Toxicology Reports最新文献_第5页

Acute and sub-chronic oral toxicity evaluation and gut microbiota modulation of indigenous Lactobacillus helveticus strains from Indonesia in rats 印度尼西亚本土helveticus乳杆菌菌株对大鼠急性和亚慢性口服毒性评价和肠道菌群调节

Toxicology Reports Pub Date : 2026-06-01 Epub Date: 2026-06-03 DOI: 10.1016/j.toxrep.2026.102286

Hery Kristiana , Medicia Kartawijaya , Lita Tuentifiany , Apriliana Wahyu Hartanti , Raymond R. Tjandrawinata

{"title":"Acute and sub-chronic oral toxicity evaluation and gut microbiota modulation of indigenous Lactobacillus helveticus strains from Indonesia in rats","authors":"Hery Kristiana , Medicia Kartawijaya , Lita Tuentifiany , Apriliana Wahyu Hartanti , Raymond R. Tjandrawinata","doi":"10.1016/j.toxrep.2026.102286","DOIUrl":"10.1016/j.toxrep.2026.102286","url":null,"abstract":"<div><div>Probiotics are widely used to support gastrointestinal health, but their safety must be evaluated on a strain-specific basis. <em>Lactobacillus helveticus</em> DLBSA201 and DLBSA202 are indigenous strains with previously demonstrated probiotic potential in vitro. However, their <em>in vivo</em> safety profile has not been fully assessed. This study aimed to evaluate the acute and sub-chronic oral toxicity of these strains and their effects on selected gut microbial parameters in Wistar rats. In the acute toxicity study, rats received a single oral dose of <em>L. helveticus</em> DLBSA201 or DLBSA202 at 2.5 × 10<sup>10</sup>, 2.5 × 10<sup>11</sup>, or 5 × 10<sup>11</sup> CFU/rat. In the sub-chronic study, rats were orally administered a 1:1 mixture of both strains daily for 90 days at doses of 1 × 10<sup>9</sup>, 1 × 10<sup>10</sup>, or 1 × 10<sup>11</sup> CFU/rat/day. Clinical observations, hematological and biochemical parameters, histopathology, bacterial translocation, bacterial enzyme activity, and fecal microbiological analyses were evaluated. No mortality or treatment-related adverse effects were observed, and the LD50 of both strains was estimated to be greater than 5 × 10<sup>11</sup> CFU/rat. No significant treatment-related toxicological abnormalities were detected in the sub-chronic study, with a NOAEL of 1 × 10<sup>11</sup> CFU/rat/day. Probiotic administration was also associated with reduced harmful bacterial enzyme activity and altered selected fecal bacterial populations. In conclusion, <em>L. helveticus</em> DLBSA201 and DLBSA202 were well tolerated in Wistar rats at the tested dose range and study duration, and warrant further investigation using comprehensive microbiome and clinical approaches.</div></div>","PeriodicalId":23129,"journal":{"name":"Toxicology Reports","volume":"16 ","pages":"Article 102286"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148167658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling melatonin’s multifaceted actions against ferroptotic neurotoxicity in ischemic stroke 揭示褪黑素在缺血性中风中抗铁致神经毒性的多方面作用

Toxicology Reports Pub Date : 2026-06-01 Epub Date: 2026-02-10 DOI: 10.1016/j.toxrep.2026.102219

Soraya Boonmag , Russel J. Reiter , Piyarat Govitrapong

{"title":"Unveiling melatonin’s multifaceted actions against ferroptotic neurotoxicity in ischemic stroke","authors":"Soraya Boonmag , Russel J. Reiter , Piyarat Govitrapong","doi":"10.1016/j.toxrep.2026.102219","DOIUrl":"10.1016/j.toxrep.2026.102219","url":null,"abstract":"<div><div>Ferroptosis, an iron-mediated form of programmed cell death, is increasingly recognized for its role in neurodegenerative diseases, with relevance to ischemic stroke, a condition that creates a permissive environment for this process. The prevalence of ischemic stroke is steadily increasing, with its mortality rates rising startlingly in recent years. The urgency of timely intervention is of utmost importance, as failure to treat patients within the narrow therapeutic window often results in severe neurological damage, including severe paralysis or mortality. The pathology of ischemic stroke has been investigated to identify the underlying mechanism and determine efficient therapeutic strategies. Melatonin, a functionally versatile natural indoleamine, has shown promise in deferring neurodegenerative processes, including those associated with stroke. Melatonin exerts pleiotropic biological roles, including being a potent antioxidant, anti-inflammatory, iron chelator, neuroprotector, promoter of neurogenesis, and immune modulator. Recent studies on melatonin have also identified its efficacy in mitigating key events of ferroptosis, introducing it as an anti-ferroptosis agent. Herein, we highlight the prevailing concept of the pathophysiology of ischemic stroke, with emphasis on the emerging significance of ferroptotic neurotoxicity. Furthermore, we discussed recent research on the application of melatonin as a remedial intervention for ischemic stroke associated with ferroptosis.</div></div>","PeriodicalId":23129,"journal":{"name":"Toxicology Reports","volume":"16 ","pages":"Article 102219"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146173135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemical composition and anti-Alzheimer potential of medicinal plants from Central and West Africa: Systematic review 中非和西非药用植物的化学成分和抗阿尔茨海默病潜能：系统综述

Toxicology Reports Pub Date : 2026-06-01 Epub Date: 2026-01-14 DOI: 10.1016/j.toxrep.2026.102205

Protais Mukunzi , Ben Shalom Byishimo , Ekom Monday Etukudo , Hyppolyte Iradukunda , Darius Benimana , Ibe Michael Usman , Augustin Oviosun , Comfort Ojochenemi Usman , David Ikwuka , Wusa Makena , Victor Bassey Archibong

{"title":"Phytochemical composition and anti-Alzheimer potential of medicinal plants from Central and West Africa: Systematic review","authors":"Protais Mukunzi , Ben Shalom Byishimo , Ekom Monday Etukudo , Hyppolyte Iradukunda , Darius Benimana , Ibe Michael Usman , Augustin Oviosun , Comfort Ojochenemi Usman , David Ikwuka , Wusa Makena , Victor Bassey Archibong","doi":"10.1016/j.toxrep.2026.102205","DOIUrl":"10.1016/j.toxrep.2026.102205","url":null,"abstract":"<div><div>In recent time, the use of medicinal plants in the management of human disease conditions has gained immense attention. The aim of the present review was to explore the phytochemical composition and anti-Alzheimer potential of medicinal plants from Central and West Africa. A structured systematic approach was used to conduct the present systematic review of articles. Scopus, PubMed, and Web of Science were searched using the following search terms combined by Boolean operators: (“Alzheimer’s disease” OR “Neurodegenerative disease” OR \"Nervous system diseases\") AND (“Extract” OR \"herbs\" OR “Plant”) AND (“West Africa” OR “Central Africa” OR “Africa”) on the 6th of July 2024 without any filters. Following the conclusion of the title, abstract, and full text screening, only 13 articles were included. Most of the included studies (10/13, 77 %) were conducted between 2014 and 2024. Geographically, 9 (69 %) studies were conducted in Nigeria. Plants identified in the present study include: <em>Solanum macrocarpon</em>, <em>Solanum nigru, Pteleopsis suberosa, Macrosphyra longistyl, Beta vulgaris, Persea americana, Syzygium aromaticum, Citrullus lanatus, Cucumeropsis mannii, Lagenaria siceraria, Achyranthes aspera Linn., Tithonia diversifolia.</em> These plants were found to contain Luteolin, Catechin, Decanoic acid methyl ester, 11,14-Eicosadienoic acid methyl ester, Caffeic acid, Syringic acid, Azelaic acid. The plant-derived phytochemicals were reported to modulate critical Alzheimer’s disease (AD) pathways, notably oxidative stress, acetylcholinesterase (AChE) inhibition, and neuroinflammation. In conclusion, Central and West African medicinal plants represent a rich reservoir of multifunctional neuroprotective metabolites capable of targeting diverse AD pathways.</div></div>","PeriodicalId":23129,"journal":{"name":"Toxicology Reports","volume":"16 ","pages":"Article 102205"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145977241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human fluoroacetate poisoning: A case series of 36 patients in Vietnam 人类氟乙酸中毒：越南36例患者的系列病例

Toxicology Reports Pub Date : 2026-06-01 Epub Date: 2025-12-14 DOI: 10.1016/j.toxrep.2025.102189

Nguyen Dang Duc , Lam Nguyen Hong Anh , Lam Nguyen Hong Khanh , Nguyen Dang Bach

{"title":"Human fluoroacetate poisoning: A case series of 36 patients in Vietnam","authors":"Nguyen Dang Duc , Lam Nguyen Hong Anh , Lam Nguyen Hong Khanh , Nguyen Dang Bach","doi":"10.1016/j.toxrep.2025.102189","DOIUrl":"10.1016/j.toxrep.2025.102189","url":null,"abstract":"<div><div>Fluoroacetate poisoning is a rare but potentially lethal condition. We retrospectively reviewed 36 consecutive patients (27 males and 9 females) with confirmed poisoning treated at the Poison Control Center, Bach Mai Hospital, Hanoi, Vietnam, from June 2023 to December 2024. The mean age was 35.4 ± 12.6 years. The median time from ingestion to hospital admission was 3.5 h. On admission, 69.4 % of patients were asymptomatic, 22.2 % had seizures, and 8.3 % presented with altered consciousness. The mean Glasgow Coma Scale (GCS) score was 13.9 ± 2.0 (range 5–15). Median serum creatinine and creatine kinase (CK) levels were 72 µmol/L and 155 U/L, respectively; 16.7 % of patients had CK > 1000 U/L. Median ionized calcium was 1.015 mmol/L, and 19.4 % had serum lactate ≥ 2 mmol/L. Gastric lavage and activated charcoal were administered in 44.4 % and 36.1 % of cases, respectively. Six patients (16.7 %) required intensive care unit (ICU) admission, and no deaths occurred. Overall, most patients presented early with mild manifestations and had favorable short-term outcomes under supportive management.</div></div>","PeriodicalId":23129,"journal":{"name":"Toxicology Reports","volume":"16 ","pages":"Article 102189"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145791811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toxic exposure and kidney function: Urinary creatinine and glomerular filtration rate in traditional sulfur miners 毒性暴露与肾功能：传统硫磺矿工的尿肌酐和肾小球滤过率

Toxicology Reports Pub Date : 2026-06-01 Epub Date: 2026-04-29 DOI: 10.1016/j.toxrep.2026.102266

Septian Hadi Susetyo , Azham Umar Abidin , Taiki Nagaya , Emi Kawaguchi , Yasuto Matsui

{"title":"Toxic exposure and kidney function: Urinary creatinine and glomerular filtration rate in traditional sulfur miners","authors":"Septian Hadi Susetyo , Azham Umar Abidin , Taiki Nagaya , Emi Kawaguchi , Yasuto Matsui","doi":"10.1016/j.toxrep.2026.102266","DOIUrl":"10.1016/j.toxrep.2026.102266","url":null,"abstract":"<div><div>The Ijen Crater Volcano, recognized by UNESCO as a biosphere reserve, has a high sulfur content and is the main source of traditional sulfur mining work. However, exposure to natural sulfur in this area can cause health problems, especially in kidney function. This study aims to evaluate the relationship between exposure to toxic natural pollution and impaired kidney function. The study focuses on investigation of the toxic natural pollutants, namely SO<sub>2</sub> and heavy metals in the air. Urine samples were collected from 60 respondents who were divided into two groups: 30 sulfur miners as the exposure group (cases) and 30 local residents (control) who were not engaged in mining activities. Urine samples were collected for creatinine level analysis, and glomerular filtration rate (GFR) was calculated to assess kidney function. In the case group, 66% (20 out of 30) had urinary creatinine levels above the normal limit (≥1.3 mg/dL), while in the control group, only 30% (9 out of 30) exceeded this value. GFR analysis showed that only two respondents (6.7%) in the case group had normal kidney function (GFR ≥90 mL/min), while 53.3% (16 respondents) were in the moderate kidney function decline category (GFR 30–59 mL/min) and 13.3% (4 respondents) had severe kidney function decline (GFR 15–29 mL/min). In contrast, the control group had eight respondents (26.7%) with normal kidney function as well as a lower prevalence of moderate (23.3%) and severe (3.3%) kidney function decline. Exposure to toxic natural pollution in Ijen Crater Volcano was significantly associated with an increased risk of kidney function impairment, as indicated by higher urinary creatinine levels and lower GFR values in the case group. These results emphasize the importance of health surveillance and implementation of preventive measures for mine workers in this biosphere reserve area.</div></div>","PeriodicalId":23129,"journal":{"name":"Toxicology Reports","volume":"16 ","pages":"Article 102266"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148167656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of genomic instability using the CBMN cytome assay in mother-newborn pairs prenatally exposed to pesticides in Colombia 使用CBMN细胞组测定在哥伦比亚产前暴露于农药的母亲-新生儿对基因组不稳定性的评估

Toxicology Reports Pub Date : 2026-06-01 Epub Date: 2026-06-05 DOI: 10.1016/j.toxrep.2026.102288

Shirley Salcedo Arteaga , Ana Peñata Taborda , Sara Soto De Leon , Dina Ricardo Caldera , Ana Carolina Negrete , Lavínia Schüler-Faccini

{"title":"Assessment of genomic instability using the CBMN cytome assay in mother-newborn pairs prenatally exposed to pesticides in Colombia","authors":"Shirley Salcedo Arteaga , Ana Peñata Taborda , Sara Soto De Leon , Dina Ricardo Caldera , Ana Carolina Negrete , Lavínia Schüler-Faccini","doi":"10.1016/j.toxrep.2026.102288","DOIUrl":"10.1016/j.toxrep.2026.102288","url":null,"abstract":"<div><div>Agricultural communities in northern Colombia face high exposure to pesticides, posing significant health risks, particularly to vulnerable populations such as pregnant women and their developing fetuses. The genotoxic impact of in utero pesticide exposure remains poorly understood in this region. To assess the association between residential prenatal pesticide exposure and genomic instability in mother-newborn pairs from a rural agricultural area in Córdoba, Colombia. A case-control study was conducted with 86 mother-newborn pairs (45 exposed, 41 non-exposed). Sociodemographic and exposure data were collected via structured questionnaires. Genomic instability was evaluated in peripheral and umbilical cord blood lymphocytes using the comprehensive Cytokinesis-Block Micronucleus (CBMN) Cytome assay. A statistically significant increase in the frequency of micronucleated binucleated cells (MNBN) was observed in both mothers and newborns from the exposed group compared to the reference group (p < 0.05). Newborns in the exposed area showed a five-fold higher prevalence of elevated MNBN frequencies (PR = 5.15; 95% CI: 2.42–10.97, p < 0.0001), confirming a strong association with residential pesticide exposure. Prenatal exposure to pesticides is strongly associated with increased genomic instability in newborns, suggesting the hypothesis of transplacental transfer of genotoxic agents or their metabolites, though shared environmental exposures cannot be ruled out. These findings highlight a critical public health issue and underscore the need for protective policies to mitigate pesticide exposure in pregnant women in agricultural regions.</div></div>","PeriodicalId":23129,"journal":{"name":"Toxicology Reports","volume":"16 ","pages":"Article 102288"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148167659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective role of methylcobalamin (Vit B12) and pyridoxine (Vit B6) combination against teratogenic effects induced by lead in chick embryo 甲基钴胺素（Vit B12）和吡哆醇（Vit B6）联合对鸡胚铅致致畸作用的保护作用

Toxicology Reports Pub Date : 2026-06-01 Epub Date: 2026-05-27 DOI: 10.1016/j.toxrep.2026.102280

Rabia Idrees , Muhammad Ali Kanwal , Syeda Nadia Ahmad , Khawaja Raees Ahmad , Waheed Ahmad , Nazish Ghazanfar , Iram Inayat , Moattar Khalid , Sadia Suleman

{"title":"Protective role of methylcobalamin (Vit B12) and pyridoxine (Vit B6) combination against teratogenic effects induced by lead in chick embryo","authors":"Rabia Idrees , Muhammad Ali Kanwal , Syeda Nadia Ahmad , Khawaja Raees Ahmad , Waheed Ahmad , Nazish Ghazanfar , Iram Inayat , Moattar Khalid , Sadia Suleman","doi":"10.1016/j.toxrep.2026.102280","DOIUrl":"10.1016/j.toxrep.2026.102280","url":null,"abstract":"<div><div>Environmental contamination through heavy metals poses significant health risks and cause detrimental effects on embryonic development of humans and animals. This study investigates the teratogenic effects induced by lead – one of poisonous heavy metals, and rescuing potential of combined dose of vitamin B6 and vitamin B12 in golden black breed of domestic chicken embryos. Experiments were carried out on 200 fertilized eggs. Eggs were weighed and distributed into four groups (50 eggs each). <strong>1</strong>. <strong>Control group 0.1 mL</strong> of patent drinking water <strong>2</strong>. <strong>Vit-B6 + Vit-B12 combination group 0.05 mL</strong> of 0.1 mg/kg vitamin B6 solution + <strong>0.05 mL</strong> of 0.1 mg/kg vitamin B12 solution in patent drinking water. <strong>3. Lead acetate group 0.1 mL</strong> of 5 mg/kg lead acetate solution in patent drinking water. <strong>4. Lead acetate and Vit-B6 + Vit-B12 combination group 0.1 mL</strong> of solution containing 5 mg/kg lead acetate, 0.1 mg/kg vitamin B6 and 0.1 mg/kg vitamin B12 solution in patent drinking water. Recovery of embryos was performed on 14th day of incubation and embryos were preserved for further studies. Significant teratogenic effects were observed in lead treated group compared to control group. Microcephaly, exopthalomus eye, abnormal beak development, skewed spine, reduced neck length and torticollis were observed in lead treated group. Appendicular abnormalities include forelimb and hind limb amelia, meromelia in hind limbs. In some chick embryos agenesis and irregular development of claws was noted. Mortality rate was higher in lead group compared to control group. This study highlights vitamin B6 and vitamin B12 ameliorative effects against lead induced developmental abnormalities in chick embryo.</div></div>","PeriodicalId":23129,"journal":{"name":"Toxicology Reports","volume":"16 ","pages":"Article 102280"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148167736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to "When herbal supplements cause heart problems: clinical case report and forensic toxicological" [Toxicol. Rep. 16 (2026) 102239]. 《当草药补充剂引起心脏问题：临床病例报告和法医毒理学》的勘误表。众议员16(2026)102239]。

Toxicology Reports Pub Date : 2026-05-26 eCollection Date: 2026-06-01 DOI: 10.1016/j.toxrep.2026.102279

Theresa Theuer, Katrin Faber, Lisa Oberli, Thomas Schweingruber, Marie-Alice Fraiture, Nancy Roosens, Adrian Kindler, Alain Rudiger, Roman Leist, Celine Vanhee

引用次数: 0

Removal notice to "Vaccines and sudden infant death: An analysis of the VAERS database 1990-2019 and review of the medical literature" [Toxicol. Rep. 8 (2021) 1324-1335]. 《疫苗与婴儿猝死：对VAERS数据库1990-2019的分析和医学文献综述》的删除通知[毒理学杂志]。众议员8(2021)1324-1335]。

Toxicology Reports Pub Date : 2026-04-09 eCollection Date: 2026-06-01 DOI: 10.1016/j.toxrep.2026.102250

Neil Z Miller

引用次数: 0

Corrigendum to "Apoptotic endocrinal toxic effects of perchlorate in human placental cells" [Toxicol. Rep. 8 (2021) 863-870]. “高氯酸盐对人胎盘细胞凋亡的内分泌毒性作用”的更正[毒理学杂志]。众议员8(2021)863-870]。

Toxicology Reports Pub Date : 2026-02-26 eCollection Date: 2026-06-01 DOI: 10.1016/j.toxrep.2026.102228

Mona M Ali, Sarah A Khater, Amel Ahmed Fayed, Dina Sabry, Samah F Ibrahim

引用次数: 0