induces these structural lesions. Nicotinamide adenine dinucleotide (NAD⁺) supports epithelial energy balance and redox homeostasis, while accelerated NAD⁺ consumption may amplify tissue injury during toxic stress. CD38 is a principal NAD⁺ hydrolase; yet, its contribution to mucosal structural injury and barrier failure has not been fully elucidated. Herein, we tested whether pharmacological inhibition of CD38 using the small-molecule CD38 inhibitor 78c preserves colonic tissue architecture in a mouse 5-FU-induced mucositis model. We also evaluated the requirement for NAD⁺ biosynthesis. 5-FU produced prominent histopathological injury marked by epithelial damage/apoptosis, crypt disorganization, inflammatory-cell infiltration, oxidative-injury, and disrupted tight junctions with barrier dysfunction. CD38 inhibition mitigated these abnormalities to preserve crypt-architecture and epithelial continuity. As a result, inflammatory infiltration, oxidative stress, and apoptotic signaling were attenuated, with concurrent restoration of tight junction integrity and intestinal barrier function. Protection was associated with significant improvement in colonic NAD⁺ levels and the NAD⁺/NADH balance, increased SIRT1 activity, reduced PARP activation, and activation of Nrf2-linked stress response. Markedly, inhibition of NAD⁺ biosynthesis with a NAMPT inhibitor abrogated the structural and barrier-protective effects of CD38 inhibition across histological, biochemical, and molecular readouts, indicating dependence on NAD⁺ availability. These findings identify the CD38-NAD⁺ axis as a metabolic regulator of colonic-crypt architecture and epithelial barrier organization during 5-FU-induced mucositis.</p>","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":"103 ","pages":"103739"},"PeriodicalIF":3.1,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148369975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to 'Huangqin decoction improves chemotherapy-induced diarrhea by restoring the intestinal mechanical barrier and Lyn/snail/E-cadherin signaling pathway' [Tissue and Cell, Vol. 104, Part 1, (2027), 103841].","authors":"Botao Wang, Qingqing Liu, Yujie Gao, Yunjing He, Chenglu Yang, Yusu Wang, Siyu Han, Yuke Ren, Ke Nie","doi":"10.1016/j.tice.2026.103862","DOIUrl":"10.1016/j.tice.2026.103862","url":null,"abstract":"","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":" ","pages":"103862"},"PeriodicalIF":3.1,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148765681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological and ultrastructural characterization of the male accessory glands in Moechotypa diphysis (Coleoptera: Cerambycidae).","authors":"Hui-Xin Tan, Xin Tong","doi":"10.1016/j.tice.2026.103744","DOIUrl":"10.1016/j.tice.2026.103744","url":null,"abstract":"<p><p>The male accessory glands (MAGs) in insects play a crucial role in the reproductive system, secreting substances such as seminal fluid, mating plugs, and spermatophores. Across various insects, MAGs exhibit significant differences in number, embryological origin, function, and secretory products, as well as in their morphological and ultrastructural characteristics. Within Cerambycidae, interspecific variations in MAGs are also evident, yet they remain understudied. Moechotypa diphysis (Coleoptera: Cerambycidae: Lamiinae) is a wood-boring pest that damages oak trees and creates ecological risks. In this study, an investigation of the histological and ultrastructural characteristics of the MAGs in M. diphysis was performed using light microscopy and transmission electron microscopy. The results demonstrate that M. diphysis possess two pairs of elongated tubular accessory glands. These glands, whose epithelia are not covered by a cuticular intima, are mesodermal glands (mesadenia) and share a common opening into the vas deferens at their base. Ultrastructurally, although both pairs of glands are composed of a muscular layer, an epithelium, and a lumen, they exhibit distinct characteristics. In one pair of glands, the nuclei are positioned close to the cell base, and the cytoplasm is predominantly occupied by extensive rough endoplasmic reticulum (RER). In the other pair, the epithelial cells contain high abundance of large autolysosomes. Additionally, significant differences were observed in microvilli structure and secretory products between the two pairs of glands. This study provides a comparative morphological and ultrastructural description of accessory glands in a species of Cerambycidae, aiming to reveal the cellular-level adaptations driven by natural selection in the context of reproductive competition.</p>","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":"103 ","pages":"103744"},"PeriodicalIF":3.1,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148369991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to ''Inhibition of proliferation, migration and invasion of RM-1 cells by roemerine: Insights from in vitro and in vivo studies'' [Tissue Cell, vol. 93, April (2025), 102693].","authors":"Juntai Xu, Hongbin Ma","doi":"10.1016/j.tice.2026.103322","DOIUrl":"10.1016/j.tice.2026.103322","url":null,"abstract":"","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":" ","pages":"103322"},"PeriodicalIF":3.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148034817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \" Knockdown of TRPM2 promotes osteogenic differentiation of Human Periodontal Ligament Stem Cells by modulating NF-κB /NLRP3 pathway\", Tissue Cell, 2023, 84: 102184.","authors":"Xiaosong Xiang, YongXin Hu, Zhiqiang Song, Chunlin Wang","doi":"10.1016/j.tice.2026.103661","DOIUrl":"10.1016/j.tice.2026.103661","url":null,"abstract":"","PeriodicalId":23201,"journal":{"name":"Tissue & cell","volume":" ","pages":"103661"},"PeriodicalIF":3.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148158369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}