Toxicology Reports最新文献

{"title":"Corrigendum to \"Heated tobacco product aerosol emission compared to cigarette smoke: A scoping review\" [Toxicol. Rep. 16 (2026) 102209].","authors":"Stefano Bellosta, Alberto Corsini, Emanuele Catena","doi":"10.1016/j.toxrep.2026.102217","DOIUrl":"https://doi.org/10.1016/j.toxrep.2026.102217","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1016/j.toxrep.2026.102209.].</p>","PeriodicalId":23129,"journal":{"name":"Toxicology Reports","volume":"16 ","pages":"102217"},"PeriodicalIF":0.0,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13308209/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148346375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"WITHDRAWN: Corrigendum to \"Apoptotic endocrinal toxic effects of perchlorate in human placental cells\" [Toxicol. Rep. 8 (2021) 863-870].","authors":"Mona M Ali, Sarah A Khater, Amel Ahmed Fayed, Dina Sabry, Samah F Ibrahim","doi":"10.1016/j.toxrep.2026.102211","DOIUrl":"https://doi.org/10.1016/j.toxrep.2026.102211","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.1016/j.toxrep.2021.04.002.].</p>","PeriodicalId":23129,"journal":{"name":"Toxicology Reports","volume":"16 ","pages":"102211"},"PeriodicalIF":0.0,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13334993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148438146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"<i>In vitro</i> and <i>in vivo</i> toxicological evaluation of 6'-Sialyllactose sodium salt produced by a novel method\" [Toxicol. Rep., Volume 15 (2025) 102101].","authors":"Rit B Gurung, Laurie C Dolan, Benjamin G Arceneaux, Hiroe Go, Eun Jung Park","doi":"10.1016/j.toxrep.2026.102201","DOIUrl":"https://doi.org/10.1016/j.toxrep.2026.102201","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1016/j.toxrep.2025.102101.].</p>","PeriodicalId":23129,"journal":{"name":"Toxicology Reports","volume":"16 ","pages":"102201"},"PeriodicalIF":0.0,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13308213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148346334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to a commentary \"Comment on \"Collateral damage: Cardiovascular and respiratory implications of tear gas deployment during peaceful protest\": Caution in interpreting the reported associations\".","authors":"Konstantine Chakhunashvili, Davit G Chakhunashvili","doi":"10.1016/j.toxrep.2025.102198","DOIUrl":"10.1016/j.toxrep.2025.102198","url":null,"abstract":"","PeriodicalId":23129,"journal":{"name":"Toxicology Reports","volume":"16 ","pages":"102198"},"PeriodicalIF":0.0,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13308215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148346392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serious concerns about \"Steroid hormone in fish, caution for present and future: A review\", by Purba Islam et al., Toxicology Report 13 (2024) 101733\".","authors":"Constantinos C Mylonas","doi":"10.1016/j.toxrep.2025.102196","DOIUrl":"https://doi.org/10.1016/j.toxrep.2025.102196","url":null,"abstract":"","PeriodicalId":23129,"journal":{"name":"Toxicology Reports","volume":"16 ","pages":"102196"},"PeriodicalIF":0.0,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13308212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148346367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Collateral damage: Cardiovascular and respiratory implications of tear gas deployment during peaceful protest\": Caution in interpreting the reported associations.","authors":"George Kandelaki","doi":"10.1016/j.toxrep.2025.102188","DOIUrl":"https://doi.org/10.1016/j.toxrep.2025.102188","url":null,"abstract":"","PeriodicalId":23129,"journal":{"name":"Toxicology Reports","volume":"16 ","pages":"102188"},"PeriodicalIF":0.0,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13308224/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148346390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the effects of dimethyl fumarate on transforming growth factor beta levels in the liver of rats with bile duct ligation-induced cholestasis","authors":"Hannaneh Vossoughi ,&nbsp;Pejman Mortazavi ,&nbsp;Mahsa Ale-Ebrahim ,&nbsp;Razieh Hosseini","doi":"10.1016/j.toxrep.2025.102115","DOIUrl":"10.1016/j.toxrep.2025.102115","url":null,"abstract":"<div><h3>Background</h3><div>Cholestasis is a reduction or cessation of bile flow in the biliary system, which can be life-threatening. Dimethyl Fumarate could induce anti-inflammatory and antioxidant effects in the body.</div></div><div><h3>Objective</h3><div>This investigation focused on assessing the impact of Dimethyl Fumarate on liver levels of transforming growth factor beta (TGF-β) to mitigate biochemical, histopathological, and immunohistochemical alterations in cholestasis-induced rat models.</div></div><div><h3>Methods</h3><div>Forty male adult Wistar rats were divided into eight groups (healthy control treated with distilled water, healthy rats treated with 50, 100, and 200 mg/kg of Dimethyl Fumarate, bile duct ligation (BDL), and experiment BDL groups were treated with 50, 100, and 200 mg/kg of Dimethyl Fumarate). After the gavage treatment period of 45 days, the rats were anesthetized and underwent blood sampling. Liver damage was assessed by measuring hepatic marker enzymes (alanine transaminase, aspartate transaminase, alkaline phosphatase, gamma-glutamyl transferase, and total bilirubin), histopathological (lesion assessment), and immunohistochemical (TGF-β expression level) observation.</div></div><div><h3>Results</h3><div>The findings demonstrated that administration of varying doses of Dimethyl Fumarate via gavage led to a statistically significant reduction in serum concentrations of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, gamma-glutamyl transferase, and total bilirubin (<em>P</em> &lt; 0.05). The optimal dosage identified was 200 mg/kg of Dimethyl Fumarate. Furthermore, the data indicated that gavage treatment with Dimethyl Fumarate significantly attenuated TGF-β expression level and mitigated hepatic damage (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>This strategy may reduce inflammation, cholestasis, and fibrosis outcomes, attributed to its anti-inflammatory and antioxidant properties. Nonetheless, further research is necessary to substantiate these findings.</div></div>","PeriodicalId":23129,"journal":{"name":"Toxicology Reports","volume":"15 ","pages":"Article 102115"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144889040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toxic metals and bioelements: Combined oxidative stress effects on liver injury and thyroid hormone disruption in subjects from different areas of Erbil province","authors":"Mahdi Yassin Ahmed,&nbsp;Kamaran Abdoulrahman","doi":"10.1016/j.toxrep.2025.102078","DOIUrl":"10.1016/j.toxrep.2025.102078","url":null,"abstract":"<div><div>In Iraq, particularly in Erbil city and Gwer road are deemed environmentally disadvantaged because of industrial pollutants and refinery activities. This study conducted 143 subjects from rural, urban, and industrial areas. The sera of subjects were taken for the analysis. The toxic metals and bioelements were assessed using ICP-MS, the oxidative stress parameters were determined via ELISA. For estimation of liver test biomarkers Kenza was used, and thyroid hormones were measured by Cobas. While their relationships were statistically analyzed. The results indicated that metals concentrations were markedly significantly increased in industrial areas, particularly for Fe 599.1 (723.9) μg/L and Mn 7.534 ± 8.793 μg/L. The median level of Cu 4082 (2824) μg/L in urban subjects is significantly lower than those of other areas. Markers for oxidative stress revealed considerably higher MDA in urban participants 1917 (1085) pg/mL, while SOD and CP exhibited significantly lower level in urban and industrial participants P-value (0.0001 and &lt;0.0001) respectively. The liver tests revealed elevated ALT in urban and industrial participants, 29.06 ± 1.723 IU/L and 21.94 ± 1.162 IU/L, respectively. The ALP levels were significantly elevated in industrial participants (P-value &lt;0.0001). The study found that industrial workers had significantly higher levels of TSH 2.209 ± 0.1032 μIU/L and low levels of T3 1.765 ± 0.0227 nmol/l compared to the rural individuals. Fe had positive correlations with ONOO^-. and TSH (r = 0.2221, r = 0.2452). Furthermore, Cu showed positively correlated with Cp (r = 0.2967; p = 0.0068), AST (r = 0.2417; p = 0.0268) and ALB (r = 0.2187; p = 0.0457). This study shows that increased levels of hazardous metals and bioelements in industrial and urban areas cause oxidative stress, which has a significant impact on public health and causes a number of health problems, including liver injury and thyroid dysfunction.</div></div>","PeriodicalId":23129,"journal":{"name":"Toxicology Reports","volume":"15 ","pages":"Article 102078"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144489873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health impacts and risk assessment of PM2.5 and PM10 at Suburban Site in Pathum Thani, Thailand","authors":"Dussadee Rattanaphra ,&nbsp;Sittinun Tawkaew ,&nbsp;Wilasinee Kingkam ,&nbsp;Sasikarn Nuchdang ,&nbsp;Kittiwan Kitpakornsanti ,&nbsp;Unchalee Suwanmanee","doi":"10.1016/j.toxrep.2025.102109","DOIUrl":"10.1016/j.toxrep.2025.102109","url":null,"abstract":"<div><div>The aim of this study was to evaluate the carcinogenic and non-carcinogenic health risks associated with heavy metals in PM₂.₅ and PM₁₀ through inhalation exposure among children and adults during both the summer and wet seasons in the Pathum Thani Province, Thailand. PM2.5 and PM10 samples were collected using a Tisch TE-Wilbur sampler, and elemental concentrations were analyzed using Proton-Induced X-Ray Emission (PIXE). Microsoft Excel was employed to determine the statistical values of PM₂.₅ and PM₁₀ concentrations, the concentrations of twelve elements, including Si, S, Cl, K, Ca, Ti, Cr, Mn, Fe, Zn, Ni, and Cu. The enrichment factor (EF), as well as health risk assessment indicators, including target hazard quotient (THQ), hazard index (HI), and carcinogenic risk (CR), were evaluated. The results showed that EF values for Zn, Ni, and Cu ranged from 10 to 100, indicating contributions from anthropogenic sources. Cr exhibited the highest EF values, ranging from 51 to 111, suggesting significant influence from industrial activities and traffic emissions. The mean PM₁₀ concentration (86.0504 µg/m³) during the wet season exceeded the WHO and EU standards but remained below the Thailand standard and the U.S. EPA limit. In contrast, the mean PM₂.₅ concentration (77.5143 µg/m³) during the same period exceeded all referenced standards. The calculated HI values were from 0.0459 to 0.1090 for adults and 0.3285–0.7811 for children. The CR values in PM₂.₅ ranged from 5.0884 × 10⁻⁸ to 7.9544 × 10⁻⁶ for adults and from 5.9364 × 10⁻⁸ to 9.2802 × 10⁻⁶ for children. For PM₁₀, the CR values ranged from 5.1865 × 10⁻⁸ to 1.0412 × 10⁻⁵ for adults and from 6.0509 × 10⁻⁸ to 1.2148 × 10⁻⁵ for children. Although both carcinogenic and non-carcinogenic risks were within acceptable limits, higher risk values were observed in children compared to adults. Therefore, targeted and effective air pollution control policies are recommended, with a particular emphasis on protecting children’s health and strengthening evidence-based air quality management strategies.</div></div>","PeriodicalId":23129,"journal":{"name":"Toxicology Reports","volume":"15 ","pages":"Article 102109"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144810509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vivo genotoxicity of Chios mastic gum in rodent bone marrow micronucleus test","authors":"Eirini-Christina Psarou ,&nbsp;Aikaterini Termentzi ,&nbsp;Katerina Kyriakopoulou ,&nbsp;Pelagia Anastasiadou ,&nbsp;Marios Meidanis ,&nbsp;Nikolas Fokialakis ,&nbsp;Kyriaki Machera","doi":"10.1016/j.toxrep.2025.102155","DOIUrl":"10.1016/j.toxrep.2025.102155","url":null,"abstract":"<div><div>Chios mastic gum (CMG) exhibits several pharmacological activities that have been confirmed by numerous studies. These include antibacterial, anti-inflammatory, hypolipidemic, hypoglycemic, antiatheromatic, and benefits for against gastrointestinal disorders. However, studies focusing on CMG’s safety are limited. The aim of the present study is to evaluate the genotoxicity of CMG using the limit test on the mammalian erythrocyte micronucleus assay, in male Wistar rats. CMG was administered by gavage to 5 rats at 2000 mg/kg bw for 3 days, while 5 rats received the vehicle and 5 rats received cyclophosphamide (positive control). Satellite groups of 3 rats were included for the negative control and CMG-treated groups to collect plasma and bone marrow for the chemical analyses. All rats were observed for mortality and clinical signs of toxicity during the dosing period. Rats were euthanatized 20 h after the last treatment, necropsied, and bone marrow was collected for smear preparation. No mortality, clinical signs of toxicity, gross organ pathology, or body weight changes were observed in CMG-treated rats compared to the negative control group. No statistically significant alteration of polychromatic erythrocytes (PCE) and the per-thousand incidences of micronucleated PCE in the bone marrow of CMG-treated rats were observed. Bone marrow exposure to CMG was unambiguously confirmed by the detection of the characteristic CMG triterpenic acids in both bone marrow extract and plasma of CMG-treated rats by UHPLC-HRMS/MS analysis. In conclusion, CMG exhibited no genotoxic effects on bone marrow erythrocytes at the tested limit dose of 2000mg/kg body weight.</div></div>","PeriodicalId":23129,"journal":{"name":"Toxicology Reports","volume":"15 ","pages":"Article 102155"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145465868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}