肺癌中铁下垂和铜下垂之间线粒体自噬介导的串扰机制。

IF 2.5 4区生物学 Q1 ANATOMY & MORPHOLOGY

Tissue & cell Pub Date : 2025-09-18 DOI:10.1016/j.tice.2025.103148

Lang Jiang , Zhijun Shen

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引用次数: 0

摘要

在全球范围内，肺癌在恶性肿瘤中具有极高的发病率和致死率。近年来，对细胞死亡机制的研究为肺癌的治疗提供了新的概念和途径。线粒体自噬作为一种重要的线粒体质量控制机制，与新形式的细胞死亡、铁下垂和铜下垂密切相关，对肺癌的发生、进展、管理和结局至关重要。为了为肺癌的精准治疗提供理论基础和可能的治疗靶点，本文综述了线粒体自噬、铁下沉和铜下沉的分子机制以及这些机制在肺癌中的相互作用。

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Mechanisms of mitochondrial autophagy-mediated crosstalk between ferroptosis and cuproptosis in lung cancer

Globally, lung cancer has an extremely high morbidity and fatality rate among malignant tumors. Studies on the mechanisms of cell death have yielded fresh concepts and treatment approaches for lung cancer in recent years. As a crucial mitochondrial quality control mechanism, mitochondrial autophagy is strongly related to new forms of cell death, ferroptosis and cuproptosis, and it is crucial for the development, progression, management, and outcomes of lung cancer. In order to provide a theoretical foundation and possible therapeutic targets for precision lung cancer treatment, this review provides an overview of the molecular mechanisms of mitochondrial autophagy, ferroptosis, and cuproptosis as well as how these mechanisms of action interact with one another in lung cancer.

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来源期刊

Tissue & cell 医学-解剖学与形态学

CiteScore

3.90

自引率

0.00%

发文量

234

期刊介绍： Tissue and Cell is devoted to original research on the organization of cells, subcellular and extracellular components at all levels, including the grouping and interrelations of cells in tissues and organs. The journal encourages submission of ultrastructural studies that provide novel insights into structure, function and physiology of cells and tissues, in health and disease. Bioengineering and stem cells studies focused on the description of morphological and/or histological data are also welcomed. Studies investigating the effect of compounds and/or substances on structure of cells and tissues are generally outside the scope of this journal. For consideration, studies should contain a clear rationale on the use of (a) given substance(s), have a compelling morphological and structural focus and present novel incremental findings from previous literature.