Toxicology Reports最新文献_第6页

Non-steroidal anti-inflammatory drugs and oxidative stress biomarkers in fish: a meta-analytic review

Toxicology Reports Pub Date : 2025-01-13 DOI: 10.1016/j.toxrep.2025.101910

Luiz Henrique Zaniolo Justi , Juliana Ferreira Silva , Manuela Santos Santana , Henrique Aparecido Laureano , Meire Ellen Pereira , Cláudia Sirlene Oliveira , Izonete Cristina Guiloski

{"title":"Non-steroidal anti-inflammatory drugs and oxidative stress biomarkers in fish: a meta-analytic review","authors":"Luiz Henrique Zaniolo Justi , Juliana Ferreira Silva , Manuela Santos Santana , Henrique Aparecido Laureano , Meire Ellen Pereira , Cláudia Sirlene Oliveira , Izonete Cristina Guiloski","doi":"10.1016/j.toxrep.2025.101910","DOIUrl":"10.1016/j.toxrep.2025.101910","url":null,"abstract":"<div><div>Drug residues have been detected in aquatic environments around the world and non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most used classes. Therefore, it is important to verify the physiological effects of these products on exposed non-target organisms such as fish. Through a meta-analytic review, we evaluated the effects of NSAIDs on oxidative stress biomarkers in fish. Overall, Diclofenac was the most frequently tested drug in the systematically selected studies while acute and hydric exposure types were the most prevalent among these studies. The meta-analysis revealed that (1) chronic and subchronic exposures to NSAIDs decreased catalase (CAT) activity, and acute exposure increased glutathione peroxidase (GPx) activity; (2) hydric exposure increased GPx activity; (3) exposure to low concentrations of NSAIDs increased GPx and superoxide dismutase (SOD) activity; (4) Paracetamol exposure increased GPx and SOD activity and lipid peroxidation levels, but reduced glutathione S-transferase (GST) activity; (5) Diclofenac exposure increased GPx activity. In conclusion, our results demonstrated that fish are sensitive to NSAIDs exposure presenting significant alterations in oxidative stress biomarkers, especially in the GPx enzyme. This enzyme exhibits strong potential as a biomarker of NSAIDs exposure in fish. Paracetamol stood out as the NSAID that altered the largest number of oxidative stress biomarkers, drawing attention to its risk to fish. In contrast, ibuprofen did not change the biomarkers evaluated. These data demonstrate the important impact of emerging contaminants such as NSAIDs on aquatic organisms and the need for strategies to mitigate these effects.</div></div>","PeriodicalId":23129,"journal":{"name":"Toxicology Reports","volume":"14 ","pages":"Article 101910"},"PeriodicalIF":0.0,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143103428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human health risks of PAHs in soil and vegetables from Tiga, Kano State, Nigeria

Toxicology Reports Pub Date : 2025-01-13 DOI: 10.1016/j.toxrep.2025.101905

Enyojo S. Okwute, Zakari Mohammed, David E. Arthur, Haruna B. Wayar, Joseph C. Akan

{"title":"Human health risks of PAHs in soil and vegetables from Tiga, Kano State, Nigeria","authors":"Enyojo S. Okwute, Zakari Mohammed, David E. Arthur, Haruna B. Wayar, Joseph C. Akan","doi":"10.1016/j.toxrep.2025.101905","DOIUrl":"10.1016/j.toxrep.2025.101905","url":null,"abstract":"<div><div>This study evaluates the concentrations of seventeen polycyclic aromatic hydrocarbons (PAHs) in soil and selected vegetable samples (onions, tomatoes, hot peppers, sweet peppers, and garden eggs) from Tiga agricultural locations in Kano State, Nigeria. Soil samples were collected from ten plots (depth profiles of 0–10 cm, 10–20 cm, and 20–30 cm) and combined at each depth to create composite samples. Additionally, 20 g of each vegetable were collected and divided into fruit, stem, and root components. Standard procedures were used for the extraction and clean-up of PAHs from both soil and vegetable samples, and instrumental analysis was conducted using SHIMADZU GC-MS (GC-17A). PAH levels in soil ranged from 1.20E-02 mg/kg to 3.80E-02 mg/kg, while vegetables showed concentrations from 1.00E-03 mg/kg to 8.90E-02 mg/kg. The 0–10 cm soil samples displayed higher PAH concentrations among all the depths studied, while the vegetables with the highest PAH concentration followed the trend: Onions > Sweet Pepper > Tomatoes > Hot Pepper > Garden Egg. Overall, total PAH concentrations in vegetables exceeded those in soil. Estimated daily PAH doses were below the Tolerable Daily Dose Limit set by FAO, indicating low health risks. Incremental lifetime cancer risk values also fell below US EPA acceptable levels (10E-06), suggesting negligible cancer risk while the hazard index was less than 1, implying no appreciable non-cancer health risks. PAH pollution was attributed to both petrogenic and pyrogenic sources. The findings of this study indicate that under the assessed conditions, the five vegetables evaluated from Tiga pose no significant risk and are considered safe for consumption.</div></div>","PeriodicalId":23129,"journal":{"name":"Toxicology Reports","volume":"14 ","pages":"Article 101905"},"PeriodicalIF":0.0,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11787604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent developments on ursolic acid and its potential biological applications

Toxicology Reports Pub Date : 2025-01-10 DOI: 10.1016/j.toxrep.2025.101900

R. Arulnangai , H. Asia Thabassoom , H. Vajiha Banu , K. Thirugnanasambandham , R. Ganesamoorthy

引用次数: 0

Corrigendum to “Saccharum officinarum molasses adversely alters reproductive functions in male Wistar rats” [Toxicol. Rep. 7 (2020) 345–352]

Toxicology Reports Pub Date : 2025-01-10 DOI: 10.1016/j.toxrep.2025.101893

Eunice Ogunwole , Olufadekemi T. Kunle-Alabi , Opeyemi O. Akindele , Yinusa Raji

引用次数: 0

Repurposing brucine as a chemopreventive agent in mammary gland carcinoma: Regulating lactate transport through MCT-4

Toxicology Reports Pub Date : 2025-01-10 DOI: 10.1016/j.toxrep.2025.101902

Asma Khatoon Zaidi , Anurag Kumar , Rohit Kumar , Jyoti Singh , Sneha Yadav , Archana Bharti Sonkar , Dharmendra Kumar , Neeraj Kumar Shrivastava , Mohd Nazam Ansari , Abdulaziz S. Saeedan , Gaurav Kaithwas

{"title":"Repurposing brucine as a chemopreventive agent in mammary gland carcinoma: Regulating lactate transport through MCT-4","authors":"Asma Khatoon Zaidi , Anurag Kumar , Rohit Kumar , Jyoti Singh , Sneha Yadav , Archana Bharti Sonkar , Dharmendra Kumar , Neeraj Kumar Shrivastava , Mohd Nazam Ansari , Abdulaziz S. Saeedan , Gaurav Kaithwas","doi":"10.1016/j.toxrep.2025.101902","DOIUrl":"10.1016/j.toxrep.2025.101902","url":null,"abstract":"<div><div>In the present study, we aim to identify a potential drug candidate that targets the Monocarboxylate Transporter-4 (MCT-4) protein. Syrosingopine (SRY) is a well-established inhibitor of lactate transport through MCT-4. We screened 2,11,192 potential leads through ZINC database, which were atleast 50 % structurally similar with SYR. After in-depth analysis, 900 molecules were shortlisted based on Lipinski's rule, optimal molecular weight, binding energy, hydrogen bonding, and ADMET (absorption, distribution, metabolism, excretion, and toxicity) properties that render them viable MCT-4 inhibitors. The outcome underscored Brucine (BRU) as the most promising lead molecule within a cohort of ten potential compounds. BRU is a monoterpenoid indole alkaloid and is used in the regulation of high blood pressure and other comparatively benign cardiac ailments. As such, no reports is available emphasizing the efficacy of BRU on lactate transport or mammary gland carcinoma. BRU demonstrated strong affinity for the MCT-4 transporter's catalytic domain, forming significant hydrophobic and polar interactions with essential amino acids at the binding site. BRU demonstrated significant cytotoxicity and increased the extracellular lactate levels in MCF-7 cells. The findings strongly encouraged BRU's effectiveness, offering promising paths for subsequent investigations.</div></div>","PeriodicalId":23129,"journal":{"name":"Toxicology Reports","volume":"14 ","pages":"Article 101902"},"PeriodicalIF":0.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11787605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vitamin D supplementation: Biochemical and inflammatory effects in non-pathological Wistar rats

Toxicology Reports Pub Date : 2025-01-09 DOI: 10.1016/j.toxrep.2025.101901

Silvia Muller de Moura Sarmento , Elizandra Gomes Schmitt , Laura Smolski dos Santos , Gênifer Erminda Schreiner , Rafael Tamborena Malheiros , Clóvis Klock , Charline Casanova Petry , Itamar Luís Gonçalves , Vanusa Manfredini

{"title":"Vitamin D supplementation: Biochemical and inflammatory effects in non-pathological Wistar rats","authors":"Silvia Muller de Moura Sarmento , Elizandra Gomes Schmitt , Laura Smolski dos Santos , Gênifer Erminda Schreiner , Rafael Tamborena Malheiros , Clóvis Klock , Charline Casanova Petry , Itamar Luís Gonçalves , Vanusa Manfredini","doi":"10.1016/j.toxrep.2025.101901","DOIUrl":"10.1016/j.toxrep.2025.101901","url":null,"abstract":"<div><div>Vitamin D<sub>3</sub> (VD<sub>3</sub>) is shown to be a biochemical and physiological modulator of the body. Debates about route of administration, prescribed dosage and serum levels have arisen, and thus the interaction of VD<sub>3</sub> with the body in overdose. Using an experimental model of Wistar rats of both sexes, rats were subdivided into 5 groups, which represents a control group, and 4 groups with VD<sub>3</sub> treatments (2.500, 7.000, 14.000 and 21.000 IU/kg/week) for one month. Thereafter biochemical, hormonal, inflammatory and histological analyses were performed. Regarding the biochemical findings, there was an increase in the levels of the AST in comparison of the control group with the treatments with higher doses (14.000 IU and 21.000 IU). Furthermore, changes in the inflammatory cytokine profile were identified at doses of 14,000 IU and 21,000 IU, with an increase in inflammatory cytokines (IL-1β, IL-6, IL-8 and TNF-α) and a decrease in the anti-inflammatory IL-10. Histological evaluation of the liver tissue also revealed changes at the highest doses. Finally, in the evaluation of a murine physiological model, it showed that the supplementation of VD<sub>3</sub> in overdoses there was an inflammatory exacerbation in the body, suggesting that the VD<sub>3</sub> supplementation should be administered with caution, and takes into account physiological factors of the individual.</div></div>","PeriodicalId":23129,"journal":{"name":"Toxicology Reports","volume":"14 ","pages":"Article 101901"},"PeriodicalIF":0.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “From prescription to pollution: The ecological consequences of NSAIDs in aquatic ecosystems” [Toxicol. Rep. 13 (2024) 101775]

Toxicology Reports Pub Date : 2025-01-09 DOI: 10.1016/j.toxrep.2025.101892

Vijaya Geetha B, Divya Lakshmi S, Vibha Murali

引用次数: 0

Neuronal effect of 0.3 % DMSO and the synergism between 0.3 % DMSO and loss function of UCH-L1 on Drosophila melanogaster model

Toxicology Reports Pub Date : 2025-01-08 DOI: 10.1016/j.toxrep.2025.101904

Mai Thi Thu Trinh , Truong Huynh Kim Thoa , Dang Thi Phuong Thao

{"title":"Neuronal effect of 0.3 % DMSO and the synergism between 0.3 % DMSO and loss function of UCH-L1 on Drosophila melanogaster model","authors":"Mai Thi Thu Trinh , Truong Huynh Kim Thoa , Dang Thi Phuong Thao","doi":"10.1016/j.toxrep.2025.101904","DOIUrl":"10.1016/j.toxrep.2025.101904","url":null,"abstract":"<div><div>Dimethyl sulfoxide (DMSO) is a polar aprotic solvent which is widely used in biological and medical studies and as a vehicle for pharmacological therapy. DMSO from 0.1 % to 0.5 %, particularly 0.3 % is commonly used as solvent to dissolve compounds when testing their effect on living cell, tissues including nerve cell. However, scientific data on the effects of DMSO on nervous system is limited. Here, we present our data of case study on investigation the effects of DMSO at 0.3 % concentration on nerve cell of <em>Drosophila melanogaster</em> model. We found that 0.3 % DMSO concentration had affected on the active zone and glutamate receptor. Notably, this study also revealed the synergistic effect of 0.3 % DMSO and loss function of dUCH (the homolog of Ubiquitin Carboxyl terminal Hydrolase -L1, UCH-L1 in <em>D. melanogaster</em>). This combination caused more serious abnormalities in synapse structure, particularly number of boutons on Neuromuscular Junction, NMJ. Furthermore, 0.3 % DMSO reduced the amount of ubiquitinylated protein aggregates in the indirect flight muscle of both normal and genectic defect fly model. Taken together, data in this sytudy indicated that 0.3 % DMSO caused the aberrant morphology of the synaptic structure and decreased the number of ubiquitinylated proteins in the indirect flight muscle of <em>Drosophila</em>. The data from the study contributed new evidence of the effects of DMSO on the nervous system. Signigicantly, this study revealed that DMSO affected on neuron cell at low concentration which widely used as pharmacological solvent.</div></div>","PeriodicalId":23129,"journal":{"name":"Toxicology Reports","volume":"14 ","pages":"Article 101904"},"PeriodicalIF":0.0,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimization of HPLC method for metanephrine and normetanephrine detection in urine: Enhancing diagnostic precision for pheochromocytoma

Toxicology Reports Pub Date : 2025-01-08 DOI: 10.1016/j.toxrep.2025.101903

Hafiza Monaza Batool , Madeeha Batool

{"title":"Optimization of HPLC method for metanephrine and normetanephrine detection in urine: Enhancing diagnostic precision for pheochromocytoma","authors":"Hafiza Monaza Batool , Madeeha Batool","doi":"10.1016/j.toxrep.2025.101903","DOIUrl":"10.1016/j.toxrep.2025.101903","url":null,"abstract":"<div><div>Catecholamines and their metabolites play critical physiological roles in the human body. Paragangliomas and pheochromocytomas are rare adrenal tumors that significantly alter catecholamine metabolism, particularly the concentrations of metanephrine (MN) and normetanephrine (NMN). This study presents the development and validation of a rapid and straightforward analytical method using reverse-phase high-performance liquid chromatography (RP-HPLC) coupled with a photodiode array (PDA) detector for quantifying MN and NMN in 24-h urine samples. Sample preparation involved adding 1 mL of urine to a tube containing the internal standard 3-methoxy-4-hydroxy benzylamine hydrochloride (MHBA) and a 2 g/L solution of 2-aminoethyl-diphenylborinate. After vortex mixing and centrifugation, ethyl acetate was used for extraction, and the organic layer was dried under nitrogen at 50–60 °C before reconstitution in the mobile phase. Chromatographic separation was achieved on an RP C-18 column with an isocratic flow of the mobile phase (sodium dihydrogen phosphate, citric acid monohydrate, acetonitrile, and sodium octyl sulfate). Detection was performed at 347 nm, with peak identification based on standard retention times. The method was validated for linearity (10–2000 ng/mL), recovery, sensitivity, precision, accuracy, selectivity, carryover, stability, and dilution effects. It showed a strong correlation coefficient (>0.99) and accuracy within ± 15 %. Inter- and intra-day precision confirmed the method reliability. This validated technique is suitable for clinical and research applications involving catecholamine metabolite screening.</div></div>","PeriodicalId":23129,"journal":{"name":"Toxicology Reports","volume":"14 ","pages":"Article 101903"},"PeriodicalIF":0.0,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anticholinergic syndrome due to mydriatic drops intoxication in a child: A case report

Toxicology Reports Pub Date : 2025-01-07 DOI: 10.1016/j.toxrep.2024.101889

J. Serralabós-Ferré , I. Barceló-Carceller

引用次数: 0