Toxicology Reports最新文献_第6页

Patulin induced neuronal cell damage in human neuroblastoma SH-SY5Y cells 展霉素诱导人神经母细胞瘤SH-SY5Y细胞的神经细胞损伤

Toxicology Reports Pub Date : 2025-01-23 DOI: 10.1016/j.toxrep.2024.101886

G.V. Jayashree , P. Rachitha , Vinay B. Raghavendra , Hemanth Kumar Kandikattu

{"title":"Patulin induced neuronal cell damage in human neuroblastoma SH-SY5Y cells","authors":"G.V. Jayashree , P. Rachitha , Vinay B. Raghavendra , Hemanth Kumar Kandikattu","doi":"10.1016/j.toxrep.2024.101886","DOIUrl":"10.1016/j.toxrep.2024.101886","url":null,"abstract":"<div><div>Patulin, a mycotoxin produced by fungal species, is found in fruits and their derivatives. Exposure to it can lead to cognitive deficits and neurodegenerative disorders. Understanding its mechanisms is crucial for assessing risks in food, emphasizing the need for strict food safety regulations to protect public health. In this study SH-SY5Y, a human neuroblastoma cell line was challenged with the mycotoxin patulin. Patulin was treated to the cells for 24 h at 25–2000 nM, concentrations respectively. The results obtained demonstrate the cytotoxicity as assessed by the MTT and LDH leakage assays with an IC50 at a dose of 500 nM. The light microscope images showed a decreased in neurites size with increase in doses of patulin. The patulin treatment showed a decrease in antioxidant enzymes SOD and catalase levels and an increase in ROS and lipid peroxidation levels. Patulin treatment also showed a decrease in mitochondrial membrane potential and mitochondrial damage, with vacuolation of mitochondria visualized by transmission electron microscope. Patulin treatment also showed DNA damage observed by comet assay. The study demonstrates that patulin induces cellular damage, and induces oxidative stress, apoptosis, mitochondrial and DNA damage.</div></div>","PeriodicalId":23129,"journal":{"name":"Toxicology Reports","volume":"14 ","pages":"Article 101886"},"PeriodicalIF":0.0,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143511087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk assessment for non-carcinogenic effect posed by sulfates in water on the health of residents around The Sumpur River, West Sumatra-Indonesia 水中硫酸盐对印度尼西亚西苏门答腊Sumpur河附近居民健康的非致癌影响风险评估

Toxicology Reports Pub Date : 2025-01-22 DOI: 10.1016/j.toxrep.2025.101921

Sukarjo , Rahmah Dewi Yustika , Cicik Oktasari Handayani , Triyani Dewi , Yustiawati , Delvi Yanti , Ai Dariah

{"title":"Risk assessment for non-carcinogenic effect posed by sulfates in water on the health of residents around The Sumpur River, West Sumatra-Indonesia","authors":"Sukarjo , Rahmah Dewi Yustika , Cicik Oktasari Handayani , Triyani Dewi , Yustiawati , Delvi Yanti , Ai Dariah","doi":"10.1016/j.toxrep.2025.101921","DOIUrl":"10.1016/j.toxrep.2025.101921","url":null,"abstract":"<div><div>The extensive agricultural activity contributes to runoff and plays a significant role in elevated sulfate concentrations in many global water bodies. In tropical regions, sulfate pollution and its associated health hazards have intensified, emerging as an international concern. However, these issues are often overlooked despite their potential impact on water and citizen safety. Present study intends to assess the risks posed by sulfate contamination to human health, given its critical implications for water quality in the area. The assessment was conducted through observations in seven water sampling stations established along the Sumpur River and its estuary in Lake Singkarak. The analysis of the collected samples reveals that sulfate concentrations at all locations remain within permissible limits, confirming the water's suitability for consumption. The Sulfate Pollution Index (SPI) values at all sampling locations are below 1, classifying them as unpolluted with respect to sulfate content. Additionally, the Hazard Index (HI) values at all locations were below 1, indicating no significant non-carcinogenic health risks to the public. However, location S5 recorded the highest average HI value, nearing 1 (0.95). One of sampling observations at S5, located near rice fields and settlement areas along the riverbanks, showed a value exceeding 1, which requires attention. Sustainable management of agricultural is crucial for mitigating potential health and dangers sulfate contamination and ensuring the safety of water for consumption in this region. Mitigating sulfate pollution from agriculture and residential areas requires a combination of technology, education, and regulatory enforcement. This approach should actively involve the community to create a healthier and more sustainable environment.</div></div>","PeriodicalId":23129,"journal":{"name":"Toxicology Reports","volume":"14 ","pages":"Article 101921"},"PeriodicalIF":0.0,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143170453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic effects of NAC and CoQ10 on aluminium phosphide poisoning as an adjuvant therapy: A Pilot study NAC和辅酶q10作为辅助治疗对磷化铝中毒的治疗效果：一项初步研究

Toxicology Reports Pub Date : 2025-01-21 DOI: 10.1016/j.toxrep.2025.101907

Maii Farag Henaidy , Maha Ghanem , Shehata Farag Shehata , Amal M. Shouair , Reda R. Mabrouk

{"title":"Therapeutic effects of NAC and CoQ10 on aluminium phosphide poisoning as an adjuvant therapy: A Pilot study","authors":"Maii Farag Henaidy , Maha Ghanem , Shehata Farag Shehata , Amal M. Shouair , Reda R. Mabrouk","doi":"10.1016/j.toxrep.2025.101907","DOIUrl":"10.1016/j.toxrep.2025.101907","url":null,"abstract":"<div><div>In aluminium phosphide (AlP) poisoning, death is mainly due to acute heart failure. There is some evidence showing that N-acetylcysteine (NAC) and coenzyme Q10 have antioxidant and cardioprotective effects. This study investigated a new approach for treating acute AlP poisoning by using NAC and Co-Q10 as adjuvant therapy.</div></div><div><h3>Subjects and methods</h3><div>The study design was a retrospective-prospective study. It was conducted in the poisoning unit of Kafer Eldwar General Hospital. Sixty patients with acute aluminium phosphide poisoning were included. The patients were divided into two groups. The first group (standard protocol) considered the control group received the standard supportive care, and their data were collected from the medical records. The second group (new protocol) in addition to the standard supportive care received the NAC and CoQ10 regimen, and all data were collected in a specially designed sheet.</div></div><div><h3>Results</h3><div>The results showed that the highest percentage of patients in both groups were aged 18–25, followed by those under 18, and females outnumbered the males. The systolic (SBP) and diastolic (DBP) blood pressure showed significant improvement in the new protocol group. A significant statistical difference was found between the two groups regarding mechanical ventilation (p = 0.015), where mechanical ventilation was used in 20 % of patients in the new protocol group and 50 % in the standard group. Regarding the outcome of patients, the survival rate reached 73.3 % upon using the new protocol, compared to 50 % who received the standard protocol.</div></div><div><h3>Conclusion</h3><div>The data imply that further investigation in using the NAC and CoQ10 regimen is warranted. It gave an improvement of the survival rate and decrease the need for mechanical ventilation in AlP</div></div>","PeriodicalId":23129,"journal":{"name":"Toxicology Reports","volume":"14 ","pages":"Article 101907"},"PeriodicalIF":0.0,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143104081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of lead and cadmium exposure through olive and corn oil consumption in Gonbad-Kavus, north of Iran: A public health risk analysis 伊朗北部Gonbad-Kavus地区通过食用橄榄油和玉米油而接触铅和镉的评估：一项公共健康风险分析

Toxicology Reports Pub Date : 2025-01-21 DOI: 10.1016/j.toxrep.2025.101922

Janan Tayeb , Mohammadhosein Movassaghghazani

{"title":"Assessment of lead and cadmium exposure through olive and corn oil consumption in Gonbad-Kavus, north of Iran: A public health risk analysis","authors":"Janan Tayeb , Mohammadhosein Movassaghghazani","doi":"10.1016/j.toxrep.2025.101922","DOIUrl":"10.1016/j.toxrep.2025.101922","url":null,"abstract":"<div><div>Lead and cadmium are common heavy metals in oils. This study assessed their levels in commercial and traditional olive and corn oils from Gonbad-Kavus City using graphite furnace atomic absorption spectrometry after microwave digestion. Hazard Quotient (HQ) and Hazard Index (HI) were calculated. The results from 60 oil samples showed quantifiable levels of lead and cadmium in all samples. Lead concentrations in commercial olive oil, traditional olive oil, commercial corn oil, and traditional corn oil were 13.27 ± 3.37, 17.48 ± 4.82, 19.27 ± 8.12, and 32.40 ± 6.13 μg/kg, respectively. Cadmium concentrations were 4.14 ± 0.53, 3.50 ± 0.72, 4.48 ± 1.80, and 5.77 ± 1.34 µg/kg, respectively. All lead levels were below the 80 µg/kg limit set by the Institute of Standards and Industrial Research of Iran (ISIRI). For a 70 kg person consuming 0.147 g of corn oil and 0.328 g of olive oil daily, the metals pose no risk to health over a lifetime. No health concerns were found for oils except traditional olive oil. Corn oil showed significant lead contamination. HI values for lead and cadmium in oils were below 1, indicating no non-carcinogenic health risk. MOE values for lead in traditional olive oil were below 10,000, while other oils were above, indicating no significant risk to consumers. These findings call for a review of national standards and increased monitoring of heavy metals in vegetable oils in the region.</div></div>","PeriodicalId":23129,"journal":{"name":"Toxicology Reports","volume":"14 ","pages":"Article 101922"},"PeriodicalIF":0.0,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143104143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Sub-chronic toxicity of the active fraction of a modified Huang-Lian-Jie-Du Decoction” [Toxicol. Rep. 13 (2024) 101682] “黄连解毒汤加味有效部位的亚慢性毒性”的勘误[毒理学杂志]。众议员13(2024)101682]。

Toxicology Reports Pub Date : 2025-01-20 DOI: 10.1016/j.toxrep.2025.101916

Lan Wang , Wen Yang , Jia-Qian Zhu , Yan-Feng Huang , Mei Zhong , Steven King Fan Loo , Siu-Po Ip , Yan-Fang Xian , Zhi-Xiu Lin

引用次数: 0

Liver morphometry and histopathology effects in Astyanax lacustris exposed to lambda-cyhalothrin pyrethroid insecticide 氯氟氰菊酯对湖虾肝脏形态及组织病理学的影响

Toxicology Reports Pub Date : 2025-01-20 DOI: 10.1016/j.toxrep.2025.101919

Tiago Venancio da Silva , André Luiz do Nascimento Silva , Karine Nathiele Nogueira Farias , Carla Leticia Gediel Rivero Wendt , Lucas de Oliveira Brasileiro , Edilaine Fogaça , Sabrina Fuzer Gonçalves , Brenda de Oliveira Martins , Maria Eduarda Corona Garcia , Lilian Franco-Belussi , Carlos Eurico S. Fernandes

{"title":"Liver morphometry and histopathology effects in Astyanax lacustris exposed to lambda-cyhalothrin pyrethroid insecticide","authors":"Tiago Venancio da Silva , André Luiz do Nascimento Silva , Karine Nathiele Nogueira Farias , Carla Leticia Gediel Rivero Wendt , Lucas de Oliveira Brasileiro , Edilaine Fogaça , Sabrina Fuzer Gonçalves , Brenda de Oliveira Martins , Maria Eduarda Corona Garcia , Lilian Franco-Belussi , Carlos Eurico S. Fernandes","doi":"10.1016/j.toxrep.2025.101919","DOIUrl":"10.1016/j.toxrep.2025.101919","url":null,"abstract":"<div><div>Lambda-cyhalothrin (LC) is a pyrethroid insecticide employed to manage various arthropods as an alternative to persistent insecticides with minimized toxic effects on birds and mammals. However, LC causes oxidative and neurotoxic damages in fish <em>Danio rerio</em>. Effects of LC in morphology of liver of fishes are scare. We aimed to establish the lethal concentration (LC<sub>50</sub> 96 h) of pyrethroid LC for <em>Astianax lacustris</em>. Then, we compare liver responses of sublethal doses of LC (i.e. 10.30 µg/L) for acute (i.e 1- and 3-days post-exposure - <em>dpe</em>) and chronic (i.e 6 and 12 <em>dpe</em>). We sought to identify pathological changes and compare liver histometric remodeling in fish subjected to acute and chronic toxicity tests. For this, liver histological changes were evaluated using the degree of tissue changes (DTC), followed by histomorphometric techniques determining structural volumetric density, glycogen cell density, and morphometry of hepatic tissue. We observed high hepatocellular injuries in exposed fishes. The main injuries included leukocyte infiltration, hyperemia, and pyknotic nuclei, especially 6 dpe. Hepatic glycogen storage decreases at 6 and 12 <em>dpe</em> showing metabolic damage. Both, density and volume of decreases after LC exposure in all exposure time. However, sinusoidal density increases after LC exposure, suggesting vascular hyperemia. These results show morphophysiological effects of LC at 10.30 µg/L in acute and chronic exposure represented by decreased glycogen storage, structural density, and volume of hepatocytes, in addition to a higher degree of histological changes.</div></div>","PeriodicalId":23129,"journal":{"name":"Toxicology Reports","volume":"14 ","pages":"Article 101919"},"PeriodicalIF":0.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143099194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms of oral ciprofloxacin-induced depressive-like behavior and the potential benefit of lactulose: A correlation analysis 口服环丙沙星诱导抑郁样行为的机制与乳果糖的潜在益处：相关分析

Toxicology Reports Pub Date : 2025-01-20 DOI: 10.1016/j.toxrep.2025.101920

Havizur Rahman , Kusnandar Anggadiredja , Lucy Sasongko

{"title":"Mechanisms of oral ciprofloxacin-induced depressive-like behavior and the potential benefit of lactulose: A correlation analysis","authors":"Havizur Rahman , Kusnandar Anggadiredja , Lucy Sasongko","doi":"10.1016/j.toxrep.2025.101920","DOIUrl":"10.1016/j.toxrep.2025.101920","url":null,"abstract":"<div><div>Prolonged administration of antibiotics may be associated with depression due to the potential risk of dysbiosis. Thus, the restoration of microbial balance, through administration of prebiotics, might overcome the problem. This study investigated the mechanisms of antibiotic-induced depression, which were explored through statistical correlation analysis. The potential benefit of lactulose, a prebiotic, on this behavioral disorder was further assessed. The rats were assigned to groups receiving 102.8 mg/kg ciprofloxacin daily for 1, 8, 15, or 22 days. A different group of rat was given the same regimen for 8 days accompanied with lactulose at 2056 mg/kg. Upon completion of ciprofloxacin administration, the rats were tested for depression-like behavior (forced swimming test, FST; and sucrose preference test, SPT). They were then sacrificed for biochemical assessment in the hippocampus and prefrontal cortex. The mechanism studies revealed significant correlation between SPT vs. serotonin in the hippocampus, and SPT vs. serotonin, cortisol, NF-κB in the prefrontal cortex. Meanwhile, FST was significantly correlated with serotonin in the hippocampus and the prefrontal cortex, while in the prefrontal cortex it was significantly correlated with cortisol, NF-κB, and IL-6. Based on the afore-mentioned results, it was found that lactulose improved FST by targeting serotonin in the hippocampus. This study indicate that ciprofloxacin induce depression-like behavior via modulation of several neurotransmitter system as well as proinflammatory cytokines in the hippocampus and prefrontal cortex. The results further suggest the potential of lactulose to improve this behavior.</div></div>","PeriodicalId":23129,"journal":{"name":"Toxicology Reports","volume":"14 ","pages":"Article 101920"},"PeriodicalIF":0.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143104142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toxicological assessment of citral and geraniol: Efflux pump inhibition in Staphylococcus aureus and invertebrate toxicity 柠檬醛和香叶醇的毒理学评估：外排泵抑制金黄色葡萄球菌和无脊椎动物的毒性

Toxicology Reports Pub Date : 2025-01-19 DOI: 10.1016/j.toxrep.2025.101917

Gildênia Alves de Araújo , Cícera Datiane de Morais Oliveira Tintino , Raimundo Luíz Silva Pereira , Isaac Moura Araújo , Cícera Laura Roque Paulo , João Arthur de Oliveira Borges , Ewerton Yago de Sousa Rodrigues , Ângella Eduarda da Silva , Francisco Assis Bezerra da Cunha , Zildene de Sousa Silveira , Nair Silva Macedo , Henrique Douglas Melo Coutinho , José Maria Barbosa Filho , Daniela Maria do Amaral Ferraz Navarro , Francisco Roberto de Azevedo , Saulo Relison Tintino

{"title":"Toxicological assessment of citral and geraniol: Efflux pump inhibition in Staphylococcus aureus and invertebrate toxicity","authors":"Gildênia Alves de Araújo , Cícera Datiane de Morais Oliveira Tintino , Raimundo Luíz Silva Pereira , Isaac Moura Araújo , Cícera Laura Roque Paulo , João Arthur de Oliveira Borges , Ewerton Yago de Sousa Rodrigues , Ângella Eduarda da Silva , Francisco Assis Bezerra da Cunha , Zildene de Sousa Silveira , Nair Silva Macedo , Henrique Douglas Melo Coutinho , José Maria Barbosa Filho , Daniela Maria do Amaral Ferraz Navarro , Francisco Roberto de Azevedo , Saulo Relison Tintino","doi":"10.1016/j.toxrep.2025.101917","DOIUrl":"10.1016/j.toxrep.2025.101917","url":null,"abstract":"<div><div>This study aimed to evaluate the antibacterial activity against multi-drug-resistant strains carrying efflux pumps and assess their toxicity on <em>Drosophila melanogaster</em> and <em>Aedes aegypti</em> models. Microdilution tests in broth were performed to determine the Minimum Inhibitory Concentration (MIC). The efflux pump inhibition was evaluated by analyzing the reduction in antibiotic MIC and Ethidium Bromide (EtBr) MIC when combined with the products. Mortality assay and negative geotaxis were conducted on <em>D. melanogaster</em> specimens, and insecticidal activity assays were performed on <em>A. aegypti</em> larvae. Only geraniol reduced the antibiotic MIC when combined, reducing from 64 µg/mL to 16 µg/mL in the 1199B strain of <em>S. aureus</em>. When combined with EtBr, both geraniol and citral reduced EtBr MIC, with geraniol decreasing from 64 µg/mL to 16 µg/mL and citral decreasing from 64 µg/mL to 32 µg/mL. Regarding the <em>S. aureus</em> K2068 strain, geraniol reduced the antibiotic MIC from 16 µg/mL to 8 µg/mL, and citral reduced it from 16 µg/mL to 4 µg/mL. In combination with EtBr, all monoterpenes reduced MIC from 64 µg/mL to 32 µg/mL. Both products exhibited toxicity in <em>D. melanogaster</em>; however, citral showed higher toxicity with a precisely determined LC50 of 2.478 μL. As for the insecticidal action on <em>A. aegypti</em>, both products demonstrated toxicity with cumulative effects and dose-dependent mortality.</div></div>","PeriodicalId":23129,"journal":{"name":"Toxicology Reports","volume":"14 ","pages":"Article 101917"},"PeriodicalIF":0.0,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143104141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unlocking the multifaceted roles of GLP-1: Physiological functions and therapeutic potential 揭示GLP-1的多方面作用：生理功能和治疗潜力

Toxicology Reports Pub Date : 2025-01-16 DOI: 10.1016/j.toxrep.2025.101895

Tohada M. AL-Noshokaty , Rehab Abdelhamid , Nourhan M. Abdelmaksoud , Aya Khaled , Mariam Hossam , Razan Ahmed , Toka Saber , Shahd Khaled , Shereen Saeid Elshaer , Ahmed I. Abulsoud

{"title":"Unlocking the multifaceted roles of GLP-1: Physiological functions and therapeutic potential","authors":"Tohada M. AL-Noshokaty , Rehab Abdelhamid , Nourhan M. Abdelmaksoud , Aya Khaled , Mariam Hossam , Razan Ahmed , Toka Saber , Shahd Khaled , Shereen Saeid Elshaer , Ahmed I. Abulsoud","doi":"10.1016/j.toxrep.2025.101895","DOIUrl":"10.1016/j.toxrep.2025.101895","url":null,"abstract":"<div><div>Glucagon (GCG) like peptide 1 (GLP-1) has emerged as a powerful player in regulating metabolism and a promising therapeutic target for various chronic diseases. This review delves into the physiological roles of GLP-1, exploring its impact on glucose homeostasis, insulin secretion, and satiety. We examine the compelling evidence supporting GLP-1 receptor agonists (GLP-1RAs) in managing type 2 diabetes (T2D), obesity, and other diseases. The intricate molecular mechanisms underlying GLP-1RAs are explored, including their interactions with pathways like extracellular signal-regulated kinase 1/2 (ERK1/2), activated protein kinase (AMPK), cyclic adenine monophosphate (cAMP), mitogen-activated protein kinase (MAPK), and protein kinase C (PKC). Expanding our understanding, the review investigates the potential role of GLP-1 in cancers. Also, microribonucleic acid (RNA) (miRNAs), critical regulators of gene expression, are introduced as potential modulators of GLP-1 signaling. We delve into the link between miRNAs and T2D obesity and explore specific miRNA examples influencing GLP-1R function. Finally, the review explores the rationale for seeking alternatives to GLP-1RAs and highlights natural products with promising GLP-1 modulatory effects.</div></div>","PeriodicalId":23129,"journal":{"name":"Toxicology Reports","volume":"14 ","pages":"Article 101895"},"PeriodicalIF":0.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143099193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of real-time instrument use and absorbent tube method for measuring formaldehyde in working environments: A health risk assessment for gross anatomy staff 实时仪器与吸收管法在工作环境中测量甲醛的比较：对总解剖人员健康风险的评估

Toxicology Reports Pub Date : 2025-01-15 DOI: 10.1016/j.toxrep.2025.101913

Phanpina Soonklang , Arroon Ketsakorn , Nontiya Homkham , Chalermchai Chaikittiporn , Saowanee Norkaew

{"title":"Comparison of real-time instrument use and absorbent tube method for measuring formaldehyde in working environments: A health risk assessment for gross anatomy staff","authors":"Phanpina Soonklang , Arroon Ketsakorn , Nontiya Homkham , Chalermchai Chaikittiporn , Saowanee Norkaew","doi":"10.1016/j.toxrep.2025.101913","DOIUrl":"10.1016/j.toxrep.2025.101913","url":null,"abstract":"<div><div>Formaldehyde is widely used for the preservation of cadavers, exposing workers to potential risks of formaldehyde exposure in the workplace. This study compared the performance of real-time instruments (Gasmet) and absorbent tube methods in controlling formaldehyde levels in gross anatomy dissections with four working process areas. The concentrations of formaldehyde were determined over working periods ranging from 2 to 5 h. For the Gasmet results, a Monte Carlo simulation was applied in the uncertainty analysis to predict the formaldehyde concentration. Data collection involved questionnaires that included personal and work-related information. The Wilcoxon matched-pairs signed-rank test and intraclass correlation coefficients (ICC) were used to test–retest reliability between the two instruments. The results showed that the Gasmet direct reading and absorbent tube concentrations were not significantly different (<em>p</em> > 0.05) in all working areas and ICC was 0.939 indicating a highly reliable test result between the two measurements. The health-risk estimation indicated the hazard quotient and carcinogenic risk of formaldehyde. The carcinogenic risk was found to be unacceptable for all staff and processes, while the hazard quotient was found to be acceptable only in the body injection process. Future studies should employ a larger sample size and a greater number of sampling points to enhance the statistical power and precision of the results. The findings of this study can be used to improve work environments and develop strategies to reduce the risks for staff who work in gross anatomy dissections.</div></div>","PeriodicalId":23129,"journal":{"name":"Toxicology Reports","volume":"14 ","pages":"Article 101913"},"PeriodicalIF":0.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143099192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0