甲基苯丙胺中毒对伊拉克男性成瘾者急性肾损伤的影响。

Q1 Environmental Science
Toxicology Reports Pub Date : 2025-06-06 eCollection Date: 2025-06-01 DOI:10.1016/j.toxrep.2025.102065
Sazan A Mirza, Nawar S Mohammed, Zahraa Q Ali, Aseel Sameer Mohamed
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引用次数: 0

摘要

甲基苯丙胺(冰毒)是一种苯丙胺的合成衍生物,用于治疗嗜睡症等疾病,但有时也会从伪麻黄碱等非处方药中非法生产,以制造“冰毒”。吸食甲基苯丙胺会对许多器官系统产生严重影响,包括肾功能衰竭、神经毒性、肺毒性和心脏毒性。增加剂量的冰毒可以提高血压和心率,从而增加严重后果的可能性。与甲基苯丙胺相关的急性肾衰竭与肾脏问题有关,如血流量减少引起的肾小管坏死和急性间质性肾炎,后者损害肾小管并损害废物过滤。生物标志物如血清尿素、肌酐、胱抑素C和中性粒细胞明胶酶相关脂钙蛋白(NGAL)水平升高表明急性肾损伤(AKI)。甲基苯丙胺引起的肾功能衰竭通常与高热、血流动力学不稳定、横纹肌溶解和坏死性脉管炎、小管坏死和间质性肾炎等肾病相关。本研究调查了伊拉克男性冰毒成瘾者肾毒性与AKI之间的关系。这项研究于2023年1月至8月在巴格达的ibn - rush精神病院进行,研究对象是168名年龄在22-43岁之间的男性,他们吸毒超过60个月。另外,154名无药物使用史的健康男性作为对照。采用药检筛查卡进行确诊。评估肾功能(尿素、肌酐)、总蛋白、血清白蛋白、钠离子、胱抑素C、肌酸激酶和NGAL水平。结果显示上瘾者和对照组之间存在显著差异,特别是上瘾者胱抑素C、肌酸激酶和NGAL水平升高。ROC曲线分析显示,肾功能测试对甲基苯丙胺引起的肾损害的敏感性提高。对一名有7年冰毒滥用史的41岁死亡男性进行组织病理学检查,发现急性肾损伤的证据,并伴有肾功能生物标志物水平显著升高。研究结果表明,长期使用甲基苯丙胺可能会导致严重的肾脏损害,表现为肾脏的结构损伤和肾功能的明显破坏。本研究强调了甲基苯丙胺对肾功能的严重影响,并强调了预防措施和有效治疗策略对控制甲基苯丙胺成瘾和减轻其有害影响的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The effects of methamphetamine intoxication on acute kidney injury in Iraqi male addicts.

Methamphetamine (METH), a synthetic derivative of amphetamine, is prescribed for disorders such as narcolepsy but is sometimes illicitly produced from over-the-counter drugs like pseudoephedrine to produce "crystal meth." Consumption of METH can have a severe impact on a number of organ systems, including renal failure, neurotoxicity, pulmonary toxicity, and cardiotoxicity. Increased doses of METH can elevate blood pressure and heart rate, hence enhancing the chance of serious repercussions. Acute renal failure associated with METH is linked to kidney issues such as renal tubular necrosis, caused by reduced blood flow, and acute interstitial nephritis, which damages kidney tubules and impairs waste filtration. Biomarkers such as elevated serum levels of urea, creatinine, cystatin C, and neutrophil gelatinase-associated lipocalin (NGAL) indicate acute kidney injury (AKI). METH-induced renal failure often correlates with hyperthermia, hemodynamic instability, rhabdomyolysis, and nephropathies like necrotizing angiitis, tubular necrosis, and interstitial nephritis. This study investigates the association between kidney toxicity and AKI in Iraqi males with METH addiction. The research, carried out at Ibn-Rushed Psychiatric Hospital in Baghdad between January and August 2023, involved 168 males aged 22-43 who had been addicted for over 60 months. Additionally, 154 healthy males with no history of drug use served as controls. Drug test screening cards were utilized to confirm the diagnosis. Kidney function tests (urea, creatinine), total protein, serum albumin, sodium ions, cystatin C, creatine kinase, and NGAL levels were assessed. Results revealed significant differences between addicts and controls, particularly elevated cystatin C, creatine kinase, and NGAL levels in addicts. A ROC curve analysis demonstrated heightened sensitivity of kidney function tests to METH-induced renal damage. Histopathological examination of a deceased male, aged 41-year-old, with a seven-year history of METH abuse revealed evidence of acute kidney injury, accompanied by significantly elevated levels of renal function biomarkers. The findings suggest that prolonged methamphetamine use may have contributed to severe renal impairment, manifesting in both structural damage to the kidneys and a marked disruption in renal function. This study highlights the severe impact of METH on kidney function and underscores the importance of preventive measures and effective treatment strategies for managing METH addiction and mitigating its harmful effects.

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Toxicology Reports
Toxicology Reports Environmental Science-Health, Toxicology and Mutagenesis
CiteScore
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